Disease #01440 (MGR1 (migraine, susceptibility 1 (MGR-1)), OMIM:157300)

Official abbreviation MGR1
Name migraine, susceptibility 1 (MGR-1)
OMIM ID 157300
Human Phenotype Ontology Project (HPO) HPO
Inheritance Autosomal dominant
Individuals reported having this disease 43
Phenotype entries for this disease 43
Associated with 0 genes -
Associated tissues -
Disease features -
Remarks -
Date created 2014-09-25 23:29:40 +02:00 (CEST)
Date last edited 2021-12-10 21:51:32 +01:00 (CET)


Individuals

43 entries on 1 page. Showing entries 1 - 43.
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00060251 - PubMed: Matesanz 2016, Journal: Matesanz 2016 - - - Spain - - - - - MGR1 - ACSL5 ACSL5 1 1 Fuencisla Matesanz
00112816 - - - - - (Germany) - - - - - MGR1 hemiplegic migraine, speech impediments SCN4A SCN4A 1 1 Birgit Neitzel
00165247 Fam2PatII-2 PubMed: Le Fort 2004 - F - Switzerland - - - - - MGR1 The patient didn't have episodes of transient visual loss. SCN1A SCN1A 1 5 Paola Carrera
00165248 Fam2PatIII-3 PubMed: Le Fort 2004 - M - Switzerland - - - - Phenytoin, phenobarbital and primidone, improvement MGR1 The patient had 3 to 10 daily episodes of transient blindness, most commonly bilaterally, since infancy. He also had migraine with aura, the attacks would begin with a scintillating scotoma, followed by unilateral sensory symptoms and weakness, initially in one limb,progressing to include the trunk, the second limb and the face. Aphasia may have occurred. The attacks lasted ca.30 minutes and were followed by 1 to 8 hours of intense pulsatile headache, photophobia and phonophobia, nausea and occasional vomiting. SCN1A SCN1A 1 1 Paola Carrera
00165249 Fam2PatIII-5 PubMed: Le Fort 2004 - F - Switzerland - - - - - MGR1 The patient, also had "elicited repetitive daily blindness" (ERDB) beginning in early childhood and FHM beginning at age 20 years. SCN1A SCN1A 1 1 Paola Carrera
00165250 Fam2PatIV-4 PubMed: Le Fort 2004 - F - Switzerland - - - - - MGR1 The patient had ERDB. Episodes occurred up to 15 times per day and were a significant handicap. Frequent falls and brief episodes of disconnection (because of blindness) at age 4 years. Since age 7 years, she has had FHM. SCN1A SCN1A 1 1 Paola Carrera
00165251 Fam2PatIV-5 PubMed: Le Fort 2004 - F - Switzerland - - - - Valproate 400 mg/day, resolution MGR1 age first HM attack 8y;p atient had identical ERDB, observed by her mother from the earliest age.At age 6 years, she had partial seizures with secondary generalization. SCN1A SCN1A 1 1 Paola Carrera
00165252 Fam10Pat1 PubMed: Dichgans 2005 - F - - Europe - - - - MGR1 age first HM attack 6y SCN1A SCN1A 1 4 Paola Carrera
00165253 Fam10Pat2 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first HM attack 10y SCN1A SCN1A 1 1 Paola Carrera
00165254 Fam10Pat3 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first HM attack 15y SCN1A SCN1A 1 1 Paola Carrera
00165255 Fam10Pat4 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first HM attack 9y SCN1A SCN1A 1 1 Paola Carrera
00165256 Fam15Pat1 PubMed: Dichgans 2005 - F - - Europe - - - - MGR1 age first HM attack 21y SCN1A SCN1A 1 9 Paola Carrera
00165257 Fam15Pat2 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first HM attack 9y (duration days) SCN1A SCN1A 1 1 Paola Carrera
00165258 Fam15Pat3 PubMed: Dichgans 2005 - F - - Europe - - - - MGR1 age first HM attack 15y SCN1A SCN1A 1 1 Paola Carrera
00165259 Fam15Pat4 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first HM attack 10y (duration 24h) SCN1A SCN1A 1 1 Paola Carrera
00165260 Fam15Pat5 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first HM attack 10y SCN1A SCN1A 1 1 Paola Carrera
00165261 Fam15Pat6 PubMed: Dichgans 2005 - F - - Europe - - - - MGR1 age first HM attack 12y SCN1A SCN1A 1 1 Paola Carrera
00165262 Fam15Pat7 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first HM attack 11y SCN1A SCN1A 1 1 Paola Carrera
00165263 Fam15Pat8 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first HM attack 11y (duration >24h); age first aura 30y SCN1A SCN1A 1 1 Paola Carrera
00165264 Fam15Pat9 PubMed: Dichgans 2005 - F - - Europe - - - - MGR1 age first HM attack 12y (duration 45h); age first aura 45y SCN1A SCN1A 1 1 Paola Carrera
00165265 Fam16Pat1 PubMed: Dichgans 2005 - F - - Europe - - - - MGR1 age first HM attack 7y; age first aura 20y SCN1A SCN1A 1 5 Paola Carrera
00165266 Fam16Pat2 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first HM attack 6y SCN1A SCN1A 1 1 Paola Carrera
00165267 Fam16Pat3 PubMed: Dichgans 2005 - M - - Europe - - - - MGR1 age first aura 30y SCN1A SCN1A 1 1 Paola Carrera
00165268 Fam16Pat4 PubMed: Dichgans 2005 - F - - Europe - - - - MGR1 age first HM attack 12y SCN1A SCN1A 1 1 Paola Carrera
00165269 Fam16Pat5 PubMed: Dichgans 2005 - F - - Europe - - - - MGR1 age first HM attack 10y SCN1A SCN1A 1 1 Paola Carrera
00165270 Fam1PatII.1 PubMed: Vanmolkot 2007 - M - United States white - - - - MGR1 age first HM attack 12y SCN1A SCN1A 1 7 Paola Carrera
00165271 Fam1PatII.2 PubMed: Vanmolkot 2007 - M - United States white - - - - MGR1 age first HM attack 11y SCN1A SCN1A 1 1 Paola Carrera
00165272 Fam1PatIII.2 PubMed: Vanmolkot 2007 - F - United States white - - - - MGR1 age first HM attack 21y SCN1A SCN1A 1 1 Paola Carrera
00165273 Fam1PatIII.4 PubMed: Vanmolkot 2007 - F - United States white - - - - MGR1 age first HM attack 10y (duration 24h); age first aura 60y SCN1A SCN1A 1 1 Paola Carrera
00165274 Fam1PatIII.5 PubMed: Vanmolkot 2007 - M - United States white - - - - MGR1 age first HM attack 24y; age first aura 15y SCN1A SCN1A 1 1 Paola Carrera
00165275 Fam1PatIV.2 PubMed: Vanmolkot 2007 - M - United States white - - - - MGR1 age first HM attack 15y SCN1A SCN1A 1 1 Paola Carrera
00165276 Fam1PatIV.3 PubMed: Vanmolkot 2007 - M - United States white - - - - MGR1 age first HM attack 19y; age first aura 45y SCN1A SCN1A 1 1 Paola Carrera
00165277 Fam1Pat1 PubMed: Gargus 2007 - F - - mixed - - - - MGR1 The patient presented, at 4 years of age, with a history of uncontrolled jerking of the limbs and trunk not noticed at birth, but observed by the family since 2 years of age. The jerking movements were exacerbated by fine motor activity and walking. Neurological examination was largerly normal, with the exception of impaired fine motor coordination, a clumsy gait and multifocal action myoclonus. Over the next few months, increased myoclonus and gait deterioration were noted, the patient started to receive intensive physical and occupational therapy. At 9 years of age she began to develop frequent "band-like" headaches weekly that were moderately severe, but lasted less than 1 hour. The headaches have never been accompained by aura, photophobia, phonophobia, nausea, vomiting or ataxia, but she reports frequent periodic colorful visual distortions unassociated with the headache. SCN1A SCN1A 1 2 Paola Carrera
00165278 Fam1Pat2 PubMed: Gargus 2007 - F - - mixed - - - - MGR1 The patient has a 12-year history of episodic migraine that includes symptoms of vertigo, ataxia, nausea, photophobia, phonophobia and nonpulsatile tinnitus. The headaches typically last 1-2 days; one episode 10 years ago was severe enough to result in prolonged hospitalization. She had never visual aura. SCN1A SCN1A 1 1 Paola Carrera
00165279 Fam7PatIII-2 PubMed: de Vries 2007 - M - - Europe, west - - - - MGR1 age first HM attack 38y SCN1A SCN1A 1 1 Paola Carrera
00165280 Fam1PatII:2 PubMed: Castro 2008 - F - Portugal - - - - carbamazepine 400 mg/day, resolution MGR1 age first HM attack 14y; age first aura 15y SCN1A SCN1A 1 5 Paola Carrera
00165281 Fam1PatII:4 PubMed: Castro 2008 - F - Portugal - - - - - MGR1 age first HM attack 16y; age first aura SCN1A SCN1A 1 1 Paola Carrera
00165282 Fam1PatII:5 PubMed: Castro 2008 - M - Portugal - - - - carbamazepine 400 mg/day, resolution MGR1 age first HM attack 18y; age first aura 1hy SCN1A SCN1A 1 1 Paola Carrera
00165283 Fam1PatIII:2 PubMed: Castro 2008 - M - Portugal - - - - - MGR1 age first HM attack 12y; age first aura SCN1A SCN1A 1 1 Paola Carrera
00165284 Fam1PatIII:4 PubMed: Castro 2008 - M - Portugal - - - - carbamazepine 600 mg/day, improvement; higher dose not tolerated MGR1 age first HM attack 10y; age first aura 15y SCN1A SCN1A 1 1 Paola Carrera
00165285 Fam1PatII-2 PubMed: Vahedi 2009 - F - France white - - - - MGR1 age first HM attack 14y;p atient never had transient episodes of blindness. First migraine episode 24 hours after a minor head trauma. SCN1A SCN1A 1 3 Paola Carrera
00165286 Fam1PatIII-1 PubMed: Vahedi 2009 - F - France white - - - - MGR1 age first HM attack 6y; age first aura 60y;p atient reports mainly unilateral aura symptoms and occasional aura with bilateral sensory and motor symptoms. Since age 6, she has had repeated, daily (up to 10 times per day) stereotyped, bilateral transient blindness of maximum 10 seconds. Complete darkness and blindness in both eyes come up from the peripheral field to the central vision. There is no associated headache or any other neurologic symptoms before, during or after the transient blindness episodes. SCN1A SCN1A 1 1 Paola Carrera
00165287 Fam1PatIII-2 PubMed: Vahedi 2009 - F - France white - - - - MGR1 age first HM attack 10y;p roband's sister (III-2) was examined at age 10 after a first episode of hemiplegic migraine that occurred shortly after a minor head trauma. She reported no episode of transient blindness. SCN1A SCN1A 1 1 Paola Carrera
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