aggrecan (ACAN) - coding DNA reference sequence

(used for variant description)

(last modified August 31, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_013227.3 in the ACAN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012794.1, covering ACAN transcript NM_013227.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               cacctacctccccg       c.-361

 .         .         .         .         .         .                g.5074
 ccgctccagagggggctcgcagagctgaggacgcgcgcagcgctgctcaaggtctctctc       c.-301

 .         .         .         .         .         .                g.5134
 tctcagcaccctcgccggccggcgtctgacgcgggtgccagggtctccgggcacctttca       c.-241

 .         .         .         .         .         .                g.5194
 gtgtccattccctcagccagccaggactccgcaacccagcagttgccgctgcggccacag       c.-181

 .         .         .         .         .         .                g.5254
 cccgaggggacctgcggacaggacgccggcaggaggaggggtgcgcagcgcccgcgcaga       c.-121

 .         .         .         .         .         .                g.5314
 gcgtctccctcgctacgcagcgagacccgggcctcccggccccaggagcccccagctgcc       c.-61

 .         .         .         .         .         .   | 02         g.37764
 tcgccaggtgtgtgggactgaagttcttggagaagggagtccaactcttcaag | gtgaact    c.-1

          .         .         .         .         .         .       g.37824
 ATGACCACTTTACTCTGGGTTTTCGTGACTCTGAGGGTCATCACTGCAGCTGTCACTGTA       c.60
 M  T  T  L  L  W  V  F  V  T  L  R  V  I  T  A  A  V  T  V         p.20

          . | 03       .         .         .         .         .    g.40270
 GAAACTTCAG | ACCATGACAACTCGCTGAGTGTCAGCATCCCCCAACCGTCCCCGCTGAGG    c.120
 E  T  S  D |   H  D  N  S  L  S  V  S  I  P  Q  P  S  P  L  R      p.40

          .         .         .         .         .         .       g.40330
 GTCCTCCTGGGGACCTCCCTCACCATCCCCTGCTATTTCATCGACCCCATGCACCCTGTG       c.180
 V  L  L  G  T  S  L  T  I  P  C  Y  F  I  D  P  M  H  P  V         p.60

          .         .         .         .         .         .       g.40390
 ACCACCGCCCCTTCTACCGCCCCACTGGCCCCAAGAATCAAGTGGAGCCGTGTGTCCAAG       c.240
 T  T  A  P  S  T  A  P  L  A  P  R  I  K  W  S  R  V  S  K         p.80

          .         .         .         .         .         .       g.40450
 GAGAAGGAGGTAGTGCTGCTGGTGGCCACTGAAGGGCGCGTGCGGGTCAACAGTGCCTAT       c.300
 E  K  E  V  V  L  L  V  A  T  E  G  R  V  R  V  N  S  A  Y         p.100

          .         .         .         .         .         .       g.40510
 CAGGACAAGGTCTCACTGCCCAACTACCCGGCCATCCCCAGTGACGCCACCTTGGAAGTC       c.360
 Q  D  K  V  S  L  P  N  Y  P  A  I  P  S  D  A  T  L  E  V         p.120

          .         .         .         .         .         .       g.40570
 CAGAGCCTGCGCTCCAATGACTCTGGGGTCTACCGCTGCGAGGTGATGCATGGCATCGAG       c.420
 Q  S  L  R  S  N  D  S  G  V  Y  R  C  E  V  M  H  G  I  E         p.140

          .         .         .     | 04   .         .         .    g.41595
 GACAGCGAGGCCACCCTGGAAGTCGTGGTGAAAG | GCATCGTGTTCCATTACAGAGCCATC    c.480
 D  S  E  A  T  L  E  V  V  V  K  G |   I  V  F  H  Y  R  A  I      p.160

          .         .         .         .         .         .       g.41655
 TCTACACGCTACACCCTCGACTTTGACAGGGCGCAGCGGGCCTGCCTGCAGAACAGTGCC       c.540
 S  T  R  Y  T  L  D  F  D  R  A  Q  R  A  C  L  Q  N  S  A         p.180

          .         .         .         .         .         .       g.41715
 ATCATTGCCACGCCTGAGCAGCTGCAGGCCGCCTACGAAGACGGCTTCCACCAGTGTGAC       c.600
 I  I  A  T  P  E  Q  L  Q  A  A  Y  E  D  G  F  H  Q  C  D         p.200

          .         .          | 05        .         .         .    g.43328
 GCCGGCTGGCTGGCTGACCAGACTGTCAG | ATACCCCATCCACACTCCCCGGGAAGGCTGC    c.660
 A  G  W  L  A  D  Q  T  V  R  |  Y  P  I  H  T  P  R  E  G  C      p.220

          .         .         .         .         .         .       g.43388
 TATGGAGACAAGGATGAGTTTCCTGGTGTGAGGACGTATGGCATCCGAGACACCAACGAG       c.720
 Y  G  D  K  D  E  F  P  G  V  R  T  Y  G  I  R  D  T  N  E         p.240

          .         .         .        | 06.         .         .    g.44935
 ACCTATGATGTGTACTGCTTCGCCGAGGAGATGGAGG | GTGAGGTCTTTTATGCAACATCT    c.780
 T  Y  D  V  Y  C  F  A  E  E  M  E  G |   E  V  F  Y  A  T  S      p.260

          .         .         .         .         .         .       g.44995
 CCAGAGAAGTTCACCTTCCAGGAAGCAGCCAATGAGTGCCGGCGGCTGGGTGCCCGGCTG       c.840
 P  E  K  F  T  F  Q  E  A  A  N  E  C  R  R  L  G  A  R  L         p.280

          .         .         .         .         .         .       g.45055
 GCCACCACGGGCCAGCTCTACCTGGCCTGGCAGGCTGGCATGGACATGTGCAGCGCCGGC       c.900
 A  T  T  G  Q  L  Y  L  A  W  Q  A  G  M  D  M  C  S  A  G         p.300

          .         .         .         .         .         .       g.45115
 TGGCTGGCCGACCGCAGCGTGCGCTACCCCATCTCCAAGGCCCGGCCCAACTGCGGTGGC       c.960
 W  L  A  D  R  S  V  R  Y  P  I  S  K  A  R  P  N  C  G  G         p.320

          .         .         .         .         .         .       g.45175
 AACCTCCTGGGCGTGAGGACCGTCTACGTGCATGCCAACCAGACGGGCTACCCCGACCCC       c.1020
 N  L  L  G  V  R  T  V  Y  V  H  A  N  Q  T  G  Y  P  D  P         p.340

          .         .         .  | 07      .         .         .    g.47091
 TCATCCCGCTACGACGCCATCTGCTACACAG | GTGAAGACTTTGTGGACATCCCAGAAAAC    c.1080
 S  S  R  Y  D  A  I  C  Y  T  G |   E  D  F  V  D  I  P  E  N      p.360

          .         .         .         .         .         .       g.47151
 TTCTTTGGAGTGGGGGGTGAGGAGGACATCACCGTCCAGACAGTGACCTGGCCTGACATG       c.1140
 F  F  G  V  G  G  E  E  D  I  T  V  Q  T  V  T  W  P  D  M         p.380

          .         .         .         .         .         .       g.47211
 GAGCTGCCACTGCCTCGAAACATCACTGAGGGTGAAGCCCGAGGCAGCGTGATCCTTACC       c.1200
 E  L  P  L  P  R  N  I  T  E  G  E  A  R  G  S  V  I  L  T         p.400

          .         .         .         .         .         .       g.47271
 GTAAAGCCCATCTTCGAGGTCTCCCCCAGTCCCCTGGAACCCGAGGAGCCCTTCACGTTT       c.1260
 V  K  P  I  F  E  V  S  P  S  P  L  E  P  E  E  P  F  T  F         p.420

          .         .         .         .         .         .       g.47331
 GCCCCTGAAATAGGGGCCACTGCCTTCGCTGAGGTTGAGAATGAGACTGGAGAGGCCACC       c.1320
 A  P  E  I  G  A  T  A  F  A  E  V  E  N  E  T  G  E  A  T         p.440

          .         .         .         .         .         .       g.47391
 AGGCCCTGGGGCTTTCCCACACCTGGCCTGGGCCCTGCCACGGCATTCACCAGTGAGGAC       c.1380
 R  P  W  G  F  P  T  P  G  L  G  P  A  T  A  F  T  S  E  D         p.460

          .         .         .         .          | 08        .    g.48811
 CTCGTCGTGCAGGTGACCGCTGTCCCTGGGCAGCCGCATTTGCCAGGGG | GGGTCGTCTTC    c.1440
 L  V  V  Q  V  T  A  V  P  G  Q  P  H  L  P  G  G |   V  V  F      p.480

          .         .         .         .         .         .       g.48871
 CACTACCGCCCGGGACCCACCCGCTACTCGCTGACCTTTGAGGAGGCACAGCAGGCCTGC       c.1500
 H  Y  R  P  G  P  T  R  Y  S  L  T  F  E  E  A  Q  Q  A  C         p.500

          .         .         .         .         .         .       g.48931
 CTGCGCACGGGGGCGGTCATTGCCTCGCCGGAGCAGCTCCAGGCCGCCTACGAAGCAGGC       c.1560
 L  R  T  G  A  V  I  A  S  P  E  Q  L  Q  A  A  Y  E  A  G         p.520

          .         .         .         .     | 09   .         .    g.49484
 TATGAGCAGTGTGACGCCGGCTGGCTGCGGGACCAGACCGTCAG | ATACCCCATTGTGAGC    c.1620
 Y  E  Q  C  D  A  G  W  L  R  D  Q  T  V  R  |  Y  P  I  V  S      p.540

          .         .         .         .         .         .       g.49544
 CCCCGGACCCCATGCGTGGGTGACAAGGACAGCAGCCCAGGGGTCAGGACCTATGGCGTG       c.1680
 P  R  T  P  C  V  G  D  K  D  S  S  P  G  V  R  T  Y  G  V         p.560

          .         .         .         .         .   | 10     .    g.51003
 CGCCCATCAACAGAGACCTACGATGTCTACTGCTTTGTAGACAGACTTGAGG | GGGAGGTG    c.1740
 R  P  S  T  E  T  Y  D  V  Y  C  F  V  D  R  L  E  G |   E  V      p.580

          .         .         .         .         .         .       g.51063
 TTCTTCGCCACACGCCTTGAGCAGTTCACCTTCCAGGAAGCACTGGAGTTCTGTGAATCT       c.1800
 F  F  A  T  R  L  E  Q  F  T  F  Q  E  A  L  E  F  C  E  S         p.600

          .         .         .         .         .         .       g.51123
 CACAATGCTACGCTGGCCACCACGGGCCAGCTCTACGCCGCCTGGAGCCGCGGCCTGGAC       c.1860
 H  N  A  T  L  A  T  T  G  Q  L  Y  A  A  W  S  R  G  L  D         p.620

          .         .         .         .         .         .       g.51183
 AAGTGCTATGCCGGCTGGCTGGCCGACGGCAGCCTCCGCTACCCCATCGTCACCCCAAGG       c.1920
 K  C  Y  A  G  W  L  A  D  G  S  L  R  Y  P  I  V  T  P  R         p.640

          .         .         .         .         .         .       g.51243
 CCTGCCTGCGGTGGGGACAAGCCAGGCGTGAGAACGGTCTACCTCTACCCTAACCAGACG       c.1980
 P  A  C  G  G  D  K  P  G  V  R  T  V  Y  L  Y  P  N  Q  T         p.660

          .         .         .         .       | 11 .         .    g.53365
 GGCCTCCCAGACCCACTGTCCCGGCACCATGCCTTCTGCTTCCGAG | GCATTTCAGCGGTT    c.2040
 G  L  P  D  P  L  S  R  H  H  A  F  C  F  R  G |   I  S  A  V      p.680

          .         .         .         .         .         .       g.53425
 CCTTCTCCAGGAGAAGAAGAGGGTGGCACACCCACATCACCCTCTGGTGTGGAGGAGTGG       c.2100
 P  S  P  G  E  E  E  G  G  T  P  T  S  P  S  G  V  E  E  W         p.700

          .         .         .         .         .         .       g.53485
 ATCGTGACCCAAGTGGTTCCTGGTGTGGCTGCTGTCCCCGTAGAAGAGGAGACAACTGCT       c.2160
 I  V  T  Q  V  V  P  G  V  A  A  V  P  V  E  E  E  T  T  A         p.720

          .         .         .         .         .         .       g.53545
 GTACCCTCAGGGGAGACTACTGCCATCCTAGAGTTCACCACCGAGCCAGAAAACCAGACA       c.2220
 V  P  S  G  E  T  T  A  I  L  E  F  T  T  E  P  E  N  Q  T         p.740

          .         .         .         .       | 12 .         .    g.56423
 GAATGGGAACCAGCCTATACCCCAGTGGGCACATCCCCGCTGCCAG | GGATCCTTCCTACT    c.2280
 E  W  E  P  A  Y  T  P  V  G  T  S  P  L  P  G |   I  L  P  T      p.760

          .         .         .         .         .         .       g.56483
 TGGCCTCCCACTGGCGCAGCAACAGAGGAAAGTACAGAAGGCCCTTCTGCAACTGAAGTG       c.2340
 W  P  P  T  G  A  A  T  E  E  S  T  E  G  P  S  A  T  E  V         p.780

          .         .         .         .         .         .       g.56543
 CCCTCTGCCTCAGAGGAACCATCCCCCTCAGAGGTGCCATTCCCCTCAGAGGAGCCATCC       c.2400
 P  S  A  S  E  E  P  S  P  S  E  V  P  F  P  S  E  E  P  S         p.800

          .         .         .         .         .         .       g.56603
 CCCTCAGAGGAACCATTCCCCTCAGTGAGGCCATTCCCCTCAGTGGAGCTGTTCCCCTCA       c.2460
 P  S  E  E  P  F  P  S  V  R  P  F  P  S  V  E  L  F  P  S         p.820

          .         .         .         .         .         .       g.56663
 GAGGAGCCATTCCCCTCCAAGGAGCCATCCCCCTCAGAGGAACCATCAGCCTCGGAAGAG       c.2520
 E  E  P  F  P  S  K  E  P  S  P  S  E  E  P  S  A  S  E  E         p.840

          .         .         .         .         .         .       g.56723
 CCGTATACACCTTCACCCCCCGTGCCCAGCTGGACTGAGCTGCCCAGCTCTGGGGAGGAA       c.2580
 P  Y  T  P  S  P  P  V  P  S  W  T  E  L  P  S  S  G  E  E         p.860

          .         .         .         .         .         .       g.56783
 TCTGGGGCCCCTGATGTCAGTGGTGACTTCACAGGCAGTGGAGATGTTTCAGGACACCTT       c.2640
 S  G  A  P  D  V  S  G  D  F  T  G  S  G  D  V  S  G  H  L         p.880

          .         .         .         .         .         .       g.56843
 GACTTCAGTGGGCAGCTGTCAGGGGACAGGGCAAGTGGACTGCCCTCTGGAGACCTGGAC       c.2700
 D  F  S  G  Q  L  S  G  D  R  A  S  G  L  P  S  G  D  L  D         p.900

          .         .         .         .         .         .       g.56903
 TCCAGTGGTCTTACTTCCACAGTGGGCTCAGGCCTGCCTGTGGAAAGTGGACTACCCTCA       c.2760
 S  S  G  L  T  S  T  V  G  S  G  L  P  V  E  S  G  L  P  S         p.920

          .         .         .         .         .         .       g.56963
 GGGGATGAAGAGAGAATTGAGTGGCCCAGCACTCCTACGGTTGGTGAACTGCCCTCTGGA       c.2820
 G  D  E  E  R  I  E  W  P  S  T  P  T  V  G  E  L  P  S  G         p.940

          .         .         .         .         .         .       g.57023
 GCTGAGATCCTAGAGGGCTCTGCCTCTGGAGTTGGGGATCTCAGTGGACTTCCTTCTGGA       c.2880
 A  E  I  L  E  G  S  A  S  G  V  G  D  L  S  G  L  P  S  G         p.960

          .         .         .         .         .         .       g.57083
 GAAGTTCTAGAGACCTCTGCCTCTGGAGTAGGAGACCTCAGTGGGCTTCCTTCTGGAGAA       c.2940
 E  V  L  E  T  S  A  S  G  V  G  D  L  S  G  L  P  S  G  E         p.980

          .         .         .         .         .         .       g.57143
 GTTCTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTT       c.3000
 V  L  E  T  T  A  P  G  V  E  D  I  S  G  L  P  S  G  E  V         p.1000

          .         .         .         .         .         .       g.57203
 CTAGAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTA       c.3060
 L  E  T  T  A  P  G  V  E  D  I  S  G  L  P  S  G  E  V  L         p.1020

          .         .         .         .         .         .       g.57263
 GAGACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAG       c.3120
 E  T  T  A  P  G  V  E  D  I  S  G  L  P  S  G  E  V  L  E         p.1040

          .         .         .         .         .         .       g.57323
 ACCACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACC       c.3180
 T  T  A  P  G  V  E  D  I  S  G  L  P  S  G  E  V  L  E  T         p.1060

          .         .         .         .         .         .       g.57383
 ACTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCACT       c.3240
 T  A  P  G  V  E  D  I  S  G  L  P  S  G  E  V  L  E  T  T         p.1080

          .         .         .         .         .         .       g.57443
 GCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCC       c.3300
 A  P  G  V  E  D  I  S  G  L  P  S  G  E  V  L  E  T  A  A         p.1100

          .         .         .         .         .         .       g.57503
 CCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCT       c.3360
 P  G  V  E  D  I  S  G  L  P  S  G  E  V  L  E  T  A  A  P         p.1120

          .         .         .         .         .         .       g.57563
 GGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGA       c.3420
 G  V  E  D  I  S  G  L  P  S  G  E  V  L  E  T  A  A  P  G         p.1140

          .         .         .         .         .         .       g.57623
 GTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTA       c.3480
 V  E  D  I  S  G  L  P  S  G  E  V  L  E  T  A  A  P  G  V         p.1160

          .         .         .         .         .         .       g.57683
 GAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAG       c.3540
 E  D  I  S  G  L  P  S  G  E  V  L  E  T  A  A  P  G  V  E         p.1180

          .         .         .         .         .         .       g.57743
 GACATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGAC       c.3600
 D  I  S  G  L  P  S  G  E  V  L  E  T  A  A  P  G  V  E  D         p.1200

          .         .         .         .         .         .       g.57803
 ATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACCGCTGCCCCTGGAGTAGAGGACATC       c.3660
 I  S  G  L  P  S  G  E  V  L  E  T  A  A  P  G  V  E  D  I         p.1220

          .         .         .         .         .         .       g.57863
 AGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGC       c.3720
 S  G  L  P  S  G  E  V  L  E  T  A  A  P  G  V  E  D  I  S         p.1240

          .         .         .         .         .         .       g.57923
 GGGCTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGG       c.3780
 G  L  P  S  G  E  V  L  E  T  A  A  P  G  V  E  D  I  S  G         p.1260

          .         .         .         .         .         .       g.57983
 CTTCCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTT       c.3840
 L  P  S  G  E  V  L  E  T  A  A  P  G  V  E  D  I  S  G  L         p.1280

          .         .         .         .         .         .       g.58043
 CCTTCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCT       c.3900
 P  S  G  E  V  L  E  T  A  A  P  G  V  E  D  I  S  G  L  P         p.1300

          .         .         .         .         .         .       g.58103
 TCTGGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCT       c.3960
 S  G  E  V  L  E  T  A  A  P  G  V  E  D  I  S  G  L  P  S         p.1320

          .         .         .         .         .         .       g.58163
 GGAGAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGA       c.4020
 G  E  V  L  E  T  A  A  P  G  V  E  D  I  S  G  L  P  S  G         p.1340

          .         .         .         .         .         .       g.58223
 GAAGTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAA       c.4080
 E  V  L  E  T  A  A  P  G  V  E  D  I  S  G  L  P  S  G  E         p.1360

          .         .         .         .         .         .       g.58283
 GTTCTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTT       c.4140
 V  L  E  T  A  A  P  G  V  E  D  I  S  G  L  P  S  G  E  V         p.1380

          .         .         .         .         .         .       g.58343
 CTAGAGACTGCTGCCCCTGGAGTAGAGGACATCAGCGGGCTTCCTTCTGGAGAAGTTCTA       c.4200
 L  E  T  A  A  P  G  V  E  D  I  S  G  L  P  S  G  E  V  L         p.1400

          .         .         .         .         .         .       g.58403
 GAGACTACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAG       c.4260
 E  T  T  A  P  G  V  E  E  I  S  G  L  P  S  G  E  V  L  E         p.1420

          .         .         .         .         .         .       g.58463
 ACTACTGCCCCTGGAGTAGATGAGATCAGTGGGCTTCCTTCTGGAGAAGTTCTAGAGACT       c.4320
 T  T  A  P  G  V  D  E  I  S  G  L  P  S  G  E  V  L  E  T         p.1440

          .         .         .         .         .         .       g.58523
 ACTGCCCCTGGAGTAGAGGAGATCAGCGGGCTTCCTTCTGGAGAAGTTCTAGAGACTTCT       c.4380
 T  A  P  G  V  E  E  I  S  G  L  P  S  G  E  V  L  E  T  S         p.1460

          .         .         .         .         .         .       g.58583
 ACCTCTGCGGTAGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGTTCTAGAGATTTCT       c.4440
 T  S  A  V  G  D  L  S  G  L  P  S  G  G  E  V  L  E  I  S         p.1480

          .         .         .         .         .         .       g.58643
 GTCTCTGGAGTAGAGGACATCAGTGGGCTTCCTTCTGGAGAGGTTGTAGAGACTTCTGCC       c.4500
 V  S  G  V  E  D  I  S  G  L  P  S  G  E  V  V  E  T  S  A         p.1500

          .         .         .         .         .         .       g.58703
 TCTGGAATAGAGGATGTCAGTGAACTTCCTTCAGGAGAAGGTCTAGAGACCTCTGCTTCT       c.4560
 S  G  I  E  D  V  S  E  L  P  S  G  E  G  L  E  T  S  A  S         p.1520

          .         .         .         .         .         .       g.58763
 GGAGTAGAGGACCTCAGCAGGCTCCCTTCTGGAGAAGAAGTTCTAGAGATTTCTGCCTCT       c.4620
 G  V  E  D  L  S  R  L  P  S  G  E  E  V  L  E  I  S  A  S         p.1540

          .         .         .         .         .         .       g.58823
 GGATTTGGGGACCTCAGTGGACTTCCTTCTGGAGGAGAAGGTCTAGAGACCTCTGCTTCT       c.4680
 G  F  G  D  L  S  G  L  P  S  G  G  E  G  L  E  T  S  A  S         p.1560

          .         .         .         .         .         .       g.58883
 GAAGTAGGGACTGACCTCAGTGGGCTTCCTTCTGGAAGGGAGGGTCTAGAGACTTCAGCT       c.4740
 E  V  G  T  D  L  S  G  L  P  S  G  R  E  G  L  E  T  S  A         p.1580

          .         .         .         .         .         .       g.58943
 TCTGGAGCTGAGGACCTCAGTGGGTTGCCTTCTGGAAAAGAAGACTTGGTGGGGTCAGCT       c.4800
 S  G  A  E  D  L  S  G  L  P  S  G  K  E  D  L  V  G  S  A         p.1600

          .         .         .         .         .         .       g.59003
 TCTGGAGACTTGGACTTGGGCAAACTGCCTTCTGGAACTCTAGGAAGTGGGCAAGCTCCA       c.4860
 S  G  D  L  D  L  G  K  L  P  S  G  T  L  G  S  G  Q  A  P         p.1620

          .         .         .         .         .         .       g.59063
 GAAACAAGTGGTCTTCCCTCTGGATTTAGTGGTGAGTATTCTGGGGTGGACCTTGGAAGT       c.4920
 E  T  S  G  L  P  S  G  F  S  G  E  Y  S  G  V  D  L  G  S         p.1640

          .         .         .         .         .         .       g.59123
 GGCCCACCCTCTGGCCTGCCTGACTTTAGTGGACTTCCATCTGGATTCCCAACTGTTTCC       c.4980
 G  P  P  S  G  L  P  D  F  S  G  L  P  S  G  F  P  T  V  S         p.1660

          .         .         .         .         .         .       g.59183
 CTAGTGGATTCTACATTGGTGGAAGTGGTCACAGCCTCCACTGCAAGTGAACTGGAAGGG       c.5040
 L  V  D  S  T  L  V  E  V  V  T  A  S  T  A  S  E  L  E  G         p.1680

          .         .         .         .         .         .       g.59243
 AGGGGAACCATTGGCATCAGTGGTGCAGGAGAAATATCTGGACTGCCCTCCAGTGAGCTG       c.5100
 R  G  T  I  G  I  S  G  A  G  E  I  S  G  L  P  S  S  E  L         p.1700

          .         .         .         .         .         .       g.59303
 GACATTAGTGGGAGAGCTAGTGGACTCCCTTCAGGAACTGAACTCAGTGGCCAAGCATCT       c.5160
 D  I  S  G  R  A  S  G  L  P  S  G  T  E  L  S  G  Q  A  S         p.1720

          .         .         .         .         .         .       g.59363
 GGGTCTCCTGATGTCAGTGGGGAAATACCTGGACTCTTTGGTGTCAGTGGACAGCCATCA       c.5220
 G  S  P  D  V  S  G  E  I  P  G  L  F  G  V  S  G  Q  P  S         p.1740

          .         .         .         .         .         .       g.59423
 GGGTTTCCTGACACTAGTGGGGAAACATCTGGAGTGACTGAGCTTAGCGGGCTGTCCTCT       c.5280
 G  F  P  D  T  S  G  E  T  S  G  V  T  E  L  S  G  L  S  S         p.1760

          .         .         .         .         .         .       g.59483
 GGACAACCAGGTATTAGTGGAGAAGCATCTGGAGTTCTTTATGGCACTAGTCAACCCTTT       c.5340
 G  Q  P  G  I  S  G  E  A  S  G  V  L  Y  G  T  S  Q  P  F         p.1780

          .         .         .         .         .         .       g.59543
 GGCATAACTGATCTGAGTGGAGAAACATCTGGGGTCCCTGATCTCAGTGGGCAGCCTTCA       c.5400
 G  I  T  D  L  S  G  E  T  S  G  V  P  D  L  S  G  Q  P  S         p.1800

          .         .         .         .         .         .       g.59603
 GGGTTACCAGGGTTCAGTGGGGCAACATCAGGAGTCCCTGACCTGGTTTCTGGTACCACG       c.5460
 G  L  P  G  F  S  G  A  T  S  G  V  P  D  L  V  S  G  T  T         p.1820

          .         .         .         .         .         .       g.59663
 AGTGGCAGCGGTGAATCTTCTGGGATTACATTTGTGGACACCAGTTTGGTTGAAGTGGCC       c.5520
 S  G  S  G  E  S  S  G  I  T  F  V  D  T  S  L  V  E  V  A         p.1840

          .         .         .         .         .         .       g.59723
 CCTACTACATTTAAAGAAGAAGAAGGCTTAGGGTCTGTGGAACTCAGTGGCCTCCCTTCC       c.5580
 P  T  T  F  K  E  E  E  G  L  G  S  V  E  L  S  G  L  P  S         p.1860

          .         .         .         .         .         .       g.59783
 GGAGAGGCAGATCTGTCAGGCAAATCTGGGATGGTGGATGTCAGTGGACAGTTTTCTGGA       c.5640
 G  E  A  D  L  S  G  K  S  G  M  V  D  V  S  G  Q  F  S  G         p.1880

          .         .         .         .         .         .       g.59843
 ACAGTCGATTCCAGTGGGTTTACATCCCAGACTCCGGAATTCAGTGGCCTACCAAGTGGC       c.5700
 T  V  D  S  S  G  F  T  S  Q  T  P  E  F  S  G  L  P  S  G         p.1900

          .         .         .         .         .         .       g.59903
 ATAGCTGAGGTCAGTGGAGAATCCTCCAGAGCTGAGATTGGGAGCAGCCTGCCCTCGGGA       c.5760
 I  A  E  V  S  G  E  S  S  R  A  E  I  G  S  S  L  P  S  G         p.1920

          .         .         .         .         .         .       g.59963
 GCATATTATGGCAGTGGAACTCCATCTAGTTTCCCCACTGTCTCTCTTGTAGACAGAACT       c.5820
 A  Y  Y  G  S  G  T  P  S  S  F  P  T  V  S  L  V  D  R  T         p.1940

          .         .         .         .         .         .       g.60023
 TTGGTGGAATCTGTAACCCAGGCTCCAACAGCCCAAGAGGCAGGAGAAGGGCCTTCTGGC       c.5880
 L  V  E  S  V  T  Q  A  P  T  A  Q  E  A  G  E  G  P  S  G         p.1960

          .         .         .         .         .         .       g.60083
 ATTTTAGAACTCAGTGGTGCTCATTCTGGAGCACCAGACATGTCTGGGGAGCATTCTGGA       c.5940
 I  L  E  L  S  G  A  H  S  G  A  P  D  M  S  G  E  H  S  G         p.1980

          .         .         .         .         .         .       g.60143
 TTTCTGGACCTAAGTGGGCTGCAGTCCGGGCTGATAGAGCCCAGCGGAGAGCCACCAGGT       c.6000
 F  L  D  L  S  G  L  Q  S  G  L  I  E  P  S  G  E  P  P  G         p.2000

          .         .         .         .         .         .       g.60203
 ACTCCATATTTTAGTGGGGATTTTGCCAGCACCACCAATGTAAGTGGAGAATCCTCTGTA       c.6060
 T  P  Y  F  S  G  D  F  A  S  T  T  N  V  S  G  E  S  S  V         p.2020

          .         .         .         .         .         .       g.60263
 GCCATGGGCACCAGTGGAGAGGCCTCAGGACTTCCAGAAGTTACTTTAATCACTTCTGAG       c.6120
 A  M  G  T  S  G  E  A  S  G  L  P  E  V  T  L  I  T  S  E         p.2040

          .         .         .         .         .         .       g.60323
 TTCGTGGAGGGTGTTACTGAACCAACTATTTCTCAGGAACTAGGCCAAAGGCCCCCTGTG       c.6180
 F  V  E  G  V  T  E  P  T  I  S  Q  E  L  G  Q  R  P  P  V         p.2060

          .         .         .         .         .         .       g.60383
 ACACACACACCCCAGCTTTTTGAGTCCAGTGGAAAAGTCTCCACAGCTGGGGACATTAGT       c.6240
 T  H  T  P  Q  L  F  E  S  S  G  K  V  S  T  A  G  D  I  S         p.2080

          .         .         .         .         .         .       g.60443
 GGAGCTACCCCAGTGCTCCCTGGGTCTGGAGTAGAAGTATCATCAGTCCCAGAATCTAGC       c.6300
 G  A  T  P  V  L  P  G  S  G  V  E  V  S  S  V  P  E  S  S         p.2100

          .         .         .         .         .         .       g.60503
 AGTGAGACGTCCGCCTATCCTGAAGCTGGGTTCGGGGCATCTGCCGCCCCTGAGGCCAGC       c.6360
 S  E  T  S  A  Y  P  E  A  G  F  G  A  S  A  A  P  E  A  S         p.2120

          .         .         .         .         .         .       g.60563
 AGAGAAGATTCTGGGTCCCCTGATCTGAGTGAAACCACCTCTGCATTCCACGAAGCTAAC       c.6420
 R  E  D  S  G  S  P  D  L  S  E  T  T  S  A  F  H  E  A  N         p.2140

          .         .         .         .         .         .       g.60623
 CTTGAGAGATCCTCTGGCCTAGGAGTGAGCGGCAGCACTTTGACATTTCAAGAAGGCGAG       c.6480
 L  E  R  S  S  G  L  G  V  S  G  S  T  L  T  F  Q  E  G  E         p.2160

          .         .         .         .         .         .       g.60683
 GCGTCCGCTGCCCCAGAAGTGAGTGGAGAATCCACCACCACCAGTGATGTGGGGACAGAG       c.6540
 A  S  A  A  P  E  V  S  G  E  S  T  T  T  S  D  V  G  T  E         p.2180

          .         .         .         .         .         .       g.60743
 GCACCAGGCTTGCCTTCAGCCACTCCCACGGCTTCTGGAGACAGGACTGAAATCAGCGGA       c.6600
 A  P  G  L  P  S  A  T  P  T  A  S  G  D  R  T  E  I  S  G         p.2200

          .         .         .         .         .         .       g.60803
 GACCTGTCTGGTCACACCTCGCAGCTGGGCGTTGTCATCAGCACCAGCATCCCAGAGTCT       c.6660
 D  L  S  G  H  T  S  Q  L  G  V  V  I  S  T  S  I  P  E  S         p.2220

          .         .         .         .         .         .       g.60863
 GAGTGGACCCAGCAGACCCAGCGCCCTGCAGAGACGCATCTAGAAATTGAGTCCTCAAGC       c.6720
 E  W  T  Q  Q  T  Q  R  P  A  E  T  H  L  E  I  E  S  S  S         p.2240

          .         .         .         .         .         .       g.60923
 CTCCTGTACTCAGGAGAAGAGACTCACACAGTCGAAACAGCCACCTCCCCAACAGATGCT       c.6780
 L  L  Y  S  G  E  E  T  H  T  V  E  T  A  T  S  P  T  D  A         p.2260

          .         .         .         .         .   | 13     .    g.61891
 TCCATCCCAGCTTCTCCGGAATGGAAACGTGAATCAGAATCAACTGCTGCAG | CCCCCGCC    c.6840
 S  I  P  A  S  P  E  W  K  R  E  S  E  S  T  A  A  A |   P  A      p.2280

          .         .         .         .         .         .       g.61951
 AGGTCCTGTGCAGAGGAGCCCTGTGGAGCTGGGACCTGCAAGGAGACAGAGGGACACGTC       c.6900
 R  S  C  A  E  E  P  C  G  A  G  T  C  K  E  T  E  G  H  V         p.2300

          .         .         .         .       | 14 .         .    g.72953
 ATATGCCTGTGCCCCCCTGGCTACACTGGCGAGCACTGTAACATAG | ACCAGGAGGTATGT    c.6960
 I  C  L  C  P  P  G  Y  T  G  E  H  C  N  I  D |   Q  E  V  C      p.2320

          .         .         .         .         .         .       g.73013
 GAGGAGGGCTGGAACAAGTACCAGGGCCACTGTTACCGCCACTTCCCGGACCGCGAGACC       c.7020
 E  E  G  W  N  K  Y  Q  G  H  C  Y  R  H  F  P  D  R  E  T         p.2340

          .         .         .         .         .         .       g.73073
 TGGGTGGATGCTGAGCGCCGGTGTCGGGAGCAGCAGTCACACCTGAGCAGCATCGTCACC       c.7080
 W  V  D  A  E  R  R  C  R  E  Q  Q  S  H  L  S  S  I  V  T         p.2360

          .         .      | 15  .         .         .         .    g.73595
 CCCGAGGAGCAGGAGTTTGTCAACA | ACAATGCCCAAGACTACCAGTGGATCGGCCTGAAC    c.7140
 P  E  E  Q  E  F  V  N  N |   N  A  Q  D  Y  Q  W  I  G  L  N      p.2380

          .         .         .         .         | 16         .    g.74450
 GACAGGACCATCGAAGGGGACTTCCGCTGGTCAGATGGACACCCCATG | CAATTTGAGAAC    c.7200
 D  R  T  I  E  G  D  F  R  W  S  D  G  H  P  M   | Q  F  E  N      p.2400

          .         .         .         .         .         .       g.74510
 TGGCGCCCCAACCAGCCTGACAACTTTTTTGCCGCTGGAGAGGACTGTGTGGTGATGATC       c.7260
 W  R  P  N  Q  P  D  N  F  F  A  A  G  E  D  C  V  V  M  I         p.2420

          .         .         .         .         .         .       g.74570
 TGGCACGAGAAGGGCGAGTGGAATGATGTTCCCTGCAATTACCACCTCCCCTTCACGTGT       c.7320
 W  H  E  K  G  E  W  N  D  V  P  C  N  Y  H  L  P  F  T  C         p.2440

          .    | 17    .         .         .         .         .    g.75446
 AAAAAGGGCACAG | TGGCCTGCGGAGAGCCCCCTGTGGTGGAGCATGCCAGGACCTTCGGG    c.7380
 K  K  G  T  V |   A  C  G  E  P  P  V  V  E  H  A  R  T  F  G      p.2460

          .         .         .         .         .         .       g.75506
 CAGAAGAAGGACCGGTATGAGATCAATTCCCTGGTGCGGTACCAGTGCACAGAGGGGTTT       c.7440
 Q  K  K  D  R  Y  E  I  N  S  L  V  R  Y  Q  C  T  E  G  F         p.2480

          .         .         .         .         .         .       g.75566
 GTCCAGCGCCACATGCCCACCATCCGGTGCCAGCCCAGCGGGCACTGGGAGGAGCCTCAG       c.7500
 V  Q  R  H  M  P  T  I  R  C  Q  P  S  G  H  W  E  E  P  Q         p.2500

          .       | 18 .         .         .         .         .    g.76006
 ATCACCTGCACAGACC | CCACCACCTACAAACGCAGACTACAGAAGCGGAGCTCACGGCAC    c.7560
 I  T  C  T  D  P |   T  T  Y  K  R  R  L  Q  K  R  S  S  R  H      p.2520

          .         .         .                                     g.76039
 CCTCGGAGGAGCCGCCCCAGCACAGCCCACTGA                                  c.7593
 P  R  R  S  R  P  S  T  A  H  X                                    p.2530

          .         .         .         .         .         .       g.76099
 gaagagcttccaggacgcacccaggacgctgagcccaggagcctgccaggctgacgtgca       c.*60

          .         .         .         .         .         .       g.76159
 tcccacccagacggtgtcctcttcttgtcgctttttgtcatataaggaatcccattaaag       c.*120

          .         .         .         .         .         .       g.76219
 aaggaaaaaaataaatcccacatttgtgtatgcacccactcacccctccaaatcagcaaa       c.*180

          .         .         .         .         .         .       g.76279
 accgcatctaatttgtccgccgaatgccaaagcaaagcaaacttattataacccttggac       c.*240

          .         .         .         .         .         .       g.76339
 tgagtttagagacatttcttcaatttcccatcgtgcctttccagggaccagtgcagggac       c.*300

          .         .         .         .         .         .       g.76399
 agggggagaaggggaggggttaagttaaataaagaagattatttttgtttcctgacttta       c.*360

          .         .         .         .         .         .       g.76459
 tccaagagcagtgcaatcgttggttatttcacctccagggagagctagggaggagggagg       c.*420

          .         .         .         .         .         .       g.76519
 agggctccaaaggagctggaaggagcagaggcctgagagcaggaagaactcggaaccgca       c.*480

          .         .         .         .         .         .       g.76579
 gctgaatgtattggatgagaaggagccaggagggctacaccatctgtatgagggaaaagc       c.*540

          .         .         .         .         .         .       g.76639
 cttgggggagaggggtgggttcctgcctcctgccgagggtaagccggcaggagagagcca       c.*600

          .         .         .         .         .         .       g.76699
 tcagagggacctccgctgcctgggagttgggttccctccaagggtccctctttcagtgtc       c.*660

          .         .         .         .         .         .       g.76759
 ctctctctcacctgggtctgccaccctaacaggtggcaactcggcagggctgctgggggc       c.*720

          .         .         .         .         .         .       g.76819
 acttcctgcccagtggggggtgccgcccaaccttctcccctccccacccccgcccccggg       c.*780

          .         .         .         .         .         .       g.76879
 accgtgcaggcaccagggttccgtgcacctatttatatttttgaaaactgaagattataa       c.*840

          .         .         .                                     g.76912
 tattataataataataaagacattggaagagat                                  c.*873

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Aggrecan protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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