retinitis pigmentosa GTPase regulator (RPGR) - coding DNA reference sequence

(used for variant description)

(last modified January 18, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_001034853.1 in the RPGR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009553.1, covering RPGR transcript NM_001034853.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             gtttgttgacttccgggagcgcggttgtagttgatctccggagtttcg       c.-121

 .         .         .         .         .         .                g.5108
 ccatgcggaacttgggggctttcgcggcccgcgtcggtgcggagtagctgctttagcccc       c.-61

 .         .         .         .         .         .                g.5168
 gaccaaaccgtcctctacagcctcctggccccggcgcaggctgcccgtactgcccgtggc       c.-1

          .         .         | 02         .         .         .    g.9043
 ATGAGGGAGCCGGAAGAGCTGATGCCCG | ATTCGGGTGCTGTGTTTACATTTGGGAAAAGT    c.60
 M  R  E  P  E  E  L  M  P  D |   S  G  A  V  F  T  F  G  K  S      p.20

          .         .         .         .         .         .       g.9103
 AAATTTGCTGAAAATAATCCCGGTAAATTCTGGTTTAAAAATGATGTCCCTGTACATCTT       c.120
 K  F  A  E  N  N  P  G  K  F  W  F  K  N  D  V  P  V  H  L         p.40

          .         .         .     | 03   .         .         .    g.9616
 TCATGTGGAGATGAACATTCTGCTGTTGTTACCG | GAAATAATAAACTTTACATGTTTGGC    c.180
 S  C  G  D  E  H  S  A  V  V  T  G |   N  N  K  L  Y  M  F  G      p.60

          .         .         .         .         .         .       g.9676
 AGTAACAACTGGGGTCAGTTAGGATTAGGATCAAAGTCAGCCATCAGCAAGCCAACATGT       c.240
 S  N  N  W  G  Q  L  G  L  G  S  K  S  A  I  S  K  P  T  C         p.80

         | 04.         .         .         .         .         .    g.11499
 GTCAAAG | CTCTAAAACCTGAAAAAGTGAAATTAGCTGCCTGTGGAAGGAACCACACCCTG    c.300
 V  K  A |   L  K  P  E  K  V  K  L  A  A  C  G  R  N  H  T  L      p.100

          . | 05       .         .         .         .         .    g.13598
 GTGTCAACAG | AAGGAGGCAATGTATATGCAACTGGTGGAAATAATGAAGGACAGTTGGGG    c.360
 V  S  T  E |   G  G  N  V  Y  A  T  G  G  N  N  E  G  Q  L  G      p.120

          .         .         .         .         .         .       g.13658
 CTTGGTGACACCGAAGAAAGAAACACTTTTCATGTAATTAGCTTTTTTACATCCGAGCAT       c.420
 L  G  D  T  E  E  R  N  T  F  H  V  I  S  F  F  T  S  E  H         p.140

          .         .         .         .          | 06        .    g.15081
 AAGATTAAGCAGCTGTCTGCTGGATCTAATACTTCAGCTGCCCTAACTG | AGGATGGAAGA    c.480
 K  I  K  Q  L  S  A  G  S  N  T  S  A  A  L  T  E |   D  G  R      p.160

          .         .         .         .         .         .       g.15141
 CTTTTTATGTGGGGTGACAATTCCGAAGGGCAAATTGGTTTAAAAAATGTAAGTAATGTC       c.540
 L  F  M  W  G  D  N  S  E  G  Q  I  G  L  K  N  V  S  N  V         p.180

          .         .         .         .         .         .       g.15201
 TGTGTCCCTCAGCAAGTGACCATTGGGAAACCTGTCTCCTGGATCTCTTGTGGATATTAC       c.600
 C  V  P  Q  Q  V  T  I  G  K  P  V  S  W  I  S  C  G  Y  Y         p.200

          .          | 07        .         .         .         .    g.21803
 CATTCAGCTTTTGTAACAA | CAGATGGTGAGCTATATGTGTTTGGAGAACCTGAGAATGGG    c.660
 H  S  A  F  V  T  T |   D  G  E  L  Y  V  F  G  E  P  E  N  G      p.220

          .         .         .         .         .         .       g.21863
 AAGTTAGGTCTTCCCAATCAGCTCCTGGGCAATCACAGAACACCCCAGCTGGTGTCTGAA       c.720
 K  L  G  L  P  N  Q  L  L  G  N  H  R  T  P  Q  L  V  S  E         p.240

          .         .         .         .         .         | 08    g.27747
 ATTCCGGAGAAGGTGATCCAAGTAGCCTGTGGTGGAGAGCATACTGTGGTTCTCACGG | AG    c.780
 I  P  E  K  V  I  Q  V  A  C  G  G  E  H  T  V  V  L  T  E |       p.260

          .         .         .         .         .         .       g.27807
 AATGCTGTGTATACCTTTGGGCTGGGACAATTTGGTCAGCTGGGTCTTGGCACTTTTCTT       c.840
 N  A  V  Y  T  F  G  L  G  Q  F  G  Q  L  G  L  G  T  F  L         p.280

          .         .         .         .         .         .       g.27867
 TTTGAAACTTCAGAACCCAAAGTCATTGAGAATATTAGGGATCAAACAATAAGTTATATT       c.900
 F  E  T  S  E  P  K  V  I  E  N  I  R  D  Q  T  I  S  Y  I         p.300

          .         .         .     | 09   .         .         .    g.31190
 TCTTGTGGAGAAAATCACACAGCTTTGATAACAG | ATATCGGCCTTATGTATACTTTTGGA    c.960
 S  C  G  E  N  H  T  A  L  I  T  D |   I  G  L  M  Y  T  F  G      p.320

          .         .         .         .         .         .       g.31250
 GATGGTCGCCACGGAAAATTAGGACTTGGACTGGAGAATTTTACCAATCACTTCATTCCT       c.1020
 D  G  R  H  G  K  L  G  L  G  L  E  N  F  T  N  H  F  I  P         p.340

          .         .         .          | 10        .         .    g.33415
 ACTTTGTGCTCTAATTTTTTGAGGTTTATAGTTAAATTG | GTTGCTTGTGGTGGATGTCAC    c.1080
 T  L  C  S  N  F  L  R  F  I  V  K  L   | V  A  C  G  G  C  H      p.360

          .         .         .         .         .         .       g.33475
 ATGGTAGTTTTTGCTGCTCCTCATCGTGGTGTGGCAAAAGAAATTGAATTCGATGAAATA       c.1140
 M  V  V  F  A  A  P  H  R  G  V  A  K  E  I  E  F  D  E  I         p.380

          .         .         .         .         .         .       g.33535
 AATGATACTTGCTTATCTGTGGCGACTTTTCTGCCGTATAGCAGTTTAACCTCAGGAAAT       c.1200
 N  D  T  C  L  S  V  A  T  F  L  P  Y  S  S  L  T  S  G  N         p.400

          .         .         .         .      | 11  .         .    g.35098
 GTACTGCAGAGGACTCTATCAGCACGTATGCGGCGAAGAGAGAGG | GAGAGGTCTCCAGAT    c.1260
 V  L  Q  R  T  L  S  A  R  M  R  R  R  E  R   | E  R  S  P  D      p.420

          .         .         .         .         .         .       g.35158
 TCTTTTTCAATGAGGAGAACACTACCTCCAATAGAAGGGACTCTTGGCCTTTCTGCTTGT       c.1320
 S  F  S  M  R  R  T  L  P  P  I  E  G  T  L  G  L  S  A  C         p.440

          .         .         .         .         .         .       g.35218
 TTTCTCCCCAATTCAGTCTTTCCACGATGTTCTGAGAGAAACCTCCAAGAGAGTGTCTTA       c.1380
 F  L  P  N  S  V  F  P  R  C  S  E  R  N  L  Q  E  S  V  L         p.460

          .         .         .     | 12   .         .         .    g.41077
 TCTGAACAGGACCTCATGCAGCCAGAGGAACCAG | ATTATTTGCTAGATGAAATGACCAAA    c.1440
 S  E  Q  D  L  M  Q  P  E  E  P  D |   Y  L  L  D  E  M  T  K      p.480

          .         .         .         .         .         .       g.41137
 GAAGCAGAGATAGATAATTCTTCAACTGTAGAAAGCCTTGGAGAAACTACTGATATCTTA       c.1500
 E  A  E  I  D  N  S  S  T  V  E  S  L  G  E  T  T  D  I  L         p.500

        | 13 .         .         .         .         .         .    g.41565
 AACATG | ACACACATCATGAGCCTGAATTCCAATGAAAAGTCATTAAAATTATCACCAGTT    c.1560
 N  M   | T  H  I  M  S  L  N  S  N  E  K  S  L  K  L  S  P  V      p.520

          .   | 14     .         .         .         .         .    g.44542
 CAGAAACAAAAG | AAACAACAAACAATTGGGGAACTGACGCAGGATACAGCTCTTACTGAA    c.1620
 Q  K  Q  K   | K  Q  Q  T  I  G  E  L  T  Q  D  T  A  L  T  E      p.540

          .         .         .         .         .         .       g.44602
 AACGATGATAGTGATGAATATGAAGAAATGTCAGAAATGAAAGAAGGGAAAGCATGTAAA       c.1680
 N  D  D  S  D  E  Y  E  E  M  S  E  M  K  E  G  K  A  C  K         p.560

          .         .         .         .         .         .       g.44662
 CAACATGTGTCACAAGGGATTTTCATGACGCAGCCAGCTACGACTATCGAAGCATTTTCA       c.1740
 Q  H  V  S  Q  G  I  F  M  T  Q  P  A  T  T  I  E  A  F  S         p.580

          .    | 15    .         .         .         .         .    g.45337
 GATGAGGAAGTAG | AGATCCCAGAGGAGAAGGAAGGAGCAGAGGATTCAAAAGGAAATGGA    c.1800
 D  E  E  V  E |   I  P  E  E  K  E  G  A  E  D  S  K  G  N  G      p.600

          .         .         .         .         .         .       g.45397
 ATAGAGGAGCAAGAGGTAGAAGCAAATGAGGAAAATGTGAAGGTGCATGGAGGAAGAAAG       c.1860
 I  E  E  Q  E  V  E  A  N  E  E  N  V  K  V  H  G  G  R  K         p.620

          .         .         .         .         .         .       g.45457
 GAGAAAACAGAGATCCTATCAGATGACCTTACAGACAAAGCAGAGGTGAGTGAAGGCAAG       c.1920
 E  K  T  E  I  L  S  D  D  L  T  D  K  A  E  V  S  E  G  K         p.640

          .         .         .         .         .         .       g.45517
 GCAAAATCAGTGGGAGAAGCAGAGGATGGGCCTGAAGGTAGAGGGGATGGAACCTGTGAG       c.1980
 A  K  S  V  G  E  A  E  D  G  P  E  G  R  G  D  G  T  C  E         p.660

          .         .         .         .         .         .       g.45577
 GAAGGTAGTTCAGGAGCAGAACACTGGCAAGATGAGGAGAGGGAGAAGGGGGAGAAAGAC       c.2040
 E  G  S  S  G  A  E  H  W  Q  D  E  E  R  E  K  G  E  K  D         p.680

          .         .         .         .         .         .       g.45637
 AAGGGTAGAGGAGAAATGGAGAGGCCAGGAGAGGGAGAGAAGGAACTAGCAGAGAAGGAA       c.2100
 K  G  R  G  E  M  E  R  P  G  E  G  E  K  E  L  A  E  K  E         p.700

          .         .         .         .         .         .       g.45697
 GAATGGAAGAAGAGGGATGGGGAAGAGCAGGAGCAAAAGGAGAGGGAGCAGGGCCATCAG       c.2160
 E  W  K  K  R  D  G  E  E  Q  E  Q  K  E  R  E  Q  G  H  Q         p.720

          .         .         .         .         .         .       g.45757
 AAGGAAAGAAACCAAGAGATGGAGGAGGGAGGGGAGGAGGAGCATGGAGAAGGAGAAGAA       c.2220
 K  E  R  N  Q  E  M  E  E  G  G  E  E  E  H  G  E  G  E  E         p.740

          .         .         .         .         .         .       g.45817
 GAGGAGGGAGACAGAGAAGAGGAAGAAGAGAAGGAGGGAGAAGGGAAAGAGGAAGGAGAA       c.2280
 E  E  G  D  R  E  E  E  E  E  K  E  G  E  G  K  E  E  G  E         p.760

          .         .         .         .         .         .       g.45877
 GGGGAAGAAGTGGAGGGAGAACGTGAAAAGGAGGAAGGAGAGAGGAAAAAGGAGGAAAGA       c.2340
 G  E  E  V  E  G  E  R  E  K  E  E  G  E  R  K  K  E  E  R         p.780

          .         .         .         .         .         .       g.45937
 GCGGGGAAGGAGGAGAAAGGAGAGGAAGAAGGAGACCAAGGAGAGGGGGAAGAGGAGGAA       c.2400
 A  G  K  E  E  K  G  E  E  E  G  D  Q  G  E  G  E  E  E  E         p.800

          .         .         .         .         .         .       g.45997
 ACAGAGGGGAGAGGGGAGGAAAAAGAGGAGGGAGGGGAAGTAGAGGGAGGGGAAGTAGAG       c.2460
 T  E  G  R  G  E  E  K  E  E  G  G  E  V  E  G  G  E  V  E         p.820

          .         .         .         .         .         .       g.46057
 GAGGGGAAAGGAGAGAGGGAAGAGGAAGAGGAGGAGGGTGAGGGGGAAGAGGAGGAAGGG       c.2520
 E  G  K  G  E  R  E  E  E  E  E  E  G  E  G  E  E  E  E  G         p.840

          .         .         .         .         .         .       g.46117
 GAGGGGGAAGAGGAGGAAGGGGAGGGGGAAGAGGAGGAAGGAGAAGGGAAAGGGGAGGAA       c.2580
 E  G  E  E  E  E  G  E  G  E  E  E  E  G  E  G  K  G  E  E         p.860

          .         .         .         .         .         .       g.46177
 GAAGGGGAAGAAGGAGAAGGGGAGGAAGAAGGGGAGGAAGGAGAAGGGGAGGGGGAAGAG       c.2640
 E  G  E  E  G  E  G  E  E  E  G  E  E  G  E  G  E  G  E  E         p.880

          .         .         .         .         .         .       g.46237
 GAGGAAGGAGAAGGGGAGGGAGAAGAGGAAGGAGAAGGGGAGGGAGAAGAGGAGGAAGGA       c.2700
 E  E  G  E  G  E  G  E  E  E  G  E  G  E  G  E  E  E  E  G         p.900

          .         .         .         .         .         .       g.46297
 GAAGGGGAGGGAGAAGAGGAAGGAGAAGGGGAGGGAGAAGAGGAGGAAGGAGAAGGGAAA       c.2760
 E  G  E  G  E  E  E  G  E  G  E  G  E  E  E  E  G  E  G  K         p.920

          .         .         .         .         .         .       g.46357
 GGGGAGGAGGAAGGAGAGGAAGGAGAAGGGGAGGGGGAAGAGGAGGAAGGAGAAGGGGAA       c.2820
 G  E  E  E  G  E  E  G  E  G  E  G  E  E  E  E  G  E  G  E         p.940

          .         .         .         .         .         .       g.46417
 GGGGAGGATGGAGAAGGGGAGGGGGAAGAGGAGGAAGGAGAATGGGAGGGGGAAGAGGAG       c.2880
 G  E  D  G  E  G  E  G  E  E  E  E  G  E  W  E  G  E  E  E         p.960

          .         .         .         .         .         .       g.46477
 GAAGGAGAAGGGGAGGGGGAAGAGGAAGGAGAAGGGGAAGGGGAGGAAGGAGAAGGGGAG       c.2940
 E  G  E  G  E  G  E  E  E  G  E  G  E  G  E  E  G  E  G  E         p.980

          .         .         .         .         .         .       g.46537
 GGGGAAGAGGAGGAAGGAGAAGGGGAGGGGGAAGAGGAGGAAGGGGAAGAAGAAGGGGAG       c.3000
 G  E  E  E  E  G  E  G  E  G  E  E  E  E  G  E  E  E  G  E         p.1000

          .         .         .         .         .         .       g.46597
 GAAGAAGGAGAGGGAGAGGAAGAAGGGGAGGGAGAAGGGGAGGAAGAAGAGGAAGGGGAA       c.3060
 E  E  G  E  G  E  E  E  G  E  G  E  G  E  E  E  E  E  G  E         p.1020

          .         .         .         .         .         .       g.46657
 GTGGAAGGGGAGGTGGAAGGGGAGGAAGGAGAGGGGGAAGGAGAGGAAGAGGAAGGAGAG       c.3120
 V  E  G  E  V  E  G  E  E  G  E  G  E  G  E  E  E  E  G  E         p.1040

          .         .         .         .         .         .       g.46717
 GAGGAAGGAGAAGAAAGGGAAAAGGAGGGGGAAGGAGAAGAAAACAGGAGGAACAGAGAA       c.3180
 E  E  G  E  E  R  E  K  E  G  E  G  E  E  N  R  R  N  R  E         p.1060

          .         .         .         .         .         .       g.46777
 GAGGAGGAGGAAGAAGAGGGGAAGTATCAGGAGACAGGCGAAGAAGAGAATGAAAGGCAG       c.3240
 E  E  E  E  E  E  G  K  Y  Q  E  T  G  E  E  E  N  E  R  Q         p.1080

          .         .         .         .         .         .       g.46837
 GATGGAGAGGAGTACAAAAAAGTGAGCAAAATAAAAGGATCTGTGAAATATGGCAAACAT       c.3300
 D  G  E  E  Y  K  K  V  S  K  I  K  G  S  V  K  Y  G  K  H         p.1100

          .         .         .         .         .         .       g.46897
 AAAACATATCAAAAAAAGTCAGTTACTAACACACAGGGAAATGGGAAAGAGCAGAGGTCC       c.3360
 K  T  Y  Q  K  K  S  V  T  N  T  Q  G  N  G  K  E  Q  R  S         p.1120

          .         .         .         .         .         .       g.46957
 AAAATGCCAGTCCAGTCAAAACGACTTTTAAAAAACGGGCCATCAGGTTCCAAAAAGTTC       c.3420
 K  M  P  V  Q  S  K  R  L  L  K  N  G  P  S  G  S  K  K  F         p.1140

          .         .         .                                     g.46996
 TGGAATAATGTATTACCACATTACTTGGAATTGAAGTAA                            c.3459
 W  N  N  V  L  P  H  Y  L  E  L  K  X                              p.1152

          .         .         .         .         .         .       g.47056
 caaaccttaaatgtgacccgattatggccagtcagacaatttaaatgccttgcatataac       c.*60

          .         .         .         .         .         .       g.47116
 gggcactcattacgtgttattaaattgattttatgtcaattattttatgtgtagtaaaaa       c.*120

          .         .         .         .         .         .       g.47176
 aaaaagcaactgatgcagctgtgttaaggagccaaagacaataggaggcactggtaaatt       c.*180

          .         .         .         .         .         .       g.47236
 ttggcctctctcaaactaaaattttcgtgtatttcccccccaaattataaaaacataact       c.*240

          .         .         .         .         .         .       g.47296
 agaaaatattaaaaggtcatatcagattattaacattatatattcattaaaggcagcttt       c.*300

          .         .         .         .         .         .       g.47356
 aggaaacaggaatatactacaagagtgttttgtttgtgtatacaaatcattccattttta       c.*360

          .         .         .         .         .         .       g.47416
 aatggcacagatgcttaagggctataaaaacttctaatttcttataaatatgttagcact       c.*420

          .         .         .         .         .         .       g.47476
 ttttttaagttagtgattacagtttacctactgtatagaataattttctaataatggatg       c.*480

          .         .         .         .         .         .       g.47536
 gtattctaaaactcaattgaggcattcacattttaaagaaagtattgtctttcacctttt       c.*540

          .         .         .         .         .         .       g.47596
 atgtgttctttttgcaaaaatctacaaagtgacagctgtgttcagagcttagatcccaaa       c.*600

          .         .         .         .         .         .       g.47656
 aacgtgatctcttttagttactatctgggcagatggtagtatatctaatgaaatggtgat       c.*660

          .         .         .         .         .         .       g.47716
 taatttaaatgtataatctggaaatatgtaaaacttgaagtattttttgtccaggcaaag       c.*720

          .         .         .         .         .         .       g.47776
 gtactcattgggcctcagtttcttcatctctaaaatggagtggatgagatgatgtgataa       c.*780

          .         .         .         .         .         .       g.47836
 ctgcagtcccttctaactcttaaattcttttcattctcacagattcactctatcattatt       c.*840

          .         .         .         .         .         .       g.47896
 gttattcatgtaagaaacgttttagggagaaaaattacactttaaaattaatttagtttt       c.*900

          .         .         .         .         .         .       g.47956
 ctatacagttgttttctttactcttgaaaagttatgacagctttaacgtctcttgtcttc       c.*960

          .         .         .         .         .         .       g.48016
 tgtaattttttatttctaaactcctatcatttccaagctttaactgtactttatcagagc       c.*1020

          .         .         .         .         .         .       g.48076
 cttcatttctggtatgtgttatatgccctcaatgtattcactgactgttctgtaatttca       c.*1080

          .                                                         g.48087
 gtttgtctgtt                                                        c.*1091

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Retinitis pigmentosa GTPase regulator protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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