TBC1 domain containing kinase (TBCK) - coding DNA reference sequence

(used for variant description)

(last modified May 17, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001163435.1 in the TBCK gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering TBCK transcript NM_001163435.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5443
                                                        agcgt       c.-361

 .         .         .         .         .         .                g.5503
 tgggtcgcggtggctgtgagggcggaagaaaaggccaggctgaggggagggtagagggtg       c.-301

 .         .         .         .         .         .                g.5563
 aaaagctcggatctgtgtttggggaaggccaggcttgcgctcctcgccgggttccgcgaa       c.-241

 .         .         .         .         .         .                g.5623
 ggttaaccttggctgacttggctcgcgagcaaagggcagcgtctgagctcccggcgttcc       c.-181

 .         .         .         .         .         .                g.5683
 aggagtggcctcttttgtaggagcacctgaaatgcagcgtctggtgcactaagccgtagc       c.-121

 .         .         .         .         .         .                g.5743
 ggcagcagcagccacagcgacagcgctggggccctgtgtagaagctccatcccccttgtc       c.-61

 .         .         .         . | 02       .         .             g.12744
 tttgtgcttgcctgcgtccccagactcagag | attatcttagaagacctaggactccaaaa    c.-1

          .         .         .         .         .         .       g.12804
 ATGTTTCCCCTGAAGGACGCTGAAATGGGAGCCTTTACCTTCTTTGCCTCGGCTCTGCCA       c.60
 M  F  P  L  K  D  A  E  M  G  A  F  T  F  F  A  S  A  L  P         p.20

          .         .         .         .         .         .       g.12864
 CATGATGTTTGTGGAAGCAATGGACTTCCTCTCACACCAAATTCCATCAAAATTTTAGGG       c.120
 H  D  V  C  G  S  N  G  L  P  L  T  P  N  S  I  K  I  L  G         p.40

          .         .         .         .         .         .       g.12924
 CGCTTTCAAATCCTTAAAACCATCACCCATCCCAGACTCTGCCAGTATGTGGATATTTCT       c.180
 R  F  Q  I  L  K  T  I  T  H  P  R  L  C  Q  Y  V  D  I  S         p.60

          .    | 03    .         .         .         .         .    g.26585
 AGGGGAAAGCATG | AACGACTAGTGGTCGTGGCTGAACATTGTGAACGTAGTCTGGAAGAC    c.240
 R  G  K  H  E |   R  L  V  V  V  A  E  H  C  E  R  S  L  E  D      p.80

          .         .       | 04 .         .         .         .    g.59526
 TTGCTTCGAGAAAGGAAACCTGTGAG | CTGTTCAACGGTTTTGTGTATAGCATTTGAGGTT    c.300
 L  L  R  E  R  K  P  V  S  |  C  S  T  V  L  C  I  A  F  E  V      p.100

          .         .         .         .         .         .       g.59586
 CTTCAGGGCTTGCAGTATATGAACAAACATGGTATAGTACACAGGGCATTGTCTCCTCAT       c.360
 L  Q  G  L  Q  Y  M  N  K  H  G  I  V  H  R  A  L  S  P  H         p.120

          .         .  | 05      .         .         .         .    g.61233
 AATATCCTGTTGGACCGAAAG | GGACATATTAAATTGGCTAAATTTGGACTTTATCACATG    c.420
 N  I  L  L  D  R  K   | G  H  I  K  L  A  K  F  G  L  Y  H  M      p.140

          .         .         .      | 06  .         .         .    g.69722
 ACAGCTCATGGTGATGATGTTGATTTCCCAATAGG | GTATCCCTCGTACTTGGCCCCTGAG    c.480
 T  A  H  G  D  D  V  D  F  P  I  G  |  Y  P  S  Y  L  A  P  E      p.160

          .         .         .         .         .         .       g.69782
 GTAATTGCACAGGGAATTTTCAAAACCACTGATCACATGCCAAGTAAAAAACCATTGCCT       c.540
 V  I  A  Q  G  I  F  K  T  T  D  H  M  P  S  K  K  P  L  P         p.180

          .         .         .         .         .        | 07.    g.71229
 TCTGGCCCCAAATCAGATGTATGGTCTCTTGGAATCATTTTATTTGAGCTTTGTGTG | GGA    c.600
 S  G  P  K  S  D  V  W  S  L  G  I  I  L  F  E  L  C  V   | G      p.200

          .         .         .         .         .         | 08    g.72724
 AGAAAATTATTTCAGAGCTTGGATATTTCTGAAAGACTAAAATTTTTGCTTACTTTGG | AT    c.660
 R  K  L  F  Q  S  L  D  I  S  E  R  L  K  F  L  L  T  L  D |       p.220

          .         .         .         .         .         .       g.72784
 TGTGTAGATGACACTTTAATAGTTCTGGCTGAAGAGCATGGTTGTTTGGACATTATAAAG       c.720
 C  V  D  D  T  L  I  V  L  A  E  E  H  G  C  L  D  I  I  K         p.240

  | 09       .         .         .         .         .         .    g.73458
  | GAGCTTCCTGAAACTGTGATAGATCTTTTGAATAAGTGCCTTACCTTCCATCCTTCTAAG    c.780
  | E  L  P  E  T  V  I  D  L  L  N  K  C  L  T  F  H  P  S  K      p.260

    | 10     .         .         .         .         .         .    g.74475
 AG | GCCAACCCCAGATCAATTAATGAAGGACAAAGTATTCAGTGAGGTATCACCTTTATAT    c.840
 R  |  P  T  P  D  Q  L  M  K  D  K  V  F  S  E  V  S  P  L  Y      p.280

          .         .         .         .         .         .       g.74535
 ACCCCCTTTACCAAACCTGCCAGTCTGTTTTCATCTTCTCTGAGATGTGCTGATTTAACT       c.900
 T  P  F  T  K  P  A  S  L  F  S  S  S  L  R  C  A  D  L  T         p.300

          .         .         .  | 11      .         .         .    g.76969
 CTGCCTGAGGATATCAGTCAGTTGTGTAAAG | ATATAAATAATGATTACCTGGCAGAAAGA    c.960
 L  P  E  D  I  S  Q  L  C  K  D |   I  N  N  D  Y  L  A  E  R      p.320

          .         .         .         .         .         .       g.77029
 TCTATTGAAGAAGTGTATTACCTTTGGTGTTTGGCTGGAGGTGACTTGGAGAAAGAGCTT       c.1020
 S  I  E  E  V  Y  Y  L  W  C  L  A  G  G  D  L  E  K  E  L         p.340

          .         .         .         .         . | 12       .    g.79145
 GTCAACAAGGAAATCATTCGATCCAAACCACCTATCTGCACACTCCCCAA | TTTTCTCTTT    c.1080
 V  N  K  E  I  I  R  S  K  P  P  I  C  T  L  P  N  |  F  L  F      p.360

          .         .         .         .         .         .       g.79205
 GAGGATGGTGAAAGCTTTGGACAAGGTCGAGATAGAAGCTCGCTTTTAGATGATACCACT       c.1140
 E  D  G  E  S  F  G  Q  G  R  D  R  S  S  L  L  D  D  T  T         p.380

          .         .         . | 13       .         .         .    g.84926
 GTGACATTGTCGTTATGCCAGCTAAGAAAT | AGATTGAAAGATGTTGGTGGAGAAGCATTT    c.1200
 V  T  L  S  L  C  Q  L  R  N   | R  L  K  D  V  G  G  E  A  F      p.400

          .         . | 14       .         .         .         .    g.85225
 TACCCATTACTTGAAGATGA | CCAGTCTAATTTACCTCATTCAAACAGCAATAATGAGTTG    c.1260
 Y  P  L  L  E  D  D  |  Q  S  N  L  P  H  S  N  S  N  N  E  L      p.420

          .         .         .         .         .         .       g.85285
 TCTGCAGCTGCCACGCTCCCTTTAATCATCAGAGAGAAGGATACAGAGTACCAACTAAAT       c.1320
 S  A  A  A  T  L  P  L  I  I  R  E  K  D  T  E  Y  Q  L  N         p.440

          .         .         . | 15       .         .         .    g.86367
 AGAATTATTCTCTTCGACAGGCTGCTAAAG | GCTTATCCATATAAAAAAAACCAAATCTGG    c.1380
 R  I  I  L  F  D  R  L  L  K   | A  Y  P  Y  K  K  N  Q  I  W      p.460

          .         .         .         .         .         .       g.86427
 AAAGAAGCAAGAGTTGACATTCCTCCTCTTATGAGAGGTTTAACCTGGGCTGCTCTTCTG       c.1440
 K  E  A  R  V  D  I  P  P  L  M  R  G  L  T  W  A  A  L  L         p.480

           | 16        .         .         .         .         .    g.88105
 GGAGTTGAG | GGAGCTATTCATGCCAAGTACGATGCAATTGATAAAGACACTCCAATTCCT    c.1500
 G  V  E   | G  A  I  H  A  K  Y  D  A  I  D  K  D  T  P  I  P      p.500

          .   | 17     .         .         .         .         .    g.88688
 ACAGATAGACAA | ATTGAAGTGGATATTCCTCGCTGTCATCAGTACGATGAACTGTTATCA    c.1560
 T  D  R  Q   | I  E  V  D  I  P  R  C  H  Q  Y  D  E  L  L  S      p.520

          .         .         .         .         .         .       g.88748
 TCACCAGAAGGTCATGCAAAATTTAGGCGTGTATTAAAAGCCTGGGTAGTGTCTCATCCT       c.1620
 S  P  E  G  H  A  K  F  R  R  V  L  K  A  W  V  V  S  H  P         p.540

          .          | 18        .         .         .         .    g.89966
 GATCTTGTGTATTGGCAAG | GTCTTGACTCACTTTGTGCTCCATTCCTATATCTAAACTTC    c.1680
 D  L  V  Y  W  Q  G |   L  D  S  L  C  A  P  F  L  Y  L  N  F      p.560

          . | 19       .         .         .         .         .    g.91308
 AATAATGAAG | CCTTGGCTTATGCATGTATGTCTGCTTTTATTCCCAAATACCTGTATAAC    c.1740
 N  N  E  A |   L  A  Y  A  C  M  S  A  F  I  P  K  Y  L  Y  N      p.580

          .         .         .     | 20   .         .         .    g.108895
 TTCTTCTTAAAAGACAACTCACATGTAATACAAG | AGTATCTGACTGTCTTCTCTCAGATG    c.1800
 F  F  L  K  D  N  S  H  V  I  Q  E |   Y  L  T  V  F  S  Q  M      p.600

          .         .         .         .         .         .       g.108955
 ATTGCATTTCATGATCCAGAGCTGAGTAATCATCTCAATGAGATTGGTTTCATTCCAGAT       c.1860
 I  A  F  H  D  P  E  L  S  N  H  L  N  E  I  G  F  I  P  D         p.620

  | 21       .         .         .        | 22.         .         . g.127957
  | CTCTATGCCATCCCTTGGTTTCTTACCATGTTTACTC | ATGTATTTCCACTACACAAAATT c.1920
  | L  Y  A  I  P  W  F  L  T  M  F  T  H |   V  F  P  L  H  K  I   p.640

          .         .         .         .         .         .       g.128017
 TTCCACCTCTGGGATACCTTACTACTTGGGAATTCCTCTTTCCCATTCTGTATTGGAGTA       c.1980
 F  H  L  W  D  T  L  L  L  G  N  S  S  F  P  F  C  I  G  V         p.660

          .         .         .         .         .         .       g.128077
 GCAATTCTTCAGCAGCTGCGGGACCGGCTTTTGGCTAATGGCTTTAATGAGTGTATTCTT       c.2040
 A  I  L  Q  Q  L  R  D  R  L  L  A  N  G  F  N  E  C  I  L         p.680

          .          | 23        .         .         .         .    g.150475
 CTCTTCTCCGATTTACCAG | AAATTGACATTGAACGCTGTGTGAGAGAATCTATCAACCTG    c.2100
 L  F  S  D  L  P  E |   I  D  I  E  R  C  V  R  E  S  I  N  L      p.700

          .         .         .         .         .         .       g.150535
 TTTTGTTGGACTCCTAAAAGTGCTACTTACAGACAGCATGCTCAACCTCCAAAGCCATCT       c.2160
 F  C  W  T  P  K  S  A  T  Y  R  Q  H  A  Q  P  P  K  P  S         p.720

          .         .         .         .         .         .       g.150595
 TCTGACAGCAGTGGAGGCAGAAGTTCGGCACCTTATTTCTCTGCTGAGTGTCCAGATCCT       c.2220
 S  D  S  S  G  G  R  S  S  A  P  Y  F  S  A  E  C  P  D  P         p.740

          .      | 24  .         .         .         .         .    g.205371
 CCAAAGACAGATCTG | TCAAGAGAATCCATCCCATTAAATGACCTGAAGTCAGAAGTATCA    c.2280
 P  K  T  D  L   | S  R  E  S  I  P  L  N  D  L  K  S  E  V  S      p.760

          .         .         .         .         .         .       g.205431
 CCACGGATTTCAGCAGAGGACCTGATTGACTTGTGTGAGCTCACAGTGACAGGCCACTTC       c.2340
 P  R  I  S  A  E  D  L  I  D  L  C  E  L  T  V  T  G  H  F         p.780

          .         .         .         .         .         .       g.205491
 AAAACACCCAGCAAGAAAACAAAGTCCAGTAAACCAAAGCTCCTGGTGGTTGACATCCGG       c.2400
 K  T  P  S  K  K  T  K  S  S  K  P  K  L  L  V  V  D  I  R         p.800

          .  | 25      .         .         .         .         .    g.226112
 AATAGTGAAGA | CTTTATTCGTGGTCACATTTCAGGAAGCATCAACATTCCATTCAGTGCT    c.2460
 N  S  E  D  |  F  I  R  G  H  I  S  G  S  I  N  I  P  F  S  A      p.820

          .         .         .         .         .         .       g.226172
 GCCTTCACTGCAGAAGGGGAGCTTACCCAGGGCCCTTACACTGCTATGCTCCAGAACTTC       c.2520
 A  F  T  A  E  G  E  L  T  Q  G  P  Y  T  A  M  L  Q  N  F         p.840

          .         .         .         .         .  | 26      .    g.275033
 AAAGGGAAGGTCATTGTCATCGTGGGGCATGTGGCAAAACACACAGCTGAG | TTTGCAGCT    c.2580
 K  G  K  V  I  V  I  V  G  H  V  A  K  H  T  A  E   | F  A  A      p.860

          .         .         .         .         .         .       g.275093
 CACCTTGTGAAGATGAAATATCCAAGAATCTGTATTCTAGATGGTGGCATTAATAAAATA       c.2640
 H  L  V  K  M  K  Y  P  R  I  C  I  L  D  G  G  I  N  K  I         p.880

          .         .         .         .                           g.275135
 AAGCCAACAGGCCTCCTCACCATCCCATCTCCTCAAATATGA                         c.2682
 K  P  T  G  L  L  T  I  P  S  P  Q  I  X                           p.893

          .         .         .         .         .         .       g.275195
 agaaccaagagtgtgactgccaaaacttagtgtggcatcagcaccaacagcacagttctt       c.*60

          .         .         .         .         .         .       g.275255
 catatccacgccactctcagacaaaactagatgtccagattgttgcatttccgtaaagtt       c.*120

          .         .         .         .         .         .       g.275315
 tgtcacgagacattttttaaaatctcataacccacatgttcagttatccatgcaagaaac       c.*180

          .         .         .         .         .         .       g.275375
 ttgactctacatgtattgctgaaagaattttcttaacagtgaaatctgatcatatatttt       c.*240

          .         .         .         .         .         .       g.275435
 taccacactgccacataaagcccaagaaattcagctgacaagacagatttagcattatca       c.*300

          .         .         .         .         .         .       g.275495
 agaaatcccatttgccctgaaaaagctgtcctccattgtactgaacagacagtcctgtcg       c.*360

          .         .         .         .         .         .       g.275555
 attgtgttatttagaaacatacactgaatgtgggctgaaatcatcatctttccataatga       c.*420

          .         .         .         .         .         .       g.275615
 aaactgagaaactattcacaatgcattccttataaataaatgctacatttagtaactcat       c.*480

          .                                                         g.275629
 ttcacccaaacaag                                                     c.*494

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The TBC1 domain containing kinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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