bestrophin 1 (BEST1) - coding DNA reference sequence

(used for variant description)

(last modified February 27, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_004183.3 in the BEST1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009033.1, covering BEST1 transcript NM_004183.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     caaggctgggaccagaaaccaggactgttgactgcagccc       c.-541

 .         .         .         .         .         .                g.5100
 ggtattcattctttccatagcccacagggctgtcaaagaccccagggcctagtcagaggc       c.-481

 .         .         .         .         .         .                g.5160
 tcctccttcctggagagttcctggcacagaagttgaagctcagcacagccccctaacccc       c.-421

 .         .         .         .         .         .                g.5220
 caactctctctgcaaggcctcaggggtcagaacactggtggagcagatcctttagcctct       c.-361

 .         .         .         .         .         .                g.5280
 ggattttagggccatggtagagggggtgttgccctaaattccagccctggtctcagccca       c.-301

 .         .         .         .         .         .                g.5340
 acaccctccaagaagaaattagaggggccatggccaggctgtgctagccgttgcttctga       c.-241

 .         .         .         .         .         .                g.5400
 gcagattacaagaagggactaagacaaggactcctttgtggaggtcctggcttagggagt       c.-181

 .         .         .         .         .         .                g.5460
 caagtgacggcggctcagcactcacgtgggcagtgccagcctctaagagtgggcaggggc       c.-121

 .         .         .         .         .         .                g.5520
 actggccacagagtcccagggagtcccaccagcctagtcgccagaccttctgtgggatca       c.-61

 .         .         .    | 02    .         .         .             g.6923
 tcggacccacctggaaccccacct | gacccaagcccacctgctgcagcccactgcctggcc    c.-1

          .         .         .         .         .         .       g.6983
 ATGACCATCACTTACACAAGCCAAGTGGCTAATGCCCGCTTAGGCTCCTTCTCCCGCCTG       c.60
 M  T  I  T  Y  T  S  Q  V  A  N  A  R  L  G  S  F  S  R  L         p.20

          .         .         .         .         .         .       g.7043
 CTGCTGTGCTGGCGGGGCAGCATCTACAAGCTGCTATATGGCGAGTTCTTAATCTTCCTG       c.120
 L  L  C  W  R  G  S  I  Y  K  L  L  Y  G  E  F  L  I  F  L         p.40

          .         .         .   | 03     .         .         .    g.10251
 CTCTGCTACTACATCATCCGCTTTATTTATAG | GCTGGCCCTCACGGAAGAACAACAGCTG    c.180
 L  C  Y  Y  I  I  R  F  I  Y  R  |  L  A  L  T  E  E  Q  Q  L      p.60

          .         .         .         .         .         .       g.10311
 ATGTTTGAGAAACTGACTCTGTATTGCGACAGCTACATCCAGCTCATCCCCATTTCCTTC       c.240
 M  F  E  K  L  T  L  Y  C  D  S  Y  I  Q  L  I  P  I  S  F         p.80

         | 04.         .         .         .         .         .    g.10887
 GTGCTGG | GCTTCTACGTGACGCTGGTCGTGACCCGCTGGTGGAACCAGTACGAGAACCTG    c.300
 V  L  G |   F  Y  V  T  L  V  V  T  R  W  W  N  Q  Y  E  N  L      p.100

          .         .         .         .         .         .       g.10947
 CCGTGGCCCGACCGCCTCATGAGCCTGGTGTCGGGCTTCGTCGAAGGCAAGGACGAGCAA       c.360
 P  W  P  D  R  L  M  S  L  V  S  G  F  V  E  G  K  D  E  Q         p.120

          .         .         .         .         .         .       g.11007
 GGCCGGCTGCTGCGGCGCACGCTCATCCGCTACGCCAACCTGGGCAACGTGCTCATCCTG       c.420
 G  R  L  L  R  R  T  L  I  R  Y  A  N  L  G  N  V  L  I  L         p.140

          .         .         .         .         .         .       g.11067
 CGCAGCGTCAGCACCGCAGTCTACAAGCGCTTCCCCAGCGCCCAGCACCTGGTGCAAGCA       c.480
 R  S  V  S  T  A  V  Y  K  R  F  P  S  A  Q  H  L  V  Q  A         p.160

   | 05      .         .         .         .         .         .    g.12019
 G | GCTTTATGACTCCGGCAGAACACAAGCAGTTGGAGAAACTGAGCCTACCACACAACATG    c.540
 G |   F  M  T  P  A  E  H  K  Q  L  E  K  L  S  L  P  H  N  M      p.180

          .         .         .         .         .         .       g.12079
 TTCTGGGTGCCCTGGGTGTGGTTTGCCAACCTGTCAATGAAGGCGTGGCTTGGAGGTCGA       c.600
 F  W  V  P  W  V  W  F  A  N  L  S  M  K  A  W  L  G  G  R         p.200

          .         .         .       | 06 .         .         .    g.12527
 ATCCGGGACCCTATCCTGCTCCAGAGCCTGCTGAAC | GAGATGAACACCTTGCGTACTCAG    c.660
 I  R  D  P  I  L  L  Q  S  L  L  N   | E  M  N  T  L  R  T  Q      p.220

          .         .         .         .         .     | 07   .    g.13268
 TGTGGACACCTGTATGCCTACGACTGGATTAGTATCCCACTGGTGTATACACAG | GTGGTG    c.720
 C  G  H  L  Y  A  Y  D  W  I  S  I  P  L  V  Y  T  Q   | V  V      p.240

          .         .         .         .         .         .       g.13328
 ACTGTGGCGGTGTACAGCTTCTTCCTGACTTGTCTAGTTGGGCGGCAGTTTCTGAACCCA       c.780
 T  V  A  V  Y  S  F  F  L  T  C  L  V  G  R  Q  F  L  N  P         p.260

          .         .         .         .         .         .       g.13388
 GCCAAGGCCTACCCTGGCCATGAGCTGGACCTCGTTGTGCCCGTCTTCACGTTCCTGCAG       c.840
 A  K  A  Y  P  G  H  E  L  D  L  V  V  P  V  F  T  F  L  Q         p.280

          .         .        | 08.         .         .         .    g.14647
 TTCTTCTTCTATGTTGGCTGGCTGAAG | GTGGCAGAGCAGCTCATCAACCCCTTTGGAGAG    c.900
 F  F  F  Y  V  G  W  L  K   | V  A  E  Q  L  I  N  P  F  G  E      p.300

          .         .         .         .         | 09         .    g.15020
 GATGATGATGATTTTGAGACCAACTGGATTGTCGACAGGAATTTGCAG | GTGTCCCTGTTG    c.960
 D  D  D  D  F  E  T  N  W  I  V  D  R  N  L  Q   | V  S  L  L      p.320

          .         .         .         .         .         .       g.15080
 GCTGTGGATGAGATGCACCAGGACCTGCCTCGGATGGAGCCGGACATGTACTGGAATAAG       c.1020
 A  V  D  E  M  H  Q  D  L  P  R  M  E  P  D  M  Y  W  N  K         p.340

          .         .         .         .         .         .       g.15140
 CCCGAGCCACAGCCCCCCTACACAGCTGCTTCCGCCCAGTTCCGTCGAGCCTCCTTTATG       c.1080
 P  E  P  Q  P  P  Y  T  A  A  S  A  Q  F  R  R  A  S  F  M         p.360

          .         . | 10       .         .         .         .    g.17411
 GGCTCCACCTTCAACATCAG | CCTGAACAAAGAGGAGATGGAGTTCCAGCCCAATCAGGAG    c.1140
 G  S  T  F  N  I  S  |  L  N  K  E  E  M  E  F  Q  P  N  Q  E      p.380

          .         .         .         .         .         .       g.17471
 GACGAGGAGGATGCTCACGCTGGCATCATTGGCCGCTTCCTAGGCCTGCAGTCCCATGAT       c.1200
 D  E  E  D  A  H  A  G  I  I  G  R  F  L  G  L  Q  S  H  D         p.400

          .         .         .         .         .         .       g.17531
 CACCATCCTCCCAGGGCAAACTCAAGGACCAAACTACTGTGGCCCAAGAGGGAATCCCTT       c.1260
 H  H  P  P  R  A  N  S  R  T  K  L  L  W  P  K  R  E  S  L         p.420

          .         .         .         .         .         .       g.17591
 CTCCACGAGGGCCTGCCCAAAAACCACAAGGCAGCCAAACAGAACGTTAGGGGCCAGGAA       c.1320
 L  H  E  G  L  P  K  N  H  K  A  A  K  Q  N  V  R  G  Q  E         p.440

          .         .         .         .         .         .       g.17651
 GACAACAAGGCCTGGAAGCTTAAGGCTGTGGACGCCTTCAAGTCTGCCCCACTGTATCAG       c.1380
 D  N  K  A  W  K  L  K  A  V  D  A  F  K  S  A  P  L  Y  Q         p.460

          .         .         .         .         .         .       g.17711
 AGGCCAGGCTACTACAGTGCCCCACAGACGCCCCTCAGCCCCACTCCCATGTTCTTCCCC       c.1440
 R  P  G  Y  Y  S  A  P  Q  T  P  L  S  P  T  P  M  F  F  P         p.480

          .         .         .         .         .         .       g.17771
 CTAGAACCATCAGCGCCGTCAAAGCTTCACAGTGTCACAGGCATAGACACCAAAGACAAA       c.1500
 L  E  P  S  A  P  S  K  L  H  S  V  T  G  I  D  T  K  D  K         p.500

          .         .         .         .         .         .       g.17831
 AGCTTAAAGACTGTGAGTTCTGGGGCCAAGAAAAGTTTTGAATTGCTCTCAGAGAGCGAT       c.1560
 S  L  K  T  V  S  S  G  A  K  K  S  F  E  L  L  S  E  S  D         p.520

          .         .         .         .         .         .       g.17891
 GGGGCCTTGATGGAGCACCCAGAAGTATCTCAAGTGAGGAGGAAAACTGTGGAGTTTAAC       c.1620
 G  A  L  M  E  H  P  E  V  S  Q  V  R  R  K  T  V  E  F  N         p.540

          .         .         .         .         .         .       g.17951
 CTGACGGATATGCCAGAGATCCCCGAAAATCACCTCAAAGAACCTTTGGAACAATCACCA       c.1680
 L  T  D  M  P  E  I  P  E  N  H  L  K  E  P  L  E  Q  S  P         p.560

          .         .         .         .         .          | 11    g.19221
 ACCAACATACACACTACACTCAAAGATCACATGGATCCTTATTGGGCCTTGGAAAACAG | G    c.1740
 T  N  I  H  T  T  L  K  D  H  M  D  P  Y  W  A  L  E  N  R  |      p.580

          .                                                         g.19239
 GATGAAGCACATTCCTAA                                                 c.1758
 D  E  A  H  S  X                                                   p.585

          .         .         .         .         .         .       g.19299
 cctgcttcctaatggggatgcttcgccagccaggtcctcacctgtgtgtacaccagcagg       c.*60

          .         .         .         .         .         .       g.19359
 acactgatccagtcacagccatacagctgtccacactgaagaacatgtcctacaacagcc       c.*120

          .         .         .         .         .         .       g.19419
 tgaatcaaatggttagcttaatagataaaaatcccagactacttcagcctttaatgcctt       c.*180

          .         .         .         .         .         .       g.19479
 ttattcataaaaactgtgaaagctagactgaaccattggaaacatttaactcagactctg       c.*240

          .         .         .         .         .         .       g.19539
 gattcagagtcgggaacccttagttctatctgaatccaagacagccacaccttagtatac       c.*300

          .         .         .         .                           g.19580
 tgcccaaactaatgagtttaataaatacaaatactcgtttc                          c.*341

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bestrophin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 12
©2004-2015 Leiden University Medical Center