Disease #04264 (DMBp (metabolism, drug, poor))

Official abbreviation	DMBp
Name	metabolism, drug, poor
OMIM ID	-
Inheritance	-
Individuals reported having this disease	203
Phenotype entries for this disease	133
Associated with 7 genes	CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A5, DPYD
Associated tissues	-
Disease features	-
Remarks	-
Date created	2015-05-14 15:38:48 +02:00 (CEST)
Date last edited	2021-12-11 13:56:28 +01:00 (CET)

Individuals

Legend

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ID_report: ID of the individual that can be publically shared, e.g. as listed in a publication

Reference: reference to publication describing the individual/family, possibly giving more phenotypic details than listed in this database entry, incl. link to PubMed or other source, e.g. "den Dunnen ASHG2003 P2346"

Remarks: remarks about the individual

Gender: gender individual
All options:

? = unknown
- = not applicable
F = female
M = male
rF = raised as female
rM = raised as male

Consanguinity: indicates whether the parents are related (consanguineous), not related (non-consanguineous) or whether consanguinity is not known (unknown)
All options:

no = non-consanguineous parents
yes = consanguineous parents
likely = consanguinity likely
? = unknown
- = not applicable

Country: where (country) does the individual live/recently came from. Give additional details (population, specific sub-group) and when parents come from different countries in "Population". Belgium = individual lives in/recently came from Belgium, (France) = reported by laboratory in France, individual's country of origin not sure
All options:

? (unknown)
- (not applicable)
Afghanistan
(Afghanistan)
Albania
(Albania)
Algeria
(Algeria)
American Samoa
(American Samoa)
Andorra
(Andorra)
Angola
(Angola)
Anguilla
(Anguilla)
Antarctica
(Antarctica)
Antigua and Barbuda
(Antigua and Barbuda)
Argentina
(Argentina)
Armenia
(Armenia)
Aruba
(Aruba)
Australia
(Australia)
Austria
(Austria)
Azerbaijan
(Azerbaijan)
Bahamas
(Bahamas)
Bahrain
(Bahrain)
Bangladesh
(Bangladesh)
Barbados
(Barbados)
Belarus
(Belarus)
Belgium
(Belgium)
Belize
(Belize)
Benin
(Benin)
Bermuda
(Bermuda)
Bhutan
(Bhutan)
Bolivia
(Bolivia)
Bosnia and Herzegovina
(Bosnia and Herzegovina)
Botswana
(Botswana)
Bouvet Island
(Bouvet Island)
Brazil
(Brazil)
British Indian Ocean Territory
(British Indian Ocean Territory)
Brunei Darussalam
(Brunei Darussalam)
Bulgaria
(Bulgaria)
Burkina Faso
(Burkina Faso)
Burundi
(Burundi)
Cambodia
(Cambodia)
Cameroon
(Cameroon)
Canada
(Canada)
Cape Verde
(Cape Verde)
Cayman Islands
(Cayman Islands)
Central African Republic
(Central African Republic)
Central Europe
Chad
(Chad)
Chile
(Chile)
China
(China)
Christmas Island
(Christmas Island)
Cocos (Keeling Islands)
(Cocos (Keeling Islands))
Colombia
(Colombia)
Comoros
(Comoros)
Congo
(Congo)
Cook Islands
(Cook Islands)
Costa Rica
(Costa Rica)
Cote D'Ivoire (Ivory Coast)
(Cote D'Ivoire (Ivory Coast))
Croatia (Hrvatska)
(Croatia (Hrvatska))
Cuba
(Cuba)
Cyprus
(Cyprus)
Czech Republic
(Czech Republic)
Denmark
(Denmark)
Djibouti
(Djibouti)
Dominica
(Dominica)
Dominican Republic
(Dominican Republic)
East Timor
(East Timor)
Ecuador
(Ecuador)
Egypt
(Egypt)
El Salvador
(El Salvador)
England
(England)
Equatorial Guinea
(Equatorial Guinea)
Eritrea
(Eritrea)
Estonia
(Estonia)
Ethiopia
(Ethiopia)
Falkland Islands (Malvinas)
(Falkland Islands (Malvinas))
Faroe Islands
(Faroe Islands)
Fiji
(Fiji)
Finland
(Finland)
France
(France)
Gabon
(Gabon)
Gambia
(Gambia)
Georgia
(Georgia)
Germany
(Germany)
Ghana
(Ghana)
Gibraltar
(Gibraltar)
Greece
(Greece)
Greenland
(Greenland)
Grenada
(Grenada)
Guadeloupe
(Guadeloupe)
Guam
(Guam)
Guatemala
(Guatemala)
Guiana, French
(Guiana, French)
Guinea
(Guinea)
Guinea-Bissau
(Guinea-Bissau)
Guyana
(Guyana)
Haiti
(Haiti)
Heard and McDonald Islands
(Heard and McDonald Islands)
Honduras
(Honduras)
Hong Kong
(Hong Kong)
Hungary
(Hungary)
Iceland
(Iceland)
India
(India)
Indonesia
(Indonesia)
Iran
(Iran)
Iraq
(Iraq)
Ireland
(Ireland)
Israel
(Israel)
Italy
(Italy)
Jamaica
(Jamaica)
Japan
(Japan)
Jordan
(Jordan)
Kazakhstan
(Kazakhstan)
Kenya
(Kenya)
Kiribati
(Kiribati)
Korea
(Korea)
Korea, North (People's Republic)
(Korea, North (People's Republic))
Korea, South (Republic)
(Korea, South (Republic))
Kosovo
(Kosovo)
Kuwait
(Kuwait)
Kyrgyzstan (Kyrgyz Republic)
(Kyrgyzstan (Kyrgyz Republic))
Laos
(Laos)
Latvia
(Latvia)
Lebanon
(Lebanon)
Lesotho
(Lesotho)
Liberia
(Liberia)
Libya
(Libya)
Liechtenstein
(Liechtenstein)
Lithuania
(Lithuania)
Luxembourg
(Luxembourg)
Macau
(Macau)
Macedonia
(Macedonia)
Madagascar
(Madagascar)
Malawi
(Malawi)
Malaysia
(Malaysia)
Maldives
(Maldives)
Mali
(Mali)
Mallorca
(Mallorca)
Malta
(Malta)
Marshall Islands
(Marshall Islands)
Martinique
(Martinique)
Mauritania
(Mauritania)
Mauritius
(Mauritius)
Mayotte
(Mayotte)
Mexico
(Mexico)
Micronesia
(Micronesia)
Moldova
(Moldova)
Monaco
(Monaco)
Mongolia
(Mongolia)
Montserrat
(Montserrat)
Morocco
(Morocco)
Mozambique
(Mozambique)
Myanmar
(Myanmar)
Namibia
(Namibia)
Nauru
(Nauru)
Nepal
(Nepal)
Netherlands
(Netherlands)
Netherlands Antilles
(Netherlands Antilles)
Neutral Zone (Saudia Arabia/Iraq)
(Neutral Zone (Saudia Arabia/Iraq))
New Caledonia
(New Caledonia)
New Zealand
(New Zealand)
Nicaragua
(Nicaragua)
Niger
(Niger)
Nigeria
(Nigeria)
Niue
(Niue)
Norfolk Island
(Norfolk Island)
Northern Ireland
(Northern Ireland)
Northern Mariana Islands
(Northern Mariana Islands)
Norway
(Norway)
Oman
(Oman)
Pakistan
(Pakistan)
Palau
(Palau)
Palestine
(Palestine)
Panama
(Panama)
Papua New Guinea
(Papua New Guinea)
Paraguay
(Paraguay)
Peru
(Peru)
Philippines
(Philippines)
Pitcairn
(Pitcairn)
Poland
(Poland)
Polynesia, French
(Polynesia, French)
Portugal
(Portugal)
Puerto Rico
(Puerto Rico)
Qatar
(Qatar)
Reunion
(Reunion)
Romania
(Romania)
Russia
(Russia)
Russian Federation
(Russian Federation)
Rwanda
(Rwanda)
S. Georgia and S. Sandwich Isls.
(S. Georgia and S. Sandwich Isls.)
Saint Kitts and Nevis
(Saint Kitts and Nevis)
Saint Lucia
(Saint Lucia)
Saint Vincent and The Grenadines
(Saint Vincent and The Grenadines)
Samoa
(Samoa)
San Marino
(San Marino)
Sao Tome and Principe
(Sao Tome and Principe)
Saudi Arabia
(Saudi Arabia)
Scotland
(Scotland)
Senegal
(Senegal)
Serbia
(Serbia)
Seychelles
(Seychelles)
Sierra Leone
(Sierra Leone)
Singapore
(Singapore)
Slovakia (Slovak Republic)
(Slovakia (Slovak Republic))
Slovenia
(Slovenia)
Solomon Islands
(Solomon Islands)
Somalia
(Somalia)
South Africa
(South Africa)
Southern Territories, French
(Southern Territories, French)
Soviet Union (former)
(Soviet Union (former))
Spain
(Spain)
Sri Lanka
(Sri Lanka)
St. Helena, Ascension and Tristan da
Cunha
(St. Helena, Ascension and Tristan da
Cunha)
St. Pierre and Miquelon
(St. Pierre and Miquelon)
Sudan
(Sudan)
Sudan, South
(Sudan, South)
Suriname
(Suriname)
Svalbard and Jan Mayen Islands
(Svalbard and Jan Mayen Islands)
Swaziland
(Swaziland)
Sweden
(Sweden)
Switzerland
(Switzerland)
Syria
(Syria)
Taiwan
(Taiwan)
Tajikistan
(Tajikistan)
Tanzania
(Tanzania)
Thailand
(Thailand)
Togo
(Togo)
Tokelau
(Tokelau)
Tonga
(Tonga)
Trinidad and Tobago
(Trinidad and Tobago)
Tunisia
(Tunisia)
Turkey
(Turkey)
Turkmenistan
(Turkmenistan)
Turks and Caicos Islands
(Turks and Caicos Islands)
Tuvalu
(Tuvalu)
Uganda
(Uganda)
Ukraine
(Ukraine)
United Arab Emirates
(United Arab Emirates)
United Kingdom (Great Britain)
(United Kingdom (Great Britain))
United States
(United States)
Uruguay
(Uruguay)
US Minor Outlying Islands
(US Minor Outlying Islands)
Uzbekistan
(Uzbekistan)
Vanuatu
(Vanuatu)
Vatican City State (Holy See)
(Vatican City State (Holy See))
Venezuela
(Venezuela)
Viet Nam
(Viet Nam)
Virgin Islands (British)
(Virgin Islands (British))
Virgin Islands (US)
(Virgin Islands (US))
Wales
(Wales)
Wallis and Futuna Islands
(Wallis and Futuna Islands)
Western Sahara
(Western Sahara)
Yemen
(Yemen)
Yugoslavia
(Yugoslavia)
Zaire
(Zaire)
Zambia
(Zambia)
Zimbabwe
(Zimbabwe)

Population: population the individual (or ancestors) belongs to; e.g. white, gypsy, Jewish-Ashkenazi, Africa-N, Sardinia, etc.

Age at death: age at which the individual deceased (when applicable):

35y = 35 years
>43y = still alive at 43y
04y08m = 4 years and 8 months
00y00m01d12h = 1 day and 12 hours
18y? = around 18 years
30y-40y = between 30 and 40 years
>54y = older than 54
? = unknown

VIP: individual/phenotype VIP-status was requested for matchmaking - need collaboration(s) to crack the case - please contact the submitter/curator. NOTE: to get VIP status ask the curator.

Data_av: are additional data available upon request: e.g. pedigree (yes/no/?)

Treatment: treatment of patient

Variants in genes: The individual has variants for this gene.

Panel size: Number of individuals this entry represents; e.g. 1 for an individual, 5 for a family with 5 affected members.

How to query this table

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Operator	Column type	Example	Matches
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space	Text	Arg Ser	all entries containing 'Arg' and 'Ser'
\|	Text	Arg\|Ser	all entries containing 'Arg' or 'Ser'
!	Text	!fs	all entries not containing 'fs'
^	Text	^p.(Arg	all entries beginning with 'p.(Arg'
$	Text	Ser)$	all entries ending with 'Ser)'
=""	Text	=""	all entries with this field empty
=""	Text	="p.0"	all entries exactly matching 'p.0'
!=""	Text	!=""	all entries with this field not empty
!=""	Text	!="p.0"	all entries not exactly matching 'p.0?'
combination	Text	*\|Ter !fs	all entries containing '*' or 'Ter' but not containing 'fs'
	Date	2020	all entries matching the year 2020
\|	Date	2020-03\|2020-04	all entries matching March or April, 2020
!	Date	!2020-03	all entries not matching March, 2020
<	Date	<2020	all entries before the year 2020
<=	Date	<=2020-06	all entries in or before June, 2020
>	Date	>2020-06	all entries after June, 2020
>=	Date	>=2020-06-15	all entries on or after June 15th, 2020
combination	Date	2019\|2020 <2020-03	all entries in 2019 or 2020, and before March, 2020
	Numeric	23	all entries exactly matching 23
\|	Numeric	23\|24	all entries exactly matching 23 or 24
!	Numeric	!23	all entries not exactly matching 23
<	Numeric	<23	all entries lower than 23
<=	Numeric	<=23	all entries lower than, or equal to, 23
>	Numeric	>23	all entries higher than 23
>=	Numeric	>=23	all entries higher than, or equal to, 23
combination	Numeric	>=20 <30 !23	all entries with values from 20 to 29, but not equal to 23

Some more advanced examples:

Example	Matches
Asian	all entries containing 'Asian', 'asian', including 'Caucasian', 'caucasian', etc.
Asian !Caucasian	all entries containing 'Asian' but not containing 'Caucasian'
Asian\|African !Caucasian	all entries containing 'Asian' or 'African', but not containing 'Caucasian'
"South Asian"	all entries containing 'South Asian', but not containing 'South East Asian'

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203 entries on 3 pages. Showing entries 1 - 100.

	Legend	How to query	« First	‹ Prev		1	2	3		Next ›	Last »

Individual ID	ID_report	Reference	Remarks	Gender	Consanguinity	Country	Population	Age at death	VIP	Data_av	Treatment	Disease	Phenotype details	Genes screened	Variants in genes	Variants	Panel size	Owner
00022436	-	PA165816585	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	VKORC1	VKORC1	3	1	Johan den Dunnen
00022437	-	PA165816586	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	VKORC1	VKORC1	4	1	Johan den Dunnen
00022440	-	PA165816589	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	VKORC1	VKORC1	5	1	Johan den Dunnen
00033760	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00033762	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00033763	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	4	1	Johan den Dunnen
00033764	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	4	1	Johan den Dunnen
00033765	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	4	1	Johan den Dunnen
00038570	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2C8	CYP2C8	6	1	Sarah C Sim
00038571	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2C8	CYP2C8	6	1	Sarah C Sim
00038572	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2C8	CYP2C8	1	1	Sarah C Sim
00038576	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2C8	CYP2C8	1	1	Sarah C Sim
00038582	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2C8	CYP2C8	1	1	Sarah C Sim
00038600	-	PubMed: Hanioka 2010	-	-	-	-	-	-	-	-	-	DMBp	-	CYP2C8	CYP2C8	1	1	Johan den Dunnen
00038601	-	PubMed: Gao 2010	-	-	-	-	-	-	-	-	-	DMBp	-	CYP2C8	CYP2C8	1	1	Johan den Dunnen
00038602	-	PubMed: Jian 2011	-	-	-	-	-	-	-	-	-	DMBp	-	CYP2C8	CYP2C8	1	1	Johan den Dunnen
00038604	-	PubMed: Gao 2010	-	-	-	-	-	-	-	-	-	DMBp	-	CYP2C8	CYP2C8	2	1	Johan den Dunnen
00038784	-	PubMed: Kuehl 2001	-	-	-	United States	African-American	-	-	-	-	DMBp	-	CYP3A5	CYP3A5	1	1	Johan den Dunnen
00046418	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00046419	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	2	1	Johan den Dunnen
00046420	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	7	1	Johan den Dunnen
00046421	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	6	1	Johan den Dunnen
00046422	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	5	1	Johan den Dunnen
00046423	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	5	1	Johan den Dunnen
00046424	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	4	1	Johan den Dunnen
00046425	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	8	1	Johan den Dunnen
00046426	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	8	1	Johan den Dunnen
00046427	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	8	1	Johan den Dunnen
00046428	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	6	1	Johan den Dunnen
00046429	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	5	1	Johan den Dunnen
00046430	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	5	1	Johan den Dunnen
00046431	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	12	1	Johan den Dunnen
00046432	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	19	1	Johan den Dunnen
00046433	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	19	1	Johan den Dunnen
00046439	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	2	1	Johan den Dunnen
00046440	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	3	1	Johan den Dunnen
00046441	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	2	1	Johan den Dunnen
00046444	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	4	1	Johan den Dunnen
00046445	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	10	1	Johan den Dunnen
00046446	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00046447	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00046448	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	5	1	Johan den Dunnen
00046449	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	4	1	Johan den Dunnen
00046466	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00046468	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	5	1	Johan den Dunnen
00046469	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	4	1	Johan den Dunnen
00046471	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	2	1	Johan den Dunnen
00046472	-	PubMed: Yamazaki 2003	-	-	-	Japan	-	-	-	-	-	DMBp	metabolic ratio capacity dextromethorphan O-demethylation 0.016 (0.0027 for CYP2D61/2)	CYP2D6	CYP2D6	4	1	Johan den Dunnen
00046478	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00046484	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00046497	-	PubMed: Buermans 2017, Journal: Buermans 2017	-	-	no	Netherlands	-	-	-	-	-	DMBp	CYP2D6 poor metaboliser	CYP2D6	CYP2D6	18	1	Henk Buermans
00046774	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00046777	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00046779	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	1	1	Johan den Dunnen
00046781	-	PubMed: Gaedigk 2003, Journal: Gaedigk 2003	-	?	no	United States	African-American	>00y12m	-	-	-	DMBp	poor metabolizer phenotype at 2w to 4m, MR (DM/DX) 0.8-1.9	CYP2D6	CYP2D6	6	1	Johan den Dunnen
00046785	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	8	1	Johan den Dunnen
00046796	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	13	1	Johan den Dunnen
00046798	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	-	CYP2D6	CYP2D6	22	1	Johan den Dunnen
00051543	-	-	2 generation family, 3 affecteds	M	no	Japan	-	-	-	-	-	DMBp	poor metabolizer, S-mephenytoin	CYP2C19	CYP2C19	2	3	Johan den Dunnen
00051548	-	-	-	M	?	United States	-	-	-	-	-	DMBp	poor metabolizer, tolbutamide	CYP2C9	CYP2C9	4	1	Johan den Dunnen
00051550	-	-	-	F	?	United States	-	-	-	-	-	DMBp	poor metabolizer, tolbutamide	CYP2C9	CYP2C9	3	1	Johan den Dunnen
00051551	-	-	-	?	?	United States	African American	-	-	-	-	DMBp	poor metaboliser, association with	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051553	-	-	-	?	?	China	-	-	-	-	-	DMBp	required lower warfarin dose	CYP2C9	CYP2C9	3	4	Johan den Dunnen
00051554	-	-	-	?	?	China	-	-	-	-	-	DMBp	required lower warfarin dose	CYP2C9	CYP2C9	2	6	Johan den Dunnen
00051555	-	-	-	?	?	China	-	-	-	-	-	DMBp	required lower warfarin dose	CYP2C9	CYP2C9	1	50	Johan den Dunnen
00051557	-	-	-	?	?	China	-	-	-	-	-	DMBp	required lower warfarin dose	CYP2C9	CYP2C9	2	15	Johan den Dunnen
00051564	-	-	2-generation family	M	no	China	-	-	-	-	-	DMBp	poor metaboliser, lornoxicam, tolbutamide half life 9-15x reduced	CYP2C9	CYP2C9	2	1	Johan den Dunnen
00051568	-	-	-	?	?	United States	-	-	-	-	-	DMBp	poor metaboliser, lornoxicam, 0.33 reduced warfarin maintenance dose	CYP2C9	CYP2C9	1	4	Johan den Dunnen
00051598	-	-	-	?	?	China	-	-	-	-	-	DMBp	drug sensitivity, warfarin	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051599	-	-	-	M	?	China	-	-	-	-	-	DMBp	drug sensitivity, warfarin	CYP2C9	CYP2C9	1	3	Johan den Dunnen
00051608	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051609	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	6	1	Johan den Dunnen
00051610	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	7	1	Johan den Dunnen
00051611	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	5	1	Johan den Dunnen
00051612	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051613	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	5	1	Johan den Dunnen
00051614	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	6	1	Johan den Dunnen
00051616	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051622	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051623	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	decreased activity	CYP2C9	CYP2C9	3	1	Johan den Dunnen
00051647	-	-	reference haplotype	-	-	-	-	-	-	-	-	DMBp	no activity	CYP2C9	CYP2C9	2	1	Johan den Dunnen
00051652	-	-	-	-	-	United Kingdom (Great Britain)	white	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	6	1	Johan den Dunnen
00051653	-	-	-	-	-	United Kingdom (Great Britain)	white	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	6	1	Johan den Dunnen
00051654	-	-	-	-	-	United Kingdom (Great Britain)	white	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	5	1	Johan den Dunnen
00051655	-	-	-	-	-	United Kingdom (Great Britain)	white	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	7	1	Johan den Dunnen
00051657	-	-	-	-	-	United Kingdom (Great Britain)	white	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	5	1	Johan den Dunnen
00051666	-	-	-	M	?	Japan	-	-	-	-	-	DMBp	epilepsy, poor metaboliser, lornoxicam	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051677	-	-	-	?	?	China	-	-	-	-	-	DMBp	required lower warfarin dose	CYP2C9	CYP2C9	3	1	Johan den Dunnen
00051678	-	-	-	?	?	China	-	-	-	-	-	DMBp	poor metaboliser warfarin,	CYP2C9	CYP2C9	4	1	Johan den Dunnen
00051684	-	-	-	-	-	India	-	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051686	-	-	-	-	-	-	white	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	6	1	Johan den Dunnen
00051687	-	-	-	-	-	-	white	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	12	1	Johan den Dunnen
00051688	-	-	-	-	-	China	-	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	6	4	Johan den Dunnen
00051690	-	-	-	-	-	India	-	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	6	4	Johan den Dunnen
00051691	-	-	-	-	-	India	-	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	12	1	Johan den Dunnen
00051693	-	-	-	-	-	Malaysia	-	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051694	-	-	-	-	-	India	-	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051696	-	-	-	-	-	China	-	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051697	-	-	-	-	-	Malaysia	-	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	1	1	Johan den Dunnen
00051698	-	-	-	-	-	China	-	-	-	-	-	DMBp	poor metaboliser, warfarin	CYP2C9	CYP2C9	1	1	Johan den Dunnen

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Global Variome shared LOVD

PINK1 (PTEN induced putative kinase 1)