acyl-CoA dehydrogenase, very long chain (ACADVL) - coding DNA reference sequence

(used for variant description)

(last modified October 28, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000018.3 in the ACADVL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007975.1, covering ACADVL transcript NM_000018.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                           aactacagctcccagcatgccccggggcccgcaa       c.-121

 .         .         .         .         .         .                g.5091
 ccgtccgccgcccggtgcactgtggacgatgagtcagggttaggggcgccaggacgtggg       c.-61

 .         .         .         .         .         .                g.5151
 cgtgcaggacgccagagctgggtcagagctcgagccagcggcgcccggagagattcggag       c.-1

          .         .         .         .         .         .       g.5211
 ATGCAGGCGGCTCGGATGGCCGCGAGCTTGGGGCGGCAGCTGCTGAGGCTCGGGGGCGGA       c.60
 M  Q  A  A  R  M  A  A  S  L  G  R  Q  L  L  R  L  G  G  G         p.20

    | 02     .         .         .         .         .         .    g.5346
 AG | CTCGCGGCTCACGGCGCTCCTGGGGCAGCCCCGGCCCGGCCCTGCCCGGCGGCCCTAT    c.120
 S  |  S  R  L  T  A  L  L  G  Q  P  R  P  G  P  A  R  R  P  Y      p.40

          .         | 03         .         .         .         .    g.5672
 GCCGGGGGTGCCGCTCAG | CTGGCTCTGGACAAGTCAGATTCCCACCCCTCTGACGCTCTG    c.180
 A  G  G  A  A  Q   | L  A  L  D  K  S  D  S  H  P  S  D  A  L      p.60

          .         .     | 04   .         .         .         .    g.5806
 ACCAGGAAAAAACCGGCCAAGGCG | GAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGC    c.240
 T  R  K  K  P  A  K  A   | E  S  K  S  F  A  V  G  M  F  K  G      p.80

          .         .         .        | 05.         .         .    g.5955
 CAGCTCACCACAGATCAGGTGTTCCCATACCCGTCCG | TGCTCAACGAAGAGCAGACACAG    c.300
 Q  L  T  T  D  Q  V  F  P  Y  P  S  V |   L  N  E  E  Q  T  Q      p.100

          .         .         .         .   | 06     .         .    g.6108
 TTTCTTAAAGAGCTGGTGGAGCCTGTGTCCCGTTTCTTCGAG | GAAGTGAACGATCCCGCC    c.360
 F  L  K  E  L  V  E  P  V  S  R  F  F  E   | E  V  N  D  P  A      p.120

          .         .         .         .         .         .       g.6168
 AAGAATGACGCTCTGGAGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGG       c.420
 K  N  D  A  L  E  M  V  E  E  T  T  W  Q  G  L  K  E  L  G         p.140

          .         .         .         .         .        | 07.    g.6707
 GCCTTTGGTCTGCAAGTGCCCAGTGAGCTGGGTGGTGTGGGCCTTTGCAACACCCAG | TAC    c.480
 A  F  G  L  Q  V  P  S  E  L  G  G  V  G  L  C  N  T  Q   | Y      p.160

          .         .         .         .         .         .       g.6767
 GCCCGTTTGGTGGAGATCGTGGGCATGCATGACCTTGGCGTGGGCATTACCCTGGGGGCC       c.540
 A  R  L  V  E  I  V  G  M  H  D  L  G  V  G  I  T  L  G  A         p.180

          .         .         .         .         .         .       g.6827
 CATCAGAGCATCGGTTTCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAA       c.600
 H  Q  S  I  G  F  K  G  I  L  L  F  G  T  K  A  Q  K  E  K         p.200

          .         .   | 08     .         .         .         .    g.7156
 TACCTCCCCAAGCTGGCATCTG | GGGAGACTGTGGCCGCTTTCTGTCTAACCGAGCCCTCA    c.660
 Y  L  P  K  L  A  S  G |   E  T  V  A  A  F  C  L  T  E  P  S      p.220

          .         .         .         .         .         .       g.7216
 AGCGGGTCAGATGCAGCCTCCATCCGAACCTCTGCTGTGCCCAGCCCCTGTGGAAAATAC       c.720
 S  G  S  D  A  A  S  I  R  T  S  A  V  P  S  P  C  G  K  Y         p.240

          .         .         .   | 09     .         .         .    g.7371
 TATACCCTCAATGGAAGCAAGCTTTGGATCAG | TAATGGGGGCCTAGCAGACATCTTCACG    c.780
 Y  T  L  N  G  S  K  L  W  I  S  |  N  G  G  L  A  D  I  F  T      p.260

          .         .         .         .         .         .       g.7431
 GTCTTTGCCAAGACACCAGTTACAGATCCAGCCACAGGAGCCGTGAAGGAGAAGATCACA       c.840
 V  F  A  K  T  P  V  T  D  P  A  T  G  A  V  K  E  K  I  T         p.280

          .         .         .         | 10         .         .    g.7855
 GCTTTTGTGGTGGAGAGGGGCTTCGGGGGCATTACCCA | TGGGCCCCCTGAGAAGAAGATG    c.900
 A  F  V  V  E  R  G  F  G  G  I  T  H  |  G  P  P  E  K  K  M      p.300

          .         .         .         .         .         .       g.7915
 GGCATCAAGGCTTCAAACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAG       c.960
 G  I  K  A  S  N  T  A  E  V  F  F  D  G  V  R  V  P  S  E         p.320

          .         .         .         .         .         .       g.7975
 AACGTGCTGGGTGAGGTTGGGAGTGGCTTCAAGGTTGCCATGCACATCCTCAACAATGGA       c.1020
 N  V  L  G  E  V  G  S  G  F  K  V  A  M  H  I  L  N  N  G         p.340

          .         .         .         .         .        | 11.    g.8302
 AGGTTTGGCATGGCTGCGGCCCTGGCAGGTACCATGAGAGGCATCATTGCTAAGGCG | GTA    c.1080
 R  F  G  M  A  A  A  L  A  G  T  M  R  G  I  I  A  K  A   | V      p.360

          .         .         .         .         .         .       g.8362
 GATCATGCCACTAATCGTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAG       c.1140
 D  H  A  T  N  R  T  Q  F  G  E  K  I  H  N  F  G  L  I  Q         p.380

          .         .         .         .   | 12     .         .    g.8828
 GAGAAGCTGGCACGGATGGTTATGCTGCAGTATGTAACTGAG | TCCATGGCTTACATGGTG    c.1200
 E  K  L  A  R  M  V  M  L  Q  Y  V  T  E   | S  M  A  Y  M  V      p.400

          .         .         .         .         .         .       g.8888
 AGTGCTAACATGGACCAGGGAGCCACGGACTTCCAGATAGAGGCCGCCATCAGCAAAATC       c.1260
 S  A  N  M  D  Q  G  A  T  D  F  Q  I  E  A  A  I  S  K  I         p.420

           | 13        .         .         .         .         .    g.9030
 TTTGGCTCG | GAGGCAGCCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATG    c.1320
 F  G  S   | E  A  A  W  K  V  T  D  E  C  I  Q  I  M  G  G  M      p.440

          .   | 14     .         .         .         .         .    g.9182
 GGCTTCATGAAG | GAACCTGGAGTAGAGCGTGTGCTCCGAGATCTTCGCATCTTCCGGATC    c.1380
 G  F  M  K   | E  P  G  V  E  R  V  L  R  D  L  R  I  F  R  I      p.460

          .         .         .         .         .     | 15   .    g.9318
 TTTGAGGGGACAAATGACATTCTTCGGCTGTTTGTGGCTCTGCAGGGCTGTATG | GACAAA    c.1440
 F  E  G  T  N  D  I  L  R  L  F  V  A  L  Q  G  C  M   | D  K      p.480

          .         .         .         .         .         .       g.9378
 GGAAAGGAGCTCTCTGGGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTC       c.1500
 G  K  E  L  S  G  L  G  S  A  L  K  N  P  F  G  N  A  G  L         p.500

          .         .         .   | 16     .         .         .    g.9515
 CTGCTAGGAGAGGCAGGCAAACAGCTGAGGCG | GCGGGCAGGGCTGGGCAGCGGCCTGAGT    c.1560
 L  L  G  E  A  G  K  Q  L  R  R  |  R  A  G  L  G  S  G  L  S      p.520

          .         .         .         .      | 17  .         .    g.9661
 CTCAGCGGACTTGTCCACCCGGAGTTGAGTCGGAGTGGCGAGCTG | GCAGTACGGGCTCTG    c.1620
 L  S  G  L  V  H  P  E  L  S  R  S  G  E  L   | A  V  R  A  L      p.540

          .         .         .         .         .         | 18    g.9810
 GAGCAGTTTGCCACTGTGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCA | AT    c.1680
 E  Q  F  A  T  V  V  E  A  K  L  I  K  H  K  K  G  I  V  N |       p.560

          .         .         .         .         .         .       g.9870
 GAACAGTTTCTGCTGCAGCGGCTGGCAGACGGGGCCATCGACCTCTATGCCATGGTGGTG       c.1740
 E  Q  F  L  L  Q  R  L  A  D  G  A  I  D  L  Y  A  M  V  V         p.580

          .  | 19      .         .         .         .         .    g.10024
 GTTCTCTCGAG | GGCCTCAAGATCCCTGAGTGAGGGCCACCCCACGGCCCAGCATGAGAAA    c.1800
 V  L  S  R  |  A  S  R  S  L  S  E  G  H  P  T  A  Q  H  E  K      p.600

          .         .        | 20.         .         .         .    g.10156
 ATGCTCTGTGACACCTGGTGTATCGAG | GCTGCAGCTCGGATCCGAGAGGGCATGGCCGCC    c.1860
 M  L  C  D  T  W  C  I  E   | A  A  A  R  I  R  E  G  M  A  A      p.620

          .         .         .         .         .         .       g.10216
 CTGCAGTCTGACCCCTGGCAGCAAGAGCTCTACCGCAACTTCAAAAGCATCTCCAAGGCC       c.1920
 L  Q  S  D  P  W  Q  Q  E  L  Y  R  N  F  K  S  I  S  K  A         p.640

          .         .         .         .                           g.10264
 TTGGTGGAGCGGGGTGGTGTGGTCACCAGCAACCCACTTGGCTTCTGA                   c.1968
 L  V  E  R  G  G  V  V  T  S  N  P  L  G  F  X                     p.655

          .         .         .         .         .         .       g.10324
 atactcccggccagggcctgtcccagttatgtgccttccctcaagccaaagccgaagccc       c.*60

          .         .         .         .         .         .       g.10384
 ctttccttaaggccctggtttgtcccgaaggggcctagtgttcccagcactgtgcctgct       c.*120

          .         .         .         .         .                 g.10434
 ctcaagagcacttactgcctcgcaaataataaaaatttctagccagtcat                 c.*170

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Acyl-CoA dehydrogenase, very long chain protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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