### LOVD-version 3000-30b ### Full data download ### To import, do not remove or alter this header ### ## Filter: (gene_public = TNFRSF10A) # charset = UTF-8 ## Genes ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{name}}" "{{chromosome}}" "{{chrom_band}}" "{{imprinting}}" "{{refseq_genomic}}" "{{refseq_UD}}" "{{reference}}" "{{url_homepage}}" "{{url_external}}" "{{allow_download}}" "{{id_hgnc}}" "{{id_entrez}}" "{{id_omim}}" "{{show_hgmd}}" "{{show_genecards}}" "{{show_genetests}}" "{{show_orphanet}}" "{{note_index}}" "{{note_listing}}" "{{refseq}}" "{{refseq_url}}" "{{disclaimer}}" "{{disclaimer_text}}" "{{header}}" "{{header_align}}" "{{footer}}" "{{footer_align}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{updated_by}}" "{{updated_date}}" "TNFRSF10A" "tumor necrosis factor receptor superfamily, member 10a" "8" "p21" "unknown" "NG_032107.1" "UD_132446007862" "" "https://www.LOVD.nl/TNFRSF10A" "" "1" "11904" "8797" "603611" "1" "1" "1" "1" "The work leading to the establishment of this LSDB was supported by the European Community\'s Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 200754 - the GEN2PHEN project." "" "g" "https://databases.lovd.nl/shared/refseq/TNFRSF10A_codingDNA.html" "1" "" "
Death Receptor Database (DRdb).
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" "-1" "" "-1" "00001" "2012-03-22 00:00:00" "00085" "2017-10-06 14:55:29" "00006" "2021-09-09 14:41:05" ## Transcripts ## Do not remove or alter this header ## ## Count = 1 "{{id}}" "{{geneid}}" "{{name}}" "{{id_mutalyzer}}" "{{id_ncbi}}" "{{id_ensembl}}" "{{id_protein_ncbi}}" "{{id_protein_ensembl}}" "{{id_protein_uniprot}}" "{{remarks}}" "{{position_c_mrna_start}}" "{{position_c_mrna_end}}" "{{position_c_cds_end}}" "{{position_g_mrna_start}}" "{{position_g_mrna_end}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00021553" "TNFRSF10A" "tumor necrosis factor receptor superfamily, member 10a" "001" "NM_003844.3" "" "NP_003835.3" "" "" "" "-106" "1644" "1407" "23082680" "23048970" "" "0000-00-00 00:00:00" "" "" ## Diseases ## Do not remove or alter this header ## ## Count = 9 "{{id}}" "{{symbol}}" "{{name}}" "{{inheritance}}" "{{id_omim}}" "{{tissues}}" "{{features}}" "{{remarks}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "00091" "CRC" "cancer, colorectal, susceptibility to (CRC)" "AD;SMu" "114500" "" "" "" "00001" "2012-12-07 10:49:46" "00006" "2021-12-10 21:51:32" "00198" "?" "unclassified / mixed" "" "" "" "" "" "00006" "2013-09-13 14:21:47" "00006" "2024-11-23 09:38:12" "00315" "cancer, bladder" "cancer, bladder" "" "109800" "" "" "" "00006" "2014-01-28 14:01:22" "" "" "00318" "cancer, breast" "cancer, breast" "" "" "" "" "" "00006" "2014-02-02 14:42:53" "00006" "2019-08-28 08:24:47" "00424" "cancer, ovarian" "cancer, ovarian" "" "167000" "" "" "" "00006" "2014-06-18 09:01:54" "" "" "00639" "cancer, lung" "cancer, lung (adenocarcinoma)" "" "211980" "" "" "" "00006" "2014-09-25 23:29:40" "00006" "2021-12-10 21:51:32" "02530" "lymphoma" "lymphoma, non-Hodgkin, familial" "" "605027" "" "" "" "00006" "2014-09-25 23:29:40" "00006" "2023-11-25 11:35:32" "04148" "BROVCA" "cancer, breast-ovarian, familial, susceptibility to" "" "" "" "" "" "00006" "2014-11-02 11:19:07" "00006" "2017-08-28 21:33:05" "05093" "cancer" "cancer" "" "" "" "" "" "00006" "2015-10-23 13:34:05" "" "" ## Genes_To_Diseases ## Do not remove or alter this header ## ## Count = 0 ## Individuals ## Do not remove or alter this header ## ## Count = 28 "{{id}}" "{{fatherid}}" "{{motherid}}" "{{panelid}}" "{{panel_size}}" "{{license}}" "{{owned_by}}" "{{Individual/Reference}}" "{{Individual/Remarks}}" "{{Individual/Gender}}" "{{Individual/Consanguinity}}" "{{Individual/Origin/Geographic}}" "{{Individual/Age_of_death}}" "{{Individual/VIP}}" "{{Individual/Data_av}}" "{{Individual/Treatment}}" "{{Individual/Origin/Population}}" "{{Individual/Individual_ID}}" "00105377" "" "" "" "1" "" "01911" "{PMID:Fisher 2001:11410508}" "" "" "" "" "" "0" "" "" "" "?" "00105378" "" "" "" "1" "" "01911" "{PMID:Ulybina 2009:19203830}" "" "" "" "" "" "0" "" "" "" "?" "00105379" "" "" "" "1" "" "01911" "{PMID:Hazra 2008:1264916}" "" "" "" "" "" "0" "" "" "" "?" "00105380" "" "" "" "1" "" "01911" "{PMID:Fisher 2001:11410508}" "" "" "" "" "" "0" "" "" "" "?" "00105381" "" "" "" "1" "" "01911" "{PMID:Ulybina 2009:19203830}" "" "" "" "" "" "0" "" "" "" "?" "00105382" "" "" "" "1" "" "01911" "{PMID:Dick 2011:21484799}" "" "" "" "" "" "0" "" "" "" "?" "00105383" "" "" "" "1" "" "01911" "{PMID:Frank 2006:17035413}" "" "" "" "" "" "0" "" "" "" "?" "00105384" "" "" "" "1" "" "01911" "{PMID:Frank 2005:15975957}" "" "" "" "" "" "0" "" "" "" "?" "00105385" "" "" "" "1" "" "01911" "{PMID8:Hazra 2008:1264916}" "" "" "" "" "" "0" "" "" "" "?" "00105386" "" "" "" "1" "" "01911" "{PMID8:Hazra 2008:1264916}" "" "" "" "" "" "0" "" "" "" "?" "00105387" "" "" "" "1" "" "01911" "{PMID:Chen 2009:19643596}" "" "" "" "" "" "0" "" "" "" "?" "00105388" "" "" "" "1" "" "01911" "{PMID:Ulybina 2009:19203830}" "" "" "" "" "" "0" "" "" "" "?" "00105389" "" "" "" "1" "" "01911" "{PMID:Dick 2011:21484799}" "" "" "" "" "" "0" "" "" "" "?" "00105390" "" "" "" "1" "" "01911" "{PMID:Frank 2006:17035413}" "" "" "" "" "" "0" "" "" "" "?" "00105391" "" "" "" "1" "" "01911" "{PMID:Frank 2005:15975957}" "" "" "" "" "" "0" "" "" "" "?" "00105392" "" "" "" "1" "" "01911" "{PMID:Chen 2009:19643596}" "" "" "" "" "" "0" "" "" "" "?" "00105393" "" "" "" "1" "" "01911" "{PMID:Wolf 2006:16217763}" "" "" "" "" "" "0" "" "" "" "?" "00105394" "" "" "" "1" "" "01911" "{PMID:Shin 2001:11431320}" "" "" "" "" "" "0" "" "" "" "22" "00105395" "" "" "" "1" "" "01911" "{PMID:Lee 2001:11313970}" "" "" "" "" "" "0" "" "" "" "9" "00105396" "" "" "" "1" "" "01911" "{PMID:Shin 2001:11431320}" "" "" "" "" "" "0" "" "" "" "16" "00105397" "" "" "" "1" "" "01911" "{PMID:Shin 2002:12085986}" "" "" "" "" "" "0" "" "" "" "11" "00105398" "" "" "" "1" "" "01911" "{PMID:Kim 2000:10690508}" "" "" "" "" "" "0" "" "" "" "?" "00105399" "" "" "" "1" "" "01911" "{PMID:Kim 2000:10690508}" "" "" "" "" "" "0" "" "" "" "?" "00105400" "" "" "" "1" "" "01911" "{PMID:Fisher 2001:11410508}" "" "" "" "" "" "0" "" "" "" "?" "00105401" "" "" "" "1" "" "01911" "{PMID:Ulybina 2009:19203830}" "" "" "" "" "" "0" "" "" "" "?" "00105402" "" "" "" "1" "" "01911" "{PMID8:Hazra 2008:1264916}" "" "" "" "" "" "0" "" "" "" "?" "00105403" "" "" "" "1" "" "01911" "{PMID:Chen 2009:19643596}" "" "" "" "" "" "0" "" "" "" "?" "00105404" "" "" "" "1" "" "01911" "{PMID:Seitz 2002:12385006}" "" "" "" "" "" "0" "" "" "" "?" ## Individuals_To_Diseases ## Do not remove or alter this header ## ## Count = 28 "{{individualid}}" "{{diseaseid}}" "00105377" "00198" "00105378" "00639" "00105379" "00424" "00105380" "00198" "00105381" "00639" "00105382" "04148" "00105383" "00091" "00105384" "00318" "00105385" "00315" "00105386" "00424" "00105387" "05093" "00105388" "00639" "00105389" "04148" "00105390" "00091" "00105391" "00318" "00105392" "05093" "00105393" "00198" "00105394" "00318" "00105395" "02530" "00105396" "00318" "00105397" "00318" "00105398" "00424" "00105399" "00315" "00105400" "00198" "00105401" "00639" "00105402" "00424" "00105403" "05093" "00105404" "00318" ## Phenotypes ## Do not remove or alter this header ## ## Note: Only showing Phenotype columns active for Diseases 00091, 00198, 00315, 00318, 00424, 00639, 02530, 04148, 05093 ## Count = 28 "{{id}}" "{{diseaseid}}" "{{individualid}}" "{{owned_by}}" "{{Phenotype/Inheritance}}" "{{Phenotype/Age}}" "{{Phenotype/Additional}}" "{{Phenotype/Age/Onset}}" "{{Phenotype/Age/Diagnosis}}" "{{Phenotype/Onset}}" "{{Phenotype/Protein}}" "{{Phenotype/Tumor/MSI}}" "{{Phenotype/Cysts}}" "{{Phenotype/Enzyme/CPK}}" "{{Phenotype/Heart/Myocardium}}" "{{Phenotype/Lung}}" "{{Phenotype/Cancer/Sub_type}}" "{{Phenotype/Eye/Retina}}" "{{Phenotype/Neoplasm}}" "{{Phenotype/Diagnosis/Definite}}" "{{Phenotype/Diagnosis/Initial}}" "{{Phenotype/Diagnosis/Criteria}}" "0000083273" "00198" "00105377" "01911" "Unknown" "" "Lung cancer and Head and Neck Cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083274" "00639" "00105378" "01911" "Unknown" "" "Lung cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083275" "00424" "00105379" "01911" "Unknown" "" "Ovarian cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083276" "00198" "00105380" "01911" "Unknown" "" "Lung cancer and Head and Neck Cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083277" "00639" "00105381" "01911" "Unknown" "" "Lung cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083278" "04148" "00105382" "01911" "Unknown" "" "Breast Cancer and Ovarian cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083279" "00091" "00105383" "01911" "Unknown" "" "Colorectal cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083280" "00318" "00105384" "01911" "Unknown" "" "Breast cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083281" "00315" "00105385" "01911" "Unknown" "" "Bladder cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083282" "00424" "00105386" "01911" "Unknown" "" "Ovarian cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083283" "05093" "00105387" "01911" "Unknown" "" "cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083284" "00639" "00105388" "01911" "Unknown" "" "Lung cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083285" "04148" "00105389" "01911" "Unknown" "" "Breast Cancer and Ovarian cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083286" "00091" "00105390" "01911" "Unknown" "" "Colorectal cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083287" "00318" "00105391" "01911" "Unknown" "" "Breast cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083288" "05093" "00105392" "01911" "Unknown" "" "cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083289" "00198" "00105393" "01911" "Unknown" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083290" "00318" "00105394" "01911" "Unknown" "" "Breast cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083291" "02530" "00105395" "01911" "Unknown" "" "Non-Hodgkin\'s lymphoma" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083292" "00318" "00105396" "01911" "Unknown" "" "Breast cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083293" "00318" "00105397" "01911" "Unknown" "" "Breast cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083294" "00424" "00105398" "01911" "Unknown" "" "Ovarian cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083295" "00315" "00105399" "01911" "Unknown" "" "Bladder cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083296" "00198" "00105400" "01911" "Unknown" "" "Lung cancer and Head and Neck Cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083297" "00639" "00105401" "01911" "Unknown" "" "Lung cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083298" "00424" "00105402" "01911" "Unknown" "" "Ovarian cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083299" "05093" "00105403" "01911" "Unknown" "" "cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "0000083300" "00318" "00105404" "01911" "Unknown" "" "Breast cancer" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ## Screenings ## Do not remove or alter this header ## ## Count = 28 "{{id}}" "{{individualid}}" "{{variants_found}}" "{{owned_by}}" "{{created_by}}" "{{created_date}}" "{{edited_by}}" "{{edited_date}}" "{{Screening/Technique}}" "{{Screening/Template}}" "{{Screening/Tissue}}" "{{Screening/Remarks}}" "0000105849" "00105377" "1" "01911" "01911" "2012-03-22 12:01:00" "01911" "2012-04-26 13:01:19" "DGGE;PCR" "DNA" "" "" "0000105850" "00105378" "1" "01911" "01911" "2012-05-03 11:36:58" "" "" "PCR" "DNA" "" "" "0000105851" "00105379" "1" "01911" "01911" "2012-04-27 11:49:30" "" "" "PCR" "DNA" "" "" "0000105852" "00105380" "1" "01911" "01911" "2012-03-22 12:07:42" "01911" "2012-04-26 13:02:05" "DGGE;PCR" "DNA" "" "" "0000105853" "00105381" "1" "01911" "01911" "2012-04-26 13:24:35" "" "" "PCR" "DNA" "" "" "0000105854" "00105382" "1" "01911" "01911" "2012-05-03 11:49:53" "" "" "PCR;SEQ" "DNA" "" "" "0000105855" "00105383" "1" "01911" "01911" "2012-04-26 15:17:36" "" "" "PCR" "DNA" "" "" "0000105856" "00105384" "1" "01911" "01911" "2012-04-26 15:33:14" "" "" "PCR" "DNA" "" "" "0000105857" "00105385" "1" "01911" "01911" "2012-04-26 15:52:22" "" "" "PCR" "DNA" "" "" "0000105858" "00105386" "1" "01911" "01911" "2012-04-27 11:50:19" "" "" "PCR" "DNA" "" "" "0000105859" "00105387" "1" "01911" "01911" "2012-04-27 12:06:21" "" "" "PCR;SEQ" "DNA" "" "" "0000105860" "00105388" "1" "01911" "01911" "2012-05-03 12:08:28" "" "" "PCR" "DNA" "" "" "0000105861" "00105389" "1" "01911" "01911" "2012-05-03 12:18:13" "" "" "PCR;SEQ" "DNA" "" "" "0000105862" "00105390" "1" "01911" "01911" "2012-04-26 15:18:20" "" "" "PCR" "DNA" "" "" "0000105863" "00105391" "1" "01911" "01911" "2012-04-26 15:33:39" "" "" "PCR" "DNA" "" "" "0000105864" "00105392" "1" "01911" "01911" "2012-04-27 12:06:47" "" "" "PCR;RT-PCR;SEQ" "DNA;RNA" "" "" "0000105865" "00105393" "1" "01911" "01911" "2012-05-03 12:01:15" "" "" "PCR;RT-PCR" "DNA;RNA" "" "" "0000105866" "00105394" "1" "01911" "01911" "2012-04-27 12:52:19" "" "" "PCR;SSCA" "DNA" "" "" "0000105867" "00105395" "1" "01911" "01911" "2012-03-22 14:38:13" "01911" "2012-04-26 14:20:57" "PCR;SSCA" "DNA" "" "" "0000105868" "00105396" "1" "01911" "01911" "2012-04-27 12:48:19" "" "" "PCR;SSCA" "DNA" "" "" "0000105869" "00105397" "1" "01911" "01911" "2012-04-27 12:44:18" "01911" "2012-12-19 13:25:52" "PCR;SSCA" "DNA" "" "" "0000105870" "00105398" "1" "01911" "01911" "2012-03-22 11:10:50" "01911" "2012-04-26 15:34:45" "PCR;RT-PCR;SEQ;Western" "DNA;RNA" "" "" "0000105871" "00105399" "1" "01911" "01911" "2012-03-22 11:13:26" "01911" "2012-04-26 15:34:45" "PCR;RT-PCR;SEQ" "DNA;RNA" "" "" "0000105872" "00105400" "1" "01911" "01911" "2012-05-03 12:23:17" "" "" "DGGE;PCR" "DNA" "" "" "0000105873" "00105401" "1" "01911" "01911" "2012-05-03 12:24:13" "" "" "PCR" "DNA" "" "" "0000105874" "00105402" "1" "01911" "01911" "2012-04-27 11:50:45" "" "" "PCR" "DNA" "" "" "0000105875" "00105403" "1" "01911" "01911" "2012-04-27 12:07:26" "" "" "RT-PCR;SEQ;Western" "DNA;RNA" "" "" "0000105876" "00105404" "1" "01911" "01911" "2012-05-01 11:22:15" "" "" "PCR;RT-PCR;SSCA" "DNA;RNA" "" "" ## Screenings_To_Genes ## Do not remove or alter this header ## ## Count = 28 "{{screeningid}}" "{{geneid}}" "0000105849" "TNFRSF10A" "0000105850" "TNFRSF10A" "0000105851" "TNFRSF10A" "0000105852" "TNFRSF10A" "0000105853" "TNFRSF10A" "0000105854" "TNFRSF10A" "0000105855" "TNFRSF10A" "0000105856" "TNFRSF10A" "0000105857" "TNFRSF10A" "0000105858" "TNFRSF10A" "0000105859" "TNFRSF10A" "0000105860" "TNFRSF10A" "0000105861" "TNFRSF10A" "0000105862" "TNFRSF10A" "0000105863" "TNFRSF10A" "0000105864" "TNFRSF10A" "0000105865" "TNFRSF10A" "0000105866" "TNFRSF10A" "0000105867" "TNFRSF10A" "0000105868" "TNFRSF10A" "0000105869" "TNFRSF10A" "0000105870" "TNFRSF10A" "0000105871" "TNFRSF10A" "0000105872" "TNFRSF10A" "0000105873" "TNFRSF10A" "0000105874" "TNFRSF10A" "0000105875" "TNFRSF10A" "0000105876" "TNFRSF10A" ## Variants_On_Genome ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Count = 77 "{{id}}" "{{allele}}" "{{effectid}}" "{{chromosome}}" "{{position_g_start}}" "{{position_g_end}}" "{{type}}" "{{average_frequency}}" "{{owned_by}}" "{{VariantOnGenome/DBID}}" "{{VariantOnGenome/DNA}}" "{{VariantOnGenome/Frequency}}" "{{VariantOnGenome/Reference}}" "{{VariantOnGenome/Restriction_site}}" "{{VariantOnGenome/Published_as}}" "{{VariantOnGenome/Remarks}}" "{{VariantOnGenome/Genetic_origin}}" "{{VariantOnGenome/Segregation}}" "{{VariantOnGenome/dbSNP}}" "{{VariantOnGenome/VIP}}" "{{VariantOnGenome/Methylation}}" "{{VariantOnGenome/ISCN}}" "{{VariantOnGenome/DNA/hg38}}" "{{VariantOnGenome/ClinVar}}" "{{VariantOnGenome/ClinicalClassification}}" "{{VariantOnGenome/ClinicalClassification/Method}}" "0000171271" "0" "55" "8" "23069664" "23069664" "dup" "0" "01911" "TNFRSF10A_000006" "g.23069664dup" "" "" "" "" "" "Germline" "" "rs34224203" "0" "" "" "g.23212151dup" "" "VUS" "" "0000171272" "0" "55" "8" "23069635" "23069635" "subst" "0.000129942" "01911" "TNFRSF10A_000035" "g.23069635G>A" "T=2/C=10757" "{EVS:TNFRSF10A}" "" "" "" "Germline" "" "" "0" "" "" "g.23212122G>A" "" "VUS" "" "0000171273" "0" "55" "8" "23059337" "23059337" "subst" "4.06128E-6" "01911" "TNFRSF10A_000037" "g.23059337G>A" "T=1/C=10757" "{EVS:TNFRSF10A}" "" "" "" "Germline" "" "" "0" "" "" "g.23201824G>A" "" "VUS" "" "0000171274" "0" "55" "8" "23056928" "23056928" "subst" "0" "01911" "TNFRSF10A_000053" "g.23056928G>A" "T=1/C=10757" "{EVS:TNFRSF10A}" "" "" "" "Germline" "" "" "0" "" "" "g.23199415G>A" "" "VUS" "" "0000171275" "0" "55" "8" "23049479" "23049479" "subst" "5.69124E-5" "01911" "TNFRSF10A_000049" "g.23049479A>G" "C=1/T=10755" "{EVS:TNFRSF10A}" "" "" "" "Germline" "" "" "0" "" "" "g.23191966A>G" "" "VUS" "" "0000171276" "0" "55" "8" "23049331" "23049331" "subst" "8.12137E-5" "01911" "TNFRSF10A_000047" "g.23049331A>G" "C=2/T=10756" "{EVS:TNFRSF10A}" "" "" "" "Germline" "" "" "0" "" "" "g.23191818A>G" "" "VUS" "" "0000171277" "0" "55" "8" "23049230" "23049230" "subst" "3.25945E-5" "01911" "TNFRSF10A_000046" "g.23049230C>T" "A=1/G=10757" "{EVS:TNFRSF10A}" "" "" "" "Germline" "" "" "0" "" "" "g.23191717C>T" "" "VUS" "" "0000171283" "0" "55" "8" "23058251" "23058251" "subst" "3.65497E-5" "01911" "TNFRSF10A_000040" "g.23058251C>A" "T=1/G=10757" "{EVS:TNFRSF10B}" "" "" "" "Germline" "" "" "0" "" "" "g.23200738C>A" "" "VUS" "" "0000171304" "0" "55" "8" "23049369" "23049369" "subst" "8.12137E-6" "01911" "TNFRSF10A_000026" "g.23049369C>A" "" "1000 Genomes 1KG_8_23049369" "" "" "" "Germline" "" "" "0" "" "" "g.23191856C>A" "" "VUS" "" "0000171305" "0" "55" "8" "23049382" "23049382" "subst" "4.46661E-5" "01911" "TNFRSF10A_000025" "g.23049382A>G" "" "1000 Genomes 1KG_8_23049382" "" "" "" "Germline" "" "" "0" "" "" "g.23191869A>G" "" "VUS" "" "0000171306" "0" "55" "8" "23054646" "23054646" "subst" "8.12117E-5" "01911" "TNFRSF10A_000022" "g.23054646C>A" "" "1000 Genomes 1KG_8_23054646" "" "" "" "Germline" "" "" "0" "" "" "g.23197133C>A" "" "VUS" "" "0000171307" "0" "55" "8" "23054713" "23054713" "subst" "0.000125879" "01911" "TNFRSF10A_000021" "g.23054713G>A" "" "1000 Genomes 1KG_8_23054713" "" "" "" "Germline" "" "" "0" "" "" "g.23197200G>A" "" "VUS" "" "0000171308" "0" "55" "8" "23056834" "23056834" "subst" "0.000361457" "01911" "TNFRSF10A_000019" "g.23056834G>A" "" "1000 Genomes 1KG_8_23056834" "" "" "" "Germline" "" "" "0" "" "" "g.23199321G>A" "" "VUS" "" "0000171309" "0" "55" "8" "23069704" "23069704" "subst" "0" "01911" "TNFRSF10A_000013" "g.23069704T>C" "" "" "" "" "" "Germline" "" "rs188027515" "0" "" "" "g.23212191T>C" "" "VUS" "" "0000171313" "0" "55" "8" "23082348" "23082348" "subst" "0" "01911" "TNFRSF10A_000010" "g.23082348G>A" "" "" "" "" "" "Germline" "" "rs113149248" "0" "" "" "g.23224835G>A" "" "VUS" "" "0000171314" "0" "55" "8" "23049326" "23049326" "subst" "1.62429E-5" "01911" "TNFRSF10A_000027" "g.23049326C>T" "" "" "" "" "" "Germline" "" "rs113162538" "0" "" "" "g.23191813C>T" "" "VUS" "" "0000171320" "0" "55" "8" "23069718" "23069718" "subst" "0.000706576" "01911" "TNFRSF10A_000012" "g.23069718G>C" "" "" "" "" "" "Germline" "" "rs11986840" "0" "" "" "g.23212205G>C" "" "VUS" "" "0000171322" "0" "55" "8" "23058244" "23058244" "subst" "0" "01911" "TNFRSF10A_000039" "g.23058244T>C" "" "" "" "" "" "Germline" "" "rs139265071" "0" "" "" "g.23200731T>C" "" "VUS" "" "0000171324" "0" "55" "8" "23056817" "23056817" "subst" "2.03092E-5" "01911" "TNFRSF10A_000051" "g.23056817C>T" "" "" "" "" "" "Germline" "" "rs140844059" "0" "" "" "g.23199304C>T" "" "VUS" "" "0000171328" "0" "55" "8" "23058081" "23058081" "subst" "4.87329E-5" "01911" "TNFRSF10A_000041" "g.23058081C>A" "" "" "" "" "" "Germline" "" "rs142205454" "0" "" "" "g.23200568C>A" "" "VUS" "" "0000171329" "0" "55" "8" "23056837" "23056837" "subst" "8.12229E-5" "01911" "TNFRSF10A_000052" "g.23056837T>C" "" "" "" "" "" "Germline" "" "rs143024890" "0" "" "" "g.23199324T>C" "" "VUS" "" "0000171330" "0" "55" "8" "23056939" "23056939" "subst" "4.06425E-6" "01911" "TNFRSF10A_000044" "g.23056939A>T" "" "" "" "" "" "Germline" "" "rs143030810" "0" "" "" "g.23199426A>T" "" "VUS" "" "0000171332" "0" "55" "8" "23069691" "23069691" "subst" "0.000332968" "01911" "TNFRSF10A_000055" "g.23069691T>C" "A=0.999/G=0.001" "" "" "" "" "Germline" "" "rs144035000" "0" "" "" "g.23212178T>C" "" "VUS" "" "0000171333" "0" "55" "8" "23058270" "23058270" "subst" "2.84403E-5" "01911" "TNFRSF10A_000038" "g.23058270G>C" "" "" "" "" "" "Germline" "" "rs144093718" "0" "" "" "g.23200757G>C" "" "VUS" "" "0000171335" "0" "55" "8" "23049343" "23049343" "subst" "7.50907E-5" "01911" "TNFRSF10A_000048" "g.23049343G>A" "" "" "" "" "" "Germline" "" "rs145301145" "0" "" "" "g.23191830G>A" "" "VUS" "" "0000171336" "0" "55" "8" "23054662" "23054662" "subst" "5.68486E-5" "01911" "TNFRSF10A_000050" "g.23054662C>T" "" "" "" "" "" "Germline" "" "rs145301693" "0" "" "" "g.23197149C>T" "" "VUS" "" "0000171345" "0" "55" "8" "23059363" "23059363" "subst" "6.90333E-5" "01911" "TNFRSF10A_000036" "g.23059363C>T" "" "" "" "" "" "Germline" "" "rs150096329" "0" "" "" "g.23201850C>T" "" "VUS" "" "0000171347" "0" "55" "8" "23056904" "23056904" "subst" "0.00365921" "01911" "TNFRSF10A_000016" "g.23056904T>G" "A=0.981/C=0.019" "" "" "" "" "Germline" "" "rs17088980" "0" "" "" "g.23199391T>G" "" "VUS" "" "0000171348" "0" "55" "8" "23082477" "23082477" "subst" "0.0174866" "01911" "TNFRSF10A_000008" "g.23082477G>A" "C=0.924/T=0.076" "" "" "" "" "Germline" "" "rs20577" "0" "" "" "g.23224964G>A" "" "VUS" "" "0000171350" "0" "55" "8" "23082543" "23082543" "subst" "0.000121861" "01911" "TNFRSF10A_000007" "g.23082543C>A" "G=0.995/T=0.005" "" "" "" "" "Germline" "" "rs34737614" "0" "" "" "g.23225030C>A" "" "VUS" "" "0000171354" "0" "55" "8" "23082369" "23082369" "subst" "0.00256006" "01911" "TNFRSF10A_000009" "g.23082369C>G" "" "" "" "" "" "Germline" "" "rs61756236" "0" "" "" "g.23224856C>G" "" "VUS" "" "0000171360" "0" "55" "8" "23056956" "23056956" "subst" "9.3553E-5" "01911" "TNFRSF10A_000042" "g.23056956A>T" "A=2/T=10756" "{EVS:TNFRSF10B}" "" "" "" "Germline" "" "" "0" "" "" "g.23199443A>T" "" "VUS" "" "0000171363" "0" "55" "8" "23056934" "23056934" "subst" "2.84446E-5" "01911" "TNFRSF10A_000054" "g.23056934G>A" "C=0.999/T=0.001" "" "" "" "" "Germline" "" "rs140805563" "0" "" "" "g.23199421G>A" "" "VUS" "" "0000171364" "0" "55" "8" "23056948" "23056948" "subst" "0.000170779" "01911" "TNFRSF10A_000043" "g.23056948C>T" "" "" "" "" "" "Germline" "" "rs144670447" "0" "" "" "g.23199435C>T" "" "VUS" "" "0000171367" "0" "55" "8" "23049405" "23049405" "subst" "7.30923E-5" "01911" "TNFRSF10A_000024" "g.23049405G>A" "" "1000 Genomes 1KG_8_23049405" "" "" "" "Germline" "" "" "0" "" "" "g.23191892G>A" "" "VUS" "" "0000171368" "0" "55" "8" "23056794" "23056794" "subst" "0" "01911" "TNFRSF10A_000020" "g.23056794C>T" "" "1000 Genomes 1KG_8_23056794" "" "" "" "Germline" "" "" "0" "" "" "g.23199281C>T" "" "VUS" "" "0000171369" "0" "55" "8" "23056902" "23056902" "subst" "0.000576692" "01911" "TNFRSF10A_000017" "g.23056902G>A" "" "1000 Genomes 1KG_8_23056902" "" "" "" "Germline" "" "" "0" "" "" "g.23199389G>A" "" "VUS" "" "0000171370" "0" "55" "8" "23060213" "23060213" "subst" "0.00101115" "01911" "TNFRSF10A_000014" "g.23060213G>T" "" "1000 Genomes 1KG_8_23060213 {dbSNP:149012704}" "" "" "" "Germline" "" "rs149012704" "0" "" "" "g.23202700G>T" "" "VUS" "" "0000171375" "0" "55" "8" "23056887" "23056887" "subst" "0.000471085" "01911" "TNFRSF10A_000018" "g.23056887G>A" "C=0.998/T=0.002" "" "" "" "" "Germline" "" "rs2230230" "0" "" "" "g.23199374G>A" "" "VUS" "" "0000171376" "0" "55" "8" "23049314" "23049314" "subst" "0.000365467" "01911" "TNFRSF10A_000028" "g.23049314T>G" "" "" "" "" "" "Germline" "" "rs61761316" "0" "" "" "g.23191801T>G" "" "VUS" "" "0000171377" "0" "55" "8" "23049273" "23049273" "subst" "0.00049959" "01911" "TNFRSF10A_000030" "g.23049273G>C" "C=0.998/G=0.002" "" "" "" "" "Germline" "" "rs77368365" "0" "" "" "g.23191760G>C" "" "VUS" "" "0000171379" "0" "55" "8" "23060155" "23060155" "subst" "0.00225421" "01911" "TNFRSF10A_000015" "g.23060155C>G" "" "1000 Genomes 1KG_8_23060155, {dbSNP:182707081}" "" "" "Splice site" "Germline" "" "" "0" "" "" "g.23202642C>G" "" "VUS" "" "0000171380" "0" "55" "8" "23082264" "23082264" "subst" "0.00639243" "01911" "TNFRSF10A_000011" "g.23082264C>G" "G=0.995/C=0.005" "" "" "" "Splice site" "Germline" "" "rs34601117" "0" "" "" "g.23224751C>G" "" "VUS" "" "0000171381" "0" "55" "8" "23054638" "23054638" "subst" "0.000629385" "01911" "TNFRSF10A_000023" "g.23054638C>T" "G=0.983/A=0.017" "" "" "" "Splice site" "Germline" "" "rs75047372" "0" "" "" "g.23197125C>T" "" "VUS" "" "0000171382" "0" "55" "8" "23049208" "23049208" "subst" "0.00133661" "01911" "TNFRSF10A_000045" "g.23049208C>A" "G=0.999/T=0.001" "" "" "" "Stop codon mutated" "Germline" "" "rs144773234" "0" "" "" "g.23191695C>A" "" "VUS" "" "0000171387" "0" "55" "8" "23049010" "23049010" "subst" "0" "01911" "TNFRSF10A_000032" "g.23049010A>C" "" "1000 Genomes 1KG_8_23049010" "" "" "UTR variant" "Germline" "" "" "0" "" "" "g.23191497A>C" "" "VUS" "" "0000171388" "0" "55" "8" "23049148" "23049148" "subst" "0" "01911" "TNFRSF10A_000034" "g.23049148A>C" "" "1000 Genomes 1KG_8_23049148" "" "" "UTR variant" "Germline" "" "" "0" "" "" "g.23191635A>C" "" "VUS" "" "0000171391" "0" "55" "8" "23049150" "23049150" "dup" "0" "01911" "TNFRSF10A_000031" "g.23049150dup" "" "" "" "" "UTR variant" "Germline" "" "rs34127830" "0" "" "" "g.23191637dup" "" "VUS" "" "0000171392" "0" "55" "8" "23049150" "23049150" "del" "0" "01911" "TNFRSF10A_000033" "g.23049150del" "" "" "" "" "UTR variant" "Germline" "" "rs35742189" "0" "" "" "g.23191637del" "" "VUS" "" "0000171428" "0" "55" "8" "23060256" "23060256" "subst" "0.534818" "01911" "TNFRSF10A_000002" "g.23060256T>C" "" "{PMID:Fisher 2001:11410508}" "" "" "A number of samples from four different cancer types were sequenced for these polymorphisms. Variants 626G>C and 422A>G may be associated with an increase in predisposition to cancer types." "Unknown" "" "rs6557634" "0" "" "" "g.23202743T>C" "" "VUS" "" "0000171429" "0" "55" "8" "23060256" "23060256" "subst" "0.534818" "01911" "TNFRSF10A_000002" "g.23060256T>C" "" "{PMID:Ulybina 2009:19203830}" "" "" "111 patients with lung cancer were sequenced for four different TRAIL-R1 variations. Polymorphism c.1322G>A was then sequenced for in a further 250 lung cancer patients. This polymorphism could be a modifier in patient risk to lung cancer." "Unknown" "" "rs6557634" "0" "" "" "g.23202743T>C" "" "VUS" "" "0000171430" "0" "55" "8" "23060256" "23060256" "subst" "0.534818" "01911" "TNFRSF10A_000002" "g.23060256T>C" "" "{PMID8:Hazra 2008:1264916}" "" "" "97 ovarian cancer samples were investigated along with controls. In all three polymorphisms no significant difference could be found between the normal and disease samples." "Unknown" "" "rs6557634" "0" "" "" "g.23202743T>C" "" "VUS" "" "0000171431" "0" "55" "8" "23059324" "23059324" "subst" "0.535935" "01911" "TNFRSF10A_000003" "g.23059324C>G" "" "{PMID:Fisher 2001:11410508}" "" "" "A number of samples from four different cancer types were sequenced for these polymorphisms. Variants 626G>C and 422A>G may be associated with an increase in predisposition to cancer types." "Unknown" "" "rs20575" "0" "" "" "g.23201811C>G" "" "VUS" "" "0000171432" "0" "55" "8" "23059324" "23059324" "subst" "0.535935" "01911" "TNFRSF10A_000003" "g.23059324C>G" "" "{PMID:Ulybina 2009:19203830}" "" "" "111 patients with lung cancer were sequenced for four different TRAIL-R1 variations. Polymorphism c.1322G>A was then sequenced for in a further 250 lung cancer patients. This polymorphism could be a modifier in patient risk to lung cancer." "Unknown" "" "rs20575" "0" "" "" "g.23201811C>G" "" "VUS" "" "0000171433" "0" "55" "8" "23059324" "23059324" "subst" "0.535935" "01911" "TNFRSF10A_000003" "g.23059324C>G" "" "{PMID:Dick 2011:21484799}" "" "" "557 female carriers of BRCA1 and 283 female carrier of BRCA2 mutations were sequenced for the presence of two TRAIL-R1 variants. Variant 683A>C appears to be associated with an increased risk of ovarian cancer. The two variants were found in the following frequencies: 622C>G:CC=266/CG=407/GG=167 683A>C:AA=522/AC=270/CC=48" "Unknown" "" "rs20575" "0" "" "" "g.23201811C>G" "" "VUS" "" "0000171434" "0" "55" "8" "23059324" "23059324" "subst" "0.535935" "01911" "TNFRSF10A_000003" "g.23059324C>G" "" "{PMID:Frank 2006:17035413}" "" "" "659 colorectal cancer patients were sequenced for these two variants. Variant 683G>C did not appear to be associated with an increased colorectal cancer risk. The 683C-626C haplotype conferred a 2.4 fold colorectal cancer risk." "Unknown" "" "rs20575" "0" "" "" "g.23201811C>G" "" "VUS" "" "0000171435" "0" "55" "8" "23059324" "23059324" "subst" "0.535935" "01911" "TNFRSF10A_000003" "g.23059324C>G" "" "{PMID:Frank 2005:15975957}" "" "" "Individually, variations 626C>G and 683A>C do not appear to be associated with an increase in breast cancer risk. However, the rare haplotype 626C-683C does appear to contribute to an increased risk to breast cancer." "Unknown" "" "rs20575" "0" "" "" "g.23201811C>G" "" "VUS" "" "0000171436" "0" "55" "8" "23059324" "23059324" "subst" "0.535935" "01911" "TNFRSF10A_000003" "g.23059324C>G" "" "{PMID8:Hazra 2008:1264916}" "" "" "253 bladder cancer patients were sampled to investigate this polymorphism. This variant is associated with the risk of bladder cancer." "Unknown" "" "rs20575" "0" "" "" "g.23201811C>G" "" "VUS" "" "0000171437" "0" "55" "8" "23059324" "23059324" "subst" "0.535935" "01911" "TNFRSF10A_000003" "g.23059324C>G" "" "{PMID8:Hazra 2008:1264916}" "" "" "97 ovarian cancer samples were investigated along with controls. In all three polymorphisms no significant difference could be found between the normal and disease samples." "Unknown" "" "rs20575" "0" "" "" "g.23201811C>G" "" "VUS" "" "0000171438" "0" "55" "8" "23059324" "23059324" "subst" "0.535935" "01911" "TNFRSF10A_000003" "g.23059324C>G" "" "{PMID:Chen 2009:19643596}" "" "" "This paper was an evidence based meta-analysis looking at a total of nine studies. Overall, all three polymorphisms were found to be associated with cancer risk." "Unknown" "" "rs20575" "0" "" "" "g.23201811C>G" "" "VUS" "" "0000171439" "0" "55" "8" "23058220" "23058220" "subst" "0.151893" "01911" "TNFRSF10A_000005" "g.23058220T>G" "" "{PMID:Ulybina 2009:19203830}" "" "" "111 patients with lung cancer were sequenced for four different TRAIL-R1 variations. Polymorphism c.1322G>A was then sequenced for in a further 250 lung cancer patients. This polymorphism could be a modifier in patient risk to lung cancer." "Unknown" "" "rs20576" "0" "" "" "g.23200707T>G" "" "VUS" "" "0000171440" "0" "55" "8" "23058220" "23058220" "subst" "0.151893" "01911" "TNFRSF10A_000005" "g.23058220T>G" "" "{PMID:Dick 2011:21484799}" "" "" "557 female carriers of BRCA1 and 283 female carrier of BRCA2 mutations were sequenced for the presence of two TRAIL-R1 variants. Variant 683A>C appears to be associated with an increased risk of ovarian cancer. The two variants were found in the following frequencies: 622C>G:CC=266/CG=407/GG=167 683A>C:AA=522/AC=270/CC=48" "Unknown" "" "rs20576" "0" "" "" "g.23200707T>G" "" "VUS" "" "0000171441" "0" "55" "8" "23058220" "23058220" "subst" "0.151893" "01911" "TNFRSF10A_000005" "g.23058220T>G" "" "{PMID:Frank 2006:17035413}" "" "" "659 colorectal cancer patients were sequenced for these two variants. Variant 683G>C did not appear to be associated with an increased colorectal cancer risk. The 683C-626C haplotype conferred a 2.4 fold colorectal cancer risk." "Unknown" "" "rs20576" "0" "" "" "g.23200707T>G" "" "VUS" "" "0000171442" "0" "55" "8" "23058220" "23058220" "subst" "0.151893" "01911" "TNFRSF10A_000005" "g.23058220T>G" "" "{PMID:Frank 2005:15975957}" "" "" "Individually, variations 626C>G and 683A>C do not appear to be associated with an increase in breast cancer risk. However, the rare haplotype 626C-683C does appear to contribute to an increased risk to breast cancer." "Unknown" "" "rs20576" "0" "" "" "g.23200707T>G" "" "VUS" "" "0000171443" "0" "55" "8" "23058220" "23058220" "subst" "0.151893" "01911" "TNFRSF10A_000005" "g.23058220T>G" "" "{PMID:Chen 2009:19643596}" "" "" "This paper was an evidence based meta-analysis looking at a total of nine studies. Overall, all three polymorphisms were found to be associated with cancer risk." "Unknown" "" "rs20576" "0" "" "" "g.23200707T>G" "" "VUS" "" "0000171444" "0" "55" "8" "23058220" "23058220" "subst" "0.151893" "01911" "TNFRSF10A_000005" "g.23058220T>G" "" "{PMID:Wolf 2006:16217763}" "" "" "101 chronic lymphocytic leukemia, 32 mantle cell lymphoma, 43 prostate cancer, 40 head and neck squamous cell carcinoma and 179 bladder cancer samples were investigated for the presence of this variant. It appears that this variant is involved in the pathomechanism of a subset of these cancer types." "Unknown" "" "rs20576" "0" "" "" "g.23200707T>G" "" "VUS" "" "0000171445" "0" "55" "8" "23049497" "23049497" "subst" "0" "01911" "TNFRSF10A_000057" "g.23049497T>C" "" "{PMID:Shin 2001:11431320}" "" "" "expression cloning into 293 other cells showed significant defects in apoptotic function; variant found in both the primary and metastatic breast cancer samples" "Unknown" "" "" "0" "" "" "g.23191984T>C" "" "VUS" "" "0000171446" "0" "55" "8" "23049487" "23049487" "subst" "0" "01911" "TNFRSF10A_000004" "g.23049487G>A" "" "{PMID:Lee 2001:11313970}" "" "" "variant may cause resistance against TRAIL induced apoptosis" "Unknown" "" "" "0" "" "" "g.23191974G>A" "" "VUS" "" "0000171447" "0" "55" "8" "23049487" "23049487" "subst" "0" "01911" "TNFRSF10A_000004" "g.23049487G>A" "" "{PMID:Shin 2001:11431320}" "" "" "expression cloning into 293 other cells showed significant defects in apoptotic function; variant found only in the metastatic breast cancer samples" "Unknown" "" "" "0" "" "" "g.23191974G>A" "" "VUS" "" "0000171448" "0" "55" "8" "23049409" "23049409" "subst" "8.1215E-6" "01911" "TNFRSF10A_000056" "g.23049409G>A" "" "{PMID:Shin 2002:12085986}" "" "" "expression cloning into 293 other cells showed significant defects in apoptotic function; variant found only in the metastatic breast cancer samples" "Unknown" "" "" "0" "" "" "g.23191896G>A" "" "VUS" "" "0000171449" "0" "55" "8" "23049292" "23049292" "subst" "0.879889" "01911" "TNFRSF10A_000001" "g.23049292C>T" "" "{PMID:Kim 2000:10690508}" "" "" "This variant appears to contribute to an increased resistance to TRAIL binding. All ovarian cancer cell samples tested in this instance were heterozygous for this variant. This variant was also found in 2 normal samples (20%), again heterozygous." "Unknown" "" "rs2230229" "0" "" "" "g.23191779C>T" "" "VUS" "" "0000171450" "0" "55" "8" "23049292" "23049292" "subst" "0.879889" "01911" "TNFRSF10A_000001" "g.23049292C>T" "" "{PMID:Kim 2000:10690508}" "" "" "This variant appears to contribute to an increased resistance to TRAIL binding. This variant was also found in 2 normal samples (20%)." "Unknown" "" "rs2230229" "0" "" "" "g.23191779C>T" "" "VUS" "" "0000171451" "0" "55" "8" "23049292" "23049292" "subst" "0.879889" "01911" "TNFRSF10A_000001" "g.23049292C>T" "" "{PMID:Fisher 2001:11410508}" "" "" "A number of samples from four different cancer types were sequenced for these polymorphisms. Variants 626G>C and 422A>G may be associated with an increase in predisposition to cancer types." "Unknown" "" "rs2230229" "0" "" "" "g.23191779C>T" "" "VUS" "" "0000171452" "0" "55" "8" "23049292" "23049292" "subst" "0.879889" "01911" "TNFRSF10A_000001" "g.23049292C>T" "" "{PMID:Ulybina 2009:19203830}" "" "" "111 patients with lung cancer were sequenced for four different TRAIL-R1 variations. Polymorphism c.1322G>A was then sequenced for in a further 250 lung cancer patients. This polymorphism could be a modifier in patient risk to lung cancer." "Unknown" "" "rs2230229" "0" "" "" "g.23191779C>T" "" "VUS" "" "0000171453" "0" "55" "8" "23049292" "23049292" "subst" "0.879889" "01911" "TNFRSF10A_000001" "g.23049292C>T" "" "{PMID8:Hazra 2008:1264916}" "" "" "97 ovarian cancer samples were investigated along with controls. In all three polymorphisms no significant difference could be found between the normal and disease samples." "Unknown" "" "rs2230229" "0" "" "" "g.23191779C>T" "" "VUS" "" "0000171454" "0" "55" "8" "23049292" "23049292" "subst" "0.879889" "01911" "TNFRSF10A_000001" "g.23049292C>T" "" "{PMID:Chen 2009:19643596}" "" "" "This paper was an evidence based meta-analysis looking at a total of nine studies. Overall, all three polymorphisms were found to be associated with cancer risk." "Unknown" "" "rs2230229" "0" "" "" "g.23191779C>T" "" "VUS" "" "0000171455" "0" "55" "8" "23049292" "23049292" "subst" "0.879889" "01911" "TNFRSF10A_000001" "g.23049292C>T" "" "{PMID:Seitz 2002:12385006}" "" "" "In this study variants in TRAIL and the four TRAIL receptor genes were investigated for in 115 tumour samples and 40 controls. Decreased mRNA expressionof these genes in breast cancer cells appear to be due to another mechanism of gene expression than the variants listed." "Unknown" "" "rs2230229" "0" "" "" "g.23191779C>T" "" "VUS" "" ## Variants_On_Transcripts ## Do not remove or alter this header ## ## Please note that not necessarily all variants found in the given individuals are shown. This output is restricted to variants in the selected gene. ## Note: Only showing Variants_On_Transcript columns active for Genes TNFRSF10A ## Count = 77 "{{id}}" "{{transcriptid}}" "{{effectid}}" "{{position_c_start}}" "{{position_c_start_intron}}" "{{position_c_end}}" "{{position_c_end_intron}}" "{{VariantOnTranscript/DNA}}" "{{VariantOnTranscript/RNA}}" "{{VariantOnTranscript/Protein}}" "{{VariantOnTranscript/Exon}}" "{{VariantOnTranscript/Predict/BioInf}}" "0000171271" "00021553" "55" "370" "0" "370" "0" "c.370dup" "r.(?)" "p.(Glu124Glyfs*3)" "2" "" "0000171272" "00021553" "55" "397" "0" "397" "0" "c.397C>T" "r.(?)" "p.(Pro133Ser)" "2" "Polyphen: probably damaging" "0000171273" "00021553" "55" "613" "0" "613" "0" "c.613C>T" "r.(?)" "p.(Arg205Trp)" "4" "Polyphen: probably damaging" "0000171274" "00021553" "55" "865" "0" "865" "0" "c.865C>T" "r.(?)" "p.(Pro289Ser)" "8" "Polyphen: probably damaging" "0000171275" "00021553" "55" "1135" "0" "1135" "0" "c.1135T>C" "r.(?)" "p.(Ser379Pro)" "10" "Polyphen: probably damaging" "0000171276" "00021553" "55" "1283" "0" "1283" "0" "c.1283T>C" "r.(?)" "p.(Leu428Pro)" "10" "Polyphen: probably damaging" "0000171277" "00021553" "55" "1384" "0" "1384" "0" "c.1384G>A" "r.(?)" "p.(Gly462Ser)" "10" "Polyphen: probably damaging" "0000171283" "00021553" "55" "652" "0" "652" "0" "c.652G>T" "r.(?)" "p.(Val218Phe)" "5" "Polyphen: probably damaging" "0000171304" "00021553" "55" "1245" "0" "1245" "0" "c.1245G>T" "r.(?)" "p.(Trp415Cys)" "10" "Polyphen: probably damaging" "0000171305" "00021553" "55" "1232" "0" "1232" "0" "c.1232T>C" "r.(?)" "p.(Met411Thr)" "10" "Polyphen: probably damaging" "0000171306" "00021553" "55" "1086" "0" "1086" "0" "c.1086G>T" "r.(?)" "p.(Glu362Asp)" "9" "Polyphen: possibly damaging" "0000171307" "00021553" "55" "1019" "0" "1019" "0" "c.1019C>T" "r.(?)" "p.(Pro340Leu)" "9" "Polyphen: probably damaging" "0000171308" "00021553" "55" "959" "0" "959" "0" "c.959C>T" "r.(?)" "p.(Pro320Leu)" "8" "Polyphen: probably damaging" "0000171309" "00021553" "55" "328" "0" "328" "0" "c.328A>G" "r.(?)" "p.(Thr110Ala)" "2" "Polyphen: benign" "0000171313" "00021553" "55" "227" "0" "227" "0" "c.227C>T" "r.(?)" "p.(Pro76Leu)" "1" "" "0000171314" "00021553" "55" "1288" "0" "1288" "0" "c.1288G>A" "r.(?)" "p.(Asp430Asn)" "10" "Polyphen: probably damaging" "0000171320" "00021553" "55" "314" "0" "314" "0" "c.314C>G" "r.(?)" "p.(Pro105Arg)" "2" "Polyphen: possibly damaging" "0000171322" "00021553" "55" "659" "0" "659" "0" "c.659A>G" "r.(?)" "p.(Asp220Gly)" "5" "" "0000171324" "00021553" "55" "976" "0" "976" "0" "c.976G>A" "r.(?)" "p.(Val326Ile)" "8" "" "0000171328" "00021553" "55" "736" "0" "736" "0" "c.736G>T" "r.(?)" "p.(Val246Leu)" "6" "" "0000171329" "00021553" "55" "956" "0" "956" "0" "c.956A>G" "r.(?)" "p.(Glu319Gly)" "8" "" "0000171330" "00021553" "55" "854" "0" "854" "0" "c.854T>A" "r.(?)" "p.(Leu285His)" "8" "" "0000171332" "00021553" "55" "341" "0" "341" "0" "c.341A>G" "r.(?)" "p.(His114Arg)" "2" "" "0000171333" "00021553" "55" "633" "0" "633" "0" "c.633C>G" "r.(?)" "p.(Cys211Trp)" "5" "" "0000171335" "00021553" "55" "1271" "0" "1271" "0" "c.1271C>T" "r.(?)" "p.(Ser424Leu)" "10" "" "0000171336" "00021553" "55" "1070" "0" "1070" "0" "c.1070G>A" "r.(?)" "p.(Gly357Asp)" "9" "" "0000171345" "00021553" "55" "587" "0" "587" "0" "c.587G>A" "r.(?)" "p.(Arg196Gln)" "4" "" "0000171347" "00021553" "55" "889" "0" "889" "0" "c.889A>C" "r.(?)" "p.(Asn297His)" "8" "Polyphen: probably damaging" "0000171348" "00021553" "55" "98" "0" "98" "0" "c.98C>T" "r.(?)" "p.(Thr33Ile)" "1" "" "0000171350" "00021553" "55" "32" "0" "32" "0" "c.32G>T" "r.(?)" "c.(Gly11Val)" "1" "" "0000171354" "00021553" "55" "206" "0" "206" "0" "c.206G>C" "r.(?)" "p.(Arg69Pro)" "1" "" "0000171360" "00021553" "55" "837" "0" "837" "0" "c.837T>A" "r.(?)" "p.(Cys279*)" "8" "" "0000171363" "00021553" "55" "859" "0" "859" "0" "c.859C>T" "r.(?)" "p.(Arg287*)" "8" "" "0000171364" "00021553" "55" "845" "0" "845" "0" "c.845G>A" "r.(?)" "p.(Arg282His)" "8" "" "0000171367" "00021553" "55" "1209" "0" "1209" "0" "c.1209C>T" "r.(?)" "p.(=)" "10" "" "0000171368" "00021553" "55" "999" "0" "999" "0" "c.999G>A" "r.(?)" "p.(=)" "8" "" "0000171369" "00021553" "55" "891" "0" "891" "0" "c.891C>T" "r.(?)" "p.(=)" "8" "" "0000171370" "00021553" "55" "465" "0" "465" "0" "c.465C>A" "r.(?)" "p.(=)" "3" "" "0000171375" "00021553" "55" "906" "0" "906" "0" "c.906C>T" "r.(?)" "p.(=)" "8" "" "0000171376" "00021553" "55" "1300" "0" "1300" "0" "c.1300A>C" "r.(?)" "p.(=)" "10" "" "0000171377" "00021553" "55" "1341" "0" "1341" "0" "c.1341C>G" "r.(?)" "p.(=)" "10" "" "0000171379" "00021553" "55" "517" "6" "517" "6" "c.517+6G>C" "r.(?)" "p.(=)" "3i" "" "0000171380" "00021553" "55" "306" "5" "306" "5" "c.306+5G>C" "r.spl?" "p.(?)" "1i" "" "0000171381" "00021553" "55" "1087" "7" "1087" "7" "c.1087+7G>A" "r.(?)" "p.(=)" "9i" "" "0000171382" "00021553" "55" "1406" "0" "1406" "0" "c.1406G>T" "r.(?)" "p.(*469Leuext*15)" "10" "" "0000171387" "00021553" "55" "1604" "0" "1604" "0" "c.*197T>G" "r.(?)" "p.(=)" "10" "" "0000171388" "00021553" "55" "1466" "0" "1466" "0" "c.*59T>G" "r.(?)" "p.(=)" "10" "" "0000171391" "00021553" "55" "1477" "0" "1477" "0" "c.*70dup" "r.(?)" "p.(=)" "10" "" "0000171392" "00021553" "55" "1477" "0" "1477" "0" "c.*70del" "r.(?)" "p.(=)" "10" "" "0000171428" "00021553" "55" "422" "0" "422" "0" "c.422A>G" "r.(?)" "p.(His141Arg)" "3" "Polyphen: possibly damaging" "0000171429" "00021553" "55" "422" "0" "422" "0" "c.422A>G" "r.(?)" "p.(His141Arg)" "3" "Polyphen: possibly damaging" "0000171430" "00021553" "55" "422" "0" "422" "0" "c.422A>G" "r.(?)" "p.(His141Arg)" "3" "Polyphen: possibly damaging" "0000171431" "00021553" "55" "626" "0" "626" "0" "c.626G>C" "r.(?)" "p.(Arg209Thr)" "4" "Polyphen: benign" "0000171432" "00021553" "55" "626" "0" "626" "0" "c.626G>C" "r.(?)" "p.(Arg209Thr)" "4" "Polyphen: benign" "0000171433" "00021553" "55" "626" "0" "626" "0" "c.626G>C" "r.(?)" "p.(Arg209Thr)" "4" "Polyphen: benign" "0000171434" "00021553" "55" "626" "0" "626" "0" "c.626G>C" "r.(?)" "p.(Arg209Thr)" "4" "Polyphen: benign" "0000171435" "00021553" "55" "626" "0" "626" "0" "c.626G>C" "r.(?)" "p.(Arg209Thr)" "4" "Polyphen: benign" "0000171436" "00021553" "55" "626" "0" "626" "0" "c.626G>C" "r.(?)" "p.(Arg209Thr)" "4" "Polyphen: benign" "0000171437" "00021553" "55" "626" "0" "626" "0" "c.626G>C" "r.(?)" "p.(Arg209Thr)" "4" "Polyphen: benign" "0000171438" "00021553" "55" "626" "0" "626" "0" "c.626G>C" "r.(?)" "p.(Arg209Thr)" "4" "Polyphen: benign" "0000171439" "00021553" "55" "683" "0" "683" "0" "c.683A>C" "r.(?)" "p.(Glu228Ala)" "5" "Polyphen: possibly damaging" "0000171440" "00021553" "55" "683" "0" "683" "0" "c.683A>C" "r.(?)" "p.(Glu228Ala)" "5" "Polyphen: possibly damaging" "0000171441" "00021553" "55" "683" "0" "683" "0" "c.683A>C" "r.(?)" "p.(Glu228Ala)" "5" "Polyphen: possibly damaging" "0000171442" "00021553" "55" "683" "0" "683" "0" "c.683A>C" "r.(?)" "p.(Glu228Ala)" "5" "Polyphen: possibly damaging" "0000171443" "00021553" "55" "683" "0" "683" "0" "c.683A>C" "r.(?)" "p.(Glu228Ala)" "5" "Polyphen: possibly damaging" "0000171444" "00021553" "55" "683" "0" "683" "0" "c.683A>C" "r.(?)" "p.(Glu228Ala)" "5" "Polyphen: possibly damaging" "0000171445" "00021553" "55" "1117" "0" "1117" "0" "c.1117A>G" "r.(?)" "p.(Asn373Asp)" "10" "" "0000171446" "00021553" "55" "1127" "0" "1127" "0" "c.1127C>T" "r.(?)" "p.(Pro376Leu)" "10" "" "0000171447" "00021553" "55" "1127" "0" "1127" "0" "c.1127C>T" "r.(?)" "p.(Pro376Leu)" "10" "" "0000171448" "00021553" "55" "1205" "0" "1205" "0" "c.1205C>T" "r.(?)" "p.(Ala402Val)" "10" "" "0000171449" "00021553" "55" "1322" "0" "1322" "0" "c.1322G>A" "r.(?)" "p.(Arg441Lys)" "10" "Polyphen: benign" "0000171450" "00021553" "55" "1322" "0" "1322" "0" "c.1322G>A" "r.(?)" "p.(Arg441Lys)" "10" "Polyphen: benign" "0000171451" "00021553" "55" "1322" "0" "1322" "0" "c.1322G>A" "r.(?)" "p.(Arg441Lys)" "10" "Polyphen: benign" "0000171452" "00021553" "55" "1322" "0" "1322" "0" "c.1322G>A" "r.(?)" "p.(Arg441Lys)" "10" "Polyphen: benign" "0000171453" "00021553" "55" "1322" "0" "1322" "0" "c.1322G>A" "r.(?)" "p.(Arg441Lys)" "10" "Polyphen: benign" "0000171454" "00021553" "55" "1322" "0" "1322" "0" "c.1322G>A" "r.(?)" "p.(Arg441Lys)" "10" "Polyphen: benign" "0000171455" "00021553" "55" "1322" "0" "1322" "0" "c.1322G>A" "r.(?)" "p.(Arg441Lys)" "10" "Polyphen: benign" ## Screenings_To_Variants ## Do not remove or alter this header ## ## Count = 28 "{{screeningid}}" "{{variantid}}" "0000105849" "0000171428" "0000105850" "0000171429" "0000105851" "0000171430" "0000105852" "0000171431" "0000105853" "0000171432" "0000105854" "0000171433" "0000105855" "0000171434" "0000105856" "0000171435" "0000105857" "0000171436" "0000105858" "0000171437" "0000105859" "0000171438" "0000105860" "0000171439" "0000105861" "0000171440" "0000105862" "0000171441" "0000105863" "0000171442" "0000105864" "0000171443" "0000105865" "0000171444" "0000105866" "0000171445" "0000105867" "0000171446" "0000105868" "0000171447" "0000105869" "0000171448" "0000105870" "0000171449" "0000105871" "0000171450" "0000105872" "0000171451" "0000105873" "0000171452" "0000105874" "0000171453" "0000105875" "0000171454" "0000105876" "0000171455"