### LOVD-version 3000-30b ### Full data download ### To import, do not remove or alter this header ### ## Filter: (gene_public = SNF8) # charset = UTF-8 ## Genes ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{name}}" "{{chromosome}}" "{{chrom_band}}" "{{imprinting}}" "{{refseq_genomic}}" "{{refseq_UD}}" "{{reference}}" "{{url_homepage}}" "{{url_external}}" "{{allow_download}}" "{{id_hgnc}}" "{{id_entrez}}" "{{id_omim}}" "{{show_hgmd}}" "{{show_genecards}}" "{{show_genetests}}" "{{show_orphanet}}" "{{note_index}}" "{{note_listing}}" "{{refseq}}" "{{refseq_url}}" "{{disclaimer}}" "{{disclaimer_text}}" "{{header}}" "{{header_align}}" "{{footer}}" "{{footer_align}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{updated_by}}" "{{updated_date}}" "SNF8" "SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)" "17" "q21.32" "unknown" "NC_000017.10" "UD_132378626668" "" "https://www.LOVD.nl/SNF8" "" "1" "17028" "11267" "610904" "1" "1" "1" "1" "Establishment of this gene variant database (LSDB) was performed by Johan den Dunnen, supported by Global Variome." "" "" "" "1" "" "" "-1" "" "-1" "00001" "2013-05-03 00:00:00" "00006" "2024-03-04 20:31:46" "00000" "2025-05-05 21:14:00" ## Transcripts ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{geneid}}" "{{name}}" "{{id_mutalyzer}}" "{{id_ncbi}}" "{{id_ensembl}}" "{{id_protein_ncbi}}" "{{id_protein_ensembl}}" "{{id_protein_uniprot}}" "{{remarks}}" "{{position_c_mrna_start}}" "{{position_c_mrna_end}}" "{{position_c_cds_end}}" "{{position_g_mrna_start}}" "{{position_g_mrna_end}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00019540" "SNF8" "SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)" "001" "NM_007241.2" "" "NP_009172.2" "" "" "" "-58" "1156" "777" "47022154" "47007458" "" "0000-00-00 00:00:00" "" "" ## Diseases ## Do not remove or alter this header ## ## Count = 2 "{{id}}" "{{symbol}}" "{{name}}" "{{inheritance}}" "{{id_omim}}" "{{tissues}}" "{{features}}" "{{remarks}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00198" "?" "unclassified / mixed" "" "" "" "" "" "00006" "2013-09-13 14:21:47" "00006" "2024-11-23 09:38:12" "07186" "DEE115" "encephalopathy, developmental and epileptic, type 115" "AR" "620783" "" "" "" "00006" "2025-09-30 18:08:53" "" "" ## Genes_To_Diseases ## Do not remove or alter this header ## ## Count = 1 "{{geneid}}" "{{diseaseid}}" "SNF8" "07186" ## Individuals ## Do not remove or alter this header ## ## Count = 9 "{{id}}" "{{fatherid}}" "{{motherid}}" "{{panelid}}" "{{panel_size}}" "{{license}}" "{{owned_by}}" "{{Individual/Reference}}" "{{Individual/Remarks}}" "{{Individual/Gender}}" "{{Individual/Consanguinity}}" "{{Individual/Origin/Geographic}}" "{{Individual/Age_of_death}}" "{{Individual/VIP}}" "{{Individual/Data_av}}" "{{Individual/Treatment}}" "{{Individual/Origin/Population}}" "{{Individual/Individual_ID}}" "00448373" "" "" "" "2" "" "00006" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "family, 2 affected sisters, unaffected heterozygous parents" "F" "" "Germany" "8m" "0" "" "" "" "FamAPatII2" "00448374" "" "" "00448373" "1" "" "00006" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "sister" "F" "" "Germany" "3m" "0" "" "" "" "FamAPatII3" "00448375" "" "" "" "1" "" "00006" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "family, 1 affected, unaffected heterozygous parents" "M" "" "Germany" ">4y6m" "0" "" "" "" "FamBPatII1" "00448376" "" "" "" "2" "" "00006" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "family, affected fetus/sister, unaffected heterozygous parents" "M" "" "Israel" "<0d" "0" "" "" "" "FamCPatII1" "00448377" "" "" "00448376" "1" "" "00006" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "sister" "F" "" "Israel" "54d" "0" "" "" "" "FamCPatII2" "00448378" "" "" "" "1" "" "00006" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "family, 1 affected, unaffected heterozygous parents" "M" "" "Italy" ">18y" "0" "" "" "" "FamDPatII2" "00448379" "" "" "" "2" "" "00006" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "family, 2 affected brothers, unaffected heterozygous parents" "M" "" "Italy" ">27y" "0" "" "" "" "FamEPatII1" "00448380" "" "" "00448379" "1" "" "00006" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "brother" "M" "" "Italy" ">17y" "0" "" "" "" "FamEPatII2" "00448381" "" "" "" "1" "" "00006" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "family, 1 affected, unaffected heterozygous parents" "F" "" "" ">4y" "0" "" "" "" "FamFPatII1" ## Individuals_To_Diseases ## Do not remove or alter this header ## ## Count = 9 "{{individualid}}" "{{diseaseid}}" "00448373" "00198" "00448374" "00198" "00448375" "00198" "00448376" "00198" "00448377" "00198" "00448378" "00198" "00448379" "00198" "00448380" "00198" "00448381" "00198" ## Phenotypes ## Do not remove or alter this header ## ## Note: Only showing Phenotype columns active for Diseases 00198, 07186 ## Count = 9 "{{id}}" "{{diseaseid}}" "{{individualid}}" "{{owned_by}}" "{{Phenotype/Inheritance}}" "{{Phenotype/Age}}" "{{Phenotype/Additional}}" "{{Phenotype/Age/Onset}}" "{{Phenotype/Age/Diagnosis}}" "{{Phenotype/Onset}}" "{{Phenotype/Protein}}" "{{Phenotype/Tumor/MSI}}" "{{Phenotype/Enzyme/CPK}}" "{{Phenotype/Heart/Myocardium}}" "{{Phenotype/Lung}}" "{{Phenotype/Diagnosis/Definite}}" "{{Phenotype/Diagnosis/Initial}}" "{{Phenotype/Diagnosis/Criteria}}" "0000337563" "00198" "00448373" "00006" "Familial, autosomal recessive" "8m" "see paper; ..., neurodevelopmental delay, regression; seizures; dysphagia; nystagmus; MRI brain severe generalized brain atrophy, hypoplasia corpus callosum, no anterior optic pathway volume reduction, no anterior optic pathway volume reduction; EEG generalized and multifocal epileptic discharges" "<1d" "" "" "" "" "" "" "" "" "" "" "0000337564" "00198" "00448374" "00006" "Familial, autosomal recessive" "3m" "see paper; ..., neurodevelopmental delay; no seizures; dysphagia; MRI brain MRI brain severe generalized brain atrophy, hypoplasia corpus callosum, no anterior optic pathway volume reduction, no anterior optic pathway volume reduction; normal EEG" "<1d" "" "" "" "" "" "" "" "" "" "" "0000337565" "00198" "00448375" "00006" "Familial, autosomal recessive" "4y6m" "see paper; ..., neurodevelopmental delay; seizures; dysphagia; nystagmus; MRI brain severe generalized brain atrophy, aplasia corpus callosum, no anterior optic pathway volume reduction, no anterior optic pathway volume reduction; EEG generalized and multifocal epileptic discharges" "<1d" "" "" "" "" "" "" "" "" "" "" "0000337566" "00198" "00448376" "00006" "Familial, autosomal recessive" "" "see paper; ..., dysgenesia corpus callosum" "" "" "" "" "" "" "" "" "" "" "" "0000337567" "00198" "00448377" "00006" "Familial, autosomal recessive" "" "see paper; ..., no seizures; dysphagia; optic atrophy, bilateral hypoplastic optic nerves; MRI brain severe generalized brain atrophy, aplasia corpus callosum, atrophy cerebellum, no anterior optic pathway volume reduction" "<1d" "" "" "" "" "" "" "" "" "" "" "0000337568" "00198" "00448378" "00006" "Familial, autosomal recessive" "18y" "see paper; ..., no neurodevelopmental delay; intellectual disability; no seizures; no dysphagia; optic atrophy; nystagmus; MRI brain mild generalized brain atrophy, total cerebral white matter volume reduction, no anomaly corpus callosum, cerebellum cortex volume reduction, anterior optic pathway volume reduction; normal EEG, pathologic visual evoked potentials" "4y" "" "" "" "" "" "" "" "" "" "" "0000337569" "00198" "00448379" "00006" "Familial, autosomal recessive" "27y" "see paper; ..., mild neurodevelopmental delay; intellectual disability; no seizures; no dysphagia; optic atrophy; nystagmus; MRI brain mild generalized brain atrophy, total cerebral white matter volume reduction, no anomaly corpus callosum, cerebellum cortex volume reduction, anterior optic pathway volume reduction; normal EEG, visual evoked potentials delayed latency and reduced amplitude" "6y" "" "" "" "" "" "" "" "" "" "" "0000337570" "00198" "00448380" "00006" "Familial, autosomal recessive" "17y" "see paper; ..., mild neurodevelopmental delay; intellectual disability; no seizures; no dysphagia; optic atrophy; nystagmus; MRI brain no generalized brain atrophy, no anomaly corpus callosum, normal cerebellum, anterior optic pathway volume reduction; normal EEG, visual evoked potentials delayed latency and reduced amplitude" "7y" "" "" "" "" "" "" "" "" "" "" "0000337571" "00198" "00448381" "00006" "Familial, autosomal recessive" "4y" "see paper; ..., mild neurodevelopmental delay; intellectual disability; no seizures; no dysphagia; no optic atrophy; no nystagmus; MRI brain no generalized brain atrophy, dysgenesia corpus callosum, cerebellar atrophy, no anterior optic pathway volume reduction; normal EEG" "15m" "" "" "" "" "" "" "" "" "" "" ## Screenings ## Do not remove or alter this header ## ## Count = 9 "{{id}}" "{{individualid}}" "{{variants_found}}" "{{owned_by}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{Screening/Technique}}" "{{Screening/Template}}" "{{Screening/Tissue}}" "{{Screening/Remarks}}" "0000449951" "00448373" "1" "00006" "00006" "2024-03-05 08:49:39" "" "" "SEQ;SEQ-NG" "DNA" "" "WES trio" "0000449952" "00448374" "1" "00006" "00006" "2024-03-05 08:49:39" "" "" "SEQ" "DNA" "" "" "0000449953" "00448375" "1" "00006" "00006" "2024-03-05 08:49:39" "" "" "SEQ;SEQ-NG" "DNA" "" "WES trio" "0000449954" "00448376" "1" "00006" "00006" "2024-03-05 08:49:39" "" "" "SEQ;SEQ-NG" "DNA" "" "WES trio" "0000449955" "00448377" "1" "00006" "00006" "2024-03-05 08:49:39" "" "" "SEQ;SEQ-NG" "DNA" "" "WES trio" "0000449956" "00448378" "1" "00006" "00006" "2024-03-05 08:49:39" "" "" "SEQ;SEQ-NG" "DNA" "" "WES" "0000449957" "00448379" "1" "00006" "00006" "2024-03-05 08:49:39" "" "" "SEQ;SEQ-NG" "DNA" "" "WES" "0000449958" "00448380" "1" "00006" "00006" "2024-03-05 08:49:39" "" "" "SEQ;SEQ-NG" "DNA" "" "WES" "0000449959" "00448381" "1" "00006" "00006" "2024-03-05 08:49:39" "" "" "SEQ;SEQ-NG" "DNA" "" "WES trio" ## Screenings_To_Genes ## Do not remove or alter this header ## ## Count = 1 "{{screeningid}}" "{{geneid}}" "0000449952" "SNF8" ## Variants_On_Genome ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Count = 17 "{{id}}" "{{allele}}" "{{effectid}}" "{{chromosome}}" "{{position_g_start}}" "{{position_g_end}}" "{{type}}" "{{average_frequency}}" "{{owned_by}}" "{{VariantOnGenome/DBID}}" "{{VariantOnGenome/DNA}}" "{{VariantOnGenome/Frequency}}" "{{VariantOnGenome/Reference}}" "{{VariantOnGenome/Restriction_site}}" "{{VariantOnGenome/Published_as}}" "{{VariantOnGenome/Remarks}}" "{{VariantOnGenome/Genetic_origin}}" "{{VariantOnGenome/Segregation}}" "{{VariantOnGenome/dbSNP}}" "{{VariantOnGenome/VIP}}" "{{VariantOnGenome/Methylation}}" "{{VariantOnGenome/ISCN}}" "{{VariantOnGenome/DNA/hg38}}" "{{VariantOnGenome/ClinVar}}" "{{VariantOnGenome/ClinicalClassification}}" "{{VariantOnGenome/ClinicalClassification/Method}}" "0000971538" "1" "70" "17" "47010630" "47010630" "subst" "4.06078E-6" "00006" "SNF8_000004" "g.47010630G>T" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48933268G>T" "" "likely pathogenic (recessive)" "" "0000971539" "1" "70" "17" "47010630" "47010630" "subst" "4.06078E-6" "00006" "SNF8_000004" "g.47010630G>T" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48933268G>T" "" "likely pathogenic (recessive)" "" "0000971540" "1" "70" "17" "47018294" "47018294" "subst" "0" "00006" "SNF8_000007" "g.47018294G>A" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "" "" "0" "" "" "g.48940932G>A" "" "likely pathogenic (recessive)" "" "0000971541" "3" "70" "17" "47009021" "47009021" "subst" "0" "00006" "SNF8_000002" "g.47009021C>A" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48931659C>A" "" "likely pathogenic (recessive)" "" "0000971542" "3" "70" "17" "47009021" "47009021" "subst" "0" "00006" "SNF8_000002" "g.47009021C>A" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48931659C>A" "" "likely pathogenic (recessive)" "" "0000971543" "1" "70" "17" "47010709" "47010709" "subst" "0" "00006" "SNF8_000005" "g.47010709C>G" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "" "" "0" "" "" "g.48933347C>G" "" "likely pathogenic (recessive)" "" "0000971544" "1" "70" "17" "47007931" "47007941" "delins" "0" "00006" "SNF8_000001" "g.47007931_47007941delinsTCCA" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48930569_48930579delinsTCCA" "" "likely pathogenic (recessive)" "" "0000971545" "1" "70" "17" "47007931" "47007941" "delins" "0" "00006" "SNF8_000001" "g.47007931_47007941delinsTCCA" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48930569_48930579delinsTCCA" "" "likely pathogenic (recessive)" "" "0000971546" "1" "70" "17" "47018294" "47018294" "subst" "0" "00006" "SNF8_000007" "g.47018294G>A" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "" "" "0" "" "" "g.48940932G>A" "" "likely pathogenic (recessive)" "" "0000971547" "2" "70" "17" "47009072" "47009072" "subst" "0" "00006" "SNF8_000003" "g.47009072C>T" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48931710C>T" "" "likely pathogenic (recessive)" "" "0000971548" "2" "70" "17" "47009072" "47009072" "subst" "0" "00006" "SNF8_000003" "g.47009072C>T" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48931710C>T" "" "likely pathogenic (recessive)" "" "0000971549" "2" "70" "17" "47009072" "47009072" "subst" "0" "00006" "SNF8_000003" "g.47009072C>T" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "" "" "0" "" "" "g.48931710C>T" "" "likely pathogenic (recessive)" "" "0000971550" "2" "70" "17" "47014427" "47014427" "subst" "0.000166484" "00006" "SNF8_000006" "g.47014427C>T" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "" "" "0" "" "" "g.48937065C>T" "" "likely pathogenic (recessive)" "" "0000971551" "2" "70" "17" "47014427" "47014427" "subst" "0.000166484" "00006" "SNF8_000006" "g.47014427C>T" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48937065C>T" "" "likely pathogenic (recessive)" "" "0000971552" "2" "90" "17" "47014427" "47014427" "subst" "0.000166484" "00006" "SNF8_000006" "g.47014427C>T" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "yes" "" "0" "" "" "g.48937065C>T" "" "pathogenic (recessive)" "" "0000971553" "2" "90" "17" "47014427" "47014427" "subst" "0.000166484" "00006" "SNF8_000006" "g.47014427C>T" "" "{PMID:Brugger 2024:38423010}, {DOI:Brugger 2024:10.1016/j.ajhg.2024.02.005}" "" "" "" "Germline" "" "" "0" "" "" "g.48937065C>T" "" "pathogenic (recessive)" "" "0001041939" "0" "30" "17" "47014635" "47014635" "subst" "0" "01804" "SNF8_000008" "g.47014635G>A" "" "" "" "SNF8(NM_001317194.2):c.-148+8C>T" "VKGL data sharing initiative Nederland" "CLASSIFICATION record" "" "" "" "" "" "" "" "likely benign" "" ## Variants_On_Transcripts ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Note: Only showing Variants_On_Transcript columns active for Genes SNF8 ## Count = 17 "{{id}}" "{{transcriptid}}" "{{effectid}}" "{{position_c_start}}" "{{position_c_start_intron}}" "{{position_c_end}}" "{{position_c_end_intron}}" "{{VariantOnTranscript/DNA}}" "{{VariantOnTranscript/RNA}}" "{{VariantOnTranscript/Protein}}" "{{VariantOnTranscript/Exon}}" "0000971538" "00019540" "70" "501" "0" "501" "0" "c.501C>A" "r.(?)" "p.(Tyr167Ter)" "" "0000971539" "00019540" "70" "501" "0" "501" "0" "c.501C>A" "r.(?)" "p.(Tyr167Ter)" "" "0000971540" "00019540" "70" "236" "0" "236" "0" "c.236C>T" "r.(?)" "p.(Pro79Leu)" "" "0000971541" "00019540" "70" "623" "0" "623" "0" "c.623G>T" "r.(?)" "p.(Arg208Leu)" "" "0000971542" "00019540" "70" "623" "0" "623" "0" "c.623G>T" "r.(?)" "p.(Arg208Leu)" "" "0000971543" "00019540" "70" "423" "-1" "423" "-1" "c.423-1G>C" "r.spl" "p.?" "" "0000971544" "00019540" "70" "673" "0" "683" "0" "c.673_683delinsTGGA" "r.(?)" "p.(Asp225TrpfsTer99)" "" "0000971545" "00019540" "70" "673" "0" "683" "0" "c.673_683delinsTGGA" "r.(?)" "p.(Asp225TrpfsTer99)" "" "0000971546" "00019540" "70" "236" "0" "236" "0" "c.236C>T" "r.(?)" "p.(Pro79Leu)" "" "0000971547" "00019540" "70" "572" "0" "572" "0" "c.572G>A" "r.(?)" "p.(Gly191Asp)" "" "0000971548" "00019540" "70" "572" "0" "572" "0" "c.572G>A" "r.(?)" "p.(Gly191Asp)" "" "0000971549" "00019540" "70" "572" "0" "572" "0" "c.572G>A" "r.(?)" "p.(Gly191Asp)" "" "0000971550" "00019540" "70" "304" "0" "304" "0" "c.304G>A" "r.(?)" "p.(Val102Ile)" "" "0000971551" "00019540" "70" "304" "0" "304" "0" "c.304G>A" "r.(?)" "p.(Val102Ile)" "" "0000971552" "00019540" "90" "304" "0" "304" "0" "c.304G>A" "r.(?)" "p.(Val102Ile)" "" "0000971553" "00019540" "90" "304" "0" "304" "0" "c.304G>A" "r.(?)" "p.(Val102Ile)" "" "0001041939" "00019540" "30" "245" "-149" "245" "-149" "c.245-149C>T" "r.(=)" "p.(=)" "" ## Screenings_To_Variants ## Do not remove or alter this header ## ## Count = 16 "{{screeningid}}" "{{variantid}}" "0000449951" "0000971538" "0000449951" "0000971547" "0000449952" "0000971539" "0000449952" "0000971548" "0000449953" "0000971540" "0000449953" "0000971549" "0000449954" "0000971541" "0000449955" "0000971542" "0000449956" "0000971543" "0000449956" "0000971550" "0000449957" "0000971544" "0000449957" "0000971551" "0000449958" "0000971545" "0000449958" "0000971552" "0000449959" "0000971546" "0000449959" "0000971553"