### LOVD-version 3000-30b ### Full data download ### To import, do not remove or alter this header ### ## Filter: (gene_public = PLG) # charset = UTF-8 ## Genes ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{name}}" "{{chromosome}}" "{{chrom_band}}" "{{imprinting}}" "{{refseq_genomic}}" "{{refseq_UD}}" "{{reference}}" "{{url_homepage}}" "{{url_external}}" "{{allow_download}}" "{{id_hgnc}}" "{{id_entrez}}" "{{id_omim}}" "{{show_hgmd}}" "{{show_genecards}}" "{{show_genetests}}" "{{show_orphanet}}" "{{note_index}}" "{{note_listing}}" "{{refseq}}" "{{refseq_url}}" "{{disclaimer}}" "{{disclaimer_text}}" "{{header}}" "{{header_align}}" "{{footer}}" "{{footer_align}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{updated_by}}" "{{updated_date}}" "PLG" "plasminogen" "6" "q26" "unknown" "NC_000006.11" "UD_132118550052" "" "https://www.LOVD.nl/PLG" "" "1" "9071" "5340" "173350" "1" "1" "1" "1" "Establishment of this gene variant database (LSDB) was performed by Johan den Dunnen, supported by Global Variome." "" "g" "https://databases.lovd.nl/shared/refseq/PLG_codingDNA.html" "1" "" "" "-1" "" "-1" "00001" "2013-05-03 00:00:00" "00006" "2023-07-07 15:09:39" "03256" "2025-11-05 17:49:45" ## Transcripts ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{geneid}}" "{{name}}" "{{id_mutalyzer}}" "{{id_ncbi}}" "{{id_ensembl}}" "{{id_protein_ncbi}}" "{{id_protein_ensembl}}" "{{id_protein_uniprot}}" "{{remarks}}" "{{position_c_mrna_start}}" "{{position_c_mrna_end}}" "{{position_c_cds_end}}" "{{position_g_mrna_start}}" "{{position_g_mrna_end}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00016356" "PLG" "transcript variant 1" "001" "NM_000301.3" "" "NP_000292.1" "" "" "" "-112" "3426" "2433" "161123225" "161175086" "" "0000-00-00 00:00:00" "" "" ## Diseases ## Do not remove or alter this header ## ## Count = 8 "{{id}}" "{{symbol}}" "{{name}}" "{{inheritance}}" "{{id_omim}}" "{{tissues}}" "{{features}}" "{{remarks}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00000" "Healthy/Control" "Healthy individual / control" "" "" "" "" "" "00000" "2012-07-26 17:29:43" "" "" "00198" "?" "unclassified / mixed" "" "" "" "" "" "00006" "2013-09-13 14:21:47" "00006" "2024-11-23 09:38:12" "01719" "-" "deficiency, plasminogen, type I" "AR" "217090" "" "" "" "00006" "2014-09-25 23:29:40" "00006" "2021-12-10 21:51:32" "02963" "HAE3" "angioedema, hereditary, type 3" "AD" "610618" "" "" "" "00006" "2014-09-25 23:29:40" "03256" "2025-04-09 18:11:52" "04214" "-" "retinal disease" "" "" "" "" "" "00006" "2015-02-27 19:48:07" "00001" "2023-03-09 14:26:26" "05711" "AHUS" "hemolyticuremic syndrome, atypical (AHUS)" "" "" "" "" "" "00006" "2020-03-10 15:20:04" "00006" "2021-12-10 21:51:32" "06944" "HAE" "angioedema, hereditary" "" "" "" "" "" "00006" "2022-07-07 09:18:20" "" "" "06980" "HAE4" "angioedema, hereditary, type 4" "AD" "619360" "" "" "" "00006" "2022-11-30 10:47:35" "" "" ## Genes_To_Diseases ## Do not remove or alter this header ## ## Count = 3 "{{geneid}}" "{{diseaseid}}" "PLG" "01719" "PLG" "06944" "PLG" "06980" ## Individuals ## Do not remove or alter this header ## ## Count = 38 "{{id}}" "{{fatherid}}" "{{motherid}}" "{{panelid}}" "{{panel_size}}" "{{license}}" "{{owned_by}}" "{{Individual/Reference}}" "{{Individual/Remarks}}" "{{Individual/Gender}}" "{{Individual/Consanguinity}}" "{{Individual/Origin/Geographic}}" "{{Individual/Age_of_death}}" "{{Individual/VIP}}" "{{Individual/Data_av}}" "{{Individual/Treatment}}" "{{Individual/Origin/Population}}" "{{Individual/Individual_ID}}" "00294025" "" "" "" "1" "" "03575" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "analysis 2794 individuals (India)" "" "" "India" "" "0" "" "" "" "" "00294026" "" "" "" "1" "" "03575" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "analysis 2794 individuals (India)" "" "" "India" "" "0" "" "" "" "" "00361803" "" "" "" "12" "" "03256" "{DOI:Bork 2020:10.1111/ddg.14036}" "One family with compound heterozygous individuals and 12 affected patients" "" "" "Germany" "" "0" "" "" "" "" "00361804" "" "" "" "74" "" "03256" "{DOI:Bork 2018:10.1111/all.13270} {DOI:Bork 2023:10.1016/j.jaip.2023.01.051} {DOI:Hintze 2023:10.3389/fphys.2022.1090732}" "Bork 2018: Thirteen families with 60 affected individuals\r\nBork 2023: Six German pedigrees have been found to carry a c.988A>G; solitary German carriers (n=6)\r\nHintze 2023: a German pedigree with 8 affected individuals" "" "no" "Germany" "" "0" "" "" "" "" "00361844" "" "" "" "4" "" "03256" "{DOI:Germenis 2018:10.1111/all.13324}" "First family with a homozygous proband for a c.988A>G variant and 3 heterozygous carriers, incl one symptomatic female individual" "" "" "Greece" "" "0" "" "" "" "" "00361847" "" "" "" "3" "" "03256" "{DOI:Germenis 2018:10.1111/all.13324}" "A single pedigree has been found as carrying a c.988A>G variant; the female proband is a homozygous carrier, 2 heterozygous carriers have been found asymptomatic." "F" "?" "Greece" "" "0" "" "" "" "" "00361882" "" "" "" "3" "" "03256" "{DOI:Parsopoulou 2020:10.1111/all.14280}" "A Spanish family with 5 heterozygous carriers of a c.988A>G variant, incl 3/5 symptomatic individuals" "" "no" "Spain" "" "0" "" "" "" "" "00361884" "" "" "" "3" "" "03256" "{DOI:Loules 2020:10.3390/jcm9113402}" "" "M" "no" "Greece" "" "0" "" "" "" "" "00361885" "" "" "" "1" "" "03256" "" "" "" "" "Australia" "" "0" "" "" "" "" "00362008" "" "" "" "1" "" "00000" "{PMID:Duvvari 2016:27007659}" "patient" "" "" "Netherlands" "" "0" "" "" "white" "Pat11AB" "00383163" "" "" "" "1" "" "03256" "{DOI:Bodian 2019:10.1186/s13223-019-0346-1}" "" "F" "" "United States" "" "0" "" "" "" "" "00383164" "" "" "" "6" "" "03256" "{DOI:Recke 2019: 10.1186/s13601-019-0247-x}" "" "" "no" "Germany" "" "0" "" "" "" "" "00383165" "" "" "" "12" "" "03256" "{DOI:Belbezier 2018:10.1111/all.13543}" "Three kindreds have been reported as carrying a c.988A>G variant, with 12 affected individuals" "" "no" "France" "" "0" "" "" "" "" "00385446" "" "" "" "1" "" "03256" "{DOI:Farkas 2021:10.3390/genes12030402}" "Hungarian pedigree with a single symptomatic carrier of a c.988A>G variant in the PLG gene" "F" "" "Hungary" "" "0" "" "" "" "" "00385447" "" "" "" "4" "" "03256" "{DOI:Yakushiji 2018:10.1111/all.13550}" "Two Japanese pedigrees have been found as carrying a c.988A>G variant in the PLG gene\r\nFamily 1 (n=2)\r\nFamily 2 (n=2)" "" "" "Japan" "" "0" "" "" "" "" "00385448" "" "" "" "1" "" "03256" "{DOI:Germenis 2018:10.1111/all.13324}" "" "F" "" "Bulgaria" "" "0" "" "" "" "" "00403772" "" "" "" "14" "" "03256" "{DOI:Manto 2021:10.36691/RJA1446}" "10 families, with 14 affected carriers, have been reported as carrying a PLG variant c.988A>G" "" "" "Russia" "" "0" "" "" "" "" "00416000" "" "" "" "1" "" "03256" "{PMID:Mathey 2022:35923707}, {DOI:Mathey 2022:10.3389/fgene.2022.914376}" "" "" "" "" "" "0" "" "" "" "" "00426343" "" "" "" "5" "" "03256" "{PMID:Yakushiji 2023:36418094}, {DOI:Yakushiji 2023:10.2169/internalmedicine.0645-22}" "3-generation family, 5 affected (4 female, 1 male); 3 carriers (1 female, 2 male) are asymptomatic" "F" "no" "Japan" "" "0" "" "" "" "FamPatII1" "00430274" "" "" "" "1" "" "03256" "{DOI:Lee 2022:10.1097/MD.0000000000029013}" "" "M" "" "Korea" "" "0" "" "" "" "" "00433192" "" "" "" "8" "" "03256" "{DOI:Hintze 2023:10.3389/fphys.2022.1090732}" "A female proband carrying both variants PLG c.988A>G;p.(lys330Glu) and F12 c.1681-1G>A; 6 compound heterozygous affected individuals, 2 heterozygous affected individuals carrying a PLG variant" "F" "" "Germany" "" "0" "" "" "" "" "00435329" "" "" "" "22" "" "03256" "{DOI:Dewald 2018:10.1016/j.bbrc.2017.12.060}" "Three independent pedigrees have been shown as carrying the variant Family 1 (n=9), Family 2 (n=4), Family 3 (n=9)" "F" "" "Germany" "" "0" "" "" "" "Fam1-3" "00436383" "" "" "" "1" "" "03256" "{DOI:Nakayama 2023:10.1093/mrcr/rxad017}" "Single individual" "F" "no" "Japan" "" "0" "" "" "" "" "00436400" "" "" "" "2" "" "03256" "{DOI:Katelaris 2023:10.1016/j.jaip.2023.06.022}" "" "F" "" "Brazil" "" "0" "" "" "white (Italy)" "" "00443695" "" "" "" "3" "" "03256" "{DOI:Friedman 2023:10.1016/j.anai.2023.08.374}" "A US family with a female proband is presenting with macroglossia, a mother with peripheral angioedema and a son died because of airway obstruction" "F" "" "United States" "" "0" "" "" "" "" "00448539" "" "" "" "1" "" "03256" "{DOI: Rozevska 2024:10.1186/s13223-024-00889-5}" "" "" "no" "Latvia" "" "0" "" "" "" "" "00449804" "" "" "" "1" "" "03256" "" "" "" "" "" "" "0" "" "" "" "" "00449806" "" "" "" "1" "" "03256" "" "" "" "" "" "" "0" "" "" "" "" "00449807" "" "" "" "1" "" "03256" "{DOI:Tefs 2006:10.1182/blood-2006-04-017350}" "" "" "" "" "" "0" "" "" "" "" "00449809" "" "" "" "1" "" "03256" "{DOI:Tefs 2006:10.1182/blood-2006-04-017350}" "" "" "" "" "" "0" "" "" "" "" "00449810" "" "" "" "8" "" "03256" "{DOI:Tefs 2006:10.1182/blood-2006-04-017350}" "Five independent families with homozygous affected patients have been shown as carrying a c.112A>G variant. Heterozygous carriers of these 5 families are not affected.\r\nThree independent families with compound heterozygous affected patients have been shown as carrying both c.112A>G and c.1468C>T variants." "" "" "" "" "0" "" "" "" "" "00450520" "" "" "" "1" "" "03256" "{DOI:Schuster 1997:10.1182/blood.V90.3.958}" "" "F" "yes" "Turkey" "" "0" "" "" "" "" "00454850" "" "" "" "2" "" "03256" "{DOI:Adatia 2024:10.1186/s13223-024-00910-x}" "" "" "" "Canada" "" "0" "" "" "" "" "00464695" "" "" "" "1" "" "03256" "{PMID:Schuster 1997:9242524}" "Single family with a compound heterozygous affected individual" "M" "" "Germany" "" "0" "" "" "" "" "00464698" "" "" "" "1" "" "03256" "{DOI:Sugimoto 2025:10.15036/arerugi.74.73}" "Single female individual affected" "F" "no" "Japan" "" "0" "" "" "" "" "00464707" "" "" "" "2" "" "03256" "{DOI:Sugimoto 2025:10.15036/arerugi.74.73}" "A single family with two affected sisters" "F" "no" "Japan" "" "0" "" "" "" "" "00465619" "" "" "" "1" "" "03256" "{DOI:de Albuquerque Campos 2023:10.1186/s13223-023-00845-9}" "" "F" "no" "Brazil" "" "0" "" "" "" "" "00465622" "" "" "" "1" "" "03256" "{DOI:Purina 2023:10.1186/s13223-023-00845-9}" "The first HAE-nC1INH patient from Latvia with identified pathogenic variant in the PLG gene." "F" "no" "Latvia" "" "0" "" "" "" "" ## Individuals_To_Diseases ## Do not remove or alter this header ## ## Count = 38 "{{individualid}}" "{{diseaseid}}" "00294025" "00198" "00294026" "00198" "00361803" "06980" "00361804" "06980" "00361844" "06980" "00361847" "06980" "00361882" "06980" "00361884" "02963" "00361885" "05711" "00362008" "04214" "00383163" "06980" "00383164" "06980" "00383165" "06980" "00385446" "06980" "00385447" "06980" "00385448" "06980" "00403772" "06980" "00416000" "00000" "00426343" "06980" "00430274" "01719" "00433192" "06980" "00435329" "06980" "00436383" "06980" "00436400" "06980" "00443695" "06980" "00448539" "06980" "00449804" "01719" "00449806" "01719" "00449807" "01719" "00449809" "01719" "00449810" "01719" "00450520" "01719" "00454850" "06980" "00464695" "01719" "00464698" "06980" "00464707" "06980" "00465619" "06980" "00465622" "06980" ## Phenotypes ## Do not remove or alter this header ## ## Note: Only showing Phenotype columns active for Diseases 00000, 00198, 01719, 02963, 04214, 05711, 06944, 06980 ## Count = 38 "{{id}}" "{{diseaseid}}" "{{individualid}}" "{{owned_by}}" "{{Phenotype/Inheritance}}" "{{Phenotype/Age}}" "{{Phenotype/Additional}}" "{{Phenotype/Age/Onset}}" "{{Phenotype/Age/Diagnosis}}" "{{Phenotype/Onset}}" "{{Phenotype/Protein}}" "{{Phenotype/Tumor/MSI}}" "{{Phenotype/Enzyme/CPK}}" "{{Phenotype/Heart/Myocardium}}" "{{Phenotype/Lung}}" "{{Phenotype/Diagnosis/Definite}}" "{{Phenotype/Diagnosis/Initial}}" "{{Phenotype/Diagnosis/Criteria}}" "0000257197" "01177" "00361803" "03256" "Familial" "" "Proband presenting with a HAE with C1-INH deficiency" "" "" "" "" "" "" "" "" "" "" "" "0000257198" "02963" "00361804" "03256" "Familial" "" "Probands presenting with a HAE-PLG phenotype with frequent macroglossia attacks" "" "" "" "" "" "" "" "" "" "" "" "0000257236" "02963" "00361844" "03256" "Familial" "" "Proband presenting with a HAE phenotype" "" "" "" "" "" "" "" "" "" "" "" "0000257239" "02963" "00361847" "03256" "Familial" "" "Proband presenting with a PLG-HAE phenotype" "" "" "" "" "" "" "" "" "" "" "" "0000257274" "02963" "00361882" "03256" "Familial" "" "Proband presenting with a HAE phenotype" "" "" "" "" "" "" "" "" "" "" "" "0000257276" "02963" "00361884" "03256" "Familial" "" "Proband and his son presenting with a HAE phenotype, but not his daughter also carrying a c.2183T>A variant" "" "" "" "" "" "" "" "" "" "" "" "0000257279" "05711" "00361885" "03256" "Unknown" "" "Proband presenting with aHUS" "" "" "" "" "" "" "" "" "" "" "" "0000257401" "04214" "00362008" "00000" "Unknown" "" "" "" "" "" "" "" "" "" "" "" "age-related macular degeneration, cuticular drusen" "" "0000276950" "02963" "00383163" "03256" "Unknown" "" "Proband presenting with a nlC-INH-HAE presenting with lips and tongue angioedema, without wheels, and resistant to H1-antihistamines" "" "" "" "" "" "" "" "" "" "" "" "0000276951" "02963" "00383164" "03256" "Familial" "64y" "Proband presenting with nl-C1-INH-HAE and recurrent swellings of tongue and lips, sometimes also larynx, throat and upper airways" "" "" "" "" "" "" "" "" "" "" "" "0000276952" "02963" "00383164" "03256" "Familial" "" "6 affected individuals among 7 c.988A>G variant carriers within a German family" "" "" "" "" "" "" "" "" "" "" "" "0000276953" "02963" "00383165" "03256" "Familial" "" "Probands presenting with a nl-C1-INH-HAE and face/tongue swelling episodes." "" "" "" "" "" "" "" "" "" "" "" "0000279241" "02963" "00385446" "03256" "Familial" "" "Proband presenting with an angioedema phenotype a the age of 17, then 20 years later, with an iatrogenic angioedema precipitated after intake of ACEi" "" "" "" "" "" "" "" "" "" "" "" "0000279242" "02963" "00385447" "03256" "Familial" "" "Probands presenting with non histamine-mediated angioedema; two female symptomatic carriers are presenting with a recurrent macroglossia." "" "" "" "" "" "" "" "" "" "" "" "0000279243" "02963" "00385448" "03256" "Unknown" "" "A single Bulgarian female patient presenting with a non histamine-dependent angioedema phenotype" "" "" "" "" "" "" "" "" "" "" "" "0000296469" "02963" "00403772" "03256" "Familial" "" "A HAE phenotype has been recorded by the authors within 10 families" "" "" "" "" "" "" "" "" "" "" "" "0000307766" "00000" "00416000" "03256" "Unknown" "" "Protection from ACEi angioedema" "" "" "" "" "" "" "" "" "" "" "" "0000317562" "06944" "00426343" "00006" "Familial, autosomal dominant" "65y" "see paper; ..., everely swollen\r\ntongue and lips" "" "" "" "" "" "" "" "" "HAE4" "angioedema" "" "0000321082" "01719" "00430274" "03256" "Familial" "" "Proband presenting with thromboembolism of bilateral superficial femoral arteries, left common femoral artery and the left lower leg" "" "" "" "" "" "" "" "" "34y" "" "" "0000323724" "06980" "00433192" "03256" "Familial" "" "Proband presenting with a bradykinin-dependent HAE phenotype" "" "68y" "" "" "" "" "" "" "" "" "" "0000325525" "06980" "00435329" "03256" "Familial" "" "Probands presenting with a bradykinin angioedema phenotype" "" "" "" "" "" "" "" "" "" "" "" "0000326563" "06980" "00436383" "03256" "Familial" "" "Recurrent acute abdomen following low-dose oestrogen-progestin therapy" "" "" "" "" "" "" "" "" "" "" "" "0000326579" "06980" "00436400" "03256" "Familial" "" "HAE-nC1-INH of the proband possibly triggered after taking ACEi (perindopril), but continues after stopping ACEi" "" "65y" "" "" "" "" "" "" "" "" "" "0000332978" "06980" "00443695" "03256" "Familial" "66" "Proband presenting with macroglossia, her mother with peripheral angioedema, her son with airway obstruction" "" "" "" "" "" "" "" "" "" "" "" "0000337722" "06980" "00448539" "03256" "Familial" "" "Proband presenting with a HAE-nC1-INH phenotype" "" "" "" "" "" "" "" "" "" "" "" "0000338950" "01719" "00449804" "03256" "Familial" "" "Thrombophilia" "" "" "" "" "" "" "" "" "" "" "" "0000338952" "01719" "00449806" "03256" "Familial" "" "Thrombophilia" "" "" "" "" "" "" "" "" "" "" "" "0000338953" "01719" "00449807" "03256" "Familial" "" "Thrombophilia" "" "" "" "" "" "" "" "" "" "" "" "0000338955" "01719" "00449809" "03256" "Familial" "" "Thrombophilia; gingiva, larynx and vagina mainly affected" "" "" "" "" "" "" "" "" "" "" "" "0000338956" "01719" "00449810" "03256" "Familial" "" "Thrombophilia; conjonctiva" "" "" "" "" "" "" "" "" "" "" "" "0000338969" "01719" "00449810" "03256" "Familial" "" "Thrombophilia; conjonctiva, gingiva, ears" "" "" "" "" "" "" "" "" "" "" "" "0000339575" "01719" "00450520" "03256" "Familial" "" "A young girl presenting with chronic bilateral ligneous conjunctivitis and occlusive hydrocephalus." "" "" "4w" "" "" "" "" "" "" "" "" "0000343457" "06980" "00454850" "03256" "Familial" "" "Proband presenting with a HAE-nC1INH phenotype" "" "" "" "" "" "" "" "" "" "" "" "0000350680" "01719" "00464695" "03256" "Familial" "" "Ligneous conjunctivitis" "" "" "" "" "" "" "" "" "" "" "" "0000350683" "06980" "00464698" "03256" "Familial" "" "Proband presenting with a HAE-PLG phenotype; recurrent acute abdominal pain after starting low-dose estrogen therapy." "" "" "" "" "" "" "" "" "" "" "" "0000350690" "06980" "00464707" "03256" "Familial" "" "Two affected sisters presenting with occasional abdominal pain and vomiting" "" "23y" "" "" "" "" "" "" "" "" "" "0000351162" "06980" "00465619" "03256" "Unknown" "" "Progressive sagging of the skin on the chest, abdomen and the face, with excessive wrinkling (cutis laxa). Development of facial angioedema after Zika virus infection with associated hives and skin swellings; poor improvement with H1-antihistamines treatment. Hives resolve after treatment with omalizumab but no change in frequency of angioedema." "" "57y" "" "" "" "" "" "" "" "" "" "0000351165" "06980" "00465622" "03256" "Unknown" "" "Rare, irregular mild episodes of swelling in the extremities lasting several days and recurrent abdominal pain. At 30 years of age she had mild episodes of edema during pregnancy and while taking oral contraceptives. No family history." "08y" "40y" "" "" "" "" "" "" "" "" "" ## Screenings ## Do not remove or alter this header ## ## Count = 39 "{{id}}" "{{individualid}}" "{{variants_found}}" "{{owned_by}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{Screening/Technique}}" "{{Screening/Template}}" "{{Screening/Tissue}}" "{{Screening/Remarks}}" "0000295193" "00294025" "1" "03575" "00006" "2020-03-11 19:30:02" "" "" "arraySNP" "DNA" "" "Infinium Global Screening Array v1.0" "0000295194" "00294026" "1" "03575" "00006" "2020-03-11 19:30:02" "" "" "arraySNP" "DNA" "" "Infinium Global Screening Array v1.0" "0000363031" "00361803" "1" "03256" "03256" "2021-04-11 09:49:55" "" "" "SEQ" "DNA" "blood" "" "0000363032" "00361804" "1" "03256" "03256" "2021-04-11 10:28:53" "" "" "SEQ" "DNA" "blood" "" "0000363073" "00361844" "1" "03256" "03256" "2021-04-11 15:25:58" "" "" "SEQ-NG-IT" "DNA" "blood" "" "0000363076" "00361847" "1" "03256" "03256" "2021-04-11 15:38:15" "" "" "SEQ-NG-IT" "DNA" "" "" "0000363111" "00361882" "1" "03256" "03256" "2021-04-11 18:41:43" "" "" "SEQ-NG-IT" "DNA" "blood" "" "0000363113" "00361884" "1" "03256" "03256" "2021-04-11 18:59:13" "" "" "SEQ-NG-IT" "DNA" "blood" "" "0000363114" "00361885" "1" "03256" "03256" "2021-04-11 19:23:16" "" "" "SEQ" "DNA" "" "" "0000363236" "00362008" "1" "00000" "00006" "2021-04-13 14:21:59" "" "" "SEQ;SEQ-NG" "DNA" "" "WES" "0000384387" "00383163" "1" "03256" "03256" "2021-09-24 09:19:12" "" "" "SEQ-NG-I" "DNA" "blood" "" "0000384388" "00383164" "1" "03256" "03256" "2021-09-24 09:33:14" "" "" "SEQ" "DNA" "blood" "" "0000384389" "00383165" "1" "03256" "03256" "2021-09-24 09:57:56" "" "" "SEQ" "DNA" "blood" "" "0000386675" "00385446" "1" "03256" "03256" "2021-10-12 10:12:36" "" "" "SEQ" "DNA" "blood" "" "0000386676" "00385447" "1" "03256" "03256" "2021-10-12 10:32:46" "" "" "SEQ" "DNA" "blood" "" "0000386677" "00385448" "1" "03256" "03256" "2021-10-12 11:19:48" "" "" "SEQ-NG-IT" "DNA" "blood" "" "0000405009" "00403772" "1" "03256" "03256" "2022-02-22 15:48:45" "" "" "SEQ" "DNA" "blood" "" "0000417280" "00416000" "1" "03256" "03256" "2022-08-19 22:11:03" "" "" "MIPsm" "DNA" "blood" "" "0000427663" "00426343" "1" "03256" "03256" "2022-11-28 20:15:39" "" "" "SEQ" "DNA" "blood" "" "0000431688" "00430274" "1" "03256" "03256" "2023-01-16 17:35:49" "" "" "SEQ" "DNA" "blood" "" "0000434646" "00433192" "1" "03256" "03256" "2023-03-03 11:58:51" "" "" "SEQ" "DNA" "blood" "" "0000436809" "00435329" "1" "03256" "03256" "2023-07-06 19:37:52" "" "" "SEQ" "DNA" "blood" "" "0000437866" "00436383" "1" "03256" "03256" "2023-09-05 18:41:45" "" "" "SEQ" "DNA" "blood" "" "0000437882" "00436400" "1" "03256" "03256" "2023-09-12 11:36:34" "" "" "SEQ" "DNA" "blood" "" "0000445188" "00443695" "1" "03256" "03256" "2023-11-30 18:17:08" "" "" "SEQ" "DNA" "blood" "" "0000450127" "00448539" "1" "03256" "03256" "2024-04-03 14:34:43" "" "" "SEQ" "DNA" "blood" "" "0000451399" "00449804" "1" "03256" "03256" "2024-05-15 13:57:17" "" "" "SEQ" "DNA" "blood" "" "0000451401" "00449806" "1" "03256" "03256" "2024-05-15 14:14:29" "" "" "?" "DNA" "blood" "" "0000451402" "00449807" "1" "03256" "03256" "2024-05-15 14:30:26" "" "" "?" "DNA" "" "" "0000451404" "00449809" "1" "03256" "03256" "2024-05-15 14:57:06" "" "" "?" "DNA" "blood" "" "0000451405" "00449810" "1" "03256" "03256" "2024-05-15 15:14:56" "" "" "?" "DNA" "blood" "" "0000451418" "00449810" "1" "03256" "03256" "2024-05-16 11:47:26" "" "" "SEQ" "DNA" "blood" "" "0000452118" "00450520" "1" "03256" "03256" "2024-05-29 17:42:44" "" "" "SEQ" "DNA" "blood" "" "0000456459" "00454850" "1" "03256" "03256" "2024-09-30 09:34:27" "" "" "SEQ" "DNA" "blood" "" "0000466342" "00464695" "1" "03256" "03256" "2025-04-09 16:18:28" "" "" "SEQ" "DNA" "" "" "0000466345" "00464698" "1" "03256" "03256" "2025-04-10 13:03:49" "" "" "SEQ" "DNA" "" "" "0000466354" "00464707" "1" "03256" "03256" "2025-04-13 15:08:23" "" "" "SEQ" "DNA" "blood" "" "0000467267" "00465619" "1" "03256" "03256" "2025-05-28 13:42:43" "" "" "SEQ-NG" "DNA" "" "" "0000467270" "00465622" "1" "03256" "03256" "2025-05-28 14:27:23" "" "" "SEQ" "DNA" "" "" ## Screenings_To_Genes ## Do not remove or alter this header ## ## Count = 36 "{{screeningid}}" "{{geneid}}" "0000363031" "PLG" "0000363032" "PLG" "0000363073" "PLG" "0000363076" "PLG" "0000363111" "PLG" "0000363113" "PLG" "0000363114" "PLG" "0000384387" "PLG" "0000384388" "PLG" "0000384389" "PLG" "0000386675" "PLG" "0000386676" "PLG" "0000386677" "PLG" "0000405009" "PLG" "0000417280" "PLG" "0000427663" "PLG" "0000431688" "PLG" "0000434646" "PLG" "0000436809" "PLG" "0000437866" "PLG" "0000437882" "PLG" "0000445188" "PLG" "0000450127" "PLG" "0000451399" "PLG" "0000451401" "PLG" "0000451402" "PLG" "0000451404" "PLG" "0000451405" "PLG" "0000451418" "PLG" "0000452118" "PLG" "0000456459" "PLG" "0000466342" "PLG" "0000466345" "PLG" "0000466354" "PLG" "0000467267" "PLG" "0000467270" "PLG" ## Variants_On_Genome ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Count = 117 "{{id}}" "{{allele}}" "{{effectid}}" "{{chromosome}}" "{{position_g_start}}" "{{position_g_end}}" "{{type}}" "{{average_frequency}}" "{{owned_by}}" "{{VariantOnGenome/DBID}}" "{{VariantOnGenome/DNA}}" "{{VariantOnGenome/Frequency}}" "{{VariantOnGenome/Reference}}" "{{VariantOnGenome/Restriction_site}}" "{{VariantOnGenome/Published_as}}" "{{VariantOnGenome/Remarks}}" "{{VariantOnGenome/Genetic_origin}}" "{{VariantOnGenome/Segregation}}" "{{VariantOnGenome/dbSNP}}" "{{VariantOnGenome/VIP}}" "{{VariantOnGenome/Methylation}}" "{{VariantOnGenome/ISCN}}" "{{VariantOnGenome/DNA/hg38}}" "{{VariantOnGenome/ClinVar}}" "{{VariantOnGenome/ClinicalClassification}}" "{{VariantOnGenome/ClinicalClassification/Method}}" "0000248565" "0" "10" "6" "161139857" "161139857" "subst" "0.213252" "02325" "PLG_000006" "g.161139857A>G" "" "" "" "PLG(NM_000301.5):c.1083A>G (p.Q361=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160718825A>G" "" "benign" "" "0000297124" "0" "10" "6" "161143608" "161143608" "subst" "0.215253" "02325" "PLG_000007" "g.161143608T>C" "" "" "" "PLG(NM_000301.5):c.1256+9T>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160722576T>C" "" "benign" "" "0000297125" "0" "10" "6" "161137663" "161137663" "subst" "0.214375" "02325" "PLG_000002" "g.161137663T>G" "" "" "" "PLG(NM_000301.5):c.669-14T>G" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160716631T>G" "" "benign" "" "0000297126" "0" "10" "6" "161137779" "161137779" "subst" "0.413892" "02325" "PLG_000003" "g.161137779T>C" "" "" "" "PLG(NM_000301.5):c.771T>C (p.C257=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160716747T>C" "" "benign" "" "0000297127" "0" "10" "6" "161139502" "161139502" "subst" "0.374673" "02325" "PLG_000005" "g.161139502G>A" "" "" "" "PLG(NM_000301.5):c.950+14G>A" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160718470G>A" "" "benign" "" "0000301038" "0" "30" "6" "161160094" "161160094" "subst" "0.00163655" "02326" "PLG_000012" "g.161160094T>C" "" "" "" "PLG(NM_000301.3):c.1878-6T>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160739062T>C" "" "likely benign" "" "0000301039" "0" "30" "6" "161160184" "161160184" "subst" "0.0010233" "02326" "PLG_000013" "g.161160184G>T" "" "" "" "PLG(NM_000301.3):c.1962G>T (p.V654=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160739152G>T" "" "likely benign" "" "0000301040" "0" "30" "6" "161134081" "161134081" "subst" "8.94636E-5" "02326" "PLG_000001" "g.161134081C>T" "" "" "" "PLG(NM_000301.3):c.471C>T (p.N157=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160713049C>T" "" "likely benign" "" "0000305896" "0" "30" "6" "161152085" "161152085" "subst" "0.00191779" "01943" "PLG_000008" "g.161152085G>A" "" "" "" "PLG(NM_000301.3):c.1259G>A (p.G420D)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160731053G>A" "" "likely benign" "" "0000305897" "0" "50" "6" "161152807" "161152807" "subst" "0.00117401" "01943" "PLG_000009" "g.161152807G>A" "" "" "" "PLG(NM_000301.3):c.1469G>A (p.R490Q), PLG(NM_000301.5):c.1469G>A (p.R490Q)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160731775G>A" "" "VUS" "" "0000305898" "0" "10" "6" "161152819" "161152819" "subst" "0.00973773" "01943" "PLG_000010" "g.161152819C>T" "" "" "" "PLG(NM_000301.3):c.1481C>T (p.A494V)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160731787C>T" "" "benign" "" "0000305899" "0" "30" "6" "161159619" "161159619" "subst" "0.00286719" "01943" "PLG_000011" "g.161159619T>C" "" "" "" "PLG(NM_000301.3):c.1852T>C (p.L618=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160738587T>C" "" "likely benign" "" "0000305900" "0" "50" "6" "161137790" "161137790" "subst" "0.00250352" "01943" "PLG_000004" "g.161137790G>A" "0.0025" "{DOI:Dias de Castro 2024:10.1016/j.anai.2024.01.027}" "" "PLG(NM_000301.3):c.782G>A (p.R261H), PLG(NM_000301.5):c.782G>A (p.(Arg261His))" "VKGL data sharing initiative Nederland\r\nRecognized as participating in HAE-PLG in a Portugese family" "CLASSIFICATION record" "" "rs4252187" "0" "" "" "g.160716758G>A" "{CV-RCV:005392468.1}" "VUS" "" "0000527828" "0" "30" "6" "161127424" "161127424" "subst" "0" "02326" "PLG_000015" "g.161127424A>T" "" "" "" "PLG(NM_000301.3):c.50-15A>T" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160706392A>T" "" "likely benign" "" "0000527829" "0" "30" "6" "161127499" "161127499" "subst" "0" "01943" "PLG_000016" "g.161127499C>G" "" "" "" "PLG(NM_000301.3):c.110C>G (p.T37S)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160706467C>G" "" "likely benign" "" "0000527830" "0" "50" "6" "161127501" "161127501" "subst" "0.0028913" "01943" "PLG_000017" "g.161127501A>G" "" "" "" "PLG(NM_000301.3):c.112A>G (p.K38E), PLG(NM_000301.5):c.112A>G (p.(Lys38Glu), p.K38E)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160706469A>G" "" "VUS" "" "0000527831" "0" "90" "6" "161127501" "161127501" "subst" "0.0028913" "02327" "PLG_000017" "g.161127501A>G" "" "" "" "PLG(NM_000301.3):c.112A>G (p.K38E), PLG(NM_000301.5):c.112A>G (p.(Lys38Glu), p.K38E)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160706469A>G" "" "pathogenic" "" "0000527832" "0" "10" "6" "161132146" "161132146" "subst" "0.255401" "02327" "PLG_000018" "g.161132146C>T" "" "" "" "" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160711114C>T" "" "benign" "" "0000527833" "0" "30" "6" "161134069" "161134069" "subst" "0.00102475" "02326" "PLG_000019" "g.161134069G>A" "" "" "" "PLG(NM_000301.3):c.459G>A (p.R153=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160713037G>A" "" "likely benign" "" "0000527834" "0" "90" "6" "161134099" "161134099" "subst" "0" "01943" "PLG_000020" "g.161134099G>A" "" "" "" "PLG(NM_000301.3):c.489G>A (p.W163*)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160713067G>A" "" "pathogenic" "" "0000527835" "0" "10" "6" "161137663" "161137663" "subst" "0.214375" "02327" "PLG_000002" "g.161137663T>G" "" "" "" "PLG(NM_000301.5):c.669-14T>G" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160716631T>G" "" "benign" "" "0000527836" "0" "10" "6" "161139480" "161139480" "subst" "0.374898" "02325" "PLG_000021" "g.161139480C>T" "" "" "" "PLG(NM_000301.5):c.942C>T (p.F314=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160718448C>T" "" "benign" "" "0000527837" "0" "50" "6" "161139504" "161139504" "subst" "0.000101605" "02327" "PLG_000022" "g.161139504T>C" "" "" "" "PLG(NM_000301.3):c.950+16T>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160718472T>C" "" "VUS" "" "0000527838" "0" "50" "6" "161139748" "161139748" "subst" "4.06709E-6" "01943" "PLG_000023" "g.161139748G>A" "" "" "" "PLG(NM_000301.3):c.974G>A (p.R325H)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160718716G>A" "" "VUS" "" "0000527839" "0" "10" "6" "161139857" "161139857" "subst" "0.213252" "02327" "PLG_000006" "g.161139857A>G" "" "" "" "PLG(NM_000301.5):c.1083A>G (p.Q361=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160718825A>G" "" "benign" "" "0000527841" "0" "10" "6" "161143608" "161143608" "subst" "0.215253" "02327" "PLG_000007" "g.161143608T>C" "" "" "" "PLG(NM_000301.5):c.1256+9T>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160722576T>C" "" "benign" "" "0000527842" "0" "30" "6" "161152085" "161152085" "subst" "0.00191779" "02326" "PLG_000008" "g.161152085G>A" "" "" "" "PLG(NM_000301.3):c.1259G>A (p.G420D)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160731053G>A" "" "likely benign" "" "0000527843" "0" "30" "6" "161152107" "161152107" "subst" "0.00381434" "01943" "PLG_000024" "g.161152107G>A" "" "" "" "PLG(NM_000301.3):c.1281G>A (p.R427=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160731075G>A" "" "likely benign" "" "0000527844" "0" "30" "6" "161152107" "161152107" "subst" "0.00381434" "02326" "PLG_000024" "g.161152107G>A" "" "" "" "PLG(NM_000301.3):c.1281G>A (p.R427=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160731075G>A" "" "likely benign" "" "0000527845" "0" "10" "6" "161152240" "161152240" "subst" "0.215187" "02327" "PLG_000025" "g.161152240G>A" "" "" "" "" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160731208G>A" "" "benign" "" "0000527847" "0" "30" "6" "161152838" "161152838" "subst" "0.000190931" "01943" "PLG_000026" "g.161152838G>A" "" "" "" "PLG(NM_000301.3):c.1500G>A (p.T500=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160731806G>A" "" "likely benign" "" "0000527848" "0" "50" "6" "161152905" "161152905" "subst" "0.0065321" "02327" "PLG_000027" "g.161152905C>T" "" "" "" "" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160731873C>T" "" "VUS" "" "0000527852" "0" "10" "6" "161160083" "161160083" "subst" "0.603507" "02327" "PLG_000028" "g.161160083G>A" "" "" "" "" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160739051G>A" "" "benign" "" "0000527853" "0" "30" "6" "161160094" "161160094" "subst" "0.00163655" "01943" "PLG_000012" "g.161160094T>C" "" "" "" "PLG(NM_000301.3):c.1878-6T>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160739062T>C" "" "likely benign" "" "0000527854" "0" "50" "6" "161160146" "161160146" "subst" "0" "01943" "PLG_000029" "g.161160146G>C" "" "" "" "PLG(NM_000301.3):c.1924G>C (p.E642Q)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160739114G>C" "" "VUS" "" "0000527855" "0" "30" "6" "161160184" "161160184" "subst" "0.0010233" "01943" "PLG_000013" "g.161160184G>T" "" "" "" "PLG(NM_000301.3):c.1962G>T (p.V654=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160739152G>T" "" "likely benign" "" "0000527856" "0" "30" "6" "161162325" "161162325" "subst" "0" "02326" "PLG_000030" "g.161162325C>T" "" "" "" "PLG(NM_000301.3):c.2019-18C>T" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160741293C>T" "" "likely benign" "" "0000527857" "0" "10" "6" "161162406" "161162406" "subst" "0.0740404" "02327" "PLG_000031" "g.161162406T>C" "" "" "" "" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160741374T>C" "" "benign" "" "0000527858" "0" "30" "6" "161162418" "161162418" "subst" "0.000198988" "02326" "PLG_000032" "g.161162418A>G" "" "" "" "PLG(NM_000301.3):c.2094A>G (p.E698=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160741386A>G" "" "likely benign" "" "0000527859" "0" "10" "6" "161173946" "161173946" "subst" "0.617453" "02327" "PLG_000033" "g.161173946T>G" "" "" "" "" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160752914T>G" "" "benign" "" "0000610193" "0" "50" "6" "161127501" "161127501" "subst" "0.0028913" "02325" "PLG_000017" "g.161127501A>G" "" "" "" "PLG(NM_000301.3):c.112A>G (p.K38E), PLG(NM_000301.5):c.112A>G (p.(Lys38Glu), p.K38E)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160706469A>G" "" "VUS" "" "0000610194" "0" "50" "6" "161137766" "161137766" "subst" "0.000837078" "01943" "PLG_000035" "g.161137766G>A" "" "" "" "PLG(NM_000301.3):c.758G>A (p.R253H)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160716734G>A" "" "VUS" "" "0000610195" "0" "10" "6" "161137779" "161137779" "subst" "0.413892" "02327" "PLG_000003" "g.161137779T>C" "" "" "" "PLG(NM_000301.5):c.771T>C (p.C257=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160716747T>C" "" "benign" "" "0000610196" "0" "10" "6" "161139480" "161139480" "subst" "0.374898" "02327" "PLG_000021" "g.161139480C>T" "" "" "" "PLG(NM_000301.5):c.942C>T (p.F314=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160718448C>T" "" "benign" "" "0000610197" "0" "10" "6" "161139502" "161139502" "subst" "0.374673" "02327" "PLG_000005" "g.161139502G>A" "" "" "" "PLG(NM_000301.5):c.950+14G>A" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160718470G>A" "" "benign" "" "0000610198" "0" "50" "6" "161139759" "161139759" "subst" "4.06745E-6" "01943" "PLG_000036" "g.161139759G>A" "" "" "" "PLG(NM_000301.3):c.985G>A (p.G329R)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160718727G>A" "" "VUS" "" "0000610200" "0" "50" "6" "161173155" "161173155" "subst" "0.000345357" "01943" "PLG_000014" "g.161173155G>A" "" "" "" "PLG(NM_000301.3):c.2134G>A (p.G712R)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160752123G>A" "" "VUS" "" "0000621664" "0" "30" "6" "161132103" "161132103" "subst" "1.21994E-5" "02326" "PLG_000034" "g.161132103C>A" "" "" "" "PLG(NM_000301.3):c.293-6C>A, PLG(NM_000301.5):c.293-6C>A" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160711071C>A" "" "likely benign" "" "0000651882" "1" "50" "6" "161152807" "161152807" "subst" "0.00117401" "03575" "PLG_000009" "g.161152807G>A" "1/2794 individuals" "{PMID:Narang 2020:32906206} {DOI:Narang 2020:10.1002/humu.24102}" "" "" "1 heterozygous, no homozygous; {DB:CLININrs140537724}" "Germline" "" "rs140537724" "0" "" "" "g.160731775G>A" "{CV-RCV:000625418.2}" "VUS" "" "0000651883" "1" "99" "6" "161159615" "161159615" "subst" "0" "03575" "PLG_000037" "g.161159615G>A" "1/2794 individuals" "{PMID:Narang 2020:32906206}, {DOI:Narang 2020:10.1002/humu.24102}" "" "" "1 heterozygous individual, no homozygous" "Germline" "" "rs121918031" "0" "" "" "g.160738583G>A" "{CV-RCV:000014546.26}" "pathogenic" "" "0000655530" "0" "30" "6" "161127589" "161127589" "subst" "0.000199419" "02326" "PLG_000038" "g.161127589G>A" "" "" "" "PLG(NM_000301.3):c.185+15G>A" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160706557G>A" "" "likely benign" "" "0000655531" "0" "50" "6" "161135876" "161135876" "subst" "0.000719302" "01943" "PLG_000039" "g.161135876A>G" "" "" "" "PLG(NM_000301.3):c.598A>G (p.T200A)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160714844A>G" "" "VUS" "" "0000655532" "0" "30" "6" "161159553" "161159553" "subst" "0.0020472" "02326" "PLG_000040" "g.161159553C>A" "" "" "" "PLG(NM_000301.3):c.1803-17C>A" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "g.160738521C>A" "" "likely benign" "" "0000655533" "0" "30" "6" "161173213" "161173213" "subst" "3.6553E-5" "02326" "PLG_000041" "g.161173213G>A" "" "" "" "PLG(NM_000301.3):c.2192G>A (p.R731H), PLG(NM_000301.5):c.2192G>A (p.R731H)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "g.160752181G>A" "" "likely benign" "" "0000677677" "0" "30" "6" "161123348" "161123348" "subst" "0.000214477" "02326" "PLG_000042" "g.161123348G>A" "" "" "" "PLG(NM_000301.3):c.12G>A (p.K4=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "" "" "likely benign" "" "0000677678" "0" "30" "6" "161152841" "161152841" "subst" "4.06237E-6" "01943" "PLG_000043" "g.161152841A>G" "" "" "" "PLG(NM_000301.3):c.1503A>G (p.P501=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000677679" "0" "30" "6" "161160157" "161160157" "subst" "8.12163E-6" "02326" "PLG_000044" "g.161160157C>T" "" "" "" "PLG(NM_000301.3):c.1935C>T (p.L645=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000720795" "0" "50" "6" "161152807" "161152807" "subst" "0.00117401" "02329" "PLG_000009" "g.161152807G>A" "" "" "" "PLG(NM_000301.3):c.1469G>A (p.R490Q), PLG(NM_000301.5):c.1469G>A (p.R490Q)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000763439" "21" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000046" "g.161139762A>G" "0.00004 (gnomAD_exome), 0.00003 (gnomAD)" "{DOI:Bork 2020:10.1111/ddg.14036}" "" "" "" "Germline" "" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000763489" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000046" "g.161139762A>G" "0.00004 (gnomAD_exome), 0.00003 (gnomAD), 6.98e-06 (gnomAD v3)" "{DOI:Bork 2018:10.1111/all.13270} {DOI:Bork 2020:10.1186/s13023-020-1334-8} {DOI:Bork 2023:10.1016/j.jaip.2023.01.051} {DOI:Hintze 2023:10.3389/fphys.2022.1090732} {DOI:Bork 2025:10.1016/j.jaip.2025.05.017}" "" "" "ACMG classification: Characterized as Class 5 (pathogenic) by ghardy\r\nBork 2018: 13 families with 60 affected individuals\r\nBork 2023: Occurrence of only one symptomatic patient per family, who had no family history of angioedema but who had symptom-free relatives carrying the same HAE-linked c.988A>G variant.\r\nHintze 2023 concluded that the kallikrein-kinin system is bypassed in HAE-PLG. Structural modeling and in vitro assays confirmed the PLG mutation c.988A>G; p.Lys330Glu to be a gain of function mutation resulting in an increased bradykinin release by direct HK cleavage.\r\nBork 2025: Hypertension risk for carriers of c.988A>G variant." "Germline/De novo (untested)" "yes" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000763491" "3" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.00003 (gnomAD); 0.000004 (1/251070, GnomAD_exome)" "{DOI:Germenis 2018:10.1111/all.13324} {DOI:Parsopoulou 2020:10.1111/all.14280}" "" "" "Homozygous carrier of p.(Lys330Glu) displays an abnormal glycosylation pattern with ~60% of PLG type I and ~40% of PLG type II.\r\nHomozygous or heterozygous (n = 8) carriers of p.(Lys330Glu) display a significantly high susceptibility to zymogen activation by streptokinase and urokinase." "Germline" "yes" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000763493" "3" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000046" "g.161139762A>G" "0.000004 (gnomAD_exome); 0.00003 (gnomAD)" "{DOI:Germenis 2018:10.1111/all.13324} {DOI:Parsopoulou 2020:10.1111/all.14280}" "" "" "Homozygous or heterozygous (n = 8) carriers of p.(Lys330Glu) display a significantly high susceptibility to the PLG activation by streptokinase and urokinase" "Germline" "yes" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000763537" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000046" "g.161139762A>G" "0.00003 (gnomAD); 0.000004 (gnomAD_exome)" "{DOI:Parsopoulou 2020:10.1111/all.14280} {DOI:Dickeson 2022:10.1182/\r\nblood.2021012945}" "" "" "The heterozygous carriers of the family present with two bands of PLG type I and PLG type II approximately equal intensity and a susceptibility to zymogen activation.\r\nThe Lys to Glu substitution introduces a Lys-binding site into the PLG kringle 3 domain, propably altering binding to kininogens. Plg residue 311 is Glu in most mammals. Glu311 in patients with HAE represents reversion to the ancestral condition. Substantial BK generation occurs during Plg-Glu311 cleavage of human HK, but not mouse HK. Mouse Plg, which has Glu311, did not liberate BK from human kininogens more rapidly than human PLG-Lys311. This indicates Glu311 is pathogenic in the context of human PLG when human kininogens are the substrates." "Germline" "yes" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000763539" "0" "77" "6" "161173204" "161173204" "subst" "0" "03256" "PLG_000048" "g.161173204T>A" "0.000007 (1/140250, GnomAD)" "{DOI:Loules 2020:10.3390/jcm9113402} {DOI:Brito-Robinson 2024:10.3389/fcvm.2024.1406953}" "" "" "p.(Val728Glu) variant is located within the plasmin serine protease domain of plasminogen (residues 562–791)\r\nFunctional studies of the variant and studies of patients cells were not performed; the variant was predicted to affect the plasminogen/plasmin system and the kinin pathway.\r\nBrito-Robinson (2024) considers that Val to Glu substitution may potentially destabilize the salt bridge between Lys708 of the\r\nSer-Protease domain and the Lys-binding site of the PLG-K2 domain (due to its proximity), which may expose the PLG activation loop, thus resulting in a more activatable PLG." "Germline" "yes" "rs1582955358" "0" "" "" "g.160752172T>A" "{CV:VCV000827591.1}" "likely pathogenic" "" "0000763540" "0" "50" "6" "161157972" "161157972" "subst" "0.00023147" "03256" "PLG_000047" "g.161157972G>A" "0.00026 (31/121370 alleles; ExAC)" "" "" "" "" "Germline" "" "" "0" "" "" "g.160736940G>A" "VCV000988227.1" "VUS" "" "0000763787" "0" "53" "6" "161128812" "161128812" "subst" "0.00609642" "00000" "PLG_000049" "g.161128812G>A" "" "{PMID:Duvvari 2016:27007659}" "" "266G>A" "Variant predicted to be damaging but not as yet correlated with any pathogenic effect.\r\nArg70 is one of the key residues of the PLG AP domain identified by X-ray crystallography to form important bonds for maintenance of PLG conformation. This residue coordinates with K4 and K5 domains through interactions with Asp413 and Asp534. A Arg to Lys transition is not expected to disrupt this coordinates between electropositive and electronegative residues." "Germline" "" "rs143079629" "0" "" "" "g.160707780G>A" "" "VUS" "" "0000802430" "0" "30" "6" "161159648" "161159648" "subst" "1.21852E-5" "01943" "PLG_000050" "g.161159648T>C" "" "" "" "PLG(NM_000301.3):c.1877+4T>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "" "" "likely benign" "" "0000802431" "0" "50" "6" "161160219" "161160219" "subst" "8.52764E-5" "02325" "PLG_000051" "g.161160219T>C" "" "" "" "PLG(NM_000301.5):c.1997T>C (p.I666T)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000811007" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.000004 (1/251070, GnomAD_exome)" "{DOI:Bodian 2019:10.1186/s13223-019-0346-1}" "" "" "" "Germline/De novo (untested)" "?" "" "0" "" "" "g.160718730A>G" "" "pathogenic" "ACMG" "0000811008" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.000004 (1/251070, GnomAD_exome)" "{DOI:Recke 2019:10.1186/s13601-019-0247-x}" "" "" "" "Germline" "?" "" "0" "" "" "g.160718730A>G" "" "pathogenic" "ACMG" "0000811009" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.000004 (1/251070, GnomAD_exome)" "{DOI:Belbezier 2018:10.1111/all.13543}" "" "" "" "Germline" "yes" "" "0" "" "" "g.160718730A>G" "" "pathogenic" "ACMG" "0000814350" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.000004 (gnomAD_exome)" "{DOI:Farkas 2021:10.3390/genes12030402}" "" "" "" "Germline" "no" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000814352" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.000004 (1/251070, GnomAD_exome)" "{DOI:Yakushiji 2018:10.1111/all.13550}" "" "" "" "Germline" "?" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000814353" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.000004 (1/251070, GnomAD_exome)" "{DOI:Germenis 2018:10.1111/all.13324}" "" "" "The proband is also carrier of a c.931T>C;p.(Cys311Arg) variant in the CPN1 gene, predicted as deleterious" "Germline/De novo (untested)" "?" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000840998" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "" "{DOI:Manto 2021:/10.36691/RJA1446}" "" "" "" "Germline" "yes" "" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000851129" "0" "30" "6" "161128723" "161128723" "subst" "0.000101692" "01943" "PLG_000052" "g.161128723G>A" "" "" "" "PLG(NM_000301.3):c.186-9G>A" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000860238" "0" "30" "6" "161135859" "161135859" "subst" "0.000768005" "02326" "PLG_000053" "g.161135859A>T" "" "" "" "PLG(NM_000301.3):c.581A>T (p.D194V)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000860239" "0" "30" "6" "161160247" "161160247" "subst" "2.03061E-5" "01943" "PLG_000054" "g.161160247G>A" "" "" "" "PLG(NM_000301.3):c.2018+7G>A" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "" "" "likely benign" "" "0000860240" "0" "50" "6" "161162404" "161162404" "subst" "2.43661E-5" "01943" "PLG_000055" "g.161162404G>A" "" "" "" "PLG(NM_000301.3):c.2080G>A (p.A694T)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0000876903" "0" "70" "6" "161152905" "161152905" "subst" "0.0065321" "03256" "PLG_000027" "g.161152905C>T" "" "{DOI:Ronald 2011:10.1161/STROKEAHA.110.591230}{PMID:Mathey 2022:35923707}, {DOI:Mathey 2022:10.3389/fgene.2022.914376}" "" "" "Located in the kringle 5 domain of plasminogen, the p.(Arg523Trp) product expression is decreased compared to the wild-type and has been associated with a protection of the carrier from ACEi angioedema." "Germline" "" "rs4252129" "0" "" "" "g.160731873C>T" "{CV:VCV000770367.4}" "association" "" "0000887113" "0" "30" "6" "161139504" "161139504" "subst" "0.000101605" "02326" "PLG_000022" "g.161139504T>C" "" "" "" "PLG(NM_000301.3):c.950+16T>C" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "" "" "likely benign" "" "0000905099" "20" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.0000029" "{PMID:Yakushiji 2023:36418094}, {DOI:Yakushiji 2023:10.2169/internalmedicine.0645-22}" "" "" "third japanese pedigree carrying c.988A>G variant and presenting with angioedema attacks; 3 carriers (1 female, 2 male) are asymptomatic" "Germline" "yes" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000912432" "0" "30" "6" "161152257" "161152257" "subst" "0.000609731" "02326" "PLG_000056" "g.161152257C>T" "" "" "" "PLG(NM_000301.3):c.1431C>T (p.S477=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000916977" "21" "90" "6" "161159625" "161159625" "subst" "0.00135658" "03256" "PLG_000057" "g.161159625G>A" "0.00083" "{DOI:Lee 2022:10.1097/MD.0000000000029013}" "" "" "The mother of the proband is a homozygous asymptomatic carrier of c.1858G>A variant.\r\nThe prevalence of c.1858G>A homozygosity is predicted to be 0.0256-0.0543% of population of East Asian countries, suggesting that the homozygous PLG c.[1858G>A];[1858G>A] variant is not related to an increased risk of thrombosis" "Germline" "no" "rs121918027" "0" "" "" "g.160738593G>A" "{CV:VCV000013574.4}" "VUS" "" "0000920499" "21" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.00003 (gnomAD); 0.000004 (1/251070, GnomAD_exome)" "{DOI:Hintze 2023:10.3389/fphys.2022.1090732}" "" "" "Compound heterozygous proband carrying PLG c.988A>G;p.(Lys330Glu) and F12 c.1681-1G>A variants" "Germline" "yes" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0000924450" "0" "30" "6" "161143441" "161143441" "subst" "1.21941E-5" "02326" "PLG_000058" "g.161143441A>T" "" "" "" "PLG(NM_000301.3):c.1098A>T (p.A366=)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0000927957" "0" "90" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.00000708" "{DOI:Dewald 2018:10.1016/j.bbrc.2017.12.060}" "" "c.1100A>G" "The variant has been erroneously identified in the 3 families as c.1100A>G" "Germline" "yes" "rs889957249" "" "" "" "g.160718730A>G" "{CV-SCV:002762862}" "pathogenic" "ACMG" "0000933295" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.0000029" "{DOI:Nakayama 2023:10.1093/mrcr/rxad017}" "" "" "A single female individuals carrying a c.988A>G variant" "Germline" "" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-SCV:002762862}" "pathogenic" "ACMG" "0000933326" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "" "{DOI:Katelaris 2023:10.1016/j.jaip.2023.06.022}" "" "" "" "Germline" "yes" "rs889957249" "0" "" "" "g.160718730A>G" "" "pathogenic" "ACMG" "0000952088" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "" "{DOI:Friedman 2023:10.1016/j.anai.2023.08.374}" "" "" "Treatment of attacks by tranexamic acid" "Germline" "yes" "" "0" "" "" "g.160718730A>G" "" "pathogenic" "ACMG" "0000963904" "0" "10" "6" "161127558" "161127558" "subst" "0.00355841" "02326" "PLG_000059" "g.161127558G>A" "" "" "" "PLG(NM_000301.3):c.169G>A (p.E57K)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "benign" "" "0000963905" "0" "50" "6" "161137720" "161137720" "subst" "3.65672E-5" "02325" "PLG_000060" "g.161137720G>A" "" "" "" "PLG(NM_000301.5):c.712G>A (p.D238N)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "0" "" "" "" "" "VUS" "" "0000963906" "0" "10" "6" "161143565" "161143565" "subst" "0.00303006" "02326" "PLG_000061" "g.161143565C>T" "" "" "" "PLG(NM_000301.3):c.1222C>T (p.R408W)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "benign" "" "0000972083" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "" "{DOI: Rozevska 2024:10.1186/s13223-024-00889-5}" "" "" "" "Germline" "yes" "" "0" "" "" "g.160718730A>G" "" "pathogenic" "ACMG" "0000985271" "0" "97" "6" "161128812" "161128812" "subst" "4.06699E-6" "03256" "PLG_000062" "g.161128812G>C" "" "" "" "" "Arg70 is a key residue identified by X-ray crystallography in PLG AP domain to form important bonds for maintenance of the PLG conformation. It coordinates with K4 and K5 domains through interactions with Asp413 and Asp534. \r\nA Arg to Thr transition is predicted as possibly damaging by disrupting the PLG closed conformation with a Thr residue being unable to interact with K4 and K5.\r\nVariant p.(Arg89Thr) has been flagged as having a potential association with plasminogen deficiency type I and hereditary angioedema with normal C1-INH function - enhanced PLG activation to plasmin and subsequent lower half-life of the zymogen." "Germline" "" "rs143079629" "0" "" "" "g.160707780G>C" "{CV-RCV:001334374.1}" "VUS" "" "0000985273" "0" "99" "6" "161127575" "161127575" "subst" "0" "03256" "PLG_000063" "g.161127575G>T" "0.00005" "" "" "" "" "Germline" "" "rs886042477" "0" "" "" "g.160706543G>T" "{CV-RCV:000403862.4}" "pathogenic" "ACMG" "0000985274" "3" "99" "6" "161137712" "161137712" "subst" "0" "03256" "PLG_000064" "g.161137712G>A" "0.0000071" "{DOI:Schuster 1997:10.1182/blood.V90.3.958} {DOI:Tefs 2006:10.1182/blood-2006-04-017350}" "" "c.780G>A; c.[704G>A];[704G>A]" "Both parents and an older sister are clinically healthy. Plasminogen functional activity in patient plasma was only 6% (normal range, 80% to 120%); heterozygous carriers exhibit 40% to 76% plasminogen activity.\r\nVariant p.Arg235His shows significant secretion impairment and enhanced degradation when expressed in COS-7 cells.\r\nArg216 residue is located proximal to strictly conserved Cys residues in the kringle K2 domain and forms a network of H-bonds that stabilize the K2 domain. The disruption of the Arg residue in this position may impairs proper folding of the domains and lead to poor secretion." "Germline" "yes" "rs121918030" "0" "" "" "g.160716680G>A" "{CV-RCV:000014545.26}" "pathogenic (recessive)" "ACMG" "0000985276" "0" "97" "6" "161152909" "161152909" "subst" "0" "03256" "PLG_000065" "g.161152909C>T" "" "{DOI:Tefs 2006:10.1182/blood-2006-04-017350}" "" "" "Conflicting observations: VUS to pathogenic" "Germline" "" "" "0" "" "" "g.160731877C>T" "{CV-RCV:003901185.1}" "VUS" "ACMG" "0000985293" "3" "99" "6" "161127501" "161127501" "subst" "0.0028913" "03256" "PLG_000017" "g.161127501A>G" "0.00282" "{DOI:Tefs 2006:10.1182/blood-2006-04-017350} {DOI:Bourrienne 2020:10.1055/s-0040-1709526}" "" "K19E" "tPA-mediated activation assays could predict the clinical outcome for Lys38Glu carriers, but fibrin-independent uPA-mediated assays could not: p.Lys38Glu variant is likely not to be able to efficiently engage fibrin, with a subsequent short half-life. \r\nLys19 is a very conserved residue among primates. One possible mechanism for plasminogen deficiency resulting from Lys to Glu substitution could be its location in the N-terminus region. In Glu1-PLG, p.Lys38Glu variant may lead to a relaxed conformational state, which is easier to activate and degrade." "Germline" "yes" "rs73015965" "0" "" "" "g.160706469A>G" "{CV-RCV:000014551.38}" "pathogenic (recessive)" "ACMG" "0000985295" "1" "77" "6" "161127501" "161127501" "subst" "0.0028913" "03256" "PLG_000017" "g.161127501A>G" "0.00282" "{DOI:Tefs 2006:10.1182/blood-2006-04-017350.}" "" "" "Variants c.112A>G and c.1468C>T have been found carried by compound heterozygous affected patients" "Germline" "yes" "rs73015965" "0" "" "" "g.160706469A>G" "{CV-RCV:000014551.38}" "pathogenic (recessive)" "ACMG" "0000985297" "2" "99" "6" "161152806" "161152806" "subst" "1.21869E-5" "03256" "PLG_000066" "g.161152806C>T" "" "{DOI:Tefs 2006:10.1182/blood-2006-04-017350}" "" "R471X" "Secretion kinetics of PLG variant Arg490Ter appears to be normal, but protein derived from truncated PLG variant was detectable as a 62-kDa band due to a lack of the PLG beta-chain and part of kringle 5 domain." "Germline" "yes" "" "0" "" "" "g.160731774C>T" "{CV-RCV:003555313.1}" "pathogenic (recessive)" "ACMG" "0000986100" "3" "99" "6" "161159615" "161159615" "subst" "0" "03256" "PLG_000037" "g.161159615G>A" "" "{DOI:Schuster 1997:10.1182/blood.V90.3.958}" "" "c.1924G>A" "<5% plasminogen functional activity was found (normal range, 80% to 120%). Heterozygous healthy carriers exibit 15% to 66% plasminogen function." "Germline" "" "rs121918031" "0" "" "" "g.160738583G>A" "{CV-RCV:000014546.26}" "pathogenic (recessive)" "ACMG" "0000995531" "0" "50" "6" "161152807" "161152807" "subst" "0.00117401" "02325" "PLG_000009" "g.161152807G>A" "" "" "" "PLG(NM_000301.3):c.1469G>A (p.R490Q), PLG(NM_000301.5):c.1469G>A (p.R490Q)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0001010143" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "" "{DOI:Adatia 2024:10.1186/s13223-024-00910-x}" "" "" "" "Germline" "" "" "0" "" "" "g.160718730A>G" "" "pathogenic" "ACMG" "0001014191" "0" "10" "6" "161152819" "161152819" "subst" "0.00973773" "02327" "PLG_000010" "g.161152819C>T" "" "" "" "PLG(NM_000301.3):c.1481C>T (p.A494V)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "benign" "" "0001025187" "0" "50" "6" "161173213" "161173213" "subst" "3.6553E-5" "02325" "PLG_000041" "g.161173213G>A" "" "" "" "PLG(NM_000301.3):c.2192G>A (p.R731H), PLG(NM_000301.5):c.2192G>A (p.R731H)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0001030300" "1" "77" "6" "161159615" "161159615" "subst" "4.06124E-6" "03256" "PLG_000067" "g.161159615G>C" "0.0000014" "{PMID:Schuster 1997:9242524}" "" "c.1924G>C; c.[1848G>A];[1848G>C]" "Affected compound heterozygous individual exhibits 15% plasminogen function. \r\nThe heterozygous sibling exhibits 66% plasminogen function and is apparently healthy." "Germline" "yes" "rs121918031" "0" "" "" "g.160738583G>C" "{CV-SCV:000034797}" "pathogenic (recessive)" "ACMG" "0001030301" "2" "77" "6" "161159615" "161159615" "subst" "0" "03256" "PLG_000037" "g.161159615G>A" "1/2794 individuals" "{PMID:Schuster 1997:9242524}" "" "c.1924G>A; c.[1848G>A];[1848G>C]" "Affected compound heterozygous individual exhibits 15% plasminogen function.\r\nThe heterozygous sibling exhibits 60% plasminogen function and is apparently healthy." "Germline" "yes" "rs121918031" "0" "" "" "g.160738583G>A" "{CV-SCV:000034797}" "pathogenic (recessive)" "ACMG" "0001030306" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.0000029" "{DOI:Sugimoto 2025:10.15036/arerugi.74.73}" "" "" "" "Germline" "yes" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.8}" "pathogenic" "ACMG" "0001030316" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "0.000004" "{DOI:Sugimoto 2025:10.15036/arerugi.74.73}" "" "" "Two affected sisters" "Germline" "yes" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0001045071" "0" "55" "6" "161135876" "161135876" "subst" "0.000719302" "03256" "PLG_000039" "g.161135876A>G" "" "{DOI:de Albuquerque Campos 2023:10.1186/s13223-023-00845-9}" "" "" "The variant c.598A>G could lead to clinical angioedema phenotype. Probably the association of HAE with cutis laxa might explain the recurrent attacks of swelling." "Germline" "" "" "0" "" "" "g.160714844A>G" "" "likely pathogenic" "" "0001045074" "0" "99" "6" "161139762" "161139762" "subst" "4.06759E-6" "03256" "PLG_000045" "g.161139762A>G" "" "{DOI:Purina 2023:10.1186/s13223-023-00845-9}" "" "" "" "Germline/De novo (untested)" "" "rs889957249" "0" "" "" "g.160718730A>G" "{CV-RCV:001507288.6}" "pathogenic" "ACMG" "0001046058" "0" "30" "6" "161132103" "161132103" "subst" "1.21994E-5" "02325" "PLG_000034" "g.161132103C>A" "" "" "" "PLG(NM_000301.3):c.293-6C>A, PLG(NM_000301.5):c.293-6C>A" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0001052542" "0" "90" "6" "161127501" "161127501" "subst" "0.0028913" "01804" "PLG_000017" "g.161127501A>G" "" "" "" "PLG(NM_000301.3):c.112A>G (p.K38E), PLG(NM_000301.5):c.112A>G (p.(Lys38Glu), p.K38E)" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "pathogenic" "" "0001052543" "0" "30" "6" "161137790" "161137790" "subst" "0.00250352" "01804" "PLG_000004" "g.161137790G>A" "" "" "" "PLG(NM_000301.3):c.782G>A (p.R261H), PLG(NM_000301.5):c.782G>A (p.(Arg261His))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" "0001052544" "0" "50" "6" "161155085" "161155085" "subst" "1.21828E-5" "01804" "PLG_000068" "g.161155085G>T" "" "" "" "PLG(NM_000301.5):c.1646G>T (p.(Arg549Ile))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" "0001052545" "0" "50" "6" "161158024" "161158024" "subst" "2.03059E-5" "01804" "PLG_000069" "g.161158024T>G" "" "" "" "PLG(NM_000301.5):c.1787T>G (p.(Val596Gly))" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "VUS" "" ## Variants_On_Transcripts ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Note: Only showing Variants_On_Transcript columns active for Genes PLG ## Count = 117 "{{id}}" "{{transcriptid}}" "{{effectid}}" "{{position_c_start}}" "{{position_c_start_intron}}" "{{position_c_end}}" "{{position_c_end_intron}}" "{{VariantOnTranscript/DNA}}" "{{VariantOnTranscript/RNA}}" "{{VariantOnTranscript/Protein}}" "{{VariantOnTranscript/Exon}}" "0000248565" "00016356" "10" "1083" "0" "1083" "0" "c.1083A>G" "r.(?)" "p.(Gln361=)" "" "0000297124" "00016356" "10" "1256" "9" "1256" "9" "c.1256+9T>C" "r.(=)" "p.(=)" "10i" "0000297125" "00016356" "10" "669" "-14" "669" "-14" "c.669-14T>G" "r.(=)" "p.(=)" "6i" "0000297126" "00016356" "10" "771" "0" "771" "0" "c.771T>C" "r.(?)" "p.(Cys257=)" "" "0000297127" "00016356" "10" "950" "14" "950" "14" "c.950+14G>A" "r.(=)" "p.(=)" "" "0000301038" "00016356" "30" "1878" "-6" "1878" "-6" "c.1878-6T>C" "r.(=)" "p.(=)" "" "0000301039" "00016356" "30" "1962" "0" "1962" "0" "c.1962G>T" "r.(?)" "p.(Val654=)" "" "0000301040" "00016356" "30" "471" "0" "471" "0" "c.471C>T" "r.(?)" "p.(Asn157=)" "" "0000305896" "00016356" "30" "1259" "0" "1259" "0" "c.1259G>A" "r.(?)" "p.(Gly420Asp)" "" "0000305897" "00016356" "50" "1469" "0" "1469" "0" "c.1469G>A" "r.(?)" "p.(Arg490Gln)" "" "0000305898" "00016356" "10" "1481" "0" "1481" "0" "c.1481C>T" "r.(?)" "p.(Ala494Val)" "" "0000305899" "00016356" "30" "1852" "0" "1852" "0" "c.1852T>C" "r.(?)" "p.(Leu618=)" "" "0000305900" "00016356" "50" "782" "0" "782" "0" "c.782G>A" "r.(?)" "p.(Arg261His)" "7" "0000527828" "00016356" "30" "50" "-15" "50" "-15" "c.50-15A>T" "r.(=)" "p.(=)" "1i" "0000527829" "00016356" "30" "110" "0" "110" "0" "c.110C>G" "r.(?)" "p.(Thr37Ser)" "2" "0000527830" "00016356" "50" "112" "0" "112" "0" "c.112A>G" "r.(?)" "p.(Lys38Glu)" "" "0000527831" "00016356" "90" "112" "0" "112" "0" "c.112A>G" "r.(?)" "p.(Lys38Glu)" "" "0000527832" "00016356" "10" "330" "0" "330" "0" "c.330C>T" "r.(?)" "p.(Asn110=)" "4" "0000527833" "00016356" "30" "459" "0" "459" "0" "c.459G>A" "r.(?)" "p.(Arg153=)" "" "0000527834" "00016356" "90" "489" "0" "489" "0" "c.489G>A" "r.(?)" "p.(Trp163Ter)" "" "0000527835" "00016356" "10" "669" "-14" "669" "-14" "c.669-14T>G" "r.(=)" "p.(=)" "" "0000527836" "00016356" "10" "942" "0" "942" "0" "c.942C>T" "r.(?)" "p.(Phe314=)" "" "0000527837" "00016356" "50" "950" "16" "950" "16" "c.950+16T>C" "r.(=)" "p.(=)" "8i" "0000527838" "00016356" "50" "974" "0" "974" "0" "c.974G>A" "r.(?)" "p.(Arg325His)" "9" "0000527839" "00016356" "10" "1083" "0" "1083" "0" "c.1083A>G" "r.(?)" "p.(Gln361=)" "" "0000527841" "00016356" "10" "1256" "9" "1256" "9" "c.1256+9T>C" "r.(=)" "p.(=)" "" "0000527842" "00016356" "30" "1259" "0" "1259" "0" "c.1259G>A" "r.(?)" "p.(Gly420Asp)" "" "0000527843" "00016356" "30" "1281" "0" "1281" "0" "c.1281G>A" "r.(?)" "p.(Arg427=)" "" "0000527844" "00016356" "30" "1281" "0" "1281" "0" "c.1281G>A" "r.(?)" "p.(Arg427=)" "" "0000527845" "00016356" "10" "1414" "0" "1414" "0" "c.1414G>A" "r.(?)" "p.(Asp472Asn)" "" "0000527847" "00016356" "30" "1500" "0" "1500" "0" "c.1500G>A" "r.(?)" "p.(Thr500=)" "" "0000527848" "00016356" "50" "1567" "0" "1567" "0" "c.1567C>T" "r.(?)" "p.(Arg523Trp)" "" "0000527852" "00016356" "10" "1878" "-17" "1878" "-17" "c.1878-17G>A" "r.(=)" "p.(=)" "" "0000527853" "00016356" "30" "1878" "-6" "1878" "-6" "c.1878-6T>C" "r.(=)" "p.(=)" "" "0000527854" "00016356" "50" "1924" "0" "1924" "0" "c.1924G>C" "r.(?)" "p.(Glu642Gln)" "" "0000527855" "00016356" "30" "1962" "0" "1962" "0" "c.1962G>T" "r.(?)" "p.(Val654=)" "16" "0000527856" "00016356" "30" "2019" "-18" "2019" "-18" "c.2019-18C>T" "r.(=)" "p.(=)" "" "0000527857" "00016356" "10" "2082" "0" "2082" "0" "c.2082T>C" "r.(?)" "p.(Ala694=)" "" "0000527858" "00016356" "30" "2094" "0" "2094" "0" "c.2094A>G" "r.(?)" "p.(Glu698=)" "" "0000527859" "00016356" "10" "2286" "0" "2286" "0" "c.2286T>G" "r.(?)" "p.(Gly762=)" "" "0000610193" "00016356" "50" "112" "0" "112" "0" "c.112A>G" "r.(?)" "p.(Lys38Glu)" "" "0000610194" "00016356" "50" "758" "0" "758" "0" "c.758G>A" "r.(?)" "p.(Arg253His)" "" "0000610195" "00016356" "10" "771" "0" "771" "0" "c.771T>C" "r.(?)" "p.(Cys257=)" "" "0000610196" "00016356" "10" "942" "0" "942" "0" "c.942C>T" "r.(?)" "p.(Phe314=)" "8" "0000610197" "00016356" "10" "950" "14" "950" "14" "c.950+14G>A" "r.(=)" "p.(=)" "8i" "0000610198" "00016356" "50" "985" "0" "985" "0" "c.985G>A" "r.(?)" "p.(Gly329Arg)" "9" "0000610200" "00016356" "50" "2134" "0" "2134" "0" "c.2134G>A" "r.(?)" "p.(Gly712Arg)" "" "0000621664" "00016356" "30" "293" "-6" "293" "-6" "c.293-6C>A" "r.(=)" "p.(=)" "3i" "0000651882" "00016356" "50" "1469" "0" "1469" "0" "c.1469G>A" "r.(?)" "p.(Arg490Gln)" "12" "0000651883" "00016356" "99" "1848" "0" "1848" "0" "c.1848G>A" "r.(?)" "p.(Trp616*)" "15" "0000655530" "00016356" "30" "185" "15" "185" "15" "c.185+15G>A" "r.(=)" "p.(=)" "" "0000655531" "00016356" "50" "598" "0" "598" "0" "c.598A>G" "r.(?)" "p.(Thr200Ala)" "" "0000655532" "00016356" "30" "1803" "-17" "1803" "-17" "c.1803-17C>A" "r.(=)" "p.(=)" "14i" "0000655533" "00016356" "30" "2192" "0" "2192" "0" "c.2192G>A" "r.(?)" "p.(Arg731His)" "" "0000677677" "00016356" "30" "12" "0" "12" "0" "c.12G>A" "r.(?)" "p.(Lys4=)" "1" "0000677678" "00016356" "30" "1503" "0" "1503" "0" "c.1503A>G" "r.(?)" "p.(Pro501=)" "" "0000677679" "00016356" "30" "1935" "0" "1935" "0" "c.1935C>T" "r.(?)" "p.(Leu645=)" "" "0000720795" "00016356" "50" "1469" "0" "1469" "0" "c.1469G>A" "r.(?)" "p.(Arg490Gln)" "" "0000763439" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000763489" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000763491" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000763493" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000763537" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000763539" "00016356" "77" "2183" "0" "2183" "0" "c.2183T>A" "r.(?)" "p.(Val728Glu)" "18" "0000763540" "00016356" "50" "1735" "0" "1735" "0" "c.1735G>A" "r.(?)" "p.(Gly579Arg)" "14" "0000763787" "00016356" "53" "266" "0" "266" "0" "c.266G>A" "r.(?)" "p.(Arg89Lys)" "3" "0000802430" "00016356" "30" "1877" "4" "1877" "4" "c.1877+4T>C" "r.spl?" "p.?" "15i" "0000802431" "00016356" "50" "1997" "0" "1997" "0" "c.1997T>C" "r.(?)" "p.(Ile666Thr)" "" "0000811007" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000811008" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000811009" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000814350" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000814352" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000814353" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000840998" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000851129" "00016356" "30" "186" "-9" "186" "-9" "c.186-9G>A" "r.(=)" "p.(=)" "" "0000860238" "00016356" "30" "581" "0" "581" "0" "c.581A>T" "r.(?)" "p.(Asp194Val)" "" "0000860239" "00016356" "30" "2018" "7" "2018" "7" "c.2018+7G>A" "r.(=)" "p.(=)" "16i" "0000860240" "00016356" "50" "2080" "0" "2080" "0" "c.2080G>A" "r.(?)" "p.(Ala694Thr)" "" "0000876903" "00016356" "70" "1567" "0" "1567" "0" "c.1567C>T" "r.(?)" "p.(Arg523Trp)" "12" "0000887113" "00016356" "30" "950" "16" "950" "16" "c.950+16T>C" "r.(=)" "p.(=)" "8i" "0000905099" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000912432" "00016356" "30" "1431" "0" "1431" "0" "c.1431C>T" "r.(?)" "p.(Ser477=)" "" "0000916977" "00016356" "90" "1858" "0" "1858" "0" "c.1858G>A" "r.(?)" "p.(Ala620Thr)" "15" "0000920499" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000924450" "00016356" "30" "1098" "0" "1098" "0" "c.1098A>T" "r.(?)" "p.(Ala366=)" "" "0000927957" "00016356" "90" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000933295" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000933326" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000952088" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000963904" "00016356" "10" "169" "0" "169" "0" "c.169G>A" "r.(?)" "p.(Glu57Lys)" "" "0000963905" "00016356" "50" "712" "0" "712" "0" "c.712G>A" "r.(?)" "p.(Asp238Asn)" "7" "0000963906" "00016356" "10" "1222" "0" "1222" "0" "c.1222C>T" "r.(?)" "p.(Arg408Trp)" "" "0000972083" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0000985271" "00016356" "97" "266" "0" "266" "0" "c.266G>C" "r.(?)" "p.(Arg89Thr)" "" "0000985273" "00016356" "99" "185" "1" "185" "1" "c.185+1G>T" "r.spl?" "p.?" "2i" "0000985274" "00016356" "99" "704" "0" "704" "0" "c.704G>A" "r.(?)" "p.(Arg235His)" "7" "0000985276" "00016356" "97" "1571" "0" "1571" "0" "c.1571C>T" "r.(?)" "p.(Ala524Val)" "" "0000985293" "00016356" "99" "112" "0" "112" "0" "c.112A>G" "r.(?)" "p.(Lys38Glu)" "2" "0000985295" "00016356" "77" "112" "0" "112" "0" "c.112A>G" "r.(?)" "p.(Lys38Glu)" "2" "0000985297" "00016356" "99" "1468" "0" "1468" "0" "c.1468C>T" "r.(?)" "p.(Arg490*)" "12" "0000986100" "00016356" "99" "1848" "0" "1848" "0" "c.1848G>A" "r.(?)" "p.(Trp616*)" "15" "0000995531" "00016356" "50" "1469" "0" "1469" "0" "c.1469G>A" "r.(?)" "p.(Arg490Gln)" "" "0001010143" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0001014191" "00016356" "10" "1481" "0" "1481" "0" "c.1481C>T" "r.(?)" "p.(Ala494Val)" "" "0001025187" "00016356" "50" "2192" "0" "2192" "0" "c.2192G>A" "r.(?)" "p.(Arg731His)" "" "0001030300" "00016356" "77" "1848" "0" "1848" "0" "c.1848G>C" "r.(?)" "p.(Trp616Cys)" "15" "0001030301" "00016356" "77" "1848" "0" "1848" "0" "c.1848G>A" "r.(?)" "p.(Trp616*)" "15" "0001030306" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0001030316" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0001045071" "00016356" "55" "598" "0" "598" "0" "c.598A>G" "r.(?)" "p.(Thr200Ala)" "6" "0001045074" "00016356" "99" "988" "0" "988" "0" "c.988A>G" "r.(?)" "p.(Lys330Glu)" "9" "0001046058" "00016356" "30" "293" "-6" "293" "-6" "c.293-6C>A" "r.(=)" "p.(=)" "" "0001052542" "00016356" "90" "112" "0" "112" "0" "c.112A>G" "r.(?)" "p.(Lys38Glu)" "" "0001052543" "00016356" "30" "782" "0" "782" "0" "c.782G>A" "r.(?)" "p.(Arg261His)" "" "0001052544" "00016356" "50" "1646" "0" "1646" "0" "c.1646G>T" "r.(?)" "p.(Arg549Ile)" "" "0001052545" "00016356" "50" "1787" "0" "1787" "0" "c.1787T>G" "r.(?)" "p.(Val596Gly)" "" ## Screenings_To_Variants ## Do not remove or alter this header ## ## Count = 41 "{{screeningid}}" "{{variantid}}" "0000295193" "0000651882" "0000295194" "0000651883" "0000363031" "0000763439" "0000363032" "0000763489" "0000363073" "0000763491" "0000363076" "0000763493" "0000363111" "0000763537" "0000363113" "0000763539" "0000363114" "0000763540" "0000363236" "0000763787" "0000384387" "0000811007" "0000384388" "0000811008" "0000384389" "0000811009" "0000386675" "0000814350" "0000386676" "0000814352" "0000386677" "0000814353" "0000405009" "0000840998" "0000417280" "0000876903" "0000427663" "0000905099" "0000431688" "0000916977" "0000434646" "0000920499" "0000436809" "0000927957" "0000437866" "0000933295" "0000437882" "0000933326" "0000445188" "0000952088" "0000450127" "0000972083" "0000451399" "0000985271" "0000451401" "0000985273" "0000451402" "0000985274" "0000451404" "0000985276" "0000451405" "0000985295" "0000451405" "0000985297" "0000451418" "0000985293" "0000452118" "0000986100" "0000456459" "0001010143" "0000466342" "0001030300" "0000466342" "0001030301" "0000466345" "0001030306" "0000466354" "0001030316" "0000467267" "0001045071" "0000467270" "0001045074"