achalasia, adrenocortical insufficiency, alacrimia (AAAS) - coding DNA reference sequence

(used for variant description)

(last modified July 21, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_015665.5 in the AAAS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016775.1, covering AAAS transcript NM_015665.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  cccgttagtcttttcttcacttccgttgagttccgcctcgccg       c.-121

 .         .         .         .         .         .                g.5103
 tttgtcccttgcggtacccgtccgcatacgaatctagcccgggaaccgagttgcgggagt       c.-61

 .         .         .         .         .         .                g.5163
 gcggtctgtgccgttccggccaggagtttgccgactgcagacgtcctgcgaaccggcaag       c.-1

          .         .         .         .         .         .       g.5223
 ATGTGCTCTCTGGGGTTGTTCCCTCCTCCACCGCCTCGGGGTCAAGTCACCCTATATGAG       c.60
 M  C  S  L  G  L  F  P  P  P  P  P  R  G  Q  V  T  L  Y  E         p.20

          .         .         .         .         .         .       g.5283
 CACAATAACGAGCTGGTGACGGGCAGTAGCTATGAGAGCCCGCCCCCCGACTTCCGGGGC       c.120
 H  N  N  E  L  V  T  G  S  S  Y  E  S  P  P  P  D  F  R  G         p.40

     | 02    .         .         .         .         .         .    g.5993
 CAG | TGGATCAATCTTCCTGTCCTACAACTGACAAAGGATCCCCTAAAGACCCCTGGAAGG    c.180
 Q   | W  I  N  L  P  V  L  Q  L  T  K  D  P  L  K  T  P  G  R      p.60

          .         .         .         .         .         .       g.6053
 CTGGACCATGGCACAAGAACTGCCTTCATCCATCACCGGGAGCAAGTGTGGAAGAGATGC       c.240
 L  D  H  G  T  R  T  A  F  I  H  H  R  E  Q  V  W  K  R  C         p.80

          .  | 03      .         .         .         .         .    g.10895
 ATCAACATTTG | GCGTGATGTGGGCCTTTTTGGGGTGCTAAATGAAATTGCAAACTCAGAA    c.300
 I  N  I  W  |  R  D  V  G  L  F  G  V  L  N  E  I  A  N  S  E      p.100

         | 04.         .         .         .         .         .    g.11255
 GAAGAGG | TGTTTGAGTGGGTGAAGACGGCATCCGGCTGGGCCCTGGCACTCTGTCGATGG    c.360
 E  E  V |   F  E  W  V  K  T  A  S  G  W  A  L  A  L  C  R  W      p.120

          .         .         .          | 05        .         .    g.11509
 GCCTCTTCCCTCCATGGGTCCCTGTTCCCCCATCTGTCT | CTCAGGAGCGAAGATCTGATC    c.420
 A  S  S  L  H  G  S  L  F  P  H  L  S   | L  R  S  E  D  L  I      p.140

          .         .       | 06 .         .         .         .    g.11813
 GCTGAATTTGCCCAAGTCACAAATTG | GTCCAGCTGCTGCTTGCGTGTCTTTGCATGGCAC    c.480
 A  E  F  A  Q  V  T  N  W  |  S  S  C  C  L  R  V  F  A  W  H      p.160

          .         .         .         .         .         .       g.11873
 CCCCACACCAACAAGTTTGCAGTGGCCCTGCTAGATGACTCAGTCCGTGTGTATAATGCC       c.540
 P  H  T  N  K  F  A  V  A  L  L  D  D  S  V  R  V  Y  N  A         p.180

       | 07  .         .         .         .         .         .    g.12242
 AGCAG | CACCATAGTCCCCTCCCTGAAGCACCGGCTGCAGCGAAATGTGGCGTCTCTGGCC    c.600
 S  S  |  T  I  V  P  S  L  K  H  R  L  Q  R  N  V  A  S  L  A      p.200

          .         .         .         .         .         .       g.12302
 TGGAAGCCCCTTAGTGCCTCTGTCTTGGCTGTGGCCTGCCAGAGCTGCATTCTTATCTGG       c.660
 W  K  P  L  S  A  S  V  L  A  V  A  C  Q  S  C  I  L  I  W         p.220

          .         .          | 08        .         .         .    g.16938
 ACCCTGGACCCTACCTCCTTGTCTACCCG | ACCCTCTTCTGGCTGTGCCCAAGTGCTGTCT    c.720
 T  L  D  P  T  S  L  S  T  R  |  P  S  S  G  C  A  Q  V  L  S      p.240

          .         .         .         .         .         .       g.16998
 CACCCTGGGCATACACCTGTTACCAGCTTGGCCTGGGCCCCCAGTGGGGGGCGGCTGCTC       c.780
 H  P  G  H  T  P  V  T  S  L  A  W  A  P  S  G  G  R  L  L         p.260

          .         .         . | 09       .         .         .    g.17377
 TCAGCTTCACCCGTGGATGCTGCTATCCGG | GTATGGGATGTCTCAACAGAGACCTGTGTC    c.840
 S  A  S  P  V  D  A  A  I  R   | V  W  D  V  S  T  E  T  C  V      p.280

          .         .         .         .         .         .       g.17437
 CCCCTTCCCTGGTTCCGAGGAGGTGGGGTGACCAACCTGCTCTGGTCCCCAGACGGCAGC       c.900
 P  L  P  W  F  R  G  G  G  V  T  N  L  L  W  S  P  D  G  S         p.300

          .         .         .      | 10  .         .         .    g.17633
 AAAATCCTGGCTACCACTCCTTCAGCTGTCTTTCG | AGTCTGGGAGGCCCAGATGTGGACT    c.960
 K  I  L  A  T  T  P  S  A  V  F  R  |  V  W  E  A  Q  M  W  T      p.320

          .         .         .       | 11 .         .         .    g.17837
 TGTGAGAGGTGGCCTACTCTATCAGGGCGCTGTCAG | ACTGGCTGCTGGAGCCCAGATGGC    c.1020
 C  E  R  W  P  T  L  S  G  R  C  Q   | T  G  C  W  S  P  D  G      p.340

          .         .         .         .         .         .       g.17897
 AGCCGACTGCTGTTCACTGTATTGGGAGAGCCACTGATTTACTCCCTGTCTTTTCCAGAA       c.1080
 S  R  L  L  F  T  V  L  G  E  P  L  I  Y  S  L  S  F  P  E         p.360

         | 12.         .         .         .         .         .    g.18153
 CGTTGTG | GTGAGGGAAAGGGGTGCGTTGGAGGTGCAAAGTCAGCAACGATTGTGGCAGAT    c.1140
 R  C  G |   E  G  K  G  C  V  G  G  A  K  S  A  T  I  V  A  D      p.380

          .         .         .         .  | 13      .         .    g.18298
 CTGTCTGAGACAACAATACAGACACCAGATGGTGAGGAGAG | GCTTGGGGGAGAGGCTCAC    c.1200
 L  S  E  T  T  I  Q  T  P  D  G  E  E  R  |  L  G  G  E  A  H      p.400

          .         .         .         .          | 14        .    g.18506
 TCCATGGTCTGGGACCCCAGTGGGGAACGTCTGGCTGTGCTTATGAAAG | GAAAGCCAAGG    c.1260
 S  M  V  W  D  P  S  G  E  R  L  A  V  L  M  K  G |   K  P  R      p.420

          .         .         .         .         .         .       g.18566
 GTACAGGATGGTAAACCAGTCATCCTCCTTTTTCGCACTCGAAACAGCCCTGTGTTTGAG       c.1320
 V  Q  D  G  K  P  V  I  L  L  F  R  T  R  N  S  P  V  F  E         p.440

          .  | 15      .         .         .         .         .    g.18748
 CTCCTTCCCTG | TGGCATTATCCAGGGGGAGCCAGGAGCCCAGCCCCAGCTCATCACTTTC    c.1380
 L  L  P  C  |  G  I  I  Q  G  E  P  G  A  Q  P  Q  L  I  T  F      p.460

          .         .         .       | 16 .         .         .    g.18939
 CATCCTTCCTTCAACAAAGGGGCCCTGCTCAGTGTG | GGCTGGTCCACAGGCCGAATTGCC    c.1440
 H  P  S  F  N  K  G  A  L  L  S  V   | G  W  S  T  G  R  I  A      p.480

          .         .         .         .         .         .       g.18999
 CACATCCCGCTGTACTTTGTCAATGCCCAGTTTCCACGTTTTAGCCCAGTGCTTGGGCGG       c.1500
 H  I  P  L  Y  F  V  N  A  Q  F  P  R  F  S  P  V  L  G  R         p.500

          .         .         .         .         .         .       g.19059
 GCCCAGGAACCCCCTGCTGGGGGTGGAGGCTCTATTCATGACCTGCCCCTCTTTACTGAG       c.1560
 A  Q  E  P  P  A  G  G  G  G  S  I  H  D  L  P  L  F  T  E         p.520

          .         .         .         .         .         .       g.19119
 ACATCCCCAACCTCTGCCCCTTGGGACCCTCTCCCAGGGCCACCACCTGTTCTGCCCCAC       c.1620
 T  S  P  T  S  A  P  W  D  P  L  P  G  P  P  P  V  L  P  H         p.540

          .         .                                               g.19140
 TCCCCACATTCCCACCTCTAA                                              c.1641
 S  P  H  S  H  L  X                                                p.546

          .         .         .                                     g.19173
 gaataaataagttttccttttgttttccactca                                  c.*33

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Achalasia, adrenocortical insufficiency, alacrimia protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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