### LOVD-version 3000-30b ### Full data download ### To import, do not remove or alter this header ### ## Filter: (gene_public = MPO) # charset = UTF-8 ## Genes ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{name}}" "{{chromosome}}" "{{chrom_band}}" "{{imprinting}}" "{{refseq_genomic}}" "{{refseq_UD}}" "{{reference}}" "{{url_homepage}}" "{{url_external}}" "{{allow_download}}" "{{id_hgnc}}" "{{id_entrez}}" "{{id_omim}}" "{{show_hgmd}}" "{{show_genecards}}" "{{show_genetests}}" "{{show_orphanet}}" "{{note_index}}" "{{note_listing}}" "{{refseq}}" "{{refseq_url}}" "{{disclaimer}}" "{{disclaimer_text}}" "{{header}}" "{{header_align}}" "{{footer}}" "{{footer_align}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{updated_by}}" "{{updated_date}}" "MPO" "myeloperoxidase" "17" "q21.3-q23" "unknown" "LRG_84" "UD_132118689702" "" "https://ww.LOVD.nl/MPO" "" "1" "7218" "4353" "606989" "1" "1" "1" "1" "Establishment of this gene variant database (LSDB) was supported by the Leiden University Medical Center (LUMC), Leiden, Nederland." "" "g" "https://databases.lovd.nl/shared/refseq/MPO_codingDNA.html" "1" "" "" "-1" "" "-1" "00001" "2013-05-03 00:00:00" "00006" "2018-10-29 12:31:27" "00000" "2025-05-05 21:14:00" ## Transcripts ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{geneid}}" "{{name}}" "{{id_mutalyzer}}" "{{id_ncbi}}" "{{id_ensembl}}" "{{id_protein_ncbi}}" "{{id_protein_ensembl}}" "{{id_protein_uniprot}}" "{{remarks}}" "{{position_c_mrna_start}}" "{{position_c_mrna_end}}" "{{position_c_cds_end}}" "{{position_g_mrna_start}}" "{{position_g_mrna_end}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00013799" "MPO" "myeloperoxidase" "001" "NM_000250.1" "" "NP_000241.1" "" "" "" "-177" "3038" "2238" "56358296" "56347217" "" "0000-00-00 00:00:00" "" "" ## Diseases ## Do not remove or alter this header ## ## Count = 7 "{{id}}" "{{symbol}}" "{{name}}" "{{inheritance}}" "{{id_omim}}" "{{tissues}}" "{{features}}" "{{remarks}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00012" "PSORS" "psoriasis, pustular, generalized (PSORS)" "" "" "" "" "" "00006" "2012-07-06 21:50:32" "00006" "2019-08-12 13:38:21" "00198" "?" "unclassified / mixed" "" "" "" "" "" "00006" "2013-09-13 14:21:47" "00006" "2024-11-23 09:38:12" "00204" "AD" "Alzheimer disease (AD)" "AD" "104300" "" "" "" "00006" "2013-09-24 20:52:38" "00006" "2021-12-10 21:51:32" "00318" "cancer, breast" "cancer, breast" "" "" "" "" "" "00006" "2014-02-02 14:42:53" "00006" "2019-08-28 08:24:47" "00344" "EE" "encephalopathy, epileptic (EE)" "" "" "" "" "" "00006" "2014-03-12 21:57:45" "00006" "2015-12-07 07:11:25" "01951" "MPOD" "myeloperoxidase deficiency (MPOD)" "AR" "254600" "" "" "" "00006" "2014-09-25 23:29:40" "00006" "2020-08-10 09:42:36" "02963" "HAE3" "angioedema, hereditary, type 3" "AD" "610618" "" "" "" "00006" "2014-09-25 23:29:40" "03256" "2025-04-09 18:11:52" ## Genes_To_Diseases ## Do not remove or alter this header ## ## Count = 2 "{{geneid}}" "{{diseaseid}}" "MPO" "00204" "MPO" "01951" ## Individuals ## Do not remove or alter this header ## ## Count = 40 "{{id}}" "{{fatherid}}" "{{motherid}}" "{{panelid}}" "{{panel_size}}" "{{license}}" "{{owned_by}}" "{{Individual/Reference}}" "{{Individual/Remarks}}" "{{Individual/Gender}}" "{{Individual/Consanguinity}}" "{{Individual/Origin/Geographic}}" "{{Individual/Age_of_death}}" "{{Individual/VIP}}" "{{Individual/Data_av}}" "{{Individual/Treatment}}" "{{Individual/Origin/Population}}" "{{Individual/Individual_ID}}" "00177082" "" "" "" "1" "" "02552" "" "mother German, father Swiss/Ghanaian" "M" "no" "Germany;Ghana;Switzerland" "" "0" "" "" "" "73450" "00248209" "" "" "" "1" "" "01474" "{PMID:Lhota 2016:26822949}" "analysis 325 breast cancer cases negative for BRCA1/BRCA2/PALB2" "F" "no" "Czech Republic" "" "0" "" "" "" "" "00248251" "" "" "" "1" "" "01474" "{PMID:Lhota 2016:26822949}" "analysis 325 breast cancer cases negative for BRCA1/BRCA2/PALB2" "F" "no" "Czech Republic" "" "0" "" "" "" "" "00248257" "" "" "" "1" "" "01474" "{PMID:Lhota 2016:26822949}" "analysis 325 breast cancer cases negative for BRCA1/BRCA2/PALB2" "F" "no" "Czech Republic" "" "0" "" "" "" "" "00291795" "" "" "" "3" "" "03575" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "analysis 2794 individuals (India)" "" "" "India" "" "0" "" "" "" "" "00291796" "" "" "" "5" "" "03575" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "analysis 2794 individuals (India)" "" "" "India" "" "0" "" "" "" "" "00291797" "" "" "" "10" "" "03575" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "analysis 2794 individuals (India)" "" "" "India" "" "0" "" "" "" "" "00307285" "" "" "" "1" "" "00006" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "2-generation family, 1 affected, unaffected parents" "F" "" "United Kingdom (Great Britain)" "" "0" "" "" "Europe" "GYFAP0014" "00307286" "" "" "" "1" "" "00006" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "2-generation family, 1 affected, unaffected parents" "F" "" "United Kingdom (Great Britain)" "" "0" "" "" "Europe" "DDPLM0001" "00307287" "" "" "" "1" "" "00006" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "2-generation family, 1 affected, unaffected parents" "F" "" "Germany" "" "0" "" "" "" "SCAR2124" "00307288" "" "" "" "1" "" "00006" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "2-generation family, 1 affected, unaffected parents" "F" "" "Germany" "" "0" "" "" "" "SCAR2567" "00307289" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat1 AP" "00307290" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat2 AA" "00307291" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat3 ZA" "00307292" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat4 BM" "00307293" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "M" "" "Italy" "" "0" "" "" "" "Pat5 BN" "00307294" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat6 CE" "00307295" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat7 CM" "00307296" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "M" "" "Italy" "" "0" "" "" "" "Pat8 CG" "00307297" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "M" "" "Italy" "" "0" "" "" "" "Pat9 CA" "00307298" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "M" "" "Italy" "" "0" "" "" "" "Pat10 DD" "00307299" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "M" "" "Italy" "" "0" "" "" "" "Pat11 LG" "00307300" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat12 MA" "00307301" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat13 RM" "00307302" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat14 SI" "00307303" "" "" "" "1" "" "00006" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "F" "" "Italy" "" "0" "" "" "" "Pat15 VO" "00307320" "" "" "" "2" "" "00006" "{PMID:Romano 1997:9354683}" "2-generation family, affected father/daughter, unaffected mother" "M" "" "Italy" "" "0" "" "" "" "FamPatDP" "00307321" "" "" "00307320" "1" "" "00006" "{PMID:Romano 1997:9354683}" "daughter" "F" "" "Italy" "" "0" "" "" "" "FamPatMP" "00307322" "" "" "" "1" "" "00006" "{PMID:Nauseef 1994:7904599}" "" "" "" "United States" "" "0" "" "" "" "PatLH" "00307323" "" "" "" "1" "" "00006" "{PMID:DeLeo 1998:9637725}" "3-generation family, 1 affected, several heterozygous carriers" "M" "" "United States" "" "0" "" "" "" "FamSPatBS" "00307324" "" "" "" "1" "" "00006" "{PMID:Reynolds 2000:11087769}" "comparison 127 patients with AD and 174 controls" "" "" "Finland" "" "0" "" "" "" "cases" "00307325" "" "" "" "1" "" "00006" "{PMID:Ohashi 2004:14980716}" "2-generation family, 1 affected, unaffected parents" "M" "" "Japan" "" "0" "" "" "" "patient" "00307326" "" "" "" "1" "" "00006" "{PMID:Kameoka 2004:17017121}, {PMID:Persad 2006:17017121}" "" "F" "" "Japan" "" "0" "" "" "" "patient" "00307327" "" "" "" "1" "" "00006" "{PMID:Kizaki 1994:8142659}" "" "F" "" "United States" "" "0" "" "" "Hispanic" "PatSQ" "00307328" "" "" "" "1" "" "00006" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "association analysis UK-biobank" "" "" "United Kingdom (Great Britain)" "" "0" "" "" "" "cases" "00307329" "" "" "" "1" "" "00006" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "association analysis UK-biobank" "" "" "United Kingdom (Great Britain)" "" "0" "" "" "" "cases" "00307330" "" "" "" "1" "" "00006" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "association analysis UK biobank" "" "" "United Kingdom (Great Britain)" "" "0" "" "" "" "cases" "00307331" "" "" "" "1" "" "00006" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "assiciation analysis UK biobank" "" "" "United Kingdom (Great Britain)" "" "0" "" "" "" "cases" "00307332" "" "" "" "1" "" "00006" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "association analysis UK biobank" "" "" "United Kingdom (Great Britain)" "" "0" "" "" "" "cases" "00359618" "" "" "" "2" "" "03256" "{DOI:Loules 2020:10.3390/jcm911340}" "" "F" "" "Hungary" "" "0" "" "" "" "" ## Individuals_To_Diseases ## Do not remove or alter this header ## ## Count = 40 "{{individualid}}" "{{diseaseid}}" "00177082" "00344" "00248209" "00318" "00248251" "00318" "00248257" "00318" "00291795" "00198" "00291796" "00198" "00291797" "00198" "00307285" "00012" "00307286" "00012" "00307287" "00012" "00307288" "00012" "00307289" "01951" "00307290" "01951" "00307291" "01951" "00307292" "01951" "00307293" "01951" "00307294" "01951" "00307295" "01951" "00307296" "01951" "00307297" "01951" "00307298" "01951" "00307299" "01951" "00307300" "01951" "00307301" "01951" "00307302" "01951" "00307303" "01951" "00307320" "01951" "00307321" "01951" "00307322" "01951" "00307323" "01951" "00307324" "00204" "00307325" "01951" "00307326" "01951" "00307327" "01951" "00307328" "00198" "00307329" "00198" "00307330" "00198" "00307331" "00198" "00307332" "00198" "00359618" "02963" ## Phenotypes ## Do not remove or alter this header ## ## Note: Only showing Phenotype columns active for Diseases 00012, 00198, 00204, 00318, 00344, 01951, 02963 ## Count = 31 "{{id}}" "{{diseaseid}}" "{{individualid}}" "{{owned_by}}" "{{Phenotype/Inheritance}}" "{{Phenotype/Age}}" "{{Phenotype/Additional}}" "{{Phenotype/Age/Onset}}" "{{Phenotype/Age/Diagnosis}}" "{{Phenotype/Onset}}" "{{Phenotype/Protein}}" "{{Phenotype/Tumor/MSI}}" "{{Phenotype/Enzyme/CPK}}" "{{Phenotype/Heart/Myocardium}}" "{{Phenotype/Lung}}" "{{Phenotype/Diagnosis/Definite}}" "{{Phenotype/Diagnosis/Initial}}" "{{Phenotype/Diagnosis/Criteria}}" "0000141877" "00344" "00177082" "02552" "Unknown" "" "HP:0008936\r\nHP:0002066\r\nHP:0011220\r\nHP:0008070\r\nHP:0002761\r\nHP:0001763" "02y" "" "" "" "" "" "" "" "" "" "" "0000187218" "00318" "00248209" "01474" "Unknown" "" "33y ductal reast cancer" "33y" "" "" "" "" "" "" "" "" "breast cancer" "" "0000187260" "00318" "00248251" "01474" "Unknown" "" "35y ductal breast cancer, subtype basal" "35y" "" "" "" "" "" "" "" "" "breast cancer" "" "0000187266" "00318" "00248257" "01474" "Unknown" "" "42y ductal breast cancer, subtype luminal B" "42y" "" "" "" "" "" "" "" "" "breast cancer" "" "0000233085" "00012" "00307285" "00006" "Familial, autosomal recessive" "54y" "10y-diagnosed with acrodermatitis continua of Hallopeau (localised pustular eruption affecting nails and distal phalanxes); history generalised pustular psoriasis flared during pregnancy (36y/39y) with widespread pustulation, high-fever, severe neutrophilia (>15,000 cells/mm3), elevated CRP levels (>100mg/L); several years quiescent disease on infliximab infusions and oral methotrexate co-therapy, 52y-treatments withdrawn, skin clearance maintained (2y follow up); comorbidities include anxiety and depression BMI 30; no concurrent plaque psoriasis or psoriatic arthritis, no family history of psoriasis" "" "" "" "" "" "" "" "" "" "acrodermatitis continua of Hallopeau" "" "0000233086" "00012" "00307286" "00006" "Familial, autosomal recessive" "35y" "24y-palmoplantar pustulosis, acrodermatitis continua of Hallopeau with nail loss left hand, chronic plaque psoriasis, psoriatic arthritis, BMI 26, ex-smoker; ciclosporin treatment for 3y with good effect; no family history of psoriasis" "" "" "" "" "" "" "" "" "" "palmoplantar pustulosis" "" "0000233087" "00012" "00307287" "00006" "Familial, autosomal recessive" "80y" "80y-presented with acute generalised exanthematous pustulosis requiring admission to hospital, widespread pustulation, fever, severe neutrophilia (>15,000 cells/mm3); culprit drugs (in order of suspicion) methotrexate, pantoprazole, sultamicillin (ampicillin/sulbactam)" "" "" "" "" "" "" "" "" "" "" "" "0000233088" "00012" "00307288" "00006" "Familial, autosomal recessive" "70y" "70y-acute generalised exanthematous pustulosis to hydroxychloroquine, high fever, pustulation requiring admission to hospital; comorbidities giant cell arteritis" "70y" "" "" "" "" "" "" "" "" "acute generalised exanthematous pustulosis" "" "0000233089" "01951" "00307289" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency deficiency" "" "0000233090" "01951" "00307290" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency deficiency" "" "0000233091" "01951" "00307291" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "partial myeloperoxidase deficiency deficiency" "" "0000233092" "01951" "00307292" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency deficiency" "" "0000233093" "01951" "00307293" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "partial myeloperoxidase deficiency deficiency" "" "0000233094" "01951" "00307294" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "partial myeloperoxidase deficiency deficiency" "" "0000233095" "01951" "00307295" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency deficiency" "" "0000233096" "01951" "00307296" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency deficiency" "" "0000233097" "01951" "00307297" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "partial myeloperoxidase deficiency deficiency" "" "0000233098" "01951" "00307298" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency deficiency" "" "0000233099" "01951" "00307299" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "partial myeloperoxidase deficiency deficiency" "" "0000233100" "01951" "00307300" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "partial myeloperoxidase deficiency deficiency" "" "0000233101" "01951" "00307301" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency deficiency" "" "0000233102" "01951" "00307302" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "partial myeloperoxidase deficiency deficiency" "" "0000233103" "01951" "00307303" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency deficiency" "" "0000233120" "01951" "00307320" "00006" "Familial, autosomal recessive" "" "absence of peroxidase activity in neutrophils" "" "" "" "" "" "" "" "" "MPOD" "myeloperoxidase deficiency" "" "0000233121" "01951" "00307321" "00006" "Unknown" "" "see paper; ..., complete absence MPO activity in neutrophils" "" "" "" "" "" "" "" "" "MPOD" "myeloperoxidase deficiency" "" "0000233122" "01951" "00307322" "00006" "Familial, autosomal recessive" "" "" "" "" "" "" "" "" "" "" "" "complete myeloperoxidase deficiency" "" "0000233123" "01951" "00307323" "00006" "Familial, autosomal recessive" "" "complete myeloperoxidase deficiencysee paper; ...," "" "" "" "" "" "" "" "" "" "complete myeloperoxidase deficiency" "" "0000233124" "01951" "00307325" "00006" "Familial, autosomal recessive" "39y" "complete MPO deficiency, signs of obstructive pulmonary disease, although no history of recurrent infections or medication known to interfere with MPO activity present or used" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency" "" "0000233125" "01951" "00307326" "00006" "Familial, autosomal recessive" "28y" "see paper; ..." "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency" "" "0000233126" "01951" "00307327" "00006" "Familial, autosomal recessive" "65y" "" "" "" "" "" "" "" "" "" "MPOD" "complete myeloperoxidase deficiency" "" "0000254891" "02963" "00359618" "03256" "Familial" "" "Proband presenting with a HAE with normal C1 inhibitor and non identified type" "" "" "" "" "" "" "" "" "" "" "" ## Screenings ## Do not remove or alter this header ## ## Count = 40 "{{id}}" "{{individualid}}" "{{variants_found}}" "{{owned_by}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{Screening/Technique}}" "{{Screening/Template}}" "{{Screening/Tissue}}" "{{Screening/Remarks}}" "0000177978" "00177082" "1" "02552" "02552" "2018-08-17 14:11:42" "" "" "SEQ-NG-I" "DNA" "blood" "WES" "0000249314" "00248209" "1" "01474" "00006" "2015-12-04 13:41:45" "" "" "SEQ-NG-S" "DNA" "blood" "581 gene panel" "0000249356" "00248251" "1" "01474" "00006" "2015-12-04 13:41:45" "" "" "SEQ-NG-S" "DNA" "blood" "581 gene panel" "0000249362" "00248257" "1" "01474" "00006" "2015-12-04 13:41:45" "" "" "SEQ-NG-S" "DNA" "blood" "581 gene panel" "0000292963" "00291795" "1" "03575" "00006" "2020-03-11 19:30:02" "" "" "arraySNP" "DNA" "" "Infinium Global Screening Array v1.0" "0000292964" "00291796" "1" "03575" "00006" "2020-03-11 19:30:02" "" "" "arraySNP" "DNA" "" "Infinium Global Screening Array v1.0" "0000292965" "00291797" "1" "03575" "00006" "2020-03-11 19:30:02" "" "" "arraySNP" "DNA" "" "Infinium Global Screening Array v1.0" "0000308427" "00307285" "1" "00006" "00006" "2020-08-10 09:06:09" "" "" "SEQ;SEQ-NG" "DNA" "" "WES" "0000308428" "00307286" "1" "00006" "00006" "2020-08-10 09:12:51" "" "" "SEQ;SEQ-NG" "DNA" "" "" "0000308429" "00307287" "1" "00006" "00006" "2020-08-10 09:17:25" "" "" "SEQ;SEQ-NG" "DNA" "" "" "0000308430" "00307288" "1" "00006" "00006" "2020-08-10 09:22:14" "" "" "SEQ;SEQ-NG" "DNA" "" "" "0000308431" "00307289" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308432" "00307290" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308433" "00307291" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308434" "00307292" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308435" "00307293" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308436" "00307294" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308437" "00307295" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308438" "00307296" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308439" "00307297" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308440" "00307298" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308441" "00307299" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308442" "00307300" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308443" "00307301" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308444" "00307302" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308445" "00307303" "1" "00006" "00006" "2020-08-10 10:25:10" "" "" "SEQ" "DNA" "" "" "0000308462" "00307320" "1" "00006" "00006" "2020-08-10 16:40:25" "" "" "RT-PCR;SEQ" "DNA;RNA" "" "" "0000308463" "00307321" "1" "00006" "00006" "2020-08-10 16:49:54" "" "" "RT-PCR;SEQ" "DNA;RNA" "" "" "0000308464" "00307322" "1" "00006" "00006" "2020-08-10 17:00:06" "" "" "SEQ" "DNA" "" "" "0000308465" "00307323" "1" "00006" "00006" "2020-08-10 17:11:29" "" "" "SEQ" "DNA" "" "" "0000308466" "00307324" "1" "00006" "00006" "2020-08-10 17:22:47" "" "" "PCR" "DNA" "" "" "0000308467" "00307325" "1" "00006" "00006" "2020-08-10 17:32:51" "" "" "RT-PCR;SEQ" "DNA;RNA" "" "" "0000308468" "00307326" "1" "00006" "00006" "2020-08-10 17:51:04" "" "" "RT-PCR;SEQ" "DNA" "" "" "0000308469" "00307327" "1" "00006" "00006" "2020-08-10 19:04:19" "" "" "SEQ" "DNA" "" "" "0000308470" "00307328" "1" "00006" "00006" "2020-08-10 19:16:58" "" "" "arraySNP" "DNA" "" "" "0000308471" "00307329" "1" "00006" "00006" "2020-08-10 19:20:32" "" "" "arraySNP" "DNA" "" "" "0000308472" "00307330" "1" "00006" "00006" "2020-08-10 19:22:34" "" "" "arraySNP" "DNA" "" "" "0000308473" "00307331" "1" "00006" "00006" "2020-08-10 19:24:21" "" "" "arraySNP" "DNA" "" "" "0000308474" "00307332" "1" "00006" "00006" "2020-08-10 19:26:01" "" "" "arraySNP" "DNA" "" "" "0000360848" "00359618" "1" "03256" "03256" "2021-04-02 10:26:50" "" "" "SEQ-NG-IT" "DNA" "blood" "" ## Screenings_To_Genes ## Do not remove or alter this header ## ## Count = 33 "{{screeningid}}" "{{geneid}}" "0000308427" "MPO" "0000308428" "MPO" "0000308429" "MPO" "0000308430" "MPO" "0000308431" "MPO" "0000308432" "MPO" "0000308433" "MPO" "0000308434" "MPO" "0000308435" "MPO" "0000308436" "MPO" "0000308437" "MPO" "0000308438" "MPO" "0000308439" "MPO" "0000308440" "MPO" "0000308441" "MPO" "0000308442" "MPO" "0000308443" "MPO" "0000308444" "MPO" "0000308445" "MPO" "0000308462" "MPO" "0000308463" "MPO" "0000308464" "MPO" "0000308465" "MPO" "0000308466" "MPO" "0000308467" "MPO" "0000308468" "MPO" "0000308469" "MPO" "0000308470" "MPO" "0000308471" "MPO" "0000308472" "MPO" "0000308473" "MPO" "0000308474" "MPO" "0000360848" "SERPING1" ## Variants_On_Genome ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Count = 78 "{{id}}" "{{allele}}" "{{effectid}}" "{{chromosome}}" "{{position_g_start}}" "{{position_g_end}}" "{{type}}" "{{average_frequency}}" "{{owned_by}}" "{{VariantOnGenome/DBID}}" "{{VariantOnGenome/DNA}}" "{{VariantOnGenome/Frequency}}" "{{VariantOnGenome/Reference}}" "{{VariantOnGenome/Restriction_site}}" "{{VariantOnGenome/Published_as}}" "{{VariantOnGenome/Remarks}}" "{{VariantOnGenome/Genetic_origin}}" "{{VariantOnGenome/Segregation}}" "{{VariantOnGenome/dbSNP}}" "{{VariantOnGenome/VIP}}" "{{VariantOnGenome/Methylation}}" "{{VariantOnGenome/ISCN}}" "{{VariantOnGenome/DNA/hg38}}" "{{VariantOnGenome/ClinVar}}" "{{VariantOnGenome/ClinicalClassification}}" "{{VariantOnGenome/ClinicalClassification/Method}}" "0000282576" "0" "10" "17" "56357818" "56357818" "subst" "0.0895617" "02325" "MPO_000010" "g.56357818C>A" "" "" "" "MPO(NM_000250.2):c.157G>T (p.V53F)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58280457C>A" "" "benign" "" "0000286639" "0" "30" "17" "56352896" "56352896" "subst" "0.000333063" "02326" "MPO_000006" "g.56352896G>A" "" "" "" "MPO(NM_000250.1):c.1365+7C>T" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58275535G>A" "" "likely benign" "" "0000286640" "0" "10" "17" "56348122" "56348122" "subst" "0.00415174" "02326" "MPO_000003" "g.56348122G>A" "" "" "" "MPO(NM_000250.1):c.2133C>T (p.T711=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58270761G>A" "" "benign" "" "0000286641" "0" "10" "17" "56348106" "56348106" "subst" "0.0238809" "02326" "MPO_000002" "g.56348106T>C" "" "" "" "MPO(NM_000250.1):c.2149A>G (p.I717V)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58270745T>C" "" "benign" "" "0000286642" "0" "90" "17" "56356914" "56356914" "subst" "0.000431105" "02326" "MPO_000009" "g.56356914T>C" "" "" "" "MPO(NM_000250.1):c.518A>G (p.Y173C)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58279553T>C" "" "pathogenic" "" "0000291962" "0" "90" "17" "56350196" "56350196" "subst" "0.00145378" "01943" "MPO_000005" "g.56350196G>A" "" "" "" "MPO(NM_000250.1):c.1705C>T (p.R569W), MPO(NM_000250.2):c.1705C>T (p.(Arg569Trp), p.R569W)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58272835G>A" "" "pathogenic" "" "0000291963" "0" "90" "17" "56348226" "56348226" "subst" "0.00432825" "01943" "MPO_000004" "g.56348226T>G" "" "" "" "MPO(NM_000250.1):c.2031-2A>C, MPO(NM_000250.2):c.2031-2A>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58270865T>G" "" "pathogenic" "" "0000291964" "0" "30" "17" "56348081" "56348081" "subst" "2.84539E-5" "01943" "MPO_000001" "g.56348081C>T" "" "" "" "MPO(NM_000250.1):c.2174G>A (p.R725Q)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58270720C>T" "" "likely benign" "" "0000291965" "0" "50" "17" "56356728" "56356728" "subst" "2.40034E-5" "01943" "MPO_000008" "g.56356728T>G" "" "" "" "MPO(NM_000250.1):c.608A>C (p.Y203S)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58279367T>G" "" "VUS" "" "0000338401" "0" "90" "17" "56348226" "56348226" "subst" "0.00432825" "02327" "MPO_000004" "g.56348226T>G" "" "" "" "MPO(NM_000250.1):c.2031-2A>C, MPO(NM_000250.2):c.2031-2A>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58270865T>G" "" "pathogenic" "" "0000338402" "0" "10" "17" "56348230" "56348230" "subst" "0.14526" "02327" "MPO_000011" "g.56348230T>G" "" "" "" "" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58270869T>G" "" "benign" "" "0000343118" "0" "90" "17" "56350196" "56350196" "subst" "0.00145378" "02327" "MPO_000005" "g.56350196G>A" "" "" "" "MPO(NM_000250.1):c.1705C>T (p.R569W), MPO(NM_000250.2):c.1705C>T (p.(Arg569Trp), p.R569W)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.58272835G>A" "" "pathogenic" "" "0000405998" "11" "90" "17" "56355397" "56355397" "subst" "0.0125619" "02552" "MPO_000007" "g.56355397G>A" "" "{PMID:Papuc 2019:30552426}" "" "" "" "Germline" "" "rs28730837" "0" "" "" "g.58278036G>A" "" "pathogenic" "" "0000405999" "21" "90" "17" "56356502" "56356502" "subst" "0.0104432" "02552" "MPO_000012" "g.56356502A>G" "" "{PMID:Papuc 2019:30552426}" "" "" "" "Germline" "" "rs56378716" "0" "" "" "g.58279141A>G" "" "pathogenic" "" "0000562395" "0" "30" "17" "56348039" "56348039" "subst" "0" "01943" "MPO_000013" "g.56348039G>T" "" "" "" "MPO(NM_000250.1):c.2216C>A (p.A739D)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58270678G>T" "" "likely benign" "" "0000562396" "0" "70" "17" "56348226" "56348226" "subst" "0.00432825" "02325" "MPO_000004" "g.56348226T>G" "" "" "" "MPO(NM_000250.1):c.2031-2A>C, MPO(NM_000250.2):c.2031-2A>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58270865T>G" "" "likely pathogenic" "" "0000562397" "0" "10" "17" "56349207" "56349207" "subst" "0.00121839" "01943" "MPO_000014" "g.56349207A>G" "" "" "" "MPO(NM_000250.1):c.1839T>C (p.T613=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58271846A>G" "" "benign" "" "0000562398" "0" "50" "17" "56350189" "56350189" "subst" "2.43645E-5" "01943" "MPO_000015" "g.56350189C>T" "" "" "" "MPO(NM_000250.1):c.1712G>A (p.R571Q)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58272828C>T" "" "VUS" "" "0000562399" "0" "90" "17" "56350196" "56350196" "subst" "0.00145378" "02325" "MPO_000005" "g.56350196G>A" "" "" "" "MPO(NM_000250.1):c.1705C>T (p.R569W), MPO(NM_000250.2):c.1705C>T (p.(Arg569Trp), p.R569W)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58272835G>A" "" "pathogenic" "" "0000562400" "0" "90" "17" "56350831" "56350844" "del" "0" "01943" "MPO_000016" "g.56350831_56350844del" "" "" "" "MPO(NM_000250.1):c.1555_1568delATGGAACCCAACCC (p.M519Pfs*21), MPO(NM_000250.2):c.1555_1568del (p.(Met519ProfsTer21))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58273470_58273483del" "" "pathogenic" "" "0000562401" "0" "50" "17" "56350849" "56350849" "subst" "0" "01943" "MPO_000017" "g.56350849T>C" "" "" "" "MPO(NM_000250.1):c.1547A>G (p.Y516C)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58273488T>C" "" "VUS" "" "0000562404" "0" "30" "17" "56356502" "56356502" "subst" "0.0104432" "02325" "MPO_000012" "g.56356502A>G" "" "" "" "MPO(NM_000250.1):c.752T>C (p.M251T), MPO(NM_000250.2):c.752T>C (p.M251T)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58279141A>G" "" "likely benign" "" "0000562405" "0" "30" "17" "56356502" "56356502" "subst" "0.0104432" "02326" "MPO_000012" "g.56356502A>G" "" "" "" "MPO(NM_000250.1):c.752T>C (p.M251T), MPO(NM_000250.2):c.752T>C (p.M251T)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58279141A>G" "" "likely benign" "" "0000562406" "0" "30" "17" "56356910" "56356910" "subst" "4.06779E-6" "02326" "MPO_000018" "g.56356910G>A" "" "" "" "MPO(NM_000250.1):c.522C>T (p.R174=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58279549G>A" "" "likely benign" "" "0000562407" "0" "90" "17" "56356914" "56356914" "subst" "0.000431105" "02327" "MPO_000009" "g.56356914T>C" "" "" "" "MPO(NM_000250.1):c.518A>G (p.Y173C)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58279553T>C" "" "pathogenic" "" "0000562408" "0" "30" "17" "56357750" "56357750" "subst" "2.03173E-5" "02326" "MPO_000019" "g.56357750C>T" "" "" "" "MPO(NM_000250.1):c.225G>A (p.K75=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.58280389C>T" "" "likely benign" "" "0000578066" "0" "50" "17" "56348226" "56348226" "subst" "0.00432825" "01474" "MPO_000004" "g.56348226T>G" "" "{PMID:Lhota 2016:26822949}" "" "" "" "Germline" "" "rs35897051" "0" "" "" "g.58270865T>G" "" "VUS" "" "0000578119" "0" "50" "17" "56348226" "56348226" "subst" "0.00432825" "01474" "MPO_000004" "g.56348226T>G" "" "{PMID:Lhota 2016:26822949}" "" "" "" "Germline" "" "rs35897051" "0" "" "" "g.58270865T>G" "" "VUS" "" "0000578127" "0" "50" "17" "56348226" "56348226" "subst" "0.00432825" "01474" "MPO_000004" "g.56348226T>G" "" "{PMID:Lhota 2016:26822949}" "" "" "" "Germline" "" "rs35897051" "0" "" "" "g.58270865T>G" "" "VUS" "" "0000649652" "1" "90" "17" "56348226" "56348226" "subst" "0.00432825" "03575" "MPO_000004" "g.56348226T>G" "3/2730 individuals" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "" "" "3 heterozygous, no homozygous; {DB:CLININrs35897051}" "Germline" "" "rs35897051" "0" "" "" "g.58270865T>G" "" "pathogenic" "" "0000649653" "1" "90" "17" "56350196" "56350196" "subst" "0.00145378" "03575" "MPO_000005" "g.56350196G>A" "5/2795 individuals" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "" "" "5 heterozygous, no homozygous; {DB:CLININrs119468010}" "Germline" "" "rs119468010" "0" "" "" "g.58272835G>A" "" "pathogenic" "" "0000649654" "1" "90" "17" "56356502" "56356502" "subst" "0.0104432" "03575" "MPO_000012" "g.56356502A>G" "10/2795 individuals" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "" "" "10 heterozygous, no homozygous; {DB:CLININrs56378716}" "Germline" "" "rs56378716" "0" "" "" "g.58279141A>G" "" "pathogenic" "" "0000680935" "0" "50" "17" "56356376" "56356376" "subst" "8.52435E-6" "02325" "MPO_000020" "g.56356376G>C" "" "" "" "MPO(NM_000250.2):c.878C>G (p.P293R)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000682828" "3" "70" "17" "56348226" "56348226" "subst" "0.00432825" "00006" "MPO_000004" "g.56348226T>G" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "" "" "" "Germline" "" "" "0" "" "" "g.58270865T>G" "" "likely pathogenic (recessive)" "" "0000682829" "3" "70" "17" "56348226" "56348226" "subst" "0.00432825" "00006" "MPO_000004" "g.56348226T>G" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "" "" "" "Germline" "" "" "0" "" "" "g.58270865T>G" "" "likely pathogenic (recessive)" "" "0000682830" "3" "70" "17" "56350831" "56350844" "del" "0" "00006" "MPO_000016" "g.56350831_56350844del" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "" "1552_1565del" "" "Germline" "" "" "0" "" "" "g.58273470_58273483del" "" "likely pathogenic (recessive)" "" "0000682831" "1" "70" "17" "56348226" "56348226" "subst" "0.00432825" "00006" "MPO_000004" "g.56348226T>G" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "" "" "" "Germline" "" "" "0" "" "" "g.58270865T>G" "" "likely pathogenic (recessive)" "" "0000682832" "2" "70" "17" "56350196" "56350196" "subst" "0.00145378" "00006" "MPO_000005" "g.56350196G>A" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "" "" "" "Germline" "" "" "0" "" "" "g.58272835G>A" "" "likely pathogenic (recessive)" "" "0000682833" "3" "90" "17" "56348226" "56348226" "subst" "0.00432825" "00006" "MPO_000004" "g.56348226T>G" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "minigene splicing assay" "Germline" "" "" "0" "" "" "g.58270865T>G" "" "pathogenic (recessive)" "" "0000682834" "1" "90" "17" "56350817" "56350830" "del" "0" "00006" "MPO_000022" "g.56350817_56350830del" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "1566_1579del14" "" "Germline" "" "" "0" "" "" "g.58273456_58273469del" "" "pathogenic (recessive)" "" "0000682835" "1" "90" "17" "56356502" "56356502" "subst" "0.0104432" "00006" "MPO_000012" "g.56356502A>G" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58279141A>G" "" "pathogenic (recessive)" "" "0000682836" "3" "90" "17" "56350817" "56350830" "del" "0" "00006" "MPO_000022" "g.56350817_56350830del" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "1566_1579del14" "" "Germline" "" "" "0" "" "" "g.58273456_58273469del" "" "pathogenic (recessive)" "" "0000682837" "1" "90" "17" "56355397" "56355397" "subst" "0.0125619" "00006" "MPO_000007" "g.56355397G>A" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58278036G>A" "" "pathogenic (recessive)" "" "0000682838" "1" "90" "17" "56357299" "56357299" "del" "0" "00006" "MPO_000028" "g.56357299del" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "325delA" "" "Germline" "" "" "0" "" "" "g.58279938del" "" "pathogenic (recessive)" "" "0000682839" "3" "90" "17" "56348226" "56348226" "subst" "0.00432825" "00006" "MPO_000004" "g.56348226T>G" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "minigene splicing assay" "Germline" "" "" "0" "" "" "g.58270865T>G" "" "pathogenic (recessive)" "" "0000682840" "1" "90" "17" "56350196" "56350196" "subst" "0.00145378" "00006" "MPO_000005" "g.56350196G>A" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58272835G>A" "" "pathogenic (recessive)" "" "0000682841" "1" "90" "17" "56356502" "56356502" "subst" "0.0104432" "00006" "MPO_000012" "g.56356502A>G" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58279141A>G" "" "pathogenic (recessive)" "" "0000682842" "1" "90" "17" "56355397" "56355397" "subst" "0.0125619" "00006" "MPO_000007" "g.56355397G>A" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58278036G>A" "" "pathogenic (recessive)" "" "0000682843" "1" "90" "17" "56350817" "56350830" "del" "0" "00006" "MPO_000022" "g.56350817_56350830del" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "1566_1579del14" "" "Germline" "" "" "0" "" "" "g.58273456_58273469del" "" "pathogenic (recessive)" "" "0000682844" "1" "90" "17" "56356502" "56356502" "subst" "0.0104432" "00006" "MPO_000012" "g.56356502A>G" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58279141A>G" "" "pathogenic (recessive)" "" "0000682845" "1" "90" "17" "56348226" "56348226" "subst" "0.00432825" "00006" "MPO_000004" "g.56348226T>G" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "minigene splicing assay" "Germline" "" "" "0" "" "" "g.58270865T>G" "" "pathogenic (recessive)" "" "0000682846" "1" "90" "17" "56355280" "56355280" "subst" "0" "00006" "MPO_000027" "g.56355280T>C" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58277919T>C" "" "pathogenic (recessive)" "" "0000682847" "1" "90" "17" "56350817" "56350830" "del" "0" "00006" "MPO_000022" "g.56350817_56350830del" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "1566_1579del14" "" "Germline" "" "" "0" "" "" "g.58273456_58273469del" "" "pathogenic (recessive)" "" "0000682848" "2" "90" "17" "56350196" "56350196" "subst" "0.00145378" "00006" "MPO_000005" "g.56350196G>A" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58272835G>A" "" "pathogenic (recessive)" "" "0000682849" "2" "90" "17" "56356502" "56356502" "subst" "0.0104432" "00006" "MPO_000012" "g.56356502A>G" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58279141A>G" "" "pathogenic (recessive)" "" "0000682850" "2" "90" "17" "56350186" "56350186" "subst" "0" "00006" "MPO_000021" "g.56350186A>C" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58272825A>C" "" "pathogenic (recessive)" "" "0000682851" "2" "90" "17" "56350817" "56350830" "del" "0" "00006" "MPO_000022" "g.56350817_56350830del" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "1566_1579del14" "" "Germline" "" "" "0" "" "" "g.58273456_58273469del" "" "pathogenic (recessive)" "" "0000682852" "2" "90" "17" "56349119" "56349119" "subst" "4.06365E-6" "00006" "MPO_000023" "g.56349119A>G" "" "{PMID:Marchetti 2004:15108282}, {DOI: Marchetti 2020:10.1002/humu.20027}" "" "" "" "Germline" "" "" "0" "" "" "g.58271758A>G" "" "pathogenic (recessive)" "" "0000682870" "1" "90" "17" "56356502" "56356502" "subst" "0.0104432" "00006" "MPO_000012" "g.56356502A>G" "" "{PMID:Romano 1997:9354683}" "" "929T>C" "" "Germline" "" "" "0" "" "" "g.58279141A>G" "" "pathogenic (recessive)" "" "0000682871" "2" "90" "17" "56350831" "56350844" "del" "0" "00006" "MPO_000016" "g.56350831_56350844del" "" "{PMID:Romano 1997:9354683}" "" "1729-1742del" "alle not expressed in RNA" "Germline" "" "" "0" "" "" "g.58273470_58273483del" "" "pathogenic (recessive)" "" "0000682872" "11" "90" "17" "56350831" "56350844" "del" "0" "00006" "MPO_000016" "g.56350831_56350844del" "" "{PMID:Romano 1997:9354683}" "" "DNA 1729-1742del, RNA 1722-1799del" "no variant 2nd allele identified" "Germline" "yes" "" "0" "" "" "g.58273470_58273483del" "" "pathogenic" "" "0000682873" "3" "90" "17" "56350196" "56350196" "subst" "0.00145378" "00006" "MPO_000005" "g.56350196G>A" "" "{PMID:Nauseef 1994:7904599}" "BglII-" "8089C>T" "" "Germline" "" "" "0" "" "" "g.58272835G>A" "" "pathogenic (recessive)" "" "0000682874" "1" "90" "17" "56356914" "56356914" "subst" "0.000431105" "00006" "MPO_000009" "g.56356914T>C" "" "{PMID:DeLeo 1998:9637725}" "" "A681G" "no variant 2nd allele identified" "Germline" "" "" "0" "" "" "g.58279553T>C" "" "pathogenic" "" "0000682875" "0" "50" "17" "56358762" "56358762" "subst" "0" "00006" "MPO_000024" "g.56358762C>T" "" "{PMID:Reynolds 2000:11087769}" "" "" "-643G>A; significantly associated with AD, in male patients carrying MPO-A and APOE-E4 alleles relative to men carrying neither allele" "Germline" "" "" "0" "" "" "g.58281401A>G" "" "association" "" "0000682876" "3" "90" "17" "56350895" "56350895" "subst" "0" "00006" "MPO_000025" "g.56350895C>T" "" "{PMID:Ohashi 2004:14980716}" "" "1051A>G (G501S)" "father not tested" "Germline" "" "" "0" "" "" "g.58277980T>C" "" "pathogenic (recessive)" "" "0000682877" "3" "90" "17" "56350901" "56350901" "subst" "2.84239E-5" "00006" "MPO_000026" "g.56350901G>A" "" "{PMID:Kameoka 2004:17017121}, {PMID:Persad 2006:17017121}" "" "" "" "Germline" "" "" "0" "" "" "g.58273540G>A" "" "pathogenic (recessive)" "" "0000682878" "3" "90" "17" "56350196" "56350196" "subst" "0.00145378" "00006" "MPO_000005" "g.56350196G>A" "" "{PMID:Kizaki 1994:8142659}" "" "CGG569TGG" "" "Germline" "" "" "0" "" "" "g.58272835G>A" "" "pathogenic (recessive)" "" "0000682879" "0" "90" "17" "56348226" "56348226" "subst" "0.00432825" "00006" "MPO_000004" "g.56348226T>G" "" "significant association with neutrophil abundance" "" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "Germline" "" "" "0" "" "" "g.58270865T>G" "" "association" "" "0000682880" "1" "90" "17" "56350196" "56350196" "subst" "0.00145378" "00006" "MPO_000005" "g.56350196G>A" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "" "" "associated with increased neutrophil accumulation" "Germline" "" "" "0" "" "" "g.58272835G>A" "" "association" "" "0000682881" "1" "90" "17" "56356914" "56356914" "subst" "0.000431105" "00006" "MPO_000009" "g.56356914T>C" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "" "" "associated with increased neutrophil accumulation" "Germline" "" "" "0" "" "" "" "" "association" "" "0000682882" "1" "90" "17" "56356502" "56356502" "subst" "0.0104432" "00006" "MPO_000012" "g.56356502A>G" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "" "" "associated with increased neutrophil accumulation" "Germline" "" "" "0" "" "" "" "" "association" "" "0000682883" "1" "90" "17" "56355397" "56355397" "subst" "0.0125619" "00006" "MPO_000007" "g.56355397G>A" "" "{PMID:Vergnano 2020:32758448}, {DOI:Vergnano 2020:10.1016/j.ajhg.2020.06.020}" "" "" "associated with increased neutrophil accumulation" "Germline" "" "" "0" "" "" "" "" "association" "" "0000763333" "0" "50" "17" "56350825" "56350825" "subst" "4.06085E-5" "03256" "MPO_000029" "g.56350825C>T" "" "{DOI:Loules 2021:10.3390/jcm9113402}" "" "" "nlC1-INH-HAE association. Variant c.1571G>A has been found combined with other alleles, as follows BDKRB1, c.844C>T; CPN1, c.1219G>A;p.(Glu407Lys); SERPING1, c.*57C>G; PLAUR, c.2039T>C;p.(Met268Val); MASP1, c.2039T>C;p.(Val680Ala); TLR4, c.842G>A;p.(Cys281Tyr)" "Germline" "yes" "" "0" "" "" "" "" "VUS" "" "0000865378" "0" "50" "17" "56353055" "56353055" "subst" "0" "02325" "MPO_000030" "g.56353055G>T" "" "" "" "MPO(NM_000250.2):c.1213C>A (p.R405S)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000865379" "0" "90" "17" "56356732" "56356732" "subst" "0.000137302" "01943" "MPO_000031" "g.56356732C>A" "" "" "" "MPO(NM_000250.1):c.604G>T (p.E202*)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "pathogenic" "" "0001042001" "0" "90" "17" "56348226" "56348226" "subst" "0.00432825" "01804" "MPO_000004" "g.56348226T>G" "" "" "" "MPO(NM_000250.1):c.2031-2A>C, MPO(NM_000250.2):c.2031-2A>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "pathogenic" "" "0001042002" "0" "90" "17" "56350196" "56350196" "subst" "0.00145378" "01804" "MPO_000005" "g.56350196G>A" "" "" "" "MPO(NM_000250.1):c.1705C>T (p.R569W), MPO(NM_000250.2):c.1705C>T (p.(Arg569Trp), p.R569W)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "pathogenic" "" "0001042003" "0" "90" "17" "56350831" "56350844" "del" "0" "01804" "MPO_000016" "g.56350831_56350844del" "" "" "" "MPO(NM_000250.1):c.1555_1568delATGGAACCCAACCC (p.M519Pfs*21), MPO(NM_000250.2):c.1555_1568del (p.(Met519ProfsTer21))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "pathogenic" "" ## Variants_On_Transcripts ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Note: Only showing Variants_On_Transcript columns active for Genes MPO ## Count = 78 "{{id}}" "{{transcriptid}}" "{{effectid}}" "{{position_c_start}}" "{{position_c_start_intron}}" "{{position_c_end}}" "{{position_c_end_intron}}" "{{VariantOnTranscript/DNA}}" "{{VariantOnTranscript/RNA}}" "{{VariantOnTranscript/Protein}}" "{{VariantOnTranscript/Exon}}" "0000282576" "00013799" "10" "157" "0" "157" "0" "c.157G>T" "r.(?)" "p.(Val53Phe)" "" "0000286639" "00013799" "30" "1365" "7" "1365" "7" "c.1365+7C>T" "r.(=)" "p.(=)" "" "0000286640" "00013799" "10" "2133" "0" "2133" "0" "c.2133C>T" "r.(?)" "p.(Thr711=)" "" "0000286641" "00013799" "10" "2149" "0" "2149" "0" "c.2149A>G" "r.(?)" "p.(Ile717Val)" "" "0000286642" "00013799" "90" "518" "0" "518" "0" "c.518A>G" "r.(?)" "p.(Tyr173Cys)" "" "0000291962" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000291963" "00013799" "90" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.spl?" "p.?" "" "0000291964" "00013799" "30" "2174" "0" "2174" "0" "c.2174G>A" "r.(?)" "p.(Arg725Gln)" "" "0000291965" "00013799" "50" "608" "0" "608" "0" "c.608A>C" "r.(?)" "p.(Tyr203Ser)" "" "0000338401" "00013799" "90" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.spl?" "p.?" "" "0000338402" "00013799" "10" "2031" "-6" "2031" "-6" "c.2031-6A>C" "r.(=)" "p.(=)" "" "0000343118" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000405998" "00013799" "90" "995" "0" "995" "0" "c.995C>T" "r.(?)" "p.(Ala332Val)" "" "0000405999" "00013799" "90" "752" "0" "752" "0" "c.752T>C" "r.(?)" "p.(Met251Thr)" "" "0000562395" "00013799" "30" "2216" "0" "2216" "0" "c.2216C>A" "r.(?)" "p.(Ala739Asp)" "" "0000562396" "00013799" "70" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.spl?" "p.?" "" "0000562397" "00013799" "10" "1839" "0" "1839" "0" "c.1839T>C" "r.(?)" "p.(Thr613=)" "" "0000562398" "00013799" "50" "1712" "0" "1712" "0" "c.1712G>A" "r.(?)" "p.(Arg571Gln)" "" "0000562399" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000562400" "00013799" "90" "1555" "0" "1568" "0" "c.1555_1568del" "r.(?)" "p.(Met519ProfsTer21)" "" "0000562401" "00013799" "50" "1547" "0" "1547" "0" "c.1547A>G" "r.(?)" "p.(Tyr516Cys)" "" "0000562404" "00013799" "30" "752" "0" "752" "0" "c.752T>C" "r.(?)" "p.(Met251Thr)" "" "0000562405" "00013799" "30" "752" "0" "752" "0" "c.752T>C" "r.(?)" "p.(Met251Thr)" "" "0000562406" "00013799" "30" "522" "0" "522" "0" "c.522C>T" "r.(?)" "p.(Arg174=)" "" "0000562407" "00013799" "90" "518" "0" "518" "0" "c.518A>G" "r.(?)" "p.(Tyr173Cys)" "" "0000562408" "00013799" "30" "225" "0" "225" "0" "c.225G>A" "r.(?)" "p.(Lys75=)" "" "0000578066" "00013799" "00" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.2030_2031ins[2031-109_2031-2;c]" "p.R677Wfs*73" "" "0000578119" "00013799" "00" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.2030_2031ins[2031-109_2031-2;c]" "p.R677Wfs*73" "" "0000578127" "00013799" "00" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.2030_2031ins[2031-109_2031-2;c]" "p.R677Wfs*73" "" "0000649652" "00013799" "90" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.spl" "p.?" "" "0000649653" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000649654" "00013799" "90" "752" "0" "752" "0" "c.752T>C" "r.(?)" "p.(Met251Thr)" "" "0000680935" "00013799" "50" "878" "0" "878" "0" "c.878C>G" "r.(?)" "p.(Pro293Arg)" "" "0000682828" "00013799" "70" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.spl" "p.?" "" "0000682829" "00013799" "70" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.spl" "p.?" "" "0000682830" "00013799" "70" "1555" "0" "1568" "0" "c.1555_1568del" "r.(?)" "p.(Met519Profs*21)" "" "0000682831" "00013799" "70" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.spl" "p.?" "" "0000682832" "00013799" "70" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000682833" "00013799" "90" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.(2030_2031ins[2031-109_2031-2;c])" "p.(Phe678fs)" "" "0000682834" "00013799" "90" "1566" "0" "1579" "0" "c.1566_1579del" "r.(1545_1621del)" "p.(Tyr516Trpfs*3)" "" "0000682835" "00013799" "90" "752" "0" "752" "0" "c.752T>C" "r.(?)" "p.(Met251Thr)" "" "0000682836" "00013799" "90" "1566" "0" "1579" "0" "c.1566_1579del" "r.(1545_1621del)" "p.(Tyr516Trpfs*3)" "" "0000682837" "00013799" "90" "995" "0" "995" "0" "c.995C>T" "r.(?)" "p.(Ala332Val)" "" "0000682838" "00013799" "90" "325" "0" "325" "0" "c.325del" "r.(?)" "p.(Thr109Profs*5)" "" "0000682839" "00013799" "90" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.(2030_2031ins[2031-109_2031-2;c])" "p.(Phe678fs)" "" "0000682840" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000682841" "00013799" "90" "752" "0" "752" "0" "c.752T>C" "r.(?)" "p.(Met251Thr)" "" "0000682842" "00013799" "90" "995" "0" "995" "0" "c.995C>T" "r.(?)" "p.(Ala332Val)" "" "0000682843" "00013799" "90" "1566" "0" "1579" "0" "c.1566_1579del" "r.(1545_1621del)" "p.(Tyr516Trpfs*3)" "" "0000682844" "00013799" "90" "752" "0" "752" "0" "c.752T>C" "r.(?)" "p.(Met251Thr)" "" "0000682845" "00013799" "90" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.(2030_2031ins[2031-109_2031-2;c])" "p.(Phe678fs)" "" "0000682846" "00013799" "90" "1112" "0" "1112" "0" "c.1112A>G" "r.(?)" "p.(Asp371Gly)" "" "0000682847" "00013799" "90" "1566" "0" "1579" "0" "c.1566_1579del" "r.(1545_1621del)" "p.(Tyr516Trpfs*3)" "" "0000682848" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000682849" "00013799" "90" "752" "0" "752" "0" "c.752T>C" "r.(?)" "p.(Met251Thr)" "" "0000682850" "00013799" "90" "1715" "0" "1715" "0" "c.1715T>G" "r.(?)" "p.(Leu572Trp)" "" "0000682851" "00013799" "90" "1566" "0" "1579" "0" "c.1566_1579del" "r.(1545_1621del)" "p.(Tyr516Trpfs*3)" "" "0000682852" "00013799" "90" "1927" "0" "1927" "0" "c.1927T>C" "r.(?)" "p.(Trp643Arg)" "" "0000682870" "00013799" "90" "752" "0" "752" "0" "c.752T>C" "r.752u>c" "p.Met251Thr" "" "0000682871" "00013799" "90" "1555" "0" "1568" "0" "c.1555_1568del" "r.0" "p.0" "" "0000682872" "00013799" "90" "1555" "0" "1568" "0" "c.1555_1568del" "r.1545_1621del" "p.Tyr516Trpfs*3" "" "0000682873" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000682874" "00013799" "90" "518" "0" "518" "0" "c.518A>G" "r.(?)" "p.(Tyr173Cys)" "" "0000682875" "00013799" "50" "0" "0" "0" "0" "-" "-" "-" "_1" "0000682876" "00013799" "90" "1501" "0" "1501" "0" "c.1501G>A" "r.1501g>a" "p.Gly501Ser" "" "0000682877" "00013799" "90" "1495" "0" "1495" "0" "c.1495C>T" "r.1495c>u" "p.Arg499Cys" "" "0000682878" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000682879" "00013799" "90" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.spl" "p.?" "" "0000682880" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0000682881" "00013799" "90" "518" "0" "518" "0" "c.518A>G" "r.(?)" "p.(Tyr173Cys)" "" "0000682882" "00013799" "90" "752" "0" "752" "0" "c.752T>C" "r.(?)" "p.(Met251Thr)" "" "0000682883" "00013799" "90" "995" "0" "995" "0" "c.995C>T" "r.(?)" "p.(Ala332Val)" "" "0000763333" "00013799" "50" "1571" "0" "1571" "0" "c.1571G>A" "r.(?)" "p.(Arg524His)" "9" "0000865378" "00013799" "50" "1213" "0" "1213" "0" "c.1213C>A" "r.(?)" "p.(Arg405Ser)" "" "0000865379" "00013799" "90" "604" "0" "604" "0" "c.604G>T" "r.(?)" "p.(Glu202*)" "" "0001042001" "00013799" "90" "2031" "-2" "2031" "-2" "c.2031-2A>C" "r.spl?" "p.?" "" "0001042002" "00013799" "90" "1705" "0" "1705" "0" "c.1705C>T" "r.(?)" "p.(Arg569Trp)" "" "0001042003" "00013799" "90" "1555" "0" "1568" "0" "c.1555_1568del" "r.(?)" "p.(Met519ProfsTer21)" "" ## Screenings_To_Variants ## Do not remove or alter this header ## ## Count = 48 "{{screeningid}}" "{{variantid}}" "0000177978" "0000405998" "0000177978" "0000405999" "0000249314" "0000578066" "0000249356" "0000578119" "0000249362" "0000578127" "0000292963" "0000649652" "0000292964" "0000649653" "0000292965" "0000649654" "0000308427" "0000682828" "0000308428" "0000682829" "0000308429" "0000682830" "0000308430" "0000682831" "0000308430" "0000682832" "0000308431" "0000682833" "0000308432" "0000682834" "0000308432" "0000682848" "0000308433" "0000682835" "0000308434" "0000682836" "0000308435" "0000682837" "0000308436" "0000682838" "0000308437" "0000682839" "0000308438" "0000682840" "0000308438" "0000682849" "0000308439" "0000682841" "0000308440" "0000682842" "0000308440" "0000682850" "0000308441" "0000682843" "0000308442" "0000682844" "0000308443" "0000682845" "0000308443" "0000682851" "0000308444" "0000682846" "0000308445" "0000682847" "0000308445" "0000682852" "0000308462" "0000682870" "0000308462" "0000682871" "0000308463" "0000682872" "0000308464" "0000682873" "0000308465" "0000682874" "0000308466" "0000682875" "0000308467" "0000682876" "0000308468" "0000682877" "0000308469" "0000682878" "0000308470" "0000682879" "0000308471" "0000682880" "0000308472" "0000682881" "0000308473" "0000682882" "0000308474" "0000682883" "0000360848" "0000763333"