acyl-CoA dehydrogenase, short/branched chain (ACADSB) - coding DNA reference sequence

(used for variant description)

(last modified August 1, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_001609.3 in the ACADSB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008003.1, covering ACADSB transcript NM_001609.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    agggattaagggggggtgtgtgcggggcgggtactgagtgggcggggccttgctcgg       c.-61

 .         .         .         .         .         .                g.5117
 gtaactcccaggggctggctagagacccagaggcgcagagcggagaggcctgcggcgagg       c.-1

          .         .         .         .   | 02     .         .    g.30461
 ATGGAGGGCCTGGCAGTGCGGTTGCTGCGCGGCAGCAGGCTG | CTAAGAAGAAATTTCCTG    c.60
 M  E  G  L  A  V  R  L  L  R  G  S  R  L   | L  R  R  N  F  L      p.20

          .         .         .         .         .         .       g.30521
 ACTTGTTTGTCTTCTTGGAAGATTCCTCCTCATGTCTCAAAATCTTCCCAGTCAGAAGCT       c.120
 T  C  L  S  S  W  K  I  P  P  H  V  S  K  S  S  Q  S  E  A         p.40

          .         .         .         .         .         .       g.30581
 CTACTCAATATAACAAATAATGGAATACACTTTGCTCCCCTGCAAACATTTACAGATGAG       c.180
 L  L  N  I  T  N  N  G  I  H  F  A  P  L  Q  T  F  T  D  E         p.60

          .         .   | 03     .         .         .         .    g.33872
 GAAATGATGATAAAGAGTTCAG | TTAAAAAATTTGCTCAGGAACAAATTGCACCTTTGGTT    c.240
 E  M  M  I  K  S  S  V |   K  K  F  A  Q  E  Q  I  A  P  L  V      p.80

          .         .         .         .         .         .       g.33932
 TCAACCATGGATGAAAATTCGAAAATGGAGAAATCAGTAATACAAGGATTATTTCAACAA       c.300
 S  T  M  D  E  N  S  K  M  E  K  S  V  I  Q  G  L  F  Q  Q         p.100

     | 04    .         .         .         .         .         .    g.36610
 GGG | TTGATGGGTATTGAAGTTGACCCAGAATATGGAGGCACAGGAGCTTCATTTTTATCC    c.360
 G   | L  M  G  I  E  V  D  P  E  Y  G  G  T  G  A  S  F  L  S      p.120

          .         .         .         .         .         .       g.36670
 ACTGTGCTCGTGATAGAGGAATTAGCCAAAGTTGATGCATCTGTGGCTGTCTTTTGTGAG       c.420
 T  V  L  V  I  E  E  L  A  K  V  D  A  S  V  A  V  F  C  E         p.140

          .         .         .         .         .         .       g.36730
 ATCCAGAACACATTAATTAACACACTGATTAGAAAACATGGAACAGAAGAACAAAAGGCC       c.480
 I  Q  N  T  L  I  N  T  L  I  R  K  H  G  T  E  E  Q  K  A         p.160

          .         .         . | 05       .         .         .    g.37326
 ACCTATTTGCCTCAGCTCACTACAGAAAAA | GTAGGAAGTTTCTGCCTTTCAGAGGCTGGA    c.540
 T  Y  L  P  Q  L  T  T  E  K   | V  G  S  F  C  L  S  E  A  G      p.180

          .         .         .         .         .         .       g.37386
 GCAGGTAGTGACTCATTTGCTTTGAAGACCAGAGCTGATAAAGAGGGAGATTATTATGTC       c.600
 A  G  S  D  S  F  A  L  K  T  R  A  D  K  E  G  D  Y  Y  V         p.200

          .         .         .         .         .         .       g.37446
 CTCAATGGATCAAAGATGTGGATCAGCAGTGCTGAGCACGCAGGGCTCTTTCTGGTGATG       c.660
 L  N  G  S  K  M  W  I  S  S  A  E  H  A  G  L  F  L  V  M         p.220

          .         .  | 06      .         .         .         .    g.39172
 GCAAATGTAGACCCTACCATT | GGATATAAGGGAATTACCTCCTTCTTAGTAGATCGTGAT    c.720
 A  N  V  D  P  T  I   | G  Y  K  G  I  T  S  F  L  V  D  R  D      p.240

          .         .         .         .         .         .       g.39232
 ACTCCGGGCCTTCATATAGGGAAACCTGAAAACAAATTGGGGCTCAGAGCTTCTTCCACC       c.780
 T  P  G  L  H  I  G  K  P  E  N  K  L  G  L  R  A  S  S  T         p.260

          .         .        | 07.         .         .         .    g.40513
 TGCCCGTTAACATTCGAAAATGTCAAG | GTTCCAGAAGCCAATATCTTGGGACAAATTGGA    c.840
 C  P  L  T  F  E  N  V  K   | V  P  E  A  N  I  L  G  Q  I  G      p.280

          .         .         .         .         .         .       g.40573
 CATGGCTATAAGTATGCCATAGGGAGTCTCAATGAAGGTAGAATAGGAATTGCTGCACAG       c.900
 H  G  Y  K  Y  A  I  G  S  L  N  E  G  R  I  G  I  A  A  Q         p.300

  | 08       .         .         .         .         .         .    g.43356
  | ATGCTGGGACTGGCGCAAGGATGTTTTGACTACACTATTCCATATATTAAAGAAAGGATA    c.960
  | M  L  G  L  A  Q  G  C  F  D  Y  T  I  P  Y  I  K  E  R  I      p.320

          .         .         . | 09       .         .         .    g.47166
 CAATTTGGCAAAAGACTATTTGATTTTCAG | GGCCTCCAACACCAAGTGGCTCACGTGGCC    c.1020
 Q  F  G  K  R  L  F  D  F  Q   | G  L  Q  H  Q  V  A  H  V  A      p.340

          .         .         .         .         .         .       g.47226
 ACCCAGCTGGAAGCTGCAAGATTACTAACATACAATGCTGCTAGGCTTTTAGAAGCTGGA       c.1080
 T  Q  L  E  A  A  R  L  L  T  Y  N  A  A  R  L  L  E  A  G         p.360

          .         .         .         .         | 10         .    g.49160
 AAGCCATTCATAAAAGAAGCGTCAATGGCCAAATACTATGCATCAGAG | ATTGCAGGACAA    c.1140
 K  P  F  I  K  E  A  S  M  A  K  Y  Y  A  S  E   | I  A  G  Q      p.380

          .         .         .         .         .         .       g.49220
 ACAACGAGTAAATGTATCGAGTGGATGGGGGGAGTAGGCTACACCAAAGATTACCCTGTG       c.1200
 T  T  S  K  C  I  E  W  M  G  G  V  G  Y  T  K  D  Y  P  V         p.400

          .         .         | 11         .         .         .    g.49814
 GAGAAATACTTCCGAGATGCAAAGATTG | GTACGATATATGAAGGAGCTTCCAACATCCAG    c.1260
 E  K  Y  F  R  D  A  K  I  G |   T  I  Y  E  G  A  S  N  I  Q      p.420

          .         .         .                                     g.49853
 TTGAACACCATTGCAAAGCATATCGATGCAGAATACTGA                            c.1299
 L  N  T  I  A  K  H  I  D  A  E  Y  X                              p.432

          .         .         .         .         .         .       g.49913
 cgtctataggagtgggacccctccctggtgtcactgctgtaaaattttaaacggttgtgt       c.*60

          .         .         .         .         .         .       g.49973
 cttgttgggagtaagtgccttgcgtgggaataaacttccacagcattcgaatattttaat       c.*120

          .         .         .         .         .         .       g.50033
 gaagcccttagtcagggtcctggtgttggcctttttggttttctcttttcaggctgttta       c.*180

          .         .         .         .         .         .       g.50093
 acttaggcacaggagatccacttttaaacttgggaaataagcacctgtatttttttccaa       c.*240

          .         .         .         .         .         .       g.50153
 aactgtttttaaagctgtatacgcatacatatatatatttttactctgtcttactctgtc       c.*300

          .         .         .         .         .         .       g.50213
 acccaggctagagtgcagtggcgcgatctcagctcactgcagccttgacctcctgggttc       c.*360

          .         .         .         .         .         .       g.50273
 cagtgattctcatgcctcatcctcccaagtagctggaactacaggtgtgcaccaccatgc       c.*420

          .         .         .         .         .         .       g.50333
 ctggttcatttttgtgtttttagtagagatggggttttaccatattgcccaggctggtct       c.*480

          .         .         .         .         .         .       g.50393
 tctggcttctggatatcgcccaccttggcctcccaaagtgctgggattacagggatgagc       c.*540

          .         .         .         .         .         .       g.50453
 caccgtgcctggctgggtatttatattatcattctagtttcagagtatacagaagtttca       c.*600

          .         .         .         .         .         .       g.50513
 tcccatcatttggaaaaataaaggcatctgaagtacaatattacttatagaaatagttta       c.*660

          .         .         .         .         .         .       g.50573
 tattcctattaaatcttaatcttgtggcatcagggaaatatttgttacatagtaggcaat       c.*720

          .         .         .         .         .         .       g.50633
 ttttatccagtactttatagattcaactctaagttgcaagcgaagtcaaaactgatgaaa       c.*780

          .         .         .         .         .         .       g.50693
 atttatttagaaaaatctaaaaattctggttttaaatatgagaatcagtggaaaataagg       c.*840

          .         .         .         .         .         .       g.50753
 gtataattttgtaggtcatatgattgaagaaaatattattttaacaatgtaaagcaatat       c.*900

          .         .         .         .         .         .       g.50813
 gatttgttactataattaacctgtataaaagatacattttatggtggtttcagtaggtca       c.*960

          .         .         .         .         .         .       g.50873
 ttttaaaaaccaatgtgcattagttttcaagtataaggtttaagtaatttggtttaataa       c.*1020

          .         .         .         .         .         .       g.50933
 tcagaaaatattcaatacagtgttggatattctgtcatgcactatttttcagttgacaat       c.*1080

          .         .         .         .         .         .       g.50993
 ttctgtattttaattgaatactgtttcttcagtcatggttattgcactttatcctgaata       c.*1140

          .         .         .         .         .         .       g.51053
 ataattcagaaattgggttttggttcagtgattctcaagaaaaagatctcttgcccatta       c.*1200

          .         .         .         .         .         .       g.51113
 agaagtgtatcaaaatctcataaggaatgagggagagaagggggctgtagagtttgaaaa       c.*1260

          .         .         .         .         .         .       g.51173
 agcatattcaatattaaaatagttttatatttgggaaggcaaaaatgaatctattgtttt       c.*1320

          .         .         .         .         .         .       g.51233
 gcaatataggttataaacaggcaaaatgcaataaaatatatatctggttgtattagtctg       c.*1380

          .         .         .         .         .         .       g.51293
 ttttcacgctgctgataaagacatacctgagaccaggaagaaaaagaggtttaattggac       c.*1440

          .         .         .         .         .         .       g.51353
 ttacagttccacatgactggggaggcctcagaatcatggtgggaggcaaaaagcacttct       c.*1500

          .         .         .         .         .         .       g.51413
 tacatggcggcagcaagagaaaatgagaaagaagcaaaagtggaaacccctaataaacct       c.*1560

          .         .         .         .         .         .       g.51473
 atcagatcttgtgagacttactatcacgagaatagcacaggaaagactggcccccatgat       c.*1620

          .         .         .         .         .         .       g.51533
 tcaattacctcccccgggtccctcccacaacacatgggaattctgagagataccatttaa       c.*1680

          .         .         .         .         .         .       g.51593
 gttgagatttcagtggggacacagccaaaccatatcattctacccctggcacctccaaat       c.*1740

          .         .         .         .         .         .       g.51653
 ctcatgtcctcacatttcaaaaccaatcatgccttcccaacagtcccccaaagtcttaac       c.*1800

          .         .         .         .         .         .       g.51713
 tcatttcagcattaacccaaaagtccgcagtccaaagtttcatctgagacaaggcaagtc       c.*1860

          .         .         .         .         .         .       g.51773
 ccttccacttatgaacctgtaaaatcaaaagtaaactagttacttcctagatacaatggg       c.*1920

          .         .         .         .         .         .       g.51833
 ggtacaggtattgggtaaatacagccattccaaatgggagaaattggccaacacaaaagg       c.*1980

          .         .         .         .         .         .       g.51893
 gtaacagggcccatgcaagtccaaaattcagcagggcagtcaaattttaaacctccaaaa       c.*2040

          .         .         .         .         .         .       g.51953
 tgatcacctttgactccacgtctcacaatcatctctctcaagttcgaagttccacaaatc       c.*2100

          .         .         .         .         .         .       g.52013
 tctaaggcaagggaaagatgctgccagtctctttgctaaaacacagcaagagtcaccttt       c.*2160

          .         .         .         .         .         .       g.52073
 actccagttcccaaaaagtttttcatctccatctgagaccacctcagcctgaattttatt       c.*2220

          .         .         .         .         .         .       g.52133
 gtcaatattgctatcagcattttgggcaaagccattcagcaagtatctaggaagttccaa       c.*2280

          .         .         .         .         .         .       g.52193
 actttcccacattttcctgtcttcttctgagcccttcaaactgttccaacctctgcctgt       c.*2340

          .         .         .         .         .         .       g.52253
 tacccagttccaaacttgctttcatatttttggctatcttttcagcaatgccccactcta       c.*2400

          .         .         .         .         .         .       g.52313
 ctgttagcagtttactgtattagtctgttttcacactgctgataaagacattcctcaaga       c.*2460

          .         .         .         .         .         .       g.52373
 ttgtgaagaaaaagaggtttaattggacttacagttccacatggccggggaggcctcaga       c.*2520

          .         .         .         .         .         .       g.52433
 atcatggcgggaggtgaaaagcacttcgtacatggtggtggcaagagaaaatgaagaaga       c.*2580

          .         .         .         .         .         .       g.52493
 agcaaaagtggaaacccctgataaacccatcagatctcatgagacttactatcatgagaa       c.*2640

          .         .         .         .         .         .       g.52553
 tagcacaggaaagactggcccccctgattcgatgacctccccctgggtccctcccacaac       c.*2700

          .         .         .         .         .         .       g.52613
 atgtgggaattccagaagataaattcaagttgcaatttcagtggggacatagccaaacca       c.*2760

          .         .         .         .         .         .       g.52673
 tatcactggtgatgccacttcttcagtattagggattctcagtcagaagagaccccctgt       c.*2820

          .         .         .         .         .         .       g.52733
 gtggcctgagtcccctcaggaggaaggtggacaacagagaaatgagagttttgatatttt       c.*2880

          .         .         .         .         .         .       g.52793
 ctgaaagaggaacatgtgttagagatgaagaatcttccaaggctcatgcagttgcttaga       c.*2940

          .         .         .         .         .         .       g.52853
 ataatcattactgttatatgagaaacattttagtaatttaataaaaggataatgtttatt       c.*3000

          .         .         .         .         .         .       g.52913
 taaaaaacctgacttttccagagtaattttgttttgcacattcatgtttattgaagtgga       c.*3060

          .         .         .         .         .         .       g.52973
 ctaatttctataatgcaaatcagagttaaatattaaaaattgtgtaaatacaattgacat       c.*3120

          .         .         .         .         .         .       g.53033
 aggaattacattaaaatattaggaagaaacaaggacaaatttagaccttgaatccgaaga       c.*3180

          .         .         .         .         .         .       g.53093
 gataaagcttacttgactttcaaatggagagatgatgaaaacccactcattcactctttc       c.*3240

          .         .         .         .         .         .       g.53153
 agaacaaaaagacagtcatctgataagagtatgacatggatgaaatgccctacaggggcc       c.*3300

          .         .         .         .         .         .       g.53213
 ttggacatctttaatttctgcgattatgtgaaagaggtggactttacagataatggagca       c.*3360

          .         .         .         .         .         .       g.53273
 gaagccaacattagtaaaaggaatcccaacttcttcccatagaattagaaacatgtgaaa       c.*3420

          .         .         .         .         .         .       g.53333
 gtacaataaacttcttgttcaaattaccagcatcagagagcttcccatttgcatctagac       c.*3480

          .         .         .         .         .         .       g.53393
 cttgaatttatatttattgatcaagttctaatttgtatgtatattttgtgcatattcacc       c.*3540

          .         .         .         .         .         .       g.53453
 aataacagttaaaattaattatgtgttatagttaatatatgcacctaccttcttccgtta       c.*3600

          .         .         .         .         .         .       g.53513
 gtgcatcagtaaatgtgttattttgtcatttttccaaagagagtgttgtaggttttccct       c.*3660

          .         .         .         .         .         .       g.53573
 gtagttcttcctttatagcttttcttctgataaccatgacttcaggagctttaaaactat       c.*3720

          .         .         .         .         .         .       g.53633
 ctatcttgcatttgtgtctggcggagaactagccatcagcctcctgaagcctgccatcat       c.*3780

          .         .         .         .         .         .       g.53693
 tgttaatttgaggactgggctgtcttggggctcagaagataaagaactatttgagcagat       c.*3840

          .         .         .         .         .         .       g.53753
 gtgtgtgggtggcactggattccacccaactgccaagttagtattgttagagatttcatt       c.*3900

          .         .         .         .         .         .       g.53813
 ttacaacacaaaaataagcctgtgtcaaagattttaaaatcatggaaagttaaaatctag       c.*3960

          .         .         .         .         .         .       g.53873
 aaagaccttagagaaccagccaaccaactctctcattttaaaagtgaaggattcatagca       c.*4020

          .         .         .         .         .         .       g.53933
 cagattacttgcctaagatcatccaggaacgaagacaagaatccaaatgtacttggggac       c.*4080

          .         .         .         .         .         .       g.53993
 aagaattagtccccaaattcagtgttcttcctagtattaaacattgcccctttcgacaaa       c.*4140

          .         .         .         .         .         .       g.54053
 ttttggatttcattcttgttatatttcagtactcttgctgatttattttaggtttaactg       c.*4200

          .         .         .         .         .         .       g.54113
 gtaaagaatgaacatttcagaagtgttaggattagtcagtgtcatcgcttatgtatatga       c.*4260

          .         .         .         .         .         .       g.54173
 atcacttgccaaagacactggctctcctcagctgtaaccagcatgtcaaatgtgaagatt       c.*4320

          .         .         .         .         .         .       g.54233
 attgtgtgggatcctttggtttcattgttatgatgtattttataaatgtactagttatat       c.*4380

          .         .         .         .         .         .       g.54293
 ccttgtttatgtatttttgctgatctttcataaagcagaatggtatgtatcggattgttt       c.*4440

          .         .         .         .         .         .       g.54353
 taatgttatatattggattgtattcgatgttacaaaaccaatattctatggagaatgaaa       c.*4500

          .         .                                               g.54378
 aaaataaaggactaaattaactgga                                          c.*4525

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Acyl-CoA dehydrogenase, short/branched chain protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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