rhodopsin (RHO) - coding DNA reference sequence

(used for variant description)

(last modified February 28, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_000539.3 in the RHO gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009115.1, covering RHO transcript NM_000539.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5035
                          agagtcatccagctggagccctgagtggctgagct       c.-61

 .         .         .         .         .         .                g.5095
 caggccttcgcagcattcttgggtgggagcagccacgggtcagccacaagggccacagcc       c.-1

          .         .         .         .         .         .       g.5155
 ATGAATGGCACAGAAGGCCCTAACTTCTACGTGCCCTTCTCCAATGCGACGGGTGTGGTA       c.60
 M  N  G  T  E  G  P  N  F  Y  V  P  F  S  N  A  T  G  V  V         p.20

          .         .         .         .         .         .       g.5215
 CGCAGCCCCTTCGAGTACCCACAGTACTACCTGGCTGAGCCATGGCAGTTCTCCATGCTG       c.120
 R  S  P  F  E  Y  P  Q  Y  Y  L  A  E  P  W  Q  F  S  M  L         p.40

          .         .         .         .         .         .       g.5275
 GCCGCCTACATGTTTCTGCTGATCGTGCTGGGCTTCCCCATCAACTTCCTCACGCTCTAC       c.180
 A  A  Y  M  F  L  L  I  V  L  G  F  P  I  N  F  L  T  L  Y         p.60

          .         .         .         .         .         .       g.5335
 GTCACCGTCCAGCACAAGAAGCTGCGCACGCCTCTCAACTACATCCTGCTCAACCTAGCC       c.240
 V  T  V  Q  H  K  K  L  R  T  P  L  N  Y  I  L  L  N  L  A         p.80

          .         .         .         .         .         .       g.5395
 GTGGCTGACCTCTTCATGGTCCTAGGTGGCTTCACCAGCACCCTCTACACCTCTCTGCAT       c.300
 V  A  D  L  F  M  V  L  G  G  F  T  S  T  L  Y  T  S  L  H         p.100

          .         .         .         .         .         .       g.5455
 GGATACTTCGTCTTCGGGCCCACAGGATGCAATTTGGAGGGCTTCTTTGCCACCCTGGGC       c.360
 G  Y  F  V  F  G  P  T  G  C  N  L  E  G  F  F  A  T  L  G         p.120

   | 02      .         .         .         .         .         .    g.7296
 G | GTGAAATTGCCCTGTGGTCCTTGGTGGTCCTGGCCATCGAGCGGTACGTGGTGGTGTGT    c.420
 G |   E  I  A  L  W  S  L  V  V  L  A  I  E  R  Y  V  V  V  C      p.140

          .         .         .         .         .         .       g.7356
 AAGCCCATGAGCAACTTCCGCTTCGGGGAGAACCATGCCATCATGGGCGTTGCCTTCACC       c.480
 K  P  M  S  N  F  R  F  G  E  N  H  A  I  M  G  V  A  F  T         p.160

          .         .         .         .         . | 03       .    g.8622
 TGGGTCATGGCGCTGGCCTGCGCCGCACCCCCACTCGCCGGCTGGTCCAG | GTACATCCCC    c.540
 W  V  M  A  L  A  C  A  A  P  P  L  A  G  W  S  R  |  Y  I  P      p.180

          .         .         .         .         .         .       g.8682
 GAGGGCCTGCAGTGCTCGTGTGGAATCGACTACTACACGCTCAAGCCGGAGGTCAACAAC       c.600
 E  G  L  Q  C  S  C  G  I  D  Y  Y  T  L  K  P  E  V  N  N         p.200

          .         .         .         .         .         .       g.8742
 GAGTCTTTTGTCATCTACATGTTCGTGGTCCACTTCACCATCCCCATGATTATCATCTTT       c.660
 E  S  F  V  I  Y  M  F  V  V  H  F  T  I  P  M  I  I  I  F         p.220

          .         .         .       | 04 .         .         .    g.8918
 TTCTGCTATGGGCAGCTCGTCTTCACCGTCAAGGAG | GCCGCTGCCCAGCAGCAGGAGTCA    c.720
 F  C  Y  G  Q  L  V  F  T  V  K  E   | A  A  A  Q  Q  Q  E  S      p.240

          .         .         .         .         .         .       g.8978
 GCCACCACACAGAAGGCAGAGAAGGAGGTCACCCGCATGGTCATCATCATGGTCATCGCT       c.780
 A  T  T  Q  K  A  E  K  E  V  T  R  M  V  I  I  M  V  I  A         p.260

          .         .         .         .         .         .       g.9038
 TTCCTGATCTGCTGGGTGCCCTACGCCAGCGTGGCATTCTACATCTTCACCCACCAGGGC       c.840
 F  L  I  C  W  V  P  Y  A  S  V  A  F  Y  I  F  T  H  Q  G         p.280

          .         .         .         .         .         .       g.9098
 TCCAACTTCGGTCCCATCTTCATGACCATCCCAGCGTTCTTTGCCAAGAGCGCCGCCATC       c.900
 S  N  F  G  P  I  F  M  T  I  P  A  F  F  A  K  S  A  A  I         p.300

          .         .         .       | 05 .         .         .    g.9993
 TACAACCCTGTCATCTATATCATGATGAACAAGCAG | TTCCGGAACTGCATGCTCACCACC    c.960
 Y  N  P  V  I  Y  I  M  M  N  K  Q   | F  R  N  C  M  L  T  T      p.320

          .         .         .         .         .         .       g.10053
 ATCTGCTGCGGCAAGAACCCACTGGGTGACGATGAGGCCTCTGCTACCGTGTCCAAGACG       c.1020
 I  C  C  G  K  N  P  L  G  D  D  E  A  S  A  T  V  S  K  T         p.340

          .         .                                               g.10080
 GAGACGAGCCAGGTGGCCCCGGCCTAA                                        c.1047
 E  T  S  Q  V  A  P  A  X                                          p.348

          .         .         .         .         .         .       g.10140
 gacctgcctaggactctgtggccgactataggcgtctcccatcccctacaccttccccca       c.*60

          .         .         .         .         .         .       g.10200
 gccacagccatcccaccaggagcagcgcctgtgcagaatgaacgaagtcacataggctcc       c.*120

          .         .         .         .         .         .       g.10260
 ttaattttttttttttttttaagaaataattaatgaggctcctcactcacctgggacagc       c.*180

          .         .         .         .         .         .       g.10320
 ctgagaagggacatccaccaagacctactgatctggagtcccacgttccccaaggccagc       c.*240

          .         .         .         .         .         .       g.10380
 gggatgtgtgcccctcctcctcccaactcatctttcaggaacacgaggattcttgctttc       c.*300

          .         .         .         .         .         .       g.10440
 tggaaaagtgtcccagcttagggataagtgtctagcacagaatggggcacacagtaggtg       c.*360

          .         .         .         .         .         .       g.10500
 cttaataaatgctggatggatgcaggaaggaatggaggaatgaatgggaagggagaacat       c.*420

          .         .         .         .         .         .       g.10560
 atctatcctctcagaccctcgcagcagcagcaactcatacttggctaatgatatggagca       c.*480

          .         .         .         .         .         .       g.10620
 gttgtttttccctccctgggcctcactttcttctcctataaaatggaaatcccagatccc       c.*540

          .         .         .         .         .         .       g.10680
 tggtcctgccgacacgcagctactgagaagaccaaaagaggtgtgtgtgtgtctatgtgt       c.*600

          .         .         .         .         .         .       g.10740
 gtgtttcagcactttgtaaatagcaagaagctgtacagattctagttaatgttgtgaata       c.*660

          .         .         .         .         .         .       g.10800
 acatcaattaatgtaactagttaattactatgattatcacctcctgatagtgaacatttt       c.*720

          .         .         .         .         .         .       g.10860
 gagattgggcattcagatgatggggtttcacccaaccttggggcaggtttttaaaaatta       c.*780

          .         .         .         .         .         .       g.10920
 gctaggcatcaaggccagaccagggctgggggttgggctgtaggcagggacagtcacagg       c.*840

          .         .         .         .         .         .       g.10980
 aatgcagaatgcagtcatcagacctgaaaaaacaacactgggggagggggacggtgaagg       c.*900

          .         .         .         .         .         .       g.11040
 ccaagttcccaatgagggtgagattgggcctggggtctcacccctagtgtggggccccag       c.*960

          .         .         .         .         .         .       g.11100
 gtcccgtgcctccccttcccaatgtggcctatggagagacaggcctttctctcagcctct       c.*1020

          .         .         .         .         .         .       g.11160
 ggaagccacctgctcttttgctctagcacctgggtcccagcatctagagcatggagcctc       c.*1080

          .         .         .         .         .         .       g.11220
 tagaagccatgctcacccgcccacatttaattaacagctgagtccctgatgtcatcctta       c.*1140

          .         .         .         .         .         .       g.11280
 tctcgaagagcttagaaacaaagagtgggaaattccactgggcctaccttccttggggat       c.*1200

          .         .         .         .         .         .       g.11340
 gttcatgggccccagtttccagtttcccttgccagacaagcccatcttcagcagttgcta       c.*1260

          .         .         .         .         .         .       g.11400
 gtccattctccattctggagaatctgctccaaaaagctggccacatctctgaggtgtcag       c.*1320

          .         .         .         .         .         .       g.11460
 aattaagctgcctcagtaactgctcccccttctccatataagcaaagccagaagctctag       c.*1380

          .         .         .         .         .         .       g.11520
 ctttacccagctctgcctggagactaaggcaaattgggccattaaaagctcagctcctat       c.*1440

          .         .         .         .         .         .       g.11580
 gttggtattaacggtggtgggttttgttgctttcacactctatccacaggatagattgaa       c.*1500

          .         .         .         .         .         .       g.11640
 actgccagcttccacctgatccctgaccctgggatggctggattgagcaatgagcagagc       c.*1560

          .         .         .         .         .         .       g.11700
 caagcagcacagagtcccctggggctagaggtggaggaggcagtcctgggaatgggaaaa       c.*1620

                                                                    g.11706
 acccca                                                             c.*1626

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Rhodopsin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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