acyl-CoA dehydrogenase, C-4 to C-12 straight chain (ACADM) - coding DNA reference sequence

(used for variant description)

(last modified October 12, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000016.4 in the ACADM gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007045.1, covering ACADM transcript NM_000016.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   cgcaagtccc       c.-421

 .         .         .         .         .         .                g.5070
 cccaccgttcagcgcaaccgggccctcccagccccgccgccgtccccctcccccgccctg       c.-361

 .         .         .         .         .         .                g.5130
 gctctctttccgcgctgcggtcagcctcggcgtcccacagagagggccagaggtggaaac       c.-301

 .         .         .         .         .         .                g.5190
 gcagaaaaccaaaccaggactatcagagattgcccggagaggggatgcgacccctcccca       c.-241

 .         .         .         .         .         .                g.5250
 ggtcgcagcgacggcgcacgcaagggtcacggagcatgcgttggctacccggcgccgggg       c.-181

 .         .         .         .         .         .                g.5310
 accgctgccaccccgcctagcgcagcgccccgtccttccgcagcccaaccgcctcttccc       c.-121

 .         .         .         .         .         .                g.5370
 gccccgccccatcccgcccacgggctccagtgggcgggaccagaggagtcccgcgttcgg       c.-61

 .         .         .         .         .         .                g.5430
 ggagtatgtcaaggccgtgacccgtgtattattgtccgagtggccggaacgggagccaac       c.-1

          .         .         . | 02       .         .         .    g.9073
 ATGGCAGCGGGGTTCGGGCGATGCTGCAGG | GTCCTGAGAAGTATTTCTCGTTTTCATTGG    c.60
 M  A  A  G  F  G  R  C  C  R   | V  L  R  S  I  S  R  F  H  W      p.20

          .         .         .         .         .         | 03    g.13288
 AGATCACAGCATACAAAAGCCAATCGACAACGTGAACCAGGATTAGGATTTAGTTTTG | AG    c.120
 R  S  Q  H  T  K  A  N  R  Q  R  E  P  G  L  G  F  S  F  E |       p.40

          .         .         .         .         .         .       g.13348
 TTCACCGAACAGCAGAAAGAATTTCAAGCTACTGCTCGTAAATTTGCCAGAGAGGAAATC       c.180
 F  T  E  Q  Q  K  E  F  Q  A  T  A  R  K  F  A  R  E  E  I         p.60

          .         .         .       | 04 .         .         .    g.13519
 ATCCCAGTGGCTGCAGAATATGATAAAACTGGTGAA | TATCCAGTCCCCCTAATTAGAAGA    c.240
 I  P  V  A  A  E  Y  D  K  T  G  E   | Y  P  V  P  L  I  R  R      p.80

          .         .         .         .       | 05 .         .    g.14184
 GCCTGGGAACTTGGTTTAATGAACACACACATTCCAGAGAACTGTG | GAGGTCTTGGACTT    c.300
 A  W  E  L  G  L  M  N  T  H  I  P  E  N  C  G |   G  L  G  L      p.100

          .         .         .         .         .         .       g.14244
 GGAACTTTTGATGCTTGTTTAATTAGTGAAGAATTGGCTTATGGATGTACAGGGGTTCAG       c.360
 G  T  F  D  A  C  L  I  S  E  E  L  A  Y  G  C  T  G  V  Q         p.120

          .         .        | 06.         .         .         .    g.15466
 ACTGCTATTGAAGGAAATTCTTTGGGG | CAAATGCCTATTATTATTGCTGGAAATGATCAA    c.420
 T  A  I  E  G  N  S  L  G   | Q  M  P  I  I  I  A  G  N  D  Q      p.140

          .         .         .         .         | 07         .    g.20634
 CAAAAGAAGAAGTATTTGGGGAGAATGACTGAGGAGCCATTGATGTGT | GCTTATTGTGTA    c.480
 Q  K  K  K  Y  L  G  R  M  T  E  E  P  L  M  C   | A  Y  C  V      p.160

          .         .         .         .         .         .       g.20694
 ACAGAACCTGGAGCAGGCTCTGATGTAGCTGGTATAAAGACCAAAGCAGAAAAGAAAGGA       c.540
 T  E  P  G  A  G  S  D  V  A  G  I  K  T  K  A  E  K  K  G         p.180

          .         .         .         .         .          | 08    g.26449
 GATGAGTATATTATTAATGGTCAGAAGATGTGGATAACCAACGGAGGAAAAGCTAATTG | G    c.600
 D  E  Y  I  I  N  G  Q  K  M  W  I  T  N  G  G  K  A  N  W  |      p.200

          .         .         .         .         .         .       g.26509
 TATTTTTTATTGGCACGTTCTGATCCAGATCCTAAAGCTCCTGCTAATAAAGCCTTTACT       c.660
 Y  F  L  L  A  R  S  D  P  D  P  K  A  P  A  N  K  A  F  T         p.220

          .         .         .         .         | 09         .    g.30073
 GGATTCATTGTGGAAGCAGATACCCCAGGAATTCAGATTGGGAGAAAG | GAATTAAACATG    c.720
 G  F  I  V  E  A  D  T  P  G  I  Q  I  G  R  K   | E  L  N  M      p.240

          .         .         .         .         .         .       g.30133
 GGCCAGCGATGTTCAGATACTAGAGGAATTGTCTTCGAAGATGTGAAAGTGCCTAAAGAA       c.780
 G  Q  R  C  S  D  T  R  G  I  V  F  E  D  V  K  V  P  K  E         p.260

          .         .         .         .         .         .       g.30193
 AATGTTTTAATTGGTGACGGAGCTGGTTTCAAAGTTGCAATGGGAGCTTTTGATAAAACC       c.840
 N  V  L  I  G  D  G  A  G  F  K  V  A  M  G  A  F  D  K  T         p.280

           | 10        .         .         .         .         .    g.31144
 AGACCTGTA | GTAGCTGCTGGTGCTGTTGGATTAGCACAAAGAGCTTTGGATGAAGCTACC    c.900
 R  P  V   | V  A  A  G  A  V  G  L  A  Q  R  A  L  D  E  A  T      p.300

          .         .         .         .      | 11  .         .    g.41779
 AAGTATGCCCTGGAAAGGAAAACTTTCGGAAAGCTACTTGTAGAG | CACCAAGCAATATCA    c.960
 K  Y  A  L  E  R  K  T  F  G  K  L  L  V  E   | H  Q  A  I  S      p.320

          .         .         .         .         .         .       g.41839
 TTTATGCTGGCTGAAATGGCAATGAAAGTTGAACTAGCTAGAATGAGTTACCAGAGAGCA       c.1020
 F  M  L  A  E  M  A  M  K  V  E  L  A  R  M  S  Y  Q  R  A         p.340

          .         .         .         .         .         .       g.41899
 GCTTGGGAGGTTGATTCTGGTCGTCGAAATACCTATTATGCTTCTATTGCAAAGGCATTT       c.1080
 A  W  E  V  D  S  G  R  R  N  T  Y  Y  A  S  I  A  K  A  F         p.360

          .         .         .         .         .         .       g.41959
 GCTGGAGATATTGCAAATCAGTTAGCTACTGATGCTGTGCAGATACTTGGAGGCAATGGA       c.1140
 A  G  D  I  A  N  Q  L  A  T  D  A  V  Q  I  L  G  G  N  G         p.380

          .         .         .         .         .     | 12   .    g.43340
 TTTAATACAGAATATCCTGTAGAAAAACTAATGAGGGATGCCAAAATCTATCAG | ATTTAT    c.1200
 F  N  T  E  Y  P  V  E  K  L  M  R  D  A  K  I  Y  Q   | I  Y      p.400

          .         .         .         .         .         .       g.43400
 GAAGGTACTTCACAAATTCAAAGACTTATTGTAGCCCGTGAACACATTGACAAGTACAAA       c.1260
 E  G  T  S  Q  I  Q  R  L  I  V  A  R  E  H  I  D  K  Y  K         p.420

                                                                    g.43406
 AATTAA                                                             c.1266
 N  X                                                               p.421

          .         .         .         .         .         .       g.43466
 aaaaattactgtagaaatattgaataactagaacacaagccactgtttcagctccagaaa       c.*60

          .         .         .         .         .         .       g.43526
 aaagaaagggctttaacgttttttccagtgaaaacaaatcctcttatattaaatctaagc       c.*120

          .         .         .         .         .         .       g.43586
 aactgcttattatagtagtttatacttttgcttaactctgttatgtctcttaagcaggtt       c.*180

          .         .         .         .         .         .       g.43646
 tggtttttattaaaatgatgtgttttctttagtaccactttacttgaattacattaacct       c.*240

          .         .         .         .         .         .       g.43706
 agaaaactacataggttattttgatctcttaagattaatgtagcagaaatttcttggaat       c.*300

          .         .         .         .         .         .       g.43766
 tttatttttgtaatgacagaaaagtgggcttagaaagtattcaagatgttacaaaattta       c.*360

          .         .         .         .         .         .       g.43826
 catttagaaaatattgtagtatttgaatactgtcaacttgacagtaactttgtagactta       c.*420

          .         .         .         .         .         .       g.43886
 atggtattattaaagttctttttattgcagtttggaaagcatttgtgaaactttctgttt       c.*480

          .         .         .         .         .         .       g.43946
 ggcacagaaacagtcaaaattttgacattcatattctcctattttacagctacaagaact       c.*540

          .         .         .         .         .         .       g.44006
 ttcttgaaaatcttatttaattctgagcccatatttcacttaccttatttaaaataaatc       c.*600

          .         .         .         .         .         .       g.44066
 aataaagcttgccttaaattatttttatatgactgttggtctctaggtagcctttggtct       c.*660

          .         .         .         .         .         .       g.44126
 attgtacacaatctcatttcatatgtttgcattttggcaaagaacttaataaaattgttc       c.*720

          .         .         .         .         .         .       g.44186
 agtgcttattatcatatctttctgtattttttccaggaaatttcattacttcgtgtaata       c.*780

          .         .         .         .         .         .       g.44246
 gtgtatatttcttgtatttactatgatgaaaaaaggtcgttttaattttgaattgaataa       c.*840

          .         .         .         .         .         .       g.44306
 agttacctgttcattttttattagatattttaaagacttcagaaaatataaatatgaaat       c.*900

                                                                    g.44313
 aatttaa                                                            c.*907

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Acyl-CoA dehydrogenase, C-4 to C-12 straight chain protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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