alanyl-tRNA synthetase (AARS) - coding DNA reference sequence

(used for variant description)

(last modified June 29, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001605.2 in the AARS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023191.1, covering AARS transcript NM_001605.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           ggtacagctgcgcgtctgcgggaataggtgcagcgggcccttggcggggg       c.-61

 .         .         .         .         | 02         .             g.11746
 actctgagggaggagctggggacggcgaccctaggagag | ttctttggggtgactttcaag    c.-1

          .         .         .         .         .         .       g.11806
 ATGGACTCTACTCTAACAGCAAGTGAAATCCGGCAGCGATTTATAGATTTCTTCAAGAGG       c.60
 M  D  S  T  L  T  A  S  E  I  R  Q  R  F  I  D  F  F  K  R         p.20

          .         .         .         .         .         .       g.11866
 AACGAGCATACGTATGTTCACTCGTCTGCCACCATCCCATTGGATGACCCCACTTTGCTC       c.120
 N  E  H  T  Y  V  H  S  S  A  T  I  P  L  D  D  P  T  L  L         p.40

          .         .     | 03   .         .         .         .    g.17391
 TTTGCCAATGCAGGCATGAACCAG | TTTAAACCCATTTTCCTGAACACAATTGACCCATCT    c.180
 F  A  N  A  G  M  N  Q   | F  K  P  I  F  L  N  T  I  D  P  S      p.60

          .         .         .         .         .         .       g.17451
 CACCCCATGGCAAAGCTGAGCAGAGCTGCCAATACCCAGAAGTGCATCCGGGCTGGGGGC       c.240
 H  P  M  A  K  L  S  R  A  A  N  T  Q  K  C  I  R  A  G  G         p.80

          .         .         .         .         .         .       g.17511
 AAACATAATGACCTGGACGATGTGGGCAAGGATGTCTATCATCACACCTTCTTCGAGATG       c.300
 K  H  N  D  L  D  D  V  G  K  D  V  Y  H  H  T  F  F  E  M         p.100

          .         .         .    | 04    .         .         .    g.17905
 CTGGGCTCTTGGTCTTTTGGAGATTACTTTAAG | GAATTGGCATGTAAGATGGCTCTGGAA    c.360
 L  G  S  W  S  F  G  D  Y  F  K   | E  L  A  C  K  M  A  L  E      p.120

          .         .         .         .         .         .       g.17965
 CTCCTCACCCAAGAGTTTGGCATTCCCATTGAAAGACTTTATGTTACTTACTTTGGCGGG       c.420
 L  L  T  Q  E  F  G  I  P  I  E  R  L  Y  V  T  Y  F  G  G         p.140

          .         .         .         .         .          | 05    g.22538
 GATGAAGCAGCTGGCTTAGAAGCAGATCTGGAATGCAAACAGATCTGGCAAAATTTGGG | G    c.480
 D  E  A  A  G  L  E  A  D  L  E  C  K  Q  I  W  Q  N  L  G  |      p.160

          .         .         .         .         .         .       g.22598
 CTGGATGACACCAAAATCCTCCCAGGCAACATGAAGGATAACTTCTGGGAGATGGGTGAC       c.540
 L  D  D  T  K  I  L  P  G  N  M  K  D  N  F  W  E  M  G  D         p.180

          .         .         .         .         .         .       g.22658
 ACGGGCCCCTGTGGTCCTTGCAGTGAGATCCACTACGACCGGATTGGTGGTCGGGACGCC       c.600
 T  G  P  C  G  P  C  S  E  I  H  Y  D  R  I  G  G  R  D  A         p.200

          .         .         .         .         .         .       g.22718
 GCACATCTTGTCAACCAGGACGACCCTAATGTGCTGGAGATCTGGAACCTTGTGTTCATC       c.660
 A  H  L  V  N  Q  D  D  P  N  V  L  E  I  W  N  L  V  F  I         p.220

          .  | 06      .         .         .         .         .    g.24218
 CAGTATAACAG | GGAAGCTGATGGCATTCTGAAACCTCTTCCCAAGAAAAGCATTGACACA    c.720
 Q  Y  N  R  |  E  A  D  G  I  L  K  P  L  P  K  K  S  I  D  T      p.240

          .         .         .         .         .         .       g.24278
 GGGATGGGCCTGGAACGACTGGTATCTGTGCTGCAGAATAAGATGTCCAACTATGACACT       c.780
 G  M  G  L  E  R  L  V  S  V  L  Q  N  K  M  S  N  Y  D  T         p.260

          .         .         .       | 07 .         .         .    g.24770
 GACCTTTTTGTCCCTTACTTTGAAGCCATTCAGAAG | GGCACAGGTGCCCGACCATACACT    c.840
 D  L  F  V  P  Y  F  E  A  I  Q  K   | G  T  G  A  R  P  Y  T      p.280

          .         .         .         .         .         .       g.24830
 GGGAAAGTTGGTGCTGAGGATGCCGATGGGATTGACATGGCCTACCGGGTGCTGGCTGAC       c.900
 G  K  V  G  A  E  D  A  D  G  I  D  M  A  Y  R  V  L  A  D         p.300

          .         .         .         .         .         .       g.24890
 CACGCTCGGACCATCACTGTGGCACTGGCTGATGGTGGCCGGCCTGACAACACAGGGCGT       c.960
 H  A  R  T  I  T  V  A  L  A  D  G  G  R  P  D  N  T  G  R         p.320

    | 08     .         .         .         .         .         .    g.26188
 GG | ATATGTGTTGAGACGGATTCTCCGCCGAGCTGTCCGATACGCCCATGAAAAGCTCAAT    c.1020
 G  |  Y  V  L  R  R  I  L  R  R  A  V  R  Y  A  H  E  K  L  N      p.340

          .         .         .         .         .  | 09      .    g.26709
 GCCAGCAGGGGCTTCTTTGCTACGTTAGTGGATGTTGTCGTCCAGTCCCTG | GGAGATGCA    c.1080
 A  S  R  G  F  F  A  T  L  V  D  V  V  V  Q  S  L   | G  D  A      p.360

          .         .         .         .         .         .       g.26769
 TTTCCTGAGCTGAAGAAGGACCCAGACATGGTGAAGGACATCATTAATGAAGAAGAGGTG       c.1140
 F  P  E  L  K  K  D  P  D  M  V  K  D  I  I  N  E  E  E  V         p.380

          .         .         .         .         .         .       g.26829
 CAGTTTCTCAAGACTCTCAGCAGAGGGCGTCGCATCCTGGACAGGAAAATTCAGAGCCTG       c.1200
 Q  F  L  K  T  L  S  R  G  R  R  I  L  D  R  K  I  Q  S  L         p.400

          .         .   | 10     .         .         .         .    g.28885
 GGAGACAGCAAGACCATTCCCG | GAGACACTGCTTGGCTCCTCTATGACACCTATGGGTTT    c.1260
 G  D  S  K  T  I  P  G |   D  T  A  W  L  L  Y  D  T  Y  G  F      p.420

          .         .         .         .         .         .       g.28945
 CCAGTGGATCTGACTGGACTGATTGCTGAAGAGAAGGGCCTGGTGGTAGACATGGATGGC       c.1320
 P  V  D  L  T  G  L  I  A  E  E  K  G  L  V  V  D  M  D  G         p.440

          .         .        | 11.         .         .         .    g.29440
 TTTGAAGAGGAGAGGAAACTGGCCCAG | CTGAAATCACAGGGCAAGGGAGCTGGTGGGGAA    c.1380
 F  E  E  E  R  K  L  A  Q   | L  K  S  Q  G  K  G  A  G  G  E      p.460

          .         .         .         .         .         .       g.29500
 GACCTCATTATGCTGGACATTTACGCTATCGAAGAGCTCCGGGCACGGGGTCTGGAGGTC       c.1440
 D  L  I  M  L  D  I  Y  A  I  E  E  L  R  A  R  G  L  E  V         p.480

          .         .         .         .         .   | 12     .    g.31993
 ACAGATGATTCCCCAAAGTACAATTACCATTTGGACTCCAGTGGTAGCTATG | TATTTGAG    c.1500
 T  D  D  S  P  K  Y  N  Y  H  L  D  S  S  G  S  Y  V |   F  E      p.500

          .         .         .         .         .         .       g.32053
 AACACAGTGGCTACGGTGATGGCTCTGCGCAGGGAGAAGATGTTCGTGGAAGAGGTGTCC       c.1560
 N  T  V  A  T  V  M  A  L  R  R  E  K  M  F  V  E  E  V  S         p.520

          .         .         .         .         .         .       g.32113
 ACAGGCCAGGAGTGTGGAGTGGTGCTGGACAAGACCTGTTTCTATGCTGAGCAAGGAGGC       c.1620
 T  G  Q  E  C  G  V  V  L  D  K  T  C  F  Y  A  E  Q  G  G         p.540

          .         .         .         .         .  | 13      .    g.33361
 CAGATCTATGACGAAGGCTACCTGGTGAAGGTGGATGACAGCAGTGAAGAT | AAAACAGAG    c.1680
 Q  I  Y  D  E  G  Y  L  V  K  V  D  D  S  S  E  D   | K  T  E      p.560

          .         .         .         .         .         .       g.33421
 TTTACAGTGAAGAATGCTCAGGTCCGAGGAGGGTATGTGCTACACATTGGAACCATCTAC       c.1740
 F  T  V  K  N  A  Q  V  R  G  G  Y  V  L  H  I  G  T  I  Y         p.580

          .         .         .         .      | 14  .         .    g.35338
 GGTGACCTGAAAGTGGGGGATCAGGTCTGGCTGTTTATTGATGAG | CCCCGACGAAGACCC    c.1800
 G  D  L  K  V  G  D  Q  V  W  L  F  I  D  E   | P  R  R  R  P      p.600

          .         .         .         .         .         .       g.35398
 ATCATGAGCAACCACACAGCTACGCACATTCTGAACTTCGCCCTGCGCTCAGTGCTTGGG       c.1860
 I  M  S  N  H  T  A  T  H  I  L  N  F  A  L  R  S  V  L  G         p.620

          .         .         .         .         .         .       g.35458
 GAAGCTGACCAGAAAGGCTCATTGGTTGCTCCTGACCGCCTCAGATTTGACTTTACTGCC       c.1920
 E  A  D  Q  K  G  S  L  V  A  P  D  R  L  R  F  D  F  T  A         p.640

          .         .         .         .         .         .       g.35518
 AAGGGAGCCATGTCCACCCAACAGATCAAGAAGGCTGAAGAGATTGCTAATGAGATGATT       c.1980
 K  G  A  M  S  T  Q  Q  I  K  K  A  E  E  I  A  N  E  M  I         p.660

          .   | 15     .         .         .         .         .    g.36340
 GAGGCAGCCAAG | GCCGTCTATACCCAGGATTGCCCCCTGGCAGCAGCGAAAGCCATCCAG    c.2040
 E  A  A  K   | A  V  Y  T  Q  D  C  P  L  A  A  A  K  A  I  Q      p.680

          .         .         .         .         .         .       g.36400
 GGCCTACGGGCTGTGTTTGATGAGACCTATCCTGACCCTGTGCGAGTCGTCTCCATTGGG       c.2100
 G  L  R  A  V  F  D  E  T  Y  P  D  P  V  R  V  V  S  I  G         p.700

          .         .         .         .         .         .       g.36460
 GTCCCGGTGTCCGAGTTGCTGGATGACCCCTCTGGGCCTGCTGGCTCCCTGACTTCTGTT       c.2160
 V  P  V  S  E  L  L  D  D  P  S  G  P  A  G  S  L  T  S  V         p.720

          .        | 16.         .         .         .         .    g.38716
 GAGTTCTGTGGGGGAAC | GCACCTGCGGAACTCGAGTCATGCAGGAGCTTTTGTGATCGTG    c.2220
 E  F  C  G  G  T  |  H  L  R  N  S  S  H  A  G  A  F  V  I  V      p.740

          .         .         .         .         .         .       g.38776
 ACGGAAGAAGCCATTGCCAAGGGTATCCGGAGGATTGTGGCTGTCACAGGTGCCGAGGCC       c.2280
 T  E  E  A  I  A  K  G  I  R  R  I  V  A  V  T  G  A  E  A         p.760

        | 17 .         .         .         .         .         .    g.39829
 CAGAAG | GCCCTCAGGAAAGCAGAGAGCTTGAAGAAATGTCTCTCTGTCATGGAAGCCAAA    c.2340
 Q  K   | A  L  R  K  A  E  S  L  K  K  C  L  S  V  M  E  A  K      p.780

          .         .         .         .         .         .       g.39889
 GTGAAGGCTCAGACTGCTCCAAACAAGGATGTGCAGAGGGAGATCGCTGACCTTGGAGAG       c.2400
 V  K  A  Q  T  A  P  N  K  D  V  Q  R  E  I  A  D  L  G  E         p.800

  | 18       .         .         .         .         .         .    g.40531
  | GCCCTGGCCACTGCAGTCATCCCCCAGTGGCAGAAGGATGAATTGCGGGAGACTCTCAAA    c.2460
  | A  L  A  T  A  V  I  P  Q  W  Q  K  D  E  L  R  E  T  L  K      p.820

          .         .         .         .         .         .       g.40591
 TCCCTAAAGAAGGTCATGGATGACTTGGACCGAGCCAGCAAAGCCGATGTCCAGAAACGA       c.2520
 S  L  K  K  V  M  D  D  L  D  R  A  S  K  A  D  V  Q  K  R         p.840

  | 19       .         .         .         .         .         .    g.40769
  | GTGTTAGAGAAGACGAAGCAGTTCATCGACAGCAACCCCAACCAGCCTCTTGTCATCCTG    c.2580
  | V  L  E  K  T  K  Q  F  I  D  S  N  P  N  Q  P  L  V  I  L      p.860

          .         .        | 20.         .         .         .    g.41161
 GAGATGGAGAGCGGCGCCTCAGCCAAG | GCCCTGAATGAAGCCTTGAAGCTCTTCAAGATG    c.2640
 E  M  E  S  G  A  S  A  K   | A  L  N  E  A  L  K  L  F  K  M      p.880

          .         .         .         .         .         .       g.41221
 CACTCCCCTCAGACTTCTGCCATGCTCTTCACGGTGGACAATGAGGCTGGCAAGATCACG       c.2700
 H  S  P  Q  T  S  A  M  L  F  T  V  D  N  E  A  G  K  I  T         p.900

          .         .  | 21      .         .         .         .    g.41642
 TGCCTGTGTCAAGTTCCCCAG | AATGCAGCCAATCGGGGCTTAAAAGCCAGCGAGTGGGTG    c.2760
 C  L  C  Q  V  P  Q   | N  A  A  N  R  G  L  K  A  S  E  W  V      p.920

          .         .         .         .         .         .       g.41702
 CAGCAGGTGTCAGGCTTGATGGACGGTAAAGGTGGTGGCAAGGATGTGTCTGCACAGGCC       c.2820
 Q  Q  V  S  G  L  M  D  G  K  G  G  G  K  D  V  S  A  Q  A         p.940

          .         .         .         .         .         .       g.41762
 ACAGGCAAGAACGTTGGCTGCCTGCAGGAGGCGCTGCAGCTGGCCACTTCCTTCGCCCAG       c.2880
 T  G  K  N  V  G  C  L  Q  E  A  L  Q  L  A  T  S  F  A  Q         p.960

          .         .                                               g.41789
 CTGCGCCTCGGGGATGTAAAGAACTGA                                        c.2907
 L  R  L  G  D  V  K  N  X                                          p.968

          .         .         .         .         .         .       g.41849
 gtggggaaggaggaggctcccactggatccatccgtccagccaagagctcttcatctgct       c.*60

          .         .         .         .         .         .       g.41909
 acaagaacatttgaatcttgggacctttaaagagcccctcctaacccagcagtaactgga       c.*120

          .         .         .         .         .         .       g.41969
 acacacttgggagcagtcctatgtctcagtgccccttaaatttctgccctgagccctcca       c.*180

          .         .         .         .         .         .       g.42029
 cgtcagtgccatcggtctagaaccactaaccccgcattgctgttgatcgtcacgctcgca       c.*240

          .         .         .         .         .         .       g.42089
 tctatagataacggctctccagacctgagctttccgcgtcagcaagtaggaatcgttttt       c.*300

          .         .                                               g.42116
 gctgcagagaataaaaggaccacgtgc                                        c.*327

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Alanyl-tRNA synthetase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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