guanylate cyclase 2D, membrane (retina-specific) (GUCY2D) - coding DNA reference sequence

(used for variant description)

(last modified February 28, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_000180.3 in the GUCY2D gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009092.1, covering GUCY2D transcript NM_000180.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               caaaagggggaccg       c.-61

 .         .         .         .         .         . | 02           g.5378
 gccctgtgacccctcaccgggggccgtgggcccgagcccccggacttccct | aagccggca    c.-1

          .         .         .         .         .         .       g.5438
 ATGACCGCCTGCGCCCGCCGAGCGGGTGGGCTTCCGGACCCCGGGCTCTGCGGTCCCGCG       c.60
 M  T  A  C  A  R  R  A  G  G  L  P  D  P  G  L  C  G  P  A         p.20

          .         .         .         .         .         .       g.5498
 TGGTGGGCTCCGTCCCTGCCCCGCCTCCCCCGGGCCCTGCCCCGGCTCCCGCTCCTGCTG       c.120
 W  W  A  P  S  L  P  R  L  P  R  A  L  P  R  L  P  L  L  L         p.40

          .         .         .         .         .         .       g.5558
 CTCCTGCTTCTGCTGCAGCCCCCCGCCCTCTCCGCCGTGTTCACGGTGGGGGTCCTGGGC       c.180
 L  L  L  L  L  Q  P  P  A  L  S  A  V  F  T  V  G  V  L  G         p.60

          .         .         .         .         .         .       g.5618
 CCCTGGGCTTGCGACCCCATCTTCTCTCGGGCTCGCCCGGACCTGGCCGCCCGCCTGGCC       c.240
 P  W  A  C  D  P  I  F  S  R  A  R  P  D  L  A  A  R  L  A         p.80

          .         .         .         .         .         .       g.5678
 GCCGCCCGCCTGAACCGCGACCCCGGCCTGGCAGGCGGTCCCCGCTTCGAGGTAGCGCTG       c.300
 A  A  R  L  N  R  D  P  G  L  A  G  G  P  R  F  E  V  A  L         p.100

          .         .         .         .         .         .       g.5738
 CTGCCCGAGCCTTGCCGGACGCCGGGCTCGCTGGGGGCCGTGTCCTCCGCGCTGGCCCGC       c.360
 L  P  E  P  C  R  T  P  G  S  L  G  A  V  S  S  A  L  A  R         p.120

          .         .         .         .         .         .       g.5798
 GTGTCGGGCCTCGTGGGTCCGGTGAACCCTGCGGCCTGCCGGCCAGCCGAGCTGCTCGCC       c.420
 V  S  G  L  V  G  P  V  N  P  A  A  C  R  P  A  E  L  L  A         p.140

          .         .         .         .         .         .       g.5858
 GAAGAAGCCGGGATCGCGCTGGTGCCCTGGGGCTGCCCCTGGACGCAGGCGGAGGGCACC       c.480
 E  E  A  G  I  A  L  V  P  W  G  C  P  W  T  Q  A  E  G  T         p.160

          .         .         .         .         .         .       g.5918
 ACGGCCCCTGCCGTGACCCCCGCCGCGGATGCCCTCTACGCCCTGCTTCGCGCATTCGGC       c.540
 T  A  P  A  V  T  P  A  A  D  A  L  Y  A  L  L  R  A  F  G         p.180

          .         .         .         .         .         .       g.5978
 TGGGCGCGCGTGGCCCTGGTCACCGCCCCCCAGGACCTGTGGGTGGAGGCGGGACGCTCA       c.600
 W  A  R  V  A  L  V  T  A  P  Q  D  L  W  V  E  A  G  R  S         p.200

          .         .         .         .         .         .       g.6038
 CTGTCCACGGCACTCAGGGCCCGGGGCCTGCCTGTCGCCTCCGTGACTTCCATGGAGCCC       c.660
 L  S  T  A  L  R  A  R  G  L  P  V  A  S  V  T  S  M  E  P         p.220

          .         .         .         .         .         .       g.6098
 TTGGACCTGTCTGGAGCCCGGGAGGCCCTGAGGAAGGTTCGGGACGGGCCCAGGGTCACA       c.720
 L  D  L  S  G  A  R  E  A  L  R  K  V  R  D  G  P  R  V  T         p.240

   | 03      .         .         .         .         .         .    g.6241
 G | CAGTGATCATGGTGATGCACTCGGTGCTGCTGGGTGGCGAGGAGCAGCGCTACCTCCTG    c.780
 A |   V  I  M  V  M  H  S  V  L  L  G  G  E  E  Q  R  Y  L  L      p.260

          .         .         .         .         .         .       g.6301
 GAGGCCGCAGAGGAGCTGGGCCTGACCGATGGCTCCCTGGTCTTCCTGCCCTTCGACACG       c.840
 E  A  A  E  E  L  G  L  T  D  G  S  L  V  F  L  P  F  D  T         p.280

          .         .         .         .         .         .       g.6361
 ATCCACTACGCCTTGTCCCCAGGCCCGGAGGCCTTGGCCGCACTCGCCAACAGCTCCCAG       c.900
 I  H  Y  A  L  S  P  G  P  E  A  L  A  A  L  A  N  S  S  Q         p.300

          .         .         .         .         .         .       g.6421
 CTTCGCAGGGCCCACGATGCCGTGCTCACCCTCACGCGCCACTGTCCCTCTGAAGGCAGC       c.960
 L  R  R  A  H  D  A  V  L  T  L  T  R  H  C  P  S  E  G  S         p.320

          .         .         .         .         .         .       g.6481
 GTGCTGGACAGCCTGCGCAGGGCTCAAGAGCGCCGCGAGCTGCCCTCTGACCTCAATCTG       c.1020
 V  L  D  S  L  R  R  A  Q  E  R  R  E  L  P  S  D  L  N  L         p.340

        | 04 .         .         .         .         .         .    g.8747
 CAGCAG | GTCTCCCCACTCTTTGGCACCATCTATGACGCGGTCTTCTTGCTGGCAAGGGGC    c.1080
 Q  Q   | V  S  P  L  F  G  T  I  Y  D  A  V  F  L  L  A  R  G      p.360

          .         .         .         .         .         .       g.8807
 GTGGCAGAAGCGCGGGCTGCCGCAGGTGGCAGATGGGTGTCCGGAGCAGCTGTGGCCCGC       c.1140
 V  A  E  A  R  A  A  A  G  G  R  W  V  S  G  A  A  V  A  R         p.380

          .         .         .         .         .         .       g.8867
 CACATCCGGGATGCGCAGGTCCCTGGCTTCTGCGGGGACCTAGGAGGAGACGAGGAGCCC       c.1200
 H  I  R  D  A  Q  V  P  G  F  C  G  D  L  G  G  D  E  E  P         p.400

          .         .         .         .         .         .       g.8927
 CCATTCGTGCTGCTAGACACGGACGCGGCGGGAGACCGGCTTTTTGCCACATACATGCTG       c.1260
 P  F  V  L  L  D  T  D  A  A  G  D  R  L  F  A  T  Y  M  L         p.420

          .         .         .         .         .         .       g.8987
 GATCCTGCCCGGGGCTCCTTCCTCTCCGCCGGTACCCGGATGCACTTCCCGCGTGGGGGA       c.1320
 D  P  A  R  G  S  F  L  S  A  G  T  R  M  H  F  P  R  G  G         p.440

          .         .         .         .         .         | 05    g.9392
 TCAGCACCCGGACCTGACCCCTCGTGCTGGTTCGATCCAAACAACATCTGCGGTGGAG | GA    c.1380
 S  A  P  G  P  D  P  S  C  W  F  D  P  N  N  I  C  G  G  G |       p.460

          .         .         .         .         .         .       g.9452
 CTGGAGCCGGGCCTCGTCTTTCTTGGCTTCCTCCTGGTGGTTGGGATGGGGCTGGCTGGG       c.1440
 L  E  P  G  L  V  F  L  G  F  L  L  V  V  G  M  G  L  A  G         p.480

          .         .    | 06    .         .         .         .    g.9793
 GCCTTCCTGGCCCATTATGTGAG | GCACCGGCTACTTCACATGCAAATGGTCTCCGGCCCC    c.1500
 A  F  L  A  H  Y  V  R  |  H  R  L  L  H  M  Q  M  V  S  G  P      p.500

          .         .         .         .         .         .       g.9853
 AACAAGATCATCCTGACCGTGGACGACATCACCTTTCTCCACCCACATGGGGGCACCTCT       c.1560
 N  K  I  I  L  T  V  D  D  I  T  F  L  H  P  H  G  G  T  S         p.520

        | 07 .         .         .         .         .         .    g.10315
 CGAAAG | GTGGCCCAGGGGAGTCGATCAAGTCTGGGTGCCCGCAGCATGTCAGACATTCGC    c.1620
 R  K   | V  A  Q  G  S  R  S  S  L  G  A  R  S  M  S  D  I  R      p.540

          .         .         .         .         | 08         .    g.11848
 AGCGGCCCCAGCCAACACTTGGACAGCCCCAACATTGGTGTCTATGAG | GGAGACAGGGTT    c.1680
 S  G  P  S  Q  H  L  D  S  P  N  I  G  V  Y  E   | G  D  R  V      p.560

          .         .         .         .         .         .       g.11908
 TGGCTGAAGAAATTCCCAGGGGATCAGCACATAGCTATCCGCCCAGCAACCAAGACGGCC       c.1740
 W  L  K  K  F  P  G  D  Q  H  I  A  I  R  P  A  T  K  T  A         p.580

           | 09        .         .         .         .         .    g.14525
 TTCTCCAAG | CTCCAGGAGCTCCGGCATGAGAACGTGGCCCTCTACCTGGGGCTTTTCCTG    c.1800
 F  S  K   | L  Q  E  L  R  H  E  N  V  A  L  Y  L  G  L  F  L      p.600

          .         .         .         .         .         .       g.14585
 GCTCGGGGAGCAGAAGGCCCTGCGGCCCTCTGGGAGGGCAACCTGGCTGTGGTCTCAGAG       c.1860
 A  R  G  A  E  G  P  A  A  L  W  E  G  N  L  A  V  V  S  E         p.620

          .         .         .         .         .         .       g.14645
 CACTGCACGCGGGGCTCTCTTCAGGACCTCCTCGCTCAGAGAGAAATAAAGCTGGACTGG       c.1920
 H  C  T  R  G  S  L  Q  D  L  L  A  Q  R  E  I  K  L  D  W         p.640

          .         .         .       | 10 .         .         .    g.14804
 ATGTTCAAGTCCTCCCTCCTGCTGGACCTTATCAAG | GGAATAAGGTATCTGCACCATCGA    c.1980
 M  F  K  S  S  L  L  L  D  L  I  K   | G  I  R  Y  L  H  H  R      p.660

          .         .         .         .         .         .       g.14864
 GGCGTGGCTCATGGGCGGCTGAAGTCACGGAACTGCATAGTGGATGGCAGATTCGTACTC       c.2040
 G  V  A  H  G  R  L  K  S  R  N  C  I  V  D  G  R  F  V  L         p.680

          .         .         .         .         .         .       g.14924
 AAGATCACTGACCACGGCCACGGGAGACTGCTGGAAGCACAGAAGGTGCTACCGGAGCCT       c.2100
 K  I  T  D  H  G  H  G  R  L  L  E  A  Q  K  V  L  P  E  P         p.700

          .    | 11    .         .         .         .         .    g.15480
 CCCAGAGCGGAGG | ACCAGCTGTGGACAGCCCCGGAGCTGCTTAGGGACCCAGCCCTGGAG    c.2160
 P  R  A  E  D |   Q  L  W  T  A  P  E  L  L  R  D  P  A  L  E      p.720

          .         .         .         .         .         .       g.15540
 CGCCGGGGAACGCTGGCCGGCGACGTCTTTAGCTTGGCCATCATCATGCAAGAAGTAGTG       c.2220
 R  R  G  T  L  A  G  D  V  F  S  L  A  I  I  M  Q  E  V  V         p.740

          .         .         .         .    | 12    .         .    g.16227
 TGCCGCAGTGCCCCTTATGCCATGCTGGAGCTCACTCCCGAGG | AAGTGGTGCAGAGGGTG    c.2280
 C  R  S  A  P  Y  A  M  L  E  L  T  P  E  E |   V  V  Q  R  V      p.760

          .         .         .         .         .         .       g.16287
 CGGAGCCCCCCTCCACTGTGTCGGCCCTTGGTGTCCATGGACCAGGCACCTGTCGAGTGT       c.2340
 R  S  P  P  P  L  C  R  P  L  V  S  M  D  Q  A  P  V  E  C         p.780

          .         .         .         .         .         .       g.16347
 ATCCTCCTGATGAAGCAGTGCTGGGCAGAGCAGCCGGAACTTCGGCCCTCCATGGACCAC       c.2400
 I  L  L  M  K  Q  C  W  A  E  Q  P  E  L  R  P  S  M  D  H         p.800

          .   | 13     .         .         .         .         .    g.16979
 ACCTTCGACCTG | TTCAAGAACATCAACAAGGGCCGGAAGACGAACATCATTGACTCGATG    c.2460
 T  F  D  L   | F  K  N  I  N  K  G  R  K  T  N  I  I  D  S  M      p.820

          .         .         .         .         .         .       g.17039
 CTTCGGATGCTGGAGCAGTACTCTAGTAACCTGGAGGATCTGATCCGGGAGCGCACGGAG       c.2520
 L  R  M  L  E  Q  Y  S  S  N  L  E  D  L  I  R  E  R  T  E         p.840

          .         .         .         .         .       | 14 .    g.17193
 GAGCTGGAGCTGGAAAAGCAGAAGACAGACCGGCTGCTTACACAGATGCTGCCTCC | GTCT    c.2580
 E  L  E  L  E  K  Q  K  T  D  R  L  L  T  Q  M  L  P  P  |  S      p.860

          .         .         .         .         .         .       g.17253
 GTGGCTGAGGCCTTGAAGACGGGGACACCAGTGGAGCCCGAGTACTTTGAGCAAGTGACA       c.2640
 V  A  E  A  L  K  T  G  T  P  V  E  P  E  Y  F  E  Q  V  T         p.880

          .         .         .         .         .         .       g.17313
 CTGTACTTTAGTGACATTGTGGGCTTCACCACCATCTCTGCCATGAGTGAGCCCATTGAG       c.2700
 L  Y  F  S  D  I  V  G  F  T  T  I  S  A  M  S  E  P  I  E         p.900

          .         .         .         .         .         .       g.17373
 GTTGTGGACCTGCTCAACGATCTCTACACACTCTTTGATGCCATCATTGGTTCCCACGAT       c.2760
 V  V  D  L  L  N  D  L  Y  T  L  F  D  A  I  I  G  S  H  D         p.920

           | 15        .         .         .         .         .    g.17709
 GTCTACAAG | GTGGAGACAATAGGGGACGCCTATATGGTGGCCTCGGGGCTGCCCCAGCGG    c.2820
 V  Y  K   | V  E  T  I  G  D  A  Y  M  V  A  S  G  L  P  Q  R      p.940

          .         .         .         .         .         .       g.17769
 AATGGGCAGCGACACGCGGCAGAGATCGCCAACATGTCACTGGACATCCTCAGTGCCGTG       c.2880
 N  G  Q  R  H  A  A  E  I  A  N  M  S  L  D  I  L  S  A  V         p.960

          .         .         .         .         .         .       g.17829
 GGCACTTTCCGCATGCGCCATATGCCTGAGGTTCCCGTGCGCATCCGCATAGGCCTGCAC       c.2940
 G  T  F  R  M  R  H  M  P  E  V  P  V  R  I  R  I  G  L  H         p.980

      | 16   .         .         .         .         .         .    g.18129
 TCGG | GTCCATGCGTGGCAGGCGTGGTGGGCCTCACCATGCCGCGGTACTGCCTGTTTGGG    c.3000
 S  G |   P  C  V  A  G  V  V  G  L  T  M  P  R  Y  C  L  F  G      p.1000

          .         .         .         .    | 17    .         .    g.18274
 GACACGGTCAACACCGCCTCGCGCATGGAGTCCACCGGGCTGC | CTTACCGCATCCACGTG    c.3060
 D  T  V  N  T  A  S  R  M  E  S  T  G  L  P |   Y  R  I  H  V      p.1020

          .         .         .         .         .         .       g.18334
 AACTTGAGCACTGTGGGGATTCTCCGTGCTCTGGACTCGGGCTACCAGGTGGAGCTGCGA       c.3120
 N  L  S  T  V  G  I  L  R  A  L  D  S  G  Y  Q  V  E  L  R         p.1040

          .         | 18         .         .         .         .    g.18577
 GGCCGCACGGAGCTGAAG | GGCAAGGGCGCCGAGGACACTTTCTGGCTAGTGGGCAGACGC    c.3180
 G  R  T  E  L  K   | G  K  G  A  E  D  T  F  W  L  V  G  R  R      p.1060

          .         .         .         .     | 19   .         .    g.18789
 GGCTTCAACAAGCCCATCCCCAAACCGCCTGACCTGCAACCGGG | GTCCAGCAACCACGGC    c.3240
 G  F  N  K  P  I  P  K  P  P  D  L  Q  P  G  |  S  S  N  H  G      p.1080

          .         .         .         .         .         .       g.18849
 ATCAGCCTGCAGGAGATCCCACCCGAGCGGCGACGGAAGCTGGAGAAGGCGCGGCCGGGC       c.3300
 I  S  L  Q  E  I  P  P  E  R  R  R  K  L  E  K  A  R  P  G         p.1100

          .                                                     g.18861
 CAGTTCTCTTGA |                                                    c.3313
 Q  F  S  X                                                      p.1103

          .         .     | 20   .         .         .         .    g.22494
 gaagtgaggcccggccccggacag | ggtctgggccctgctccctgtcccatctgcagtgga    c.*60

          .         .         .         .         .         .       g.22554
 ccccaggcacccccctttgaggaggtggggtgaactgctccttggcagggatttgtgaca       c.*120

          .         .         .         .         .         .       g.22614
 ctgcattgctgggctgtgttcctcgggctcttctggaccttgcaccgtggataccaggcc       c.*180

          .         .         .         .         .                 g.22671
 atgtgccatggtatttgggtcctgggagggtgggtgaaataaaggcatgctgtcttc          c.*237

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Guanylate cyclase 2D, membrane (retina-specific) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 12
©2004-2015 Leiden University Medical Center