### LOVD-version 3000-30b ### Full data download ### To import, do not remove or alter this header ### ## Filter: (gene_public = DDR2) # charset = UTF-8 ## Genes ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{name}}" "{{chromosome}}" "{{chrom_band}}" "{{imprinting}}" "{{refseq_genomic}}" "{{refseq_UD}}" "{{reference}}" "{{url_homepage}}" "{{url_external}}" "{{allow_download}}" "{{id_hgnc}}" "{{id_entrez}}" "{{id_omim}}" "{{show_hgmd}}" "{{show_genecards}}" "{{show_genetests}}" "{{show_orphanet}}" "{{note_index}}" "{{note_listing}}" "{{refseq}}" "{{refseq_url}}" "{{disclaimer}}" "{{disclaimer_text}}" "{{header}}" "{{header_align}}" "{{footer}}" "{{footer_align}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{updated_by}}" "{{updated_date}}" "DDR2" "discoidin domain receptor tyrosine kinase 2" "1" "q12-q23" "unknown" "LRG_1390" "UD_132118887524" "" "https://www.LOVD.nl/DDR2" "" "1" "2731" "4921" "191311" "1" "1" "1" "1" "Establishment of this gene variant database (LSDB) was supported by the Leiden University Medical Center (LUMC), Leiden, Nederland." "" "" "" "1" "" "" "-1" "" "-1" "00001" "2013-05-03 00:00:00" "00006" "2019-08-05 09:22:26" "00000" "2025-05-05 21:14:00" ## Transcripts ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{geneid}}" "{{name}}" "{{id_mutalyzer}}" "{{id_ncbi}}" "{{id_ensembl}}" "{{id_protein_ncbi}}" "{{id_protein_ensembl}}" "{{id_protein_uniprot}}" "{{remarks}}" "{{position_c_mrna_start}}" "{{position_c_mrna_end}}" "{{position_c_cds_end}}" "{{position_g_mrna_start}}" "{{position_g_mrna_end}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00006207" "DDR2" "transcript variant 2" "002" "NM_006182.2" "" "NP_006173.2" "" "" "" "-385" "2787" "2568" "162602228" "162750255" "" "0000-00-00 00:00:00" "" "" ## Diseases ## Do not remove or alter this header ## ## Count = 5 "{{id}}" "{{symbol}}" "{{name}}" "{{inheritance}}" "{{id_omim}}" "{{tissues}}" "{{features}}" "{{remarks}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00198" "?" "unclassified / mixed" "" "" "" "" "" "00006" "2013-09-13 14:21:47" "00006" "2024-11-23 09:38:12" "00695" "OSMEDB" "Otospondylomegaepiphyseal dysplasia, autosomal recessive" "AR" "215150" "" "" "" "00006" "2014-09-25 23:29:40" "00006" "2021-12-10 21:51:32" "01544" "RB1" "retinoblastoma, type 1" "AD;SMu" "180200" "" "" "" "00006" "2014-09-25 23:29:40" "00006" "2025-01-14 18:01:23" "02083" "SMEDSL" "dysplasia, spondylometaepiphyseal, short limb-hand type" "AR" "271665" "" "" "autosomal recessive" "00006" "2014-09-25 23:29:40" "00006" "2021-12-11 13:56:28" "06041" "WRCN" "Warburg-Cinotti syndrome" "AD" "618175" "" "" "" "00006" "2021-12-10 23:20:41" "" "" ## Genes_To_Diseases ## Do not remove or alter this header ## ## Count = 2 "{{geneid}}" "{{diseaseid}}" "DDR2" "02083" "DDR2" "06041" ## Individuals ## Do not remove or alter this header ## ## Count = 3 "{{id}}" "{{fatherid}}" "{{motherid}}" "{{panelid}}" "{{panel_size}}" "{{license}}" "{{owned_by}}" "{{Individual/Reference}}" "{{Individual/Remarks}}" "{{Individual/Gender}}" "{{Individual/Consanguinity}}" "{{Individual/Origin/Geographic}}" "{{Individual/Age_of_death}}" "{{Individual/VIP}}" "{{Individual/Data_av}}" "{{Individual/Treatment}}" "{{Individual/Origin/Population}}" "{{Individual/Individual_ID}}" "00250195" "" "" "" "1" "" "03321" "" "" "M" "" "Iran" "" "0" "" "" "" "" "00289572" "" "" "" "1" "" "03575" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "analysis 2794 individuals (India)" "" "" "India" "" "0" "" "" "" "" "00307257" "" "" "" "1" "" "03753" "{PMID:Mendonca 2021:34478740}" "" "M" "" "Brazil" "" "0" "" "" "" "Patient 62" ## Individuals_To_Diseases ## Do not remove or alter this header ## ## Count = 3 "{{individualid}}" "{{diseaseid}}" "00250195" "00695" "00289572" "00198" "00307257" "01544" ## Phenotypes ## Do not remove or alter this header ## ## Note: Only showing Phenotype columns active for Diseases 00198, 00695, 01544, 02083, 06041 ## Count = 1 "{{id}}" "{{diseaseid}}" "{{individualid}}" "{{owned_by}}" "{{Phenotype/Inheritance}}" "{{Phenotype/Age}}" "{{Phenotype/Additional}}" "{{Phenotype/Age/Onset}}" "{{Phenotype/Age/Diagnosis}}" "{{Phenotype/Onset}}" "{{Phenotype/Protein}}" "{{Phenotype/Tumor/MSI}}" "{{Phenotype/Enzyme/CPK}}" "{{Phenotype/Heart/Myocardium}}" "{{Phenotype/Lung}}" "{{Phenotype/Diagnosis/Definite}}" "{{Phenotype/Diagnosis/Initial}}" "{{Phenotype/Diagnosis/Criteria}}" "0000233061" "01544" "00307257" "03753" "Unknown" "" "Unilateral" "" "00y22m" "HP:0000486" "" "" "" "" "" "" "" "" ## Screenings ## Do not remove or alter this header ## ## Count = 3 "{{id}}" "{{individualid}}" "{{variants_found}}" "{{owned_by}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{Screening/Technique}}" "{{Screening/Template}}" "{{Screening/Tissue}}" "{{Screening/Remarks}}" "0000251301" "00250195" "1" "03321" "03321" "2019-08-05 06:25:03" "" "" "ARMS" "DNA" "" "" "0000290740" "00289572" "1" "03575" "00006" "2020-03-11 19:30:02" "" "" "arraySNP" "DNA" "" "Infinium Global Screening Array v1.0" "0000308399" "00307257" "1" "03753" "03753" "2020-08-06 23:25:39" "" "" "SEQ-NG-I" "DNA" "blood/FFPE tumor" "160 genes" ## Screenings_To_Genes ## Do not remove or alter this header ## ## Count = 1 "{{screeningid}}" "{{geneid}}" "0000251301" "DDR2" ## Variants_On_Genome ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Count = 31 "{{id}}" "{{allele}}" "{{effectid}}" "{{chromosome}}" "{{position_g_start}}" "{{position_g_end}}" "{{type}}" "{{average_frequency}}" "{{owned_by}}" "{{VariantOnGenome/DBID}}" "{{VariantOnGenome/DNA}}" "{{VariantOnGenome/Frequency}}" "{{VariantOnGenome/Reference}}" "{{VariantOnGenome/Restriction_site}}" "{{VariantOnGenome/Published_as}}" "{{VariantOnGenome/Remarks}}" "{{VariantOnGenome/Genetic_origin}}" "{{VariantOnGenome/Segregation}}" "{{VariantOnGenome/dbSNP}}" "{{VariantOnGenome/VIP}}" "{{VariantOnGenome/Methylation}}" "{{VariantOnGenome/ISCN}}" "{{VariantOnGenome/DNA/hg38}}" "{{VariantOnGenome/ClinVar}}" "{{VariantOnGenome/ClinicalClassification}}" "{{VariantOnGenome/ClinicalClassification/Method}}" "0000267301" "0" "10" "1" "162740327" "162740327" "subst" "0.988332" "02325" "DDR2_000001" "g.162740327T>C" "" "" "" "DDR2(NM_001014796.3):c.1504+25T>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.162770537T>C" "" "benign" "" "0000504057" "0" "30" "1" "162735785" "162735785" "subst" "5.69138E-5" "01804" "DDR2_000005" "g.162735785T>C" "" "" "" "DDR2(NM_001014796.1):c.1100-6T>C (p.(=))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.162765995T>C" "" "likely benign" "" "0000504058" "0" "30" "1" "162745945" "162745945" "subst" "0.000622032" "01804" "DDR2_000006" "g.162745945A>G" "" "" "" "DDR2(NM_001014796.1):c.2068A>G (p.(Met690Val))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.162776155A>G" "" "likely benign" "" "0000580733" "3" "90" "1" "162729770" "162729770" "subst" "0" "03321" "DDR2_000007" "g.162729770G>A" "" "" "" "" "GTCTCGCCATGCTGCTCCTGGGCCTGCTGCTGCTGCtgCccCTGctgGctGgCgcCCgcCTGctGA" "Germline" "?" "" "0" "" "" "g.162759980G>A" "" "pathogenic (recessive)" "" "0000604968" "0" "30" "1" "162729712" "162729712" "subst" "0" "01804" "DDR2_000009" "g.162729712T>A" "" "" "" "DDR2(NM_001014796.1):c.798T>A (p.(Asn266Lys))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.162759922T>A" "" "likely benign" "" "0000604969" "0" "30" "1" "162731100" "162731100" "subst" "0" "01943" "DDR2_000010" "g.162731100T>G" "" "" "" "DDR2(NM_001014796.2):c.955T>G (p.S319A)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.162761310T>G" "" "likely benign" "" "0000604970" "0" "30" "1" "162740121" "162740121" "subst" "0.014622" "01804" "DDR2_000011" "g.162740121G>A" "" "" "" "DDR2(NM_001014796.1):c.1323G>A (p.(Met441Ile))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.162770331G>A" "" "likely benign" "" "0000604971" "0" "30" "1" "162740187" "162740187" "subst" "0.000174706" "01943" "DDR2_000012" "g.162740187T>C" "" "" "" "DDR2(NM_001014796.2):c.1389T>C (p.S463=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.162770397T>C" "" "likely benign" "" "0000620427" "0" "30" "1" "162725473" "162725473" "subst" "0" "01943" "DDR2_000008" "g.162725473T>C" "" "" "" "DDR2(NM_006182.4):c.585T>C (p.N195=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.162755683T>C" "" "likely benign" "" "0000647429" "1" "70" "1" "162724415" "162724415" "subst" "5.69912E-5" "03575" "DDR2_000013" "g.162724415C>G" "1/2794 individuals" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "" "" "1 heterozygous, no homozygous; {DB:CLININrs144594252}" "Germline" "" "rs144594252" "0" "" "" "g.162754625C>G" "" "likely pathogenic" "" "0000653798" "0" "50" "1" "162743300" "162743301" "del" "0" "01943" "DDR2_000014" "g.162743300_162743301del" "" "" "" "DDR2(NM_006182.4):c.1770_1771delCA (p.D590Efs*31)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.162773510_162773511del" "" "VUS" "" "0000682709" "0" "70" "1" "162753071" "162753072" "ins" "0" "03753" "DDR2_000015" "g.162753071_162753072insAT" "0.054" "{PMID:Mendonca 2021:34478740}" "" "" "" "Germline" "" "" "" "" "" "" "" "pathogenic" "ACMG" "0000687930" "0" "30" "1" "162729634" "162729634" "subst" "0.000390542" "01943" "DDR2_000016" "g.162729634C>T" "" "" "" "DDR2(NM_006182.4):c.720C>T (p.D240=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000687931" "0" "50" "1" "162746088" "162746088" "subst" "0" "01943" "DDR2_000017" "g.162746088T>A" "" "" "" "DDR2(NM_006182.4):c.2211T>A (p.S737R)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000716956" "0" "50" "1" "162724965" "162724965" "subst" "4.47078E-5" "01804" "DDR2_000018" "g.162724965A>G" "" "" "" "DDR2(NM_001014796.1):c.437A>G (p.(Asn146Ser))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000798888" "0" "30" "1" "162740230" "162740230" "subst" "0.000174737" "01804" "DDR2_000019" "g.162740230C>T" "" "" "" "DDR2(NM_001014796.1):c.1432C>T (p.(Arg478Cys))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000882895" "0" "30" "1" "162724471" "162724471" "subst" "0.000312927" "01804" "DDR2_000020" "g.162724471T>A" "" "" "" "DDR2(NM_001014796.1):c.243T>A (p.(Asp81Glu))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000882896" "0" "70" "1" "162746023" "162746023" "subst" "0" "01804" "DDR2_000021" "g.162746023T>C" "" "" "" "DDR2(NM_001014796.1):c.2146T>C (p.(Cys716Arg))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely pathogenic" "" "0000882897" "0" "50" "1" "162748430" "162748430" "subst" "0" "01804" "DDR2_000022" "g.162748430A>G" "" "" "" "DDR2(NM_001014796.1):c.2344A>G (p.(Thr782Ala))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000947029" "0" "50" "1" "162722890" "162722890" "subst" "0" "01804" "DDR2_000023" "g.162722890T>C" "" "" "" "DDR2(NM_001014796.1):c.88T>C (p.(Cys30Arg))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000990519" "0" "30" "1" "162688875" "162688875" "subst" "0" "01804" "DDR2_000024" "g.162688875C>A" "" "" "" "DDR2(NM_006182.2):c.22C>A (p.(Leu8Ile))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000990521" "0" "50" "1" "162725022" "162725022" "subst" "2.84421E-5" "01804" "DDR2_000025" "g.162725022G>A" "" "" "" "DDR2(NM_006182.2):c.494G>A (p.(Arg165Gln))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000990523" "0" "50" "1" "162729702" "162729702" "subst" "0" "01804" "DDR2_000026" "g.162729702G>C" "" "" "" "DDR2(NM_006182.2):c.788G>C (p.(Ser263Thr))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000990525" "0" "30" "1" "162740308" "162740308" "subst" "0" "01804" "DDR2_000027" "g.162740308G>A" "" "" "" "DDR2(NM_006182.2):c.1504+6G>A (p.?)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0001031430" "0" "30" "1" "162688941" "162688941" "subst" "8.13809E-6" "01804" "DDR2_000028" "g.162688941A>G" "" "" "" "DDR2(NM_006182.4):c.82+6A>G" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0001031431" "0" "50" "1" "162722896" "162722896" "subst" "8.13736E-6" "01804" "DDR2_000029" "g.162722896T>C" "" "" "" "DDR2(NM_006182.4):c.94T>C (p.(Tyr32His))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0001031432" "0" "30" "1" "162730994" "162730994" "subst" "4.08934E-6" "01804" "DDR2_000030" "g.162730994C>T" "" "" "" "DDR2(NM_006182.4):c.856-7C>T" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0001031433" "0" "50" "1" "162731116" "162731116" "subst" "7.31672E-5" "01804" "DDR2_000031" "g.162731116T>C" "" "" "" "DDR2(NM_006182.4):c.971T>C (p.(Leu324Pro))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0001031434" "0" "50" "1" "162740150" "162740150" "subst" "2.03212E-5" "01804" "DDR2_000032" "g.162740150C>T" "" "" "" "DDR2(NM_006182.4):c.1352C>T (p.(Ser451Phe))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0001031435" "0" "50" "1" "162746138" "162746138" "subst" "0" "01804" "DDR2_000033" "g.162746138T>C" "" "" "" "DDR2(NM_006182.4):c.2261T>C (p.(Met754Thr))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0001031436" "0" "70" "1" "162748409" "162748409" "del" "0" "01804" "DDR2_000034" "g.162748409del" "" "" "" "DDR2(NM_006182.4):c.2323del (p.(Val775Leufs*53))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely pathogenic" "" ## Variants_On_Transcripts ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Note: Only showing Variants_On_Transcript columns active for Genes DDR2 ## Count = 31 "{{id}}" "{{transcriptid}}" "{{effectid}}" "{{position_c_start}}" "{{position_c_start_intron}}" "{{position_c_end}}" "{{position_c_end_intron}}" "{{VariantOnTranscript/DNA}}" "{{VariantOnTranscript/RNA}}" "{{VariantOnTranscript/Protein}}" "{{VariantOnTranscript/Exon}}" "0000267301" "00006207" "10" "1504" "25" "1504" "25" "c.1504+25T>C" "r.(=)" "p.(=)" "" "0000504057" "00006207" "30" "1100" "-6" "1100" "-6" "c.1100-6T>C" "r.(=)" "p.(=)" "" "0000504058" "00006207" "30" "2068" "0" "2068" "0" "c.2068A>G" "r.(?)" "p.(Met690Val)" "" "0000580733" "00006207" "90" "855" "1" "855" "1" "c.855+1G>A" "r.spl" "p.?" "8" "0000604968" "00006207" "30" "798" "0" "798" "0" "c.798T>A" "r.(?)" "p.(Asn266Lys)" "" "0000604969" "00006207" "30" "955" "0" "955" "0" "c.955T>G" "r.(?)" "p.(Ser319Ala)" "" "0000604970" "00006207" "30" "1323" "0" "1323" "0" "c.1323G>A" "r.(?)" "p.(Met441Ile)" "" "0000604971" "00006207" "30" "1389" "0" "1389" "0" "c.1389T>C" "r.(?)" "p.(Ser463=)" "" "0000620427" "00006207" "30" "585" "0" "585" "0" "c.585T>C" "r.(?)" "p.(Asn195=)" "" "0000647429" "00006207" "70" "187" "0" "187" "0" "c.187C>G" "r.(?)" "p.(Leu63Val)" "" "0000653798" "00006207" "50" "1770" "0" "1771" "0" "c.1770_1771del" "r.(?)" "p.(Asp590GlufsTer31)" "" "0000682709" "00006207" "70" "5603" "0" "5604" "0" "c.*3035_*3036insAT" "r.(=)" "p.(=)" "" "0000687930" "00006207" "30" "720" "0" "720" "0" "c.720C>T" "r.(?)" "p.(Asp240=)" "" "0000687931" "00006207" "50" "2211" "0" "2211" "0" "c.2211T>A" "r.(?)" "p.(Ser737Arg)" "" "0000716956" "00006207" "50" "437" "0" "437" "0" "c.437A>G" "r.(?)" "p.(Asn146Ser)" "" "0000798888" "00006207" "30" "1432" "0" "1432" "0" "c.1432C>T" "r.(?)" "p.(Arg478Cys)" "" "0000882895" "00006207" "30" "243" "0" "243" "0" "c.243T>A" "r.(?)" "p.(Asp81Glu)" "" "0000882896" "00006207" "70" "2146" "0" "2146" "0" "c.2146T>C" "r.(?)" "p.(Cys716Arg)" "" "0000882897" "00006207" "50" "2344" "0" "2344" "0" "c.2344A>G" "r.(?)" "p.(Thr782Ala)" "" "0000947029" "00006207" "50" "88" "0" "88" "0" "c.88T>C" "r.(?)" "p.(Cys30Arg)" "" "0000990519" "00006207" "30" "22" "0" "22" "0" "c.22C>A" "r.(?)" "p.(Leu8Ile)" "" "0000990521" "00006207" "50" "494" "0" "494" "0" "c.494G>A" "r.(?)" "p.(Arg165Gln)" "" "0000990523" "00006207" "50" "788" "0" "788" "0" "c.788G>C" "r.(?)" "p.(Ser263Thr)" "" "0000990525" "00006207" "30" "1504" "6" "1504" "6" "c.1504+6G>A" "r.(=)" "p.(=)" "" "0001031430" "00006207" "30" "82" "6" "82" "6" "c.82+6A>G" "r.(=)" "p.(=)" "" "0001031431" "00006207" "50" "94" "0" "94" "0" "c.94T>C" "r.(?)" "p.(Tyr32His)" "" "0001031432" "00006207" "30" "856" "-7" "856" "-7" "c.856-7C>T" "r.(=)" "p.(=)" "" "0001031433" "00006207" "50" "971" "0" "971" "0" "c.971T>C" "r.(?)" "p.(Leu324Pro)" "" "0001031434" "00006207" "50" "1352" "0" "1352" "0" "c.1352C>T" "r.(?)" "p.(Ser451Phe)" "" "0001031435" "00006207" "50" "2261" "0" "2261" "0" "c.2261T>C" "r.(?)" "p.(Met754Thr)" "" "0001031436" "00006207" "70" "2323" "0" "2323" "0" "c.2323del" "r.(?)" "p.(Val775Leufs*53)" "" ## Screenings_To_Variants ## Do not remove or alter this header ## ## Count = 3 "{{screeningid}}" "{{variantid}}" "0000251301" "0000580733" "0000290740" "0000647429" "0000308399" "0000682709"