KIT ligand (KITLG) - coding DNA reference sequence

(used for variant description)

(last modified July 21, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000899.4 in the KITLG gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012098.1, covering KITLG transcript NM_000899.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5003
                                              gggcttcgctcgccg       c.-181

 .         .         .         .         .         .                g.5063
 cctcgcgccgagactagaagcgctgcgggaagcagggacagtggagagggcgctgcgctc       c.-121

 .         .         .         .         .         .                g.5123
 gggctacccaatgcgtggactatctgccgccgctgttcgtgcaatatgctggagctccag       c.-61

 .         .         .         .         .         .                g.5183
 aacagctaaacggagtcgccacaccactgtttgtgctggatcgcagcgctgcctttcctt       c.-1

          .      | 02  .         .         .         .         .    g.39641
 ATGAAGAAGACACAA | ACTTGGATTCTCACTTGCATTTATCTTCAGCTGCTCCTATTTAAT    c.60
 M  K  K  T  Q   | T  W  I  L  T  C  I  Y  L  Q  L  L  L  F  N      p.20

          .         .         .         .         .         .       g.39701
 CCTCTCGTCAAAACTGAAGGGATCTGCAGGAATCGTGTGACTAATAATGTAAAAGACGTC       c.120
 P  L  V  K  T  E  G  I  C  R  N  R  V  T  N  N  V  K  D  V         p.40

           | 03        .         .         .         .         .    g.53009
 ACTAAATTG | GTGGCAAATCTTCCAAAAGACTACATGATAACCCTCAAATATGTCCCCGGG    c.180
 T  K  L   | V  A  N  L  P  K  D  Y  M  I  T  L  K  Y  V  P  G      p.60

          .   | 04     .         .         .         .         .    g.66642
 ATGGATGTTTTG | CCAAGTCATTGTTGGATAAGCGAGATGGTAGTACAATTGTCAGACAGC    c.240
 M  D  V  L   | P  S  H  C  W  I  S  E  M  V  V  Q  L  S  D  S      p.80

          .         .         .         .         .         .       g.66702
 TTGACTGATCTTCTGGACAAGTTTTCAAATATTTCTGAAGGCTTGAGTAATTATTCCATC       c.300
 L  T  D  L  L  D  K  F  S  N  I  S  E  G  L  S  N  Y  S  I         p.100

          .         .         .         .         .         .       g.66762
 ATAGACAAACTTGTGAATATAGTGGATGACCTTGTGGAGTGCGTGAAAGAAAACTCATCT       c.360
 I  D  K  L  V  N  I  V  D  D  L  V  E  C  V  K  E  N  S  S         p.120

     | 05    .         .         .         .         .         .    g.69028
 AAG | GATCTAAAAAAATCATTCAAGAGCCCAGAACCCAGGCTCTTTACTCCTGAAGAATTC    c.420
 K   | D  L  K  K  S  F  K  S  P  E  P  R  L  F  T  P  E  E  F      p.140

          .         .         .         .         .         .       g.69088
 TTTAGAATTTTTAATAGATCCATTGATGCCTTCAAGGACTTTGTAGTGGCATCTGAAACT       c.480
 F  R  I  F  N  R  S  I  D  A  F  K  D  F  V  V  A  S  E  T         p.160

          .         .         .         . | 06       .         .    g.69864
 AGTGATTGTGTGGTTTCTTCAACATTAAGTCCTGAGAAAG | ATTCCAGAGTCAGTGTCACA    c.540
 S  D  C  V  V  S  S  T  L  S  P  E  K  D |   S  R  V  S  V  T      p.180

          .         .         .         .         .         .       g.69924
 AAACCATTTATGTTACCCCCTGTTGCAGCCAGCTCCCTTAGGAATGACAGCAGTAGCAGT       c.600
 K  P  F  M  L  P  P  V  A  A  S  S  L  R  N  D  S  S  S  S         p.200

      | 07   .         .         .         .         .         .    g.78380
 AATA | GGAAGGCCAAAAATCCCCCTGGAGACTCCAGCCTACACTGGGCAGCCATGGCATTG    c.660
 N  R |   K  A  K  N  P  P  G  D  S  S  L  H  W  A  A  M  A  L      p.220

          .         .         .         .         .     | 08   .    g.79089
 CCAGCATTGTTTTCTCTTATAATTGGCTTTGCTTTTGGAGCCTTATACTGGAAG | AAGAGA    c.720
 P  A  L  F  S  L  I  I  G  F  A  F  G  A  L  Y  W  K   | K  R      p.240

          .         .         .         .         .         .       g.79149
 CAGCCAAGTCTTACAAGGGCAGTTGAAAATATACAAATTAATGAAGAGGATAATGAGATA       c.780
 Q  P  S  L  T  R  A  V  E  N  I  Q  I  N  E  E  D  N  E  I         p.260

    | 09     .         .         .         .                        g.80284
 AG | TATGTTGCAAGAGAAAGAGAGAGAGTTTCAAGAAGTGTAA                      c.822
 S  |  M  L  Q  E  K  E  R  E  F  Q  E  V  X                        p.273

          .         .         .        | 10.         .         .    g.88321
 ttgtggcttgtatcaacactgttactttcgtacattg | gctggtaacagttcatgtttgct    c.*60

          .         .         .         .         .         .       g.88381
 tcataaatgaagcagctttaaacaaattcatattctgtctggagtgacagaccacatctt       c.*120

          .         .         .         .         .         .       g.88441
 tatctgttcttgctacccatgactttatatggatgattcagaaattggaacagaatgttt       c.*180

          .         .         .         .         .         .       g.88501
 tactgtgaaactggcactgaattaatcatctataaagaagaacttgcatggagcaggact       c.*240

          .         .         .         .         .         .       g.88561
 ctattttaaggactgcgggacttgggtctcatttagaacttgcagctgatgttggaagag       c.*300

          .         .         .         .         .         .       g.88621
 aaagcacgtgtctcagactgcatgtaccatttgcatggctccagaaatgtctaaatgctg       c.*360

          .         .         .         .         .         .       g.88681
 aaaaaacacctagctttattcttcagatacaaactgcagcctgtagttatcctggtctct       c.*420

          .         .         .         .         .         .       g.88741
 gcaagtagatttcagcttggatagtgagggtaacaatttttctcaaagggatctggaaaa       c.*480

          .         .         .         .         .         .       g.88801
 aatgtttaaaactcagtagtgtcagccactgtacagtgtagaaagcagtgggaactgtga       c.*540

          .         .         .         .         .         .       g.88861
 ttggatttggcaacatgtcagctttatagttgccgattagtgatatgggtctgatttcga       c.*600

          .         .         .         .         .         .       g.88921
 tctcttcctgatgtaaaccatgctcacccatatcccactatacaaatgcaaatggttgcc       c.*660

          .         .         .         .         .         .       g.88981
 tggttccatttatgcaagggagccagtactgaattatgccttggcagaggggagactcca       c.*720

          .         .         .         .         .         .       g.89041
 aaagagtcatcgcaggaagaagttaagaacactgaacatcagaacagtctgccaagaagg       c.*780

          .         .         .         .         .         .       g.89101
 acattggcatcctgggaaagtccgccttttcccttgaccactatagggtgtataaatcgt       c.*840

          .         .         .         .         .         .       g.89161
 gtttgcaaaatgtgttatgatgtgtttatattctaaaactattacagagctatgtaaagg       c.*900

          .         .         .         .         .         .       g.89221
 gacttaggagaaaatgctgaatgtaagatggtcccatttcaatttccaccatgggagagc       c.*960

          .         .         .         .         .         .       g.89281
 ctaaaaataaattatgacatttagtatctaaggttagaaaaccacgcccacatgctaata       c.*1020

          .         .         .         .         .         .       g.89341
 tgggtgttgaaaactaggttacttataatgcaaggaatcaggaaactttagttatttata       c.*1080

          .         .         .         .         .         .       g.89401
 gtataatcaccattatctgtttaaaggatccatttagttaaaatcgggcactctatattc       c.*1140

          .         .         .         .         .         .       g.89461
 attaaggtttatgaattaaaaagaaagctttatgtagttatgcatgtcagtttgctattt       c.*1200

          .         .         .         .         .         .       g.89521
 aaaatgtgtgacagtgtttgtcatattaagagtgaatttggcaggaattcccaagatgga       c.*1260

          .         .         .         .         .         .       g.89581
 cattgtgcttttaaactagaacttgtaagacattatgtgaatatcccttgccaatttttt       c.*1320

          .         .         .         .         .         .       g.89641
 ttataataagaaaacatctgactaaagtcaaagaatgatttcttatggtttattttgatg       c.*1380

          .         .         .         .         .         .       g.89701
 aaagttcttttaacatgtcttgaatgtacacataaaggaatccaaagctttccattctaa       c.*1440

          .         .         .         .         .         .       g.89761
 cttaatctttgtgataacattattgccatgttctacaaccgtaagatgacagttttcaat       c.*1500

          .         .         .         .         .         .       g.89821
 gtagtgacacaaaagggcatgaaaaactaactgctagctttcctttcatttcaaaagtcc       c.*1560

          .         .         .         .         .         .       g.89881
 aagaatttctagtatatttggattttagcttctgttcaaagcaaatccagatgcaactcc       c.*1620

          .         .         .         .         .         .       g.89941
 agtaagtggcctttgctcttttttgtaccaaagagcccagatgattcctacagtcccttt       c.*1680

          .         .         .         .         .         .       g.90001
 cttctctaacatgctgtggttccttaaatatgagtaatttctctaagatataacccaggt       c.*1740

          .         .         .         .         .         .       g.90061
 gctttgagaagctgcattaaggtgttcaggccctcagatatcacatggtacacttgatta       c.*1800

          .         .         .         .         .         .       g.90121
 gtaataaaaccagagatcaatttaaattgctgataggtcctgtctcagtgtgtggcattg       c.*1860

          .         .         .         .         .         .       g.90181
 actgttttcaggaaaatagatacagattaatatgagttatgcgtgtaggttgtgtataga       c.*1920

          .         .         .         .         .         .       g.90241
 ttgagaagatagatacttctcaatctagtagtttgatttatttaaccaatggtttcagtt       c.*1980

          .         .         .         .         .         .       g.90301
 tgcttgagcatatgaaaatcctgcttaatgtgcttaagagtataataaatgtgtactttt       c.*2040

          .         .         .         .         .         .       g.90361
 gtcctcaaacctagtagctgggttttaacactcatggacatggtcttaatcaatggagtt       c.*2100

          .         .         .         .         .         .       g.90421
 aaataaacaaattcagcaagttattaaatctgacatggtaggagaggggagatgtgtcct       c.*2160

          .         .         .         .         .         .       g.90481
 gcttattaaatgtgttggtccattgaaagttacatggattgccaatttttaaaacactaa       c.*2220

          .         .         .         .         .         .       g.90541
 agttgaataaaatgcatgaacaatagaaaaatgctgaacattattttggatgctagctgc       c.*2280

          .         .         .         .         .         .       g.90601
 ttggacattaactgtgttatttctgctttgagatgaaaatatatatttatctttgcttat       c.*2340

          .         .         .         .         .         .       g.90661
 tttatcccagatgtgttctgaatatccttcttcataaatcatggaaaactcactgctgag       c.*2400

          .         .         .         .         .         .       g.90721
 atagtaaaccatgaaatcgccttttcagttggtgccatgtatctgacagttccatcttgg       c.*2460

          .         .         .         .         .         .       g.90781
 aaggtttcaaaattaccttttaaaatgatctcagaagtctgtagattctcaatgatactg       c.*2520

          .         .         .         .         .         .       g.90841
 aaagctttgcacctctttggtagaaaccaggtctatttagaaaatggctttatgataaat       c.*2580

          .         .         .         .         .         .       g.90901
 gttgcctcctgagtgataatgaagtgttcctggatattgtattgtaatttaatgtgctta       c.*2640

          .         .         .         .         .         .       g.90961
 ccacactgccacattttaatgagtcagagaaaaattaatttttcttcaatacaataatag       c.*2700

          .         .         .         .         .         .       g.91021
 aacaagtagcctattctcttaaaaagtatgtgaaaagaaaattatgaaaaaatatgcata       c.*2760

          .         .         .         .         .         .       g.91081
 cctaatgaagtattggttttagtaagaattaaatacatttcattgagctttaaagtactt       c.*2820

          .         .         .         .         .         .       g.91141
 tggagaaactttggggcacgttttcctactctaattcaactaaagttataaataaagaga       c.*2880

          .         .         .         .         .         .       g.91201
 aaaactcattcagaaatcatggattttaaaaatattttactgcagccaagttttcatttc       c.*2940

          .         .         .         .         .         .       g.91261
 aaaatgtaatttcagtttggagcttttaggcattatgtatatttaaaaaatatattcttc       c.*3000

          .         .         .         .         .         .       g.91321
 aaaaatgcattttggcatggtgggatggatgttgcaaaagatatccggagcctccagtct       c.*3060

          .         .         .         .         .         .       g.91381
 gtcattaactgatatggtaaatcacctctcttctttgggtctcaattttttatttatcta       c.*3120

          .         .         .         .         .         .       g.91441
 tatggtaaactcagagatcactccttaggggtgagtcctattgcaatatgaccgacaaag       c.*3180

          .         .         .         .         .         .       g.91501
 aagacaaaatagcattgaaactaacccatacaaaatatccaactctggattctgtgaata       c.*3240

          .         .         .         .         .         .       g.91561
 agtatcttgaccataaaaagtcattgctgttcttgtttctaatgtaaatagtgtccatta       c.*3300

          .         .         .         .         .         .       g.91621
 gtaaaagtgaaattcagtcttaagtagggtgaattggatcaccatttacacaagagatgg       c.*3360

          .         .         .         .         .         .       g.91681
 ctttttcctttgcttgaataaacattttggatcacctccaaagaatgaaaaccagtagta       c.*3420

          .         .         .         .         .         .       g.91741
 cgttttagtcatattagtcaggatgagaaactataagatgtgtgtaacatttggaaatgc       c.*3480

          .         .         .         .         .         .       g.91801
 accaaagtgagcgtttaaatcttctcattttattgaaaactaagagcagaaaatgtaaaa       c.*3540

          .         .         .         .         .         .       g.91861
 tgctcatgaaggttttgaatgccaaaagatattttagaatcaatttataaaggggtaatt       c.*3600

          .         .         .         .         .         .       g.91921
 cattaattacactttaaaattggaaagtgggataagaaatctaaagtaaaccagcttatc       c.*3660

          .         .         .         .         .         .       g.91981
 tttgaaacaatattattttgaaattggctttaaaataaaaccattcagattgaaattcta       c.*3720

          .         .         .         .         .         .       g.92041
 attagctcatttgtggagtttgatcacacaattcataatgttgctgctttccattaacta       c.*3780

          .         .         .         .         .         .       g.92101
 gtcttgaaatgcctttgtttgtaaaaataaaataatggtactttcattttataacaaggt       c.*3840

          .         .         .         .         .         .       g.92161
 gtttttttcaagaaataatccatgctaaaatggatatttgtgatcctgaaatgtttacta       c.*3900

          .         .         .         .         .         .       g.92221
 agcattgtaaatttatttataactgccatctccaactacatccttatgatgtttttaaca       c.*3960

          .         .         .         .         .         .       g.92281
 ataaaattaaaacaactgttaaactaaaaaccacaccgttttccagtacttgatctctga       c.*4020

          .         .         .         .         .         .       g.92341
 gctacaatactcactaaatataattttccaatcaaaatattctattctatattctaaggg       c.*4080

          .         .         .         .         .         .       g.92401
 ttaatatgtgattatagtgtccacttgccaccatttttttaaatcaatggacttgaaaag       c.*4140

          .         .         .         .         .         .       g.92461
 tattaatttagatggatgcgcagatataccctcagttcagtcatagattggagtttgcat       c.*4200

          .         .         .         .         .         .       g.92521
 ataataatgtaaatgtatgtcgacactattctaaatagttctattatgactgaaatttaa       c.*4260

          .         .         .         .         .         .       g.92581
 ttaaataaaaaaggttgtaaaatgtgatgtgtatgtgtatatactgtatgtgtacttttt       c.*4320

          .         .         .         .         .         .       g.92641
 aaaataggtgtatgtcccaacccttttttatacaggtttgaatttaaaattacatgatat       c.*4380

          .         .         .         .                           g.92687
 atacatatactttattgttctaaataaagaattttatgcactctca                     c.*4426

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The KIT ligand protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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