c-abl oncogene 1, non-receptor tyrosine kinase (ABL1) - coding DNA reference sequence

(used for variant description)

(last modified November 16, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_005157.4 in the ABL1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012034.1, covering ABL1 transcript NM_005157.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.126566
                                                          aaa       c.-1

          .         .         .         .         .         .       g.126626
 ATGTTGGAGATCTGCCTGAAGCTGGTGGGCTGCAAATCCAAGAAGGGGCTGTCCTCGTCC       c.60
 M  L  E  I  C  L  K  L  V  G  C  K  S  K  K  G  L  S  S  S         p.20

          .          | 02        .         .         .         .    g.145224
 TCCAGCTGTTATCTGGAAG | AAGCCCTTCAGCGGCCAGTAGCATCTGACTTTGAGCCTCAG    c.120
 S  S  C  Y  L  E  E |   A  L  Q  R  P  V  A  S  D  F  E  P  Q      p.40

          .         .         .         .         .         .       g.145284
 GGTCTGAGTGAAGCCGCTCGTTGGAACTCCAAGGAAAACCTTCTCGCTGGACCCAGTGAA       c.180
 G  L  S  E  A  A  R  W  N  S  K  E  N  L  L  A  G  P  S  E         p.60

          .         .         .         .         .         .       g.145344
 AATGACCCCAACCTTTTCGTTGCACTGTATGATTTTGTGGCCAGTGGAGATAACACTCTA       c.240
 N  D  P  N  L  F  V  A  L  Y  D  F  V  A  S  G  D  N  T  L         p.80

          .    | 03    .         .         .         .         .    g.145967
 AGCATAACTAAAG | GTGAAAAGCTCCGGGTCTTAGGCTATAATCACAATGGGGAATGGTGT    c.300
 S  I  T  K  G |   E  K  L  R  V  L  G  Y  N  H  N  G  E  W  C      p.100

          .         .         .         .         .         .       g.146027
 GAAGCCCAAACCAAAAATGGCCAAGGCTGGGTCCCAAGCAACTACATCACGCCAGTCAAC       c.360
 E  A  Q  T  K  N  G  Q  G  W  V  P  S  N  Y  I  T  P  V  N         p.120

          .         .         .         .         .         .       g.146087
 AGTCTGGAGAAACACTCCTGGTACCATGGGCCTGTGTCCCGCAATGCCGCTGAGTATCTG       c.420
 S  L  E  K  H  S  W  Y  H  G  P  V  S  R  N  A  A  E  Y  L         p.140

          .         .         .         .         .         .       g.146147
 CTGAGCAGCGGGATCAATGGCAGCTTCTTGGTGCGTGAGAGTGAGAGCAGTCCTGGCCAG       c.480
 L  S  S  G  I  N  G  S  F  L  V  R  E  S  E  S  S  P  G  Q         p.160

          .         .         .         .         .         .       g.146207
 AGGTCCATCTCGCTGAGATACGAAGGGAGGGTGTACCATTACAGGATCAACACTGCTTCT       c.540
 R  S  I  S  L  R  Y  E  G  R  V  Y  H  Y  R  I  N  T  A  S         p.180

           | 04        .         .         .         .         .    g.153933
 GATGGCAAG | CTCTACGTCTCCTCCGAGAGCCGCTTCAACACCCTGGCCGAGTTGGTTCAT    c.600
 D  G  K   | L  Y  V  S  S  E  S  R  F  N  T  L  A  E  L  V  H      p.200

          .         .         .         .         .         .       g.153993
 CATCATTCAACGGTGGCCGACGGGCTCATCACCACGCTCCATTATCCAGCCCCAAAGCGC       c.660
 H  H  S  T  V  A  D  G  L  I  T  T  L  H  Y  P  A  P  K  R         p.220

          .         .         .         .         .         .       g.154053
 AACAAGCCCACTGTCTATGGTGTGTCCCCCAACTACGACAAGTGGGAGATGGAACGCACG       c.720
 N  K  P  T  V  Y  G  V  S  P  N  Y  D  K  W  E  M  E  R  T         p.240

          .         .         .         .         .         .       g.154113
 GACATCACCATGAAGCACAAGCTGGGCGGGGGCCAGTACGGGGAGGTGTACGAGGGCGTG       c.780
 D  I  T  M  K  H  K  L  G  G  G  Q  Y  G  E  V  Y  E  G  V         p.260

          .         .         .         .   | 05     .         .    g.163266
 TGGAAGAAATACAGCCTGACGGTGGCCGTGAAGACCTTGAAG | GAGGACACCATGGAGGTG    c.840
 W  K  K  Y  S  L  T  V  A  V  K  T  L  K   | E  D  T  M  E  V      p.280

          .         .         .         .         .         .       g.163326
 GAAGAGTTCTTGAAAGAAGCTGCAGTCATGAAAGAGATCAAACACCCTAACCTGGTGCAG       c.900
 E  E  F  L  K  E  A  A  V  M  K  E  I  K  H  P  N  L  V  Q         p.300

         | 06.         .         .         .         .         .    g.164032
 CTCCTTG | GGGTCTGCACCCGGGAGCCCCCGTTCTATATCATCACTGAGTTCATGACCTAC    c.960
 L  L  G |   V  C  T  R  E  P  P  F  Y  I  I  T  E  F  M  T  Y      p.320

          .         .         .         .         .         .       g.164092
 GGGAACCTCCTGGACTACCTGAGGGAGTGCAACCGGCAGGAGGTGAACGCCGTGGTGCTG       c.1020
 G  N  L  L  D  Y  L  R  E  C  N  R  Q  E  V  N  A  V  V  L         p.340

          .         .         .         .         .         .       g.164152
 CTGTACATGGCCACTCAGATCTCGTCAGCCATGGAGTACCTGGAGAAGAAAAACTTCATC       c.1080
 L  Y  M  A  T  Q  I  S  S  A  M  E  Y  L  E  K  K  N  F  I         p.360

       | 07  .         .         .         .         .         .    g.166042
 CACAG | AGATCTTGCTGCCCGAAACTGCCTGGTAGGGGAGAACCACTTGGTGAAGGTAGCT    c.1140
 H  R  |  D  L  A  A  R  N  C  L  V  G  E  N  H  L  V  K  V  A      p.380

          .         .         .         .         .         .       g.166102
 GATTTTGGCCTGAGCAGGTTGATGACAGGGGACACCTACACAGCCCATGCTGGAGCCAAG       c.1200
 D  F  G  L  S  R  L  M  T  G  D  T  Y  T  A  H  A  G  A  K         p.400

          .         .         .         .         .         .       g.166162
 TTCCCCATCAAATGGACTGCACCCGAGAGCCTGGCCTACAACAAGTTCTCCATCAAGTCC       c.1260
 F  P  I  K  W  T  A  P  E  S  L  A  Y  N  K  F  S  I  K  S         p.420

          . | 08       .         .         .         .         .    g.169584
 GACGTCTGGG | CATTTGGAGTATTGCTTTGGGAAATTGCTACCTATGGCATGTCCCCTTAC    c.1320
 D  V  W  A |   F  G  V  L  L  W  E  I  A  T  Y  G  M  S  P  Y      p.440

          .         .         .         .         .         .       g.169644
 CCGGGAATTGACCTGTCCCAGGTGTATGAGCTGCTAGAGAAGGACTACCGCATGGAGCGC       c.1380
 P  G  I  D  L  S  Q  V  Y  E  L  L  E  K  D  Y  R  M  E  R         p.460

          .         .         .         .    | 09    .         .    g.171204
 CCAGAAGGCTGCCCAGAGAAGGTCTATGAACTCATGCGAGCAT | GTTGGCAGTGGAATCCC    c.1440
 P  E  G  C  P  E  K  V  Y  E  L  M  R  A  C |   W  Q  W  N  P      p.480

          .         .         .         .         .         .       g.171264
 TCTGACCGGCCCTCCTTTGCTGAAATCCACCAAGCCTTTGAAACAATGTTCCAGGAATCC       c.1500
 S  D  R  P  S  F  A  E  I  H  Q  A  F  E  T  M  F  Q  E  S         p.500

          .    | 10    .         .         .         .         .    g.171666
 AGTATCTCAGACG | AAGTGGAAAAGGAGCTGGGGAAACAAGGCGTCCGTGGGGCTGTGAGT    c.1560
 S  I  S  D  E |   V  E  K  E  L  G  K  Q  G  V  R  G  A  V  S      p.520

          .         .         .         .         .         .       g.171726
 ACCTTGCTGCAGGCCCCAGAGCTGCCCACCAAGACGAGGACCTCCAGGAGAGCTGCAGAG       c.1620
 T  L  L  Q  A  P  E  L  P  T  K  T  R  T  S  R  R  A  A  E         p.540

          .         .         .         .         .         | 11    g.175090
 CACAGAGACACCACTGACGTGCCTGAGATGCCTCACTCCAAGGGCCAGGGAGAGAGCG | AT    c.1680
 H  R  D  T  T  D  V  P  E  M  P  H  S  K  G  Q  G  E  S  D |       p.560

          .         .         .         .         .         .       g.175150
 CCTCTGGACCATGAGCCTGCCGTGTCTCCATTGCTCCCTCGAAAAGAGCGAGGTCCCCCG       c.1740
 P  L  D  H  E  P  A  V  S  P  L  L  P  R  K  E  R  G  P  P         p.580

          .         .         .         .         .         .       g.175210
 GAGGGCGGCCTGAATGAAGATGAGCGCCTTCTCCCCAAAGACAAAAAGACCAACTTGTTC       c.1800
 E  G  G  L  N  E  D  E  R  L  L  P  K  D  K  K  T  N  L  F         p.600

          .         .         .         .         .         .       g.175270
 AGCGCCTTGATCAAGAAGAAGAAGAAGACAGCCCCAACCCCTCCCAAACGCAGCAGCTCC       c.1860
 S  A  L  I  K  K  K  K  K  T  A  P  T  P  P  K  R  S  S  S         p.620

          .         .         .         .         .         .       g.175330
 TTCCGGGAGATGGACGGCCAGCCGGAGCGCAGAGGGGCCGGCGAGGAAGAGGGCCGAGAC       c.1920
 F  R  E  M  D  G  Q  P  E  R  R  G  A  G  E  E  E  G  R  D         p.640

          .         .         .         .         .         .       g.175390
 ATCAGCAACGGGGCACTGGCTTTCACCCCCTTGGACACAGCTGACCCAGCCAAGTCCCCA       c.1980
 I  S  N  G  A  L  A  F  T  P  L  D  T  A  D  P  A  K  S  P         p.660

          .         .         .         .         .         .       g.175450
 AAGCCCAGCAATGGGGCTGGGGTCCCCAATGGAGCCCTCCGGGAGTCCGGGGGCTCAGGC       c.2040
 K  P  S  N  G  A  G  V  P  N  G  A  L  R  E  S  G  G  S  G         p.680

          .         .         .         .         .         .       g.175510
 TTCCGGTCTCCCCACCTGTGGAAGAAGTCCAGCACGCTGACCAGCAGCCGCCTAGCCACC       c.2100
 F  R  S  P  H  L  W  K  K  S  S  T  L  T  S  S  R  L  A  T         p.700

          .         .         .         .         .         .       g.175570
 GGCGAGGAGGAGGGCGGTGGCAGCTCCAGCAAGCGCTTCCTGCGCTCTTGCTCCGCCTCC       c.2160
 G  E  E  E  G  G  G  S  S  S  K  R  F  L  R  S  C  S  A  S         p.720

          .         .         .         .         .         .       g.175630
 TGCGTTCCCCATGGGGCCAAGGACACGGAGTGGAGGTCAGTCACGCTGCCTCGGGACTTG       c.2220
 C  V  P  H  G  A  K  D  T  E  W  R  S  V  T  L  P  R  D  L         p.740

          .         .         .         .         .         .       g.175690
 CAGTCCACGGGAAGACAGTTTGACTCGTCCACATTTGGAGGGCACAAAAGTGAGAAGCCG       c.2280
 Q  S  T  G  R  Q  F  D  S  S  T  F  G  G  H  K  S  E  K  P         p.760

          .         .         .         .         .         .       g.175750
 GCTCTGCCTCGGAAGAGGGCAGGGGAGAACAGGTCTGACCAGGTGACCCGAGGCACAGTA       c.2340
 A  L  P  R  K  R  A  G  E  N  R  S  D  Q  V  T  R  G  T  V         p.780

          .         .         .         .         .         .       g.175810
 ACGCCTCCCCCCAGGCTGGTGAAAAAGAATGAGGAAGCTGCTGATGAGGTCTTCAAAGAC       c.2400
 T  P  P  P  R  L  V  K  K  N  E  E  A  A  D  E  V  F  K  D         p.800

          .         .         .         .         .         .       g.175870
 ATCATGGAGTCCAGCCCGGGCTCCAGCCCGCCCAACCTGACTCCAAAACCCCTCCGGCGG       c.2460
 I  M  E  S  S  P  G  S  S  P  P  N  L  T  P  K  P  L  R  R         p.820

          .         .         .         .         .         .       g.175930
 CAGGTCACCGTGGCCCCTGCCTCGGGCCTCCCCCACAAGGAAGAAGCTGGAAAGGGCAGT       c.2520
 Q  V  T  V  A  P  A  S  G  L  P  H  K  E  E  A  G  K  G  S         p.840

          .         .         .         .         .         .       g.175990
 GCCTTAGGGACCCCTGCTGCAGCTGAGCCAGTGACCCCCACCAGCAAAGCAGGCTCAGGT       c.2580
 A  L  G  T  P  A  A  A  E  P  V  T  P  T  S  K  A  G  S  G         p.860

          .         .         .         .         .         .       g.176050
 GCACCAGGGGGCACCAGCAAGGGCCCCGCCGAGGAGTCCAGAGTGAGGAGGCACAAGCAC       c.2640
 A  P  G  G  T  S  K  G  P  A  E  E  S  R  V  R  R  H  K  H         p.880

          .         .         .         .         .         .       g.176110
 TCCTCTGAGTCGCCAGGGAGGGACAAGGGGAAATTGTCCAGGCTCAAACCTGCCCCGCCG       c.2700
 S  S  E  S  P  G  R  D  K  G  K  L  S  R  L  K  P  A  P  P         p.900

          .         .         .         .         .         .       g.176170
 CCCCCACCAGCAGCCTCTGCAGGGAAGGCTGGAGGAAAGCCCTCGCAGAGCCCGAGCCAG       c.2760
 P  P  P  A  A  S  A  G  K  A  G  G  K  P  S  Q  S  P  S  Q         p.920

          .         .         .         .         .         .       g.176230
 GAGGCGGCCGGGGAGGCAGTCCTGGGCGCAAAGACAAAAGCCACGAGTCTGGTTGATGCT       c.2820
 E  A  A  G  E  A  V  L  G  A  K  T  K  A  T  S  L  V  D  A         p.940

          .         .         .         .         .         .       g.176290
 GTGAACAGTGACGCTGCCAAGCCCAGCCAGCCGGGAGAGGGCCTCAAAAAGCCCGTGCTC       c.2880
 V  N  S  D  A  A  K  P  S  Q  P  G  E  G  L  K  K  P  V  L         p.960

          .         .         .         .         .         .       g.176350
 CCGGCCACTCCAAAGCCACAGTCCGCCAAGCCGTCGGGGACCCCCATCAGCCCAGCCCCC       c.2940
 P  A  T  P  K  P  Q  S  A  K  P  S  G  T  P  I  S  P  A  P         p.980

          .         .         .         .         .         .       g.176410
 GTTCCCTCCACGTTGCCATCAGCATCCTCGGCCCTGGCAGGGGACCAGCCGTCTTCCACC       c.3000
 V  P  S  T  L  P  S  A  S  S  A  L  A  G  D  Q  P  S  S  T         p.1000

          .         .         .         .         .         .       g.176470
 GCCTTCATCCCTCTCATATCAACCCGAGTGTCTCTTCGGAAAACCCGCCAGCCTCCAGAG       c.3060
 A  F  I  P  L  I  S  T  R  V  S  L  R  K  T  R  Q  P  P  E         p.1020

          .         .         .         .         .         .       g.176530
 CGGATCGCCAGCGGCGCCATCACCAAGGGCGTGGTCCTGGACAGCACCGAGGCGCTGTGC       c.3120
 R  I  A  S  G  A  I  T  K  G  V  V  L  D  S  T  E  A  L  C         p.1040

          .         .         .         .         .         .       g.176590
 CTCGCCATCTCTAGGAACTCCGAGCAGATGGCCAGCCACAGCGCAGTGCTGGAGGCCGGC       c.3180
 L  A  I  S  R  N  S  E  Q  M  A  S  H  S  A  V  L  E  A  G         p.1060

          .         .         .         .         .         .       g.176650
 AAAAACCTCTACACGTTCTGCGTGAGCTATGTGGATTCCATCCAGCAAATGAGGAACAAG       c.3240
 K  N  L  Y  T  F  C  V  S  Y  V  D  S  I  Q  Q  M  R  N  K         p.1080

          .         .         .         .         .         .       g.176710
 TTTGCCTTCCGAGAGGCCATCAACAAACTGGAGAATAATCTCCGGGAGCTTCAGATCTGC       c.3300
 F  A  F  R  E  A  I  N  K  L  E  N  N  L  R  E  L  Q  I  C         p.1100

          .         .         .         .         .         .       g.176770
 CCGGCGACAGCAGGCAGTGGTCCAGCGGCCACTCAGGACTTCAGCAAGCTCCTCAGTTCG       c.3360
 P  A  T  A  G  S  G  P  A  A  T  Q  D  F  S  K  L  L  S  S         p.1120

          .         .         .                                     g.176803
 GTGAAGGAAATCAGTGACATAGTGCAGAGGTAG                                  c.3393
 V  K  E  I  S  D  I  V  Q  R  X                                    p.1130

          .         .         .         .         .         .       g.176863
 cagcagtcaggggtcaggtgtcaggcccgtcggagctgcctgcagcacatgcgggctcgc       c.*60

          .         .         .         .         .         .       g.176923
 ccatacccgtgacagtggctgacaagggactagtgagtcagcaccttggcccaggagctc       c.*120

          .         .         .         .         .         .       g.176983
 tgcgccaggcagagctgagggccctgtggagtccagctctactacctacgtttgcaccgc       c.*180

          .         .         .         .         .         .       g.177043
 ctgccctcccgcaccttcctcctccccgctccgtctctgtcctcgaattttatctgtgga       c.*240

          .         .         .         .         .         .       g.177103
 gttcctgctccgtggactgcagtcggcatgccaggacccgccagccccgctcccacctag       c.*300

          .         .         .         .         .         .       g.177163
 tgccccagactgagctctccaggccaggtgggaacggctgatgtggactgtctttttcat       c.*360

          .         .         .         .         .         .       g.177223
 ttttttctctctggagcccctcctcccccggctgggcctccttcttccacttctccaaga       c.*420

          .         .         .         .         .         .       g.177283
 atggaagcctgaactgaggccttgtgtgtcaggccctctgcctgcactccctggccttgc       c.*480

          .         .         .         .         .         .       g.177343
 ccgtcgtgtgctgaagacatgtttcaagaaccgcatttcgggaagggcatgcacgggcat       c.*540

          .         .         .         .         .         .       g.177403
 gcacacggctggtcactctgccctctgctgctgcccggggtggggtgcactcgccatttc       c.*600

          .         .         .         .         .         .       g.177463
 ctcacgtgcaggacagctcttgatttgggtggaaaacagggtgctaaagccaaccagcct       c.*660

          .         .         .         .         .         .       g.177523
 ttgggtcctgggcaggtgggagctgaaaaggatcgaggcatggggcatgtcctttccatc       c.*720

          .         .         .         .         .         .       g.177583
 tgtccacatccccagagcccagctcttgctctcttgtgacgtgcactgtgaatcctggca       c.*780

          .         .         .         .         .         .       g.177643
 agaaagcttgagtctcaagggtggcaggtcactgtcactgccgacatccctcccccagca       c.*840

          .         .         .         .         .         .       g.177703
 gaatggaggcaggggacaagggaggcagtggctagtggggtgaacagctggtgccaaata       c.*900

          .         .         .         .         .         .       g.177763
 gccccagactgggcccaggcaggtctgcaagggcccagagtgaaccgtcctttcacacat       c.*960

          .         .         .         .         .         .       g.177823
 ctgggtgccctgaaagggcccttcccctcccccactcctctaagacaaagtagattctta       c.*1020

          .         .         .         .         .         .       g.177883
 caaggccctttcctttggaacaagacagccttcacttttctgagttcttgaagcatttca       c.*1080

          .         .         .         .         .         .       g.177943
 aagccctgcctctgtgtagccgccctgagagagaatagagctgccactgggcacctgcgc       c.*1140

          .         .         .         .         .         .       g.178003
 acaggtgggaggaaagggcctggccagtcctggtcctggctgcactcttgaactgggcga       c.*1200

          .         .         .         .         .         .       g.178063
 atgtcttatttaattaccgtgagtgacatagcctcatgttctgtgggggtcatcagggag       c.*1260

          .         .         .         .         .         .       g.178123
 ggttaggaaaaccacaaacggagcccctgaaagcctcacgtatttcacagagcacgcctg       c.*1320

          .         .         .         .         .         .       g.178183
 ccatcttctccccgaggctgccccaggccggagcccagatacgggggctgtgactctggg       c.*1380

          .         .         .         .         .         .       g.178243
 cagggacccggggtctcctggaccttgacagagcagctaactccgagagcagtgggcagg       c.*1440

          .         .         .         .         .         .       g.178303
 tggccgcccctgaggcttcacgccgggagaagccaccttcccaccccttcataccgcctc       c.*1500

          .         .         .         .         .         .       g.178363
 gtgccagcagcctcgcacaggccctagctttacgctcatcacctaaacttgtactttatt       c.*1560

          .         .         .         .         .         .       g.178423
 tttctgatagaaatggtttcctctggatcgttttatgcggttcttacagcacatcacctc       c.*1620

          .         .         .         .         .         .       g.178483
 tttgcccccgacggctgtgacgcagccggagggaggcactagtcaccgacagcggccttg       c.*1680

          .         .         .         .         .         .       g.178543
 aagacagagcaaagcgcccacccaggtcccccgactgcctgtctccatgaggtactggtc       c.*1740

          .         .         .         .         .         .       g.178603
 ccttccttttgttaacgtgatgtgccactatattttacacgtatctcttggtatgcatct       c.*1800

          .         .         .         .         .         .       g.178663
 tttatagacgctcttttctaagtggcgtgtgcatagcgtcctgccctgccccctcggggg       c.*1860

          .         .         .         .         .         .       g.178723
 cctgtggtggctccccctctgcttctcggggtccagtgcattttgtttctgtatatgatt       c.*1920

          .         .         .         .         .         .       g.178783
 ctctgtggttttttttgaatccaaatctgtcctctgtagtattttttaaataaatcagtg       c.*1980

          .                                                         g.178795
 tttacattagaa                                                       c.*1992

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The C-abl oncogene 1, non-receptor tyrosine kinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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