Disease #04264 (DMBp (metabolism, drug, poor))

Official abbreviation DMBp
Name metabolism, drug, poor
OMIM ID -
Inheritance -
Individuals reported having this disease 203
Phenotype entries for this disease 133
Associated with 7 genes CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A5, DPYD
Associated tissues -
Disease features -
Remarks -


Individuals

203 entries on 3 pages. Showing entries 1 - 100.
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00022436 - PA165816585 reference haplotype - - - (not applicable) - - 0 - - DMBp decreased activity VKORC1 VKORC1 3 1 Johan den Dunnen
00022437 - PA165816586 reference haplotype - - - (not applicable) - - 0 - - DMBp decreased activity VKORC1 VKORC1 4 1 Johan den Dunnen
00022440 - PA165816589 reference haplotype - - - (not applicable) - - 0 - - DMBp decreased activity VKORC1 VKORC1 5 1 Johan den Dunnen
00033760 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00033762 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00033763 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 4 1 Johan den Dunnen
00033764 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 4 1 Johan den Dunnen
00033765 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 4 1 Johan den Dunnen
00038570 - - reference haplotype - - - - - 0 - - DMBp - CYP2C8 CYP2C8 6 1 Sarah C Sim
00038571 - - reference haplotype - - - - - 0 - - DMBp - CYP2C8 CYP2C8 6 1 Sarah C Sim
00038572 - - reference haplotype - - - - - 0 - - DMBp - CYP2C8 CYP2C8 1 1 Sarah C Sim
00038576 - - reference haplotype - - - - - 0 - - DMBp - CYP2C8 CYP2C8 1 1 Sarah C Sim
00038582 - - reference haplotype - - - - - 0 - - DMBp - CYP2C8 CYP2C8 1 1 Sarah C Sim
00038600 - PubMed: Hanioka 2010 - - - - (not applicable) - - 0 - - DMBp - CYP2C8 CYP2C8 1 1 Johan den Dunnen
00038601 - PubMed: Gao 2010 - - - - (not applicable) - - 0 - - DMBp - CYP2C8 CYP2C8 1 1 Johan den Dunnen
00038602 - PubMed: Jian 2011 - - - - (not applicable) - - 0 - - DMBp - CYP2C8 CYP2C8 1 1 Johan den Dunnen
00038604 - PubMed: Gao 2010 - - - - (not applicable) - - 0 - - DMBp - CYP2C8 CYP2C8 2 1 Johan den Dunnen
00038784 - PubMed: Kuehl 2001 - - - United States African-American - 0 - - DMBp - CYP3A5 CYP3A5 1 1 Johan den Dunnen
00046418 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00046419 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 2 1 Johan den Dunnen
00046420 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 7 1 Johan den Dunnen
00046421 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 6 1 Johan den Dunnen
00046422 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 5 1 Johan den Dunnen
00046423 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 5 1 Johan den Dunnen
00046424 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 4 1 Johan den Dunnen
00046425 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 8 1 Johan den Dunnen
00046426 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 8 1 Johan den Dunnen
00046427 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 8 1 Johan den Dunnen
00046428 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 6 1 Johan den Dunnen
00046429 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 5 1 Johan den Dunnen
00046430 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 5 1 Johan den Dunnen
00046431 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 12 1 Johan den Dunnen
00046432 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 19 1 Johan den Dunnen
00046433 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 19 1 Johan den Dunnen
00046439 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 2 1 Johan den Dunnen
00046440 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 3 1 Johan den Dunnen
00046441 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 2 1 Johan den Dunnen
00046444 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 4 1 Johan den Dunnen
00046445 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 10 1 Johan den Dunnen
00046446 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00046447 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00046448 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 5 1 Johan den Dunnen
00046449 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 4 1 Johan den Dunnen
00046466 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00046468 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 5 1 Johan den Dunnen
00046469 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 4 1 Johan den Dunnen
00046471 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 2 1 Johan den Dunnen
00046472 - PubMed: Yamazaki 2003 - - - Japan - - 0 - - DMBp metabolic ratio capacity dextromethorphan O-demethylation 0.016 (0.0027 for CYP2D6*1/*2) CYP2D6 CYP2D6 4 1 Johan den Dunnen
00046478 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00046484 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00046497 - PubMed: Buermans 2017, Journal: Buermans 2017 - - no Netherlands - - 0 - - DMBp CYP2D6 poor metaboliser CYP2D6 CYP2D6 18 1 Henk Buermans
00046774 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00046777 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00046779 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 1 1 Johan den Dunnen
00046781 - PubMed: Gaedigk 2003, Journal: Gaedigk 2003 - ? no United States African-American >00y12m 0 - - DMBp poor metabolizer phenotype at 2w to 4m, MR (DM/DX) 0.8-1.9 CYP2D6 CYP2D6 6 1 Johan den Dunnen
00046785 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 8 1 Johan den Dunnen
00046796 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 13 1 Johan den Dunnen
00046798 - - reference haplotype - - - (not applicable) - - 0 - - DMBp - CYP2D6 CYP2D6 22 1 Johan den Dunnen
00051543 - - 2 generation family, 3 affecteds M no Japan - - 0 - - DMBp poor metabolizer, S-mephenytoin CYP2C19 CYP2C19 2 3 Johan den Dunnen
00051548 - - - M ? United States - - 0 - - DMBp poor metabolizer, tolbutamide CYP2C9 CYP2C9 4 1 Johan den Dunnen
00051550 - - - F ? United States - - 0 - - DMBp poor metabolizer, tolbutamide CYP2C9 CYP2C9 3 1 Johan den Dunnen
00051551 - - - ? ? United States African American - 0 - - DMBp poor metaboliser, association with CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051553 - - - ? ? China - - 0 - - DMBp required lower warfarin dose CYP2C9 CYP2C9 3 4 Johan den Dunnen
00051554 - - - ? ? China - - 0 - - DMBp required lower warfarin dose CYP2C9 CYP2C9 2 6 Johan den Dunnen
00051555 - - - ? ? China - - 0 - - DMBp required lower warfarin dose CYP2C9 CYP2C9 1 50 Johan den Dunnen
00051557 - - - ? ? China - - 0 - - DMBp required lower warfarin dose CYP2C9 CYP2C9 2 15 Johan den Dunnen
00051564 - - 2-generation family M no China - - 0 - - DMBp poor metaboliser, lornoxicam, tolbutamide half life 9-15x reduced CYP2C9 CYP2C9 2 1 Johan den Dunnen
00051568 - - - ? ? United States - - 0 - - DMBp poor metaboliser, lornoxicam, 0.33 reduced warfarin maintenance dose CYP2C9 CYP2C9 1 4 Johan den Dunnen
00051598 - - - ? ? China - - 0 - - DMBp drug sensitivity, warfarin CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051599 - - - M ? China - - 0 - - DMBp drug sensitivity, warfarin CYP2C9 CYP2C9 1 3 Johan den Dunnen
00051608 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051609 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 6 1 Johan den Dunnen
00051610 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 7 1 Johan den Dunnen
00051611 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 5 1 Johan den Dunnen
00051612 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051613 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 5 1 Johan den Dunnen
00051614 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 6 1 Johan den Dunnen
00051616 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051622 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051623 - - reference haplotype - - - - - 0 - - DMBp decreased activity CYP2C9 CYP2C9 3 1 Johan den Dunnen
00051647 - - reference haplotype - - - - - 0 - - DMBp no activity CYP2C9 CYP2C9 2 1 Johan den Dunnen
00051652 - - - - - United Kingdom (Great Britain) white - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 6 1 Johan den Dunnen
00051653 - - - - - United Kingdom (Great Britain) white - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 6 1 Johan den Dunnen
00051654 - - - - - United Kingdom (Great Britain) white - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 5 1 Johan den Dunnen
00051655 - - - - - United Kingdom (Great Britain) white - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 7 1 Johan den Dunnen
00051657 - - - - - United Kingdom (Great Britain) white - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 5 1 Johan den Dunnen
00051666 - - - M ? Japan - - 0 - - DMBp epilepsy, poor metaboliser, lornoxicam CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051677 - - - ? ? China - - 0 - - DMBp required lower warfarin dose CYP2C9 CYP2C9 3 1 Johan den Dunnen
00051678 - - - ? ? China - - 0 - - DMBp poor metaboliser warfarin, CYP2C9 CYP2C9 4 1 Johan den Dunnen
00051684 - - - - - India - - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051686 - - - - - - white - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 6 1 Johan den Dunnen
00051687 - - - - - - white - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 12 1 Johan den Dunnen
00051688 - - - - - China - - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 6 4 Johan den Dunnen
00051690 - - - - - India - - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 6 4 Johan den Dunnen
00051691 - - - - - India - - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 12 1 Johan den Dunnen
00051693 - - - - - Malaysia - - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051694 - - - - - India - - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051696 - - - - - China - - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051697 - - - - - Malaysia - - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 1 1 Johan den Dunnen
00051698 - - - - - China - - 0 - - DMBp poor metaboliser, warfarin CYP2C9 CYP2C9 1 1 Johan den Dunnen
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