Disease #00517 (MRTES (Muir-Torre syndrome (MRTES)), OMIM:158320)

Official abbreviation	MRTES
Name	Muir-Torre syndrome (MRTES)
OMIM ID	158320
Human Phenotype Ontology Project (HPO)	HPO
Inheritance	Autosomal dominant
Individuals reported having this disease	70
Phenotype entries for this disease	3
Associated with 2 genes	MLH1, MSH2
Associated tissues	-
Disease features	-
Remarks	-
Date created	2014-08-22 11:42:43 +02:00 (CEST)
Date last edited	2021-12-10 21:51:32 +01:00 (CET)

Individuals

Legend

Please note that a short description of a certain column can be displayed when you move your mouse cursor over the column's header and hold it still. Below, a more detailed description is shown per column.

ID_report: ID of the individual that can be publically shared, e.g. as listed in a publication

Reference: reference to publication describing the individual/family, possibly giving more phenotypic details than listed in this database entry, incl. link to PubMed or other source, e.g. "den Dunnen ASHG2003 P2346"

Remarks: remarks about the individual

Gender: gender individual
All options:

? = unknown
- = not applicable
F = female
M = male
rF = raised as female
rM = raised as male

Consanguinity: indicates whether the parents are related (consanguineous), not related (non-consanguineous) or whether consanguinity is not known (unknown)
All options:

no = non-consanguineous parents
yes = consanguineous parents
likely = consanguinity likely
? = unknown
- = not applicable

Country: where (country) does the individual live/recently came from. Give additional details (population, specific sub-group) and when parents come from different countries in "Population". Belgium = individual lives in/recently came from Belgium, (France) = reported by laboratory in France, individual's country of origin not sure
All options:

? (unknown)
- (not applicable)
Afghanistan
(Afghanistan)
Albania
(Albania)
Algeria
(Algeria)
American Samoa
(American Samoa)
Andorra
(Andorra)
Angola
(Angola)
Anguilla
(Anguilla)
Antarctica
(Antarctica)
Antigua and Barbuda
(Antigua and Barbuda)
Argentina
(Argentina)
Armenia
(Armenia)
Aruba
(Aruba)
Australia
(Australia)
Austria
(Austria)
Azerbaijan
(Azerbaijan)
Bahamas
(Bahamas)
Bahrain
(Bahrain)
Bangladesh
(Bangladesh)
Barbados
(Barbados)
Belarus
(Belarus)
Belgium
(Belgium)
Belize
(Belize)
Benin
(Benin)
Bermuda
(Bermuda)
Bhutan
(Bhutan)
Bolivia
(Bolivia)
Bosnia and Herzegovina
(Bosnia and Herzegovina)
Botswana
(Botswana)
Bouvet Island
(Bouvet Island)
Brazil
(Brazil)
British Indian Ocean Territory
(British Indian Ocean Territory)
Brunei Darussalam
(Brunei Darussalam)
Bulgaria
(Bulgaria)
Burkina Faso
(Burkina Faso)
Burundi
(Burundi)
Cambodia
(Cambodia)
Cameroon
(Cameroon)
Canada
(Canada)
Cape Verde
(Cape Verde)
Cayman Islands
(Cayman Islands)
Central African Republic
(Central African Republic)
Central Europe
Chad
(Chad)
Chile
(Chile)
China
(China)
Christmas Island
(Christmas Island)
Cocos (Keeling Islands)
(Cocos (Keeling Islands))
Colombia
(Colombia)
Comoros
(Comoros)
Congo
(Congo)
Cook Islands
(Cook Islands)
Costa Rica
(Costa Rica)
Cote D'Ivoire (Ivory Coast)
(Cote D'Ivoire (Ivory Coast))
Croatia (Hrvatska)
(Croatia (Hrvatska))
Cuba
(Cuba)
Cyprus
(Cyprus)
Czech Republic
(Czech Republic)
Denmark
(Denmark)
Djibouti
(Djibouti)
Dominica
(Dominica)
Dominican Republic
(Dominican Republic)
East Timor
(East Timor)
Ecuador
(Ecuador)
Egypt
(Egypt)
El Salvador
(El Salvador)
England
(England)
Equatorial Guinea
(Equatorial Guinea)
Eritrea
(Eritrea)
Estonia
(Estonia)
Ethiopia
(Ethiopia)
Falkland Islands (Malvinas)
(Falkland Islands (Malvinas))
Faroe Islands
(Faroe Islands)
Fiji
(Fiji)
Finland
(Finland)
France
(France)
Gabon
(Gabon)
Gambia
(Gambia)
Georgia
(Georgia)
Germany
(Germany)
Ghana
(Ghana)
Gibraltar
(Gibraltar)
Greece
(Greece)
Greenland
(Greenland)
Grenada
(Grenada)
Guadeloupe
(Guadeloupe)
Guam
(Guam)
Guatemala
(Guatemala)
Guiana, French
(Guiana, French)
Guinea
(Guinea)
Guinea-Bissau
(Guinea-Bissau)
Guyana
(Guyana)
Haiti
(Haiti)
Heard and McDonald Islands
(Heard and McDonald Islands)
Honduras
(Honduras)
Hong Kong
(Hong Kong)
Hungary
(Hungary)
Iceland
(Iceland)
India
(India)
Indonesia
(Indonesia)
Iran
(Iran)
Iraq
(Iraq)
Ireland
(Ireland)
Israel
(Israel)
Italy
(Italy)
Jamaica
(Jamaica)
Japan
(Japan)
Jordan
(Jordan)
Kazakhstan
(Kazakhstan)
Kenya
(Kenya)
Kiribati
(Kiribati)
Korea
(Korea)
Korea, North (People's Republic)
(Korea, North (People's Republic))
Korea, South (Republic)
(Korea, South (Republic))
Kosovo
(Kosovo)
Kuwait
(Kuwait)
Kyrgyzstan (Kyrgyz Republic)
(Kyrgyzstan (Kyrgyz Republic))
Laos
(Laos)
Latvia
(Latvia)
Lebanon
(Lebanon)
Lesotho
(Lesotho)
Liberia
(Liberia)
Libya
(Libya)
Liechtenstein
(Liechtenstein)
Lithuania
(Lithuania)
Luxembourg
(Luxembourg)
Macau
(Macau)
Macedonia
(Macedonia)
Madagascar
(Madagascar)
Malawi
(Malawi)
Malaysia
(Malaysia)
Maldives
(Maldives)
Mali
(Mali)
Mallorca
(Mallorca)
Malta
(Malta)
Marshall Islands
(Marshall Islands)
Martinique
(Martinique)
Mauritania
(Mauritania)
Mauritius
(Mauritius)
Mayotte
(Mayotte)
Mexico
(Mexico)
Micronesia
(Micronesia)
Moldova
(Moldova)
Monaco
(Monaco)
Mongolia
(Mongolia)
Montserrat
(Montserrat)
Morocco
(Morocco)
Mozambique
(Mozambique)
Myanmar
(Myanmar)
Namibia
(Namibia)
Nauru
(Nauru)
Nepal
(Nepal)
Netherlands
(Netherlands)
Netherlands Antilles
(Netherlands Antilles)
Neutral Zone (Saudia Arabia/Iraq)
(Neutral Zone (Saudia Arabia/Iraq))
New Caledonia
(New Caledonia)
New Zealand
(New Zealand)
Nicaragua
(Nicaragua)
Niger
(Niger)
Nigeria
(Nigeria)
Niue
(Niue)
Norfolk Island
(Norfolk Island)
Northern Ireland
(Northern Ireland)
Northern Mariana Islands
(Northern Mariana Islands)
Norway
(Norway)
Oman
(Oman)
Pakistan
(Pakistan)
Palau
(Palau)
Palestine
(Palestine)
Panama
(Panama)
Papua New Guinea
(Papua New Guinea)
Paraguay
(Paraguay)
Peru
(Peru)
Philippines
(Philippines)
Pitcairn
(Pitcairn)
Poland
(Poland)
Polynesia, French
(Polynesia, French)
Portugal
(Portugal)
Puerto Rico
(Puerto Rico)
Qatar
(Qatar)
Reunion
(Reunion)
Romania
(Romania)
Russia
(Russia)
Russian Federation
(Russian Federation)
Rwanda
(Rwanda)
S. Georgia and S. Sandwich Isls.
(S. Georgia and S. Sandwich Isls.)
Saint Kitts and Nevis
(Saint Kitts and Nevis)
Saint Lucia
(Saint Lucia)
Saint Vincent and The Grenadines
(Saint Vincent and The Grenadines)
Samoa
(Samoa)
San Marino
(San Marino)
Sao Tome and Principe
(Sao Tome and Principe)
Saudi Arabia
(Saudi Arabia)
Scotland
(Scotland)
Senegal
(Senegal)
Serbia
(Serbia)
Seychelles
(Seychelles)
Sierra Leone
(Sierra Leone)
Singapore
(Singapore)
Slovakia (Slovak Republic)
(Slovakia (Slovak Republic))
Slovenia
(Slovenia)
Solomon Islands
(Solomon Islands)
Somalia
(Somalia)
South Africa
(South Africa)
Southern Territories, French
(Southern Territories, French)
Soviet Union (former)
(Soviet Union (former))
Spain
(Spain)
Sri Lanka
(Sri Lanka)
St. Helena, Ascension and Tristan da
Cunha
(St. Helena, Ascension and Tristan da
Cunha)
St. Pierre and Miquelon
(St. Pierre and Miquelon)
Sudan
(Sudan)
Sudan, South
(Sudan, South)
Suriname
(Suriname)
Svalbard and Jan Mayen Islands
(Svalbard and Jan Mayen Islands)
Swaziland
(Swaziland)
Sweden
(Sweden)
Switzerland
(Switzerland)
Syria
(Syria)
Taiwan
(Taiwan)
Tajikistan
(Tajikistan)
Tanzania
(Tanzania)
Thailand
(Thailand)
Togo
(Togo)
Tokelau
(Tokelau)
Tonga
(Tonga)
Trinidad and Tobago
(Trinidad and Tobago)
Tunisia
(Tunisia)
Turkey
(Turkey)
Turkmenistan
(Turkmenistan)
Turks and Caicos Islands
(Turks and Caicos Islands)
Tuvalu
(Tuvalu)
Uganda
(Uganda)
Ukraine
(Ukraine)
United Arab Emirates
(United Arab Emirates)
United Kingdom (Great Britain)
(United Kingdom (Great Britain))
United States
(United States)
Uruguay
(Uruguay)
US Minor Outlying Islands
(US Minor Outlying Islands)
Uzbekistan
(Uzbekistan)
Vanuatu
(Vanuatu)
Vatican City State (Holy See)
(Vatican City State (Holy See))
Venezuela
(Venezuela)
Viet Nam
(Viet Nam)
Virgin Islands (British)
(Virgin Islands (British))
Virgin Islands (US)
(Virgin Islands (US))
Wales
(Wales)
Wallis and Futuna Islands
(Wallis and Futuna Islands)
Western Sahara
(Western Sahara)
Yemen
(Yemen)
Yugoslavia
(Yugoslavia)
Zaire
(Zaire)
Zambia
(Zambia)
Zimbabwe
(Zimbabwe)

Population: population the individual (or ancestors) belongs to; e.g. white, gypsy, Jewish-Ashkenazi, Africa-N, Sardinia, etc.

Age at death: age at which the individual deceased (when applicable):

35y = 35 years
>43y = still alive at 43y
04y08m = 4 years and 8 months
00y00m01d12h = 1 day and 12 hours
18y? = around 18 years
30y-40y = between 30 and 40 years
>54y = older than 54
? = unknown

VIP: individual/phenotype VIP-status was requested for matchmaking - need collaboration(s) to crack the case - please contact the submitter/curator. NOTE: to get VIP status ask the curator.

Data_av: are additional data available upon request: e.g. pedigree (yes/no/?)

Treatment: treatment of patient

Variants in genes: The individual has variants for this gene.

Panel size: Number of individuals this entry represents; e.g. 1 for an individual, 5 for a family with 5 affected members.

How to query this table

All list views have search fields which can be used to search data. You can search for a complete word or you can search for a part of a search term. If you enclose two or more words in double quotes, LOVD will search for the combination of those words only exactly in the order you specify. Note that search terms are case-insensitive and that wildcards such as * are treated as normal text! For all options, like "and", "or", and "not" searches, or searching for prefixes or suffixes, see the table below.

Operator	Column type	Example	Matches
	Text	Arg	all entries containing 'Arg'
space	Text	Arg Ser	all entries containing 'Arg' and 'Ser'
\|	Text	Arg\|Ser	all entries containing 'Arg' or 'Ser'
!	Text	!fs	all entries not containing 'fs'
^	Text	^p.(Arg	all entries beginning with 'p.(Arg'
$	Text	Ser)$	all entries ending with 'Ser)'
=""	Text	=""	all entries with this field empty
=""	Text	="p.0"	all entries exactly matching 'p.0'
!=""	Text	!=""	all entries with this field not empty
!=""	Text	!="p.0"	all entries not exactly matching 'p.0?'
combination	Text	*\|Ter !fs	all entries containing '*' or 'Ter' but not containing 'fs'
	Date	2020	all entries matching the year 2020
\|	Date	2020-03\|2020-04	all entries matching March or April, 2020
!	Date	!2020-03	all entries not matching March, 2020
<	Date	<2020	all entries before the year 2020
<=	Date	<=2020-06	all entries in or before June, 2020
>	Date	>2020-06	all entries after June, 2020
>=	Date	>=2020-06-15	all entries on or after June 15th, 2020
combination	Date	2019\|2020 <2020-03	all entries in 2019 or 2020, and before March, 2020
	Numeric	23	all entries exactly matching 23
\|	Numeric	23\|24	all entries exactly matching 23 or 24
!	Numeric	!23	all entries not exactly matching 23
<	Numeric	<23	all entries lower than 23
<=	Numeric	<=23	all entries lower than, or equal to, 23
>	Numeric	>23	all entries higher than 23
>=	Numeric	>=23	all entries higher than, or equal to, 23
combination	Numeric	>=20 <30 !23	all entries with values from 20 to 29, but not equal to 23

Some more advanced examples:

Example	Matches
Asian	all entries containing 'Asian', 'asian', including 'Caucasian', 'caucasian', etc.
Asian !Caucasian	all entries containing 'Asian' but not containing 'Caucasian'
Asian\|African !Caucasian	all entries containing 'Asian' or 'African', but not containing 'Caucasian'
"South Asian"	all entries containing 'South Asian', but not containing 'South East Asian'

To sort on a certain column, click on the column header or on the arrows. If that column is already selected to sort on, the sort order will be swapped. The column currently sorted on has a darker blue background color than the other columns. The up and down arrows next to the column name indicate the current sorting direction. When sorting on any field other than the default, LOVD will sort secondarily on the default sort column.

70 entries on 1 page. Showing entries 1 - 70.

Legend

How to query

Individual ID	ID_report	Reference	Remarks	Gender	Consanguinity	Country	Population	Age at death	VIP	Data_av	Treatment	Disease	Phenotype details	Genes screened	Variants in genes	Variants	Panel size	Owner
00188035	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH6	MSH6	1	1	Michael Woods
00189715	-	-	-	?	-	Germany	-	-	-	-	-	?, MRTES	-	MLH1	MLH1	1	1	INSiGHT group
00191352	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MLH1	MLH1	1	1	Michael Woods
00192471	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MLH1	MLH1	1	1	Michael Woods
00192975	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MLH1	MLH1	1	1	Michael Woods
00193082	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MLH1	MLH1	1	1	Michael Woods
00193083	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MLH1	MLH1	1	1	Michael Woods
00193932	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MLH1	MLH1	1	1	Michael Woods
00194035	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MLH1	MLH1	1	1	Michael Woods
00195527	-	-	-	F	-	Spain	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Daniel Rueda
00195564	-	-	-	-	-	Spain	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Daniel Rueda
00195585	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00195615	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00195616	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00195809	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196064	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196065	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196111	-	-	-	?	-	Germany	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00196114	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196262	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196384	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196385	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196460	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196658	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196736	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00196738	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00197000	-	-	-	?	-	Germany	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00197002	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00197097	-	-	-	?	-	Canada	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00197098	-	-	-	?	-	Canada	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00197128	-	-	-	?	-	Canada	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00197131	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00197172	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00197301	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2, MSH6	MSH2, MSH6	2	1	Michael Woods
00197505	-	-	-	?	-	Australia	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00197654	-	-	-	M	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00197656	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00197785	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00197863	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198082	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198169	-	-	-	?	-	Sweden	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00198174	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198265	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198592	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198597	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198598	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198601	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198801	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198805	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00198850	-	-	-	?	-	Germany	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00198854	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199092	-	-	-	?	-	-	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00199127	-	-	-	?	-	Germany	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00199128	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199357	-	-	-	?	-	-	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00199378	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199469	-	-	-	?	-	Germany	-	-	-	-	-	?, MRTES	-	MSH2	MSH2	1	1	INSiGHT group
00199486	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199540	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199541	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199558	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199695	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199703	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199742	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199847	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199877	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199884	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00199991	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00200015	-	-	-	?	-	-	-	-	-	-	-	MRTES	-	MSH2	MSH2	1	1	Michael Woods
00201827	-	PubMed: Lewis 2017	family history of endometrial, colon, and brain cancers	M	-	United States	-	-	-	-	-	?, MRTES	both tumor sites exhibiting loss of staining of MSH2 and MSH6, Erythematous mycosis fungoides (MF) patches on the left thigh.; ; loss of staining of MSH2 and MSH6 was also observed via immunohistochemistry in the original MF patch on his left thigh, suggesting a possible association between MF and MTS."""""""""MSH2-;MSH6-	-	MSH2	1	1	InSiGHT - John-Paul Plazzer

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Global Variome shared LOVD

COL4A3 (collagen, type IV, alpha 3 (Goodpasture an...))