ATP-binding cassette, sub-family B (MDR/TAP), member 7 (ABCB7) - coding DNA reference sequence

(used for variant description)

(last modified November 17, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_004299.4 in the ABCB7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007980.1, covering ABCB7 transcript NM_004299.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.4965
                                                     aggtagcc       c.-61

 .         .         .         .         .         .                g.5025
 gaattcagtccgccagtgtcccataatcctcttctctcggttcctctttcctcgctcaag       c.-1

          .         .         .         .         .         .       g.5085
 ATGGCGCTGCTCGCGATGCATTCTTGGCGCTGGGCGGCCGCGGCGGCTGCTTTCGAAAAG       c.60
 M  A  L  L  A  M  H  S  W  R  W  A  A  A  A  A  A  F  E  K         p.20

          .         .         .         .         .         .       g.5145
 CGCCGGCACTCCGCGATTCTGATCCGGCCTTTAGTCTCTGTTAGCGGCTCAGGTCCGCAG       c.120
 R  R  H  S  A  I  L  I  R  P  L  V  S  V  S  G  S  G  P  Q         p.40

          .         .         .         .         | 02         .    g.46475
 TGGAGGCCACATCAACTCGGCGCCTTGGGAACCGCTCGAGCCTACCAG | CAGATTCCAGAG    c.180
 W  R  P  H  Q  L  G  A  L  G  T  A  R  A  Y  Q   | Q  I  P  E      p.60

          .         .         .         .         .         .       g.46535
 TCATTAAAAAGTATCACATGGCAGAGATTGGGAAAAGGCAATTCAGGACAGTTCTTAGAT       c.240
 S  L  K  S  I  T  W  Q  R  L  G  K  G  N  S  G  Q  F  L  D         p.80

           | 03        .         .         .         .         .    g.48376
 GCTGCAAAG | GCTCTCCAGGTATGGCCACTGATAGAAAAGAGGACATGTTGGCATGGTCAT    c.300
 A  A  K   | A  L  Q  V  W  P  L  I  E  K  R  T  C  W  H  G  H      p.100

          .         .         .       | 04 .         .         .    g.62260
 GCAGGAGGAGGACTCCACACAGACCCAAAAGAAGGG | TTAAAAGATGTTGATACTCGGAAA    c.360
 A  G  G  G  L  H  T  D  P  K  E  G   | L  K  D  V  D  T  R  K      p.120

          .         .         .         .         .         .       g.62320
 ATCATAAAAGCAATGCTTTCTTATGTGTGGCCCAAAGACAGGCCAGATCTACGAGCTAGA       c.420
 I  I  K  A  M  L  S  Y  V  W  P  K  D  R  P  D  L  R  A  R         p.140

          .         .         .       | 05 .         .         .    g.84667
 GTTGCCATTTCGCTGGGATTTTTGGGTGGTGCAAAG | GCCATGAATATTGTGGTTCCCTTC    c.480
 V  A  I  S  L  G  F  L  G  G  A  K   | A  M  N  I  V  V  P  F      p.160

          .         .         .         .         .         .       g.84727
 ATGTTTAAATATGCTGTAGACAGCCTCAACCAGATGTCGGGAAACATGCTGAACCTGAGT       c.540
 M  F  K  Y  A  V  D  S  L  N  Q  M  S  G  N  M  L  N  L  S         p.180

          .         .         .         .          | 06        .    g.85678
 GATGCACCAAATACAGTTGCAACCATGGCAACAGCAGTTCTGATTGGCT | ATGGTGTATCA    c.600
 D  A  P  N  T  V  A  T  M  A  T  A  V  L  I  G  Y |   G  V  S      p.200

          .         .         .         .         .         .       g.85738
 AGAGCTGGAGCTGCTTTTTTTAACGAAGTTCGAAATGCAGTATTTGGCAAGGTAGCCCAG       c.660
 R  A  G  A  A  F  F  N  E  V  R  N  A  V  F  G  K  V  A  Q         p.220

          .         .         .         .         .         .       g.85798
 AATTCAATCCGAAGAATAGCCAAAAATGTCTTTCTCCATCTTCACAACCTGGATCTGGGT       c.720
 N  S  I  R  R  I  A  K  N  V  F  L  H  L  H  N  L  D  L  G         p.240

          .         .         .         .         .         .       g.85858
 TTTCACCTGAGCAGACAGACGGGAGCTTTATCTAAGGCTATTGACAGAGGAACAAGGGGT       c.780
 F  H  L  S  R  Q  T  G  A  L  S  K  A  I  D  R  G  T  R  G         p.260

          .         .         .         .         .         .       g.85918
 ATCAGTTTTGTCCTGAGTGCTTTGGTATTTAATCTTCTTCCCATCATGTTTGAAGTGATG       c.840
 I  S  F  V  L  S  A  L  V  F  N  L  L  P  I  M  F  E  V  M         p.280

          .         | 07         .         .         .         .    g.87383
 CTTGTCAGTGGTGTTTTG | TATTACAAATGCGGTGCCCAGTTTGCTTTGGTAACCCTTGGA    c.900
 L  V  S  G  V  L   | Y  Y  K  C  G  A  Q  F  A  L  V  T  L  G      p.300

          .         .         .         .        | 08.         .    g.87534
 ACACTTGGTACATACACAGCATTCACAGTTGCAGTCACACGGTGGAG | AACTAGATTTAGA    c.960
 T  L  G  T  Y  T  A  F  T  V  A  V  T  R  W  R  |  T  R  F  R      p.320

          .         .         .         .         .         .       g.87594
 ATAGAAATGAACAAAGCAGATAATGATGCAGGTAATGCTGCTATAGACTCACTGCTGAAT       c.1020
 I  E  M  N  K  A  D  N  D  A  G  N  A  A  I  D  S  L  L  N         p.340

          .      | 09  .         .         .         .         .    g.89659
 TATGAAACTGTGAAG | TATTTTAATAATGAAAGATATGAAGCACAGAGATATGATGGATTT    c.1080
 Y  E  T  V  K   | Y  F  N  N  E  R  Y  E  A  Q  R  Y  D  G  F      p.360

          .         .         .         .         .         .       g.89719
 TTGAAGACGTATGAGACTGCTTCATTGAAAAGTACCTCTACTCTGGCTATGCTGAACTTT       c.1140
 L  K  T  Y  E  T  A  S  L  K  S  T  S  T  L  A  M  L  N  F         p.380

          .         .         .         .         .         .       g.89779
 GGTCAAAGTGCTATTTTCAGTGTCGGTTTAACAGCTATAATGGTGCTCGCCAGTCAGGGA       c.1200
 G  Q  S  A  I  F  S  V  G  L  T  A  I  M  V  L  A  S  Q  G         p.400

          . | 10       .         .         .         .         .    g.90825
 ATTGTGGCAG | GTACCCTTACTGTTGGAGATCTAGTAATGGTGAATGGACTGCTTTTTCAG    c.1260
 I  V  A  G |   T  L  T  V  G  D  L  V  M  V  N  G  L  L  F  Q      p.420

          .         .         .         .         .         .       g.90885
 CTTTCATTACCCCTGAACTTTCTGGGAACTGTATATAGAGAGACTAGACAAGCACTCATA       c.1320
 L  S  L  P  L  N  F  L  G  T  V  Y  R  E  T  R  Q  A  L  I         p.440

          .         .         .         .         | 11         .    g.91855
 GATATGAACACCTTGTTTACTCTACTCAAGGTAGACACCCAAATTAAA | GACAAAGTGATG    c.1380
 D  M  N  T  L  F  T  L  L  K  V  D  T  Q  I  K   | D  K  V  M      p.460

          .         .         .         .         .         .       g.91915
 GCATCTCCCCTTCAGATCACACCACAGACAGCTACCGTGGCCTTTGATAATGTGCATTTT       c.1440
 A  S  P  L  Q  I  T  P  Q  T  A  T  V  A  F  D  N  V  H  F         p.480

          .         .         .         .         .         .       g.91975
 GAATACATTGAGGGCCAGAAAGTCCTTAGTGGAATATCCTTTGAAGTCCCTGCAGGAAAG       c.1500
 E  Y  I  E  G  Q  K  V  L  S  G  I  S  F  E  V  P  A  G  K         p.500

          .         .         .   | 12     .         .         .    g.92189
 AAAGTGGCCATTGTAGGAGGTAGTGGGTCAGG | GAAAAGCACAATAGTGAGGCTATTATTT    c.1560
 K  V  A  I  V  G  G  S  G  S  G  |  K  S  T  I  V  R  L  L  F      p.520

          .         .         .         .         .         .       g.92249
 CGCTTCTATGAGCCTCAAAAGGGTAGCATTTATCTTGCTGGTCAAAATATACAAGATGTG       c.1620
 R  F  Y  E  P  Q  K  G  S  I  Y  L  A  G  Q  N  I  Q  D  V         p.540

          .         .         .         .   | 13     .         .    g.96074
 AGCCTGGAAAGCCTTCGGAGGGCAGTGGGAGTGGTACCTCAG | GATGCTGTCCTCTTCCAT    c.1680
 S  L  E  S  L  R  R  A  V  G  V  V  P  Q   | D  A  V  L  F  H      p.560

          .         .         .         .         .         .       g.96134
 AATACTATTTATTACAACCTCTTATATGGAAACATCAGTGCTTCACCTGAGGAAGTGTAT       c.1740
 N  T  I  Y  Y  N  L  L  Y  G  N  I  S  A  S  P  E  E  V  Y         p.580

          .         .         .         .         .         .       g.96194
 GCAGTGGCAAAATTAGCTGGACTTCATGATGCAATTCTTCGAATGCCACATGGATATGAC       c.1800
 A  V  A  K  L  A  G  L  H  D  A  I  L  R  M  P  H  G  Y  D         p.600

          .         .         .     | 14   .         .         .    g.98892
 ACCCAAGTAGGGGAACGAGGACTCAAGCTTTCAG | GAGGAGAAAAGCAAAGAGTAGCAATT    c.1860
 T  Q  V  G  E  R  G  L  K  L  S  G |   G  E  K  Q  R  V  A  I      p.620

          .         .         .         .         .         .       g.98952
 GCAAGAGCCATTTTGAAGGACCCCCCAGTCATACTCTATGATGAAGCTACTTCATCGTTA       c.1920
 A  R  A  I  L  K  D  P  P  V  I  L  Y  D  E  A  T  S  S  L         p.640

          .         | 15         .         .         .         .    g.101009
 GATTCGATTACTGAAGAG | ACTATTCTTGGTGCCATGAAGGATGTGGTCAAACACAGAACT    c.1980
 D  S  I  T  E  E   | T  I  L  G  A  M  K  D  V  V  K  H  R  T      p.660

          .         .         .         .         .         .       g.101069
 TCTATTTTCATTGCACACAGATTGTCAACAGTGGTTGATGCAGATGAAATCATTGTCTTG       c.2040
 S  I  F  I  A  H  R  L  S  T  V  V  D  A  D  E  I  I  V  L         p.680

        | 16 .         .         .         .         .         .    g.107766
 GATCAG | GGTAAGGTAGCCGAACGTGGTACCCACCATGGTTTGCTTGCTAACCCTCATAGT    c.2100
 D  Q   | G  K  V  A  E  R  G  T  H  H  G  L  L  A  N  P  H  S      p.700

          .         .         .         .         .         .       g.107826
 ATCTATTCAGAAATGTGGCATACACAGAGCAGCCGTGTGCAGAACCATGATAACCCCAAA       c.2160
 I  Y  S  E  M  W  H  T  Q  S  S  R  V  Q  N  H  D  N  P  K         p.720

          .         .         .         .         .         .       g.107886
 TGGGAAGCAAAGAAAGAAAATATATCCAAAGAGGAGGAAAGAAAGAAACTACAAGAAGAA       c.2220
 W  E  A  K  K  E  N  I  S  K  E  E  E  R  K  K  L  Q  E  E         p.740

          .         .         .         .                           g.107928
 ATTGTCAATAGTGTGAAAGGCTGTGGAAACTGTTCGTGCTAA                         c.2262
 I  V  N  S  V  K  G  C  G  N  C  S  C  X                           p.753

          .         .         .         .         .         .       g.107988
 gtcacataagacattttctttttttgttgttttggactacatatttgcactgaagcagaa       c.*60

          .         .         .         .         .         .       g.108048
 ttgttttattaaaaaaatcatacattcccattttctataatccttcttttagataagatt       c.*120

          .         .         .         .         .         .       g.108108
 tatttaaaaggggatttgagttttacatctttcatagtctatttaatgtggcatctgtat       c.*180

          .                                                         g.108126
 ttatccccaaattatttt                                                 c.*198

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ATP-binding cassette, sub-family B (MDR/TAP), member 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 25b
©2004-2020 Leiden University Medical Center