aminoadipate aminotransferase (AADAT) - coding DNA reference sequence

(used for variant description)

(last modified April 20, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_016228.3 in the AADAT gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering AADAT transcript NM_016228.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5231
                   aggccacggcgcggggcgggagggggcgcggcgaggcccgcg       c.-301

 .         .         .         .         .         .                g.5291
 gcggggcaaaaccggcctgggccctggcggccgcaggagcgcgtgcggcgtggactttgc       c.-241

 .         .         .         .         .         .                g.5351
 cgggctcgccacacagccccagacccgtttaggaccgggagaccgaacgcagcgtccagc       c.-181

 .         .         .         .         .         .                g.5411
 cggggagtttcggcggcgttctccgggcaccgcgcgcgggaagccagacgcagcgggggg       c.-121

 .         .         .         .         .         .                g.5471
 acacatctcgcggtggcgttgccagagtgaggagttagcaggcaggacttgacgaggctc       c.-61

 .         .         .         .         .         .                g.5531
 tttggtttttctagtcctcaaccactgaagaagaagcttgatgcttggctgtcagaagac       c.-1

          .         .         .         .         .         .       g.5591
 ATGAATTACGCACGGTTCATCACGGCAGCGAGCGCAGCCAGAAACCCTTCTCCCATCCGG       c.60
 M  N  Y  A  R  F  I  T  A  A  S  A  A  R  N  P  S  P  I  R         p.20

         | 02.         .         .         .         .         .    g.6710
 ACCATGA | CTGACATATTGAGCAGAGGACCAAAATCGATGATCTCCTTGGCTGGTGGCTTA    c.120
 T  M  T |   D  I  L  S  R  G  P  K  S  M  I  S  L  A  G  G  L      p.40

          .         .         .         .         .         .       g.6770
 CCAAATCCAAACATGTTTCCTTTTAAGACTGCCGTAATCACTGTAGAAAATGGAAAGACC       c.180
 P  N  P  N  M  F  P  F  K  T  A  V  I  T  V  E  N  G  K  T         p.60

          .         .         .         .         .       | 03 .    g.7977
 ATCCAATTTGGAGAAGAGATGATGAAGAGAGCACTTCAGTATTCTCCGAGTGCTGG | AATT    c.240
 I  Q  F  G  E  E  M  M  K  R  A  L  Q  Y  S  P  S  A  G  |  I      p.80

          .         .         .         .         .         .       g.8037
 CCAGAGCTTTTGTCCTGGCTAAAACAGTTACAAATAAAATTGCATAATCCTCCTACCATC       c.300
 P  E  L  L  S  W  L  K  Q  L  Q  I  K  L  H  N  P  P  T  I         p.100

          .         .         .         .         .         .       g.8097
 CATTACCCACCCAGTCAAGGACAAATGGATCTATGTGTCACATCTGGCAGCCAACAAGGT       c.360
 H  Y  P  P  S  Q  G  Q  M  D  L  C  V  T  S  G  S  Q  Q  G         p.120

           | 04        .         .         .         .         .    g.16689
 CTTTGTAAG | GTGTTTGAAATGATCATTAATCCTGGAGATAATGTCCTCCTAGATGAACCT    c.420
 L  C  K   | V  F  E  M  I  I  N  P  G  D  N  V  L  L  D  E  P      p.140

          .         .     | 05   .         .         .         .    g.21912
 GCTTATTCAGGAACTCTTCAAAGT | CTGCACCCACTGGGCTGCAACATTATTAATGTTGCC    c.480
 A  Y  S  G  T  L  Q  S   | L  H  P  L  G  C  N  I  I  N  V  A      p.160

          .         .         .         .         .         .       g.21972
 AGTGATGAAAGTGGGATTGTTCCAGATTCCCTAAGAGACATACTTTCCAGATGGAAACCA       c.540
 S  D  E  S  G  I  V  P  D  S  L  R  D  I  L  S  R  W  K  P         p.180

          .         .         .         .         .         .       g.22032
 GAAGATGCAAAGAATCCCCAGAAAAACACCCCCAAATTTCTTTATACTGTTCCAAATGGC       c.600
 E  D  A  K  N  P  Q  K  N  T  P  K  F  L  Y  T  V  P  N  G         p.200

          .         .         .         .         .     | 06   .    g.24575
 AACAACCCTACTGGAAACTCATTAACCAGTGAACGCAAAAAGGAAATCTATGAG | CTTGCA    c.660
 N  N  P  T  G  N  S  L  T  S  E  R  K  K  E  I  Y  E   | L  A      p.220

          .         .         .         .         .         .       g.24635
 AGAAAATATGATTTCCTCATAATAGAAGATGATCCTTACTATTTTCTCCAGTTTAACAAG       c.720
 R  K  Y  D  F  L  I  I  E  D  D  P  Y  Y  F  L  Q  F  N  K         p.240

  | 07       .         .         .         .         .         .    g.26051
  | TTCAGGGTACCAACATTTCTTTCCATGGATGTTGATGGACGTGTCATCAGAGCTGACTCT    c.780
  | F  R  V  P  T  F  L  S  M  D  V  D  G  R  V  I  R  A  D  S      p.260

          .         .    | 08    .         .         .         .    g.26571
 TTTTCAAAAATCATTTCCTCTGG | GTTGAGAATAGGATTTTTAACTGGTCCAAAACCCTTA    c.840
 F  S  K  I  I  S  S  G  |  L  R  I  G  F  L  T  G  P  K  P  L      p.280

          .         .         .         .         .         .       g.26631
 ATAGAGAGAGTTATTTTACACATACAAGTTTCAACATTGCACCCCAGCACTTTTAACCAG       c.900
 I  E  R  V  I  L  H  I  Q  V  S  T  L  H  P  S  T  F  N  Q         p.300

  | 09       .         .         .         .         .         .    g.27893
  | CTCATGATATCACAGCTTCTACACGAATGGGGAGAAGAAGGTTTCATGGCTCATGTAGAC    c.960
  | L  M  I  S  Q  L  L  H  E  W  G  E  E  G  F  M  A  H  V  D      p.320

    | 10     .         .         .         .         .         .    g.28801
 AG | GGTTATTGATTTCTATAGTAACCAGAAGGATGCAATACTGGCAGCTGCAGACAAGTGG    c.1020
 R  |  V  I  D  F  Y  S  N  Q  K  D  A  I  L  A  A  A  D  K  W      p.340

         | 11.         .         .         .         .         .    g.30449
 TTAACTG | GTTTGGCAGAATGGCATGTTCCTGCTGCTGGAATGTTTTTATGGATTAAAGTT    c.1080
 L  T  G |   L  A  E  W  H  V  P  A  A  G  M  F  L  W  I  K  V      p.360

          .         .         .         .         .     | 12   .    g.33234
 AAAGGCATTAATGATGTAAAAGAACTGATTGAAGAAAAGGCCGTTAAGATGGGG | GTATTA    c.1140
 K  G  I  N  D  V  K  E  L  I  E  E  K  A  V  K  M  G   | V  L      p.380

          .         .         .         .         .         .       g.33294
 ATGCTCCCTGGAAATGCTTTCTACGTCGATAGCTCAGCTCCTAGCCCTTACTTGAGAGCA       c.1200
 M  L  P  G  N  A  F  Y  V  D  S  S  A  P  S  P  Y  L  R  A         p.400

          .         .         .       | 13 .         .         .    g.34276
 TCCTTCTCTTCAGCTTCTCCAGAACAGATGGATGTG | GCCTTCCAGGTATTAGCACAACTT    c.1260
 S  F  S  S  A  S  P  E  Q  M  D  V   | A  F  Q  V  L  A  Q  L      p.420

          .                                                         g.34294
 ATAAAAGAATCTTTATGA                                                 c.1278
 I  K  E  S  L  X                                                   p.425

          .         .         .         .         .         .       g.34354
 agaaattaaactaggttgggcatggtggctcacacctataatcccagcactttgggaggc       c.*60

          .         .         .         .         .         .       g.34414
 agaggagggaggatcacttgaacccaggaattcaaggctgcagtaagctacgatcacacc       c.*120

          .         .         .         .         .         .       g.34474
 actgcactctggcctgcatgcactctggcctgcatggcagaacaagaccctgtctctaaa       c.*180

          .         .         .         .         .         .       g.34534
 aaaagagaaagaaatcaaactaatcatgctgctcatggatttttccaataaatttcttgt       c.*240

          .         .         .         .         .         .       g.34594
 tttggcaggaagaaatgaacactggtattagacttaaagattaaatttcctcaaacatgt       c.*300

          .         .         .         .         .         .       g.34654
 cctatctgtagtagttcaactagacaccttttaaagtgcctctaaattcatcagatggcc       c.*360

          .         .         .         .         .         .       g.34714
 aaactgtatttataatccacttaggcattttgaaaaactttcaacctgtaaaaagttact       c.*420

          .         .         .         .         .         .       g.34774
 tttatcttggatttattatgaagaactttgtagttgctttgtaatttcccataaattgtc       c.*480

          .         .         .         .         .         .       g.34834
 tttgaaactaacattttacactgaattattttgagattttaaagaagtaattaagtgcaa       c.*540

          .         .         .         .         .         .       g.34894
 aatggtatataatgtgtactttttctacttttaggaaaatttaatgagagcttattgcaa       c.*600

          .         .         .         .         .         .       g.34954
 aaattgttataatttggtcattataagtgacttttagtaaaagtaccataaaccttatgt       c.*660

          .         .         .         .                           g.35000
 tatgccacagaaattcctttaaaataaaattcttaaactaaacata                     c.*706

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Aminoadipate aminotransferase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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