acetyl-CoA acetyltransferase 1 (ACAT1) - coding DNA reference sequence

(used for variant description)

(last modified February 17, 2026)


This file was created to facilitate the description of sequence variants on transcript NM_000019.3 in the ACAT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering ACAT1 transcript NM_000019.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             ggccgctaggggtgcg       c.-61

 .         .         .         .         .         .                g.5076
 gggttggggaggaggccgctagtctacgcctgtggagccgatactcagccctctgcgacc       c.-1

          .         .         .         .         .         .       g.5136
 ATGGCTGTGCTGGCGGCACTTCTGCGCAGCGGCGCCCGCAGCCGCAGCCCCCTGCTCCGG       c.60
 M  A  V  L  A  A  L  L  R  S  G  A  R  S  R  S  P  L  L  R         p.20

          .   | 02     .         .         .         .         .    g.15424
 AGGCTGGTGCAG | GAAATAAGATATGTGGAACGGAGTTATGTATCAAAACCCACTTTGAAG    c.120
 R  L  V  Q   | E  I  R  Y  V  E  R  S  Y  V  S  K  P  T  L  K      p.40

  | 03       .         .         .         .         .         .    g.17349
  | GAAGTGGTCATAGTAAGTGCTACAAGAACACCCATTGGATCTTTTTTAGGCAGCCTTTCC    c.180
  | E  V  V  I  V  S  A  T  R  T  P  I  G  S  F  L  G  S  L  S      p.60

          .         .         .         .         .         | 04    g.17692
 TTGCTGCCAGCCACTAAGCTTGGTTCCATTGCAATTCAGGGAGCCATTGAAAAGGCAG | GG    c.240
 L  L  P  A  T  K  L  G  S  I  A  I  Q  G  A  I  E  K  A  G |       p.80

          .         .         .         .         .         .       g.17752
 ATTCCAAAAGAAGAAGTGAAAGAAGCATACATGGGTAATGTTCTACAAGGAGGTGAAGGA       c.300
 I  P  K  E  E  V  K  E  A  Y  M  G  N  V  L  Q  G  G  E  G         p.100

          .         .         .     | 05   .         .         .    g.18637
 CAAGCTCCTACAAGGCAGGCAGTATTGGGTGCAG | GCTTACCTATTTCTACTCCATGTACC    c.360
 Q  A  P  T  R  Q  A  V  L  G  A  G |   L  P  I  S  T  P  C  T      p.120

          .         .         .         .         .         .       g.18697
 ACCATAAACAAAGTTTGTGCTTCAGGAATGAAAGCCATCATGATGGCCTCTCAAAGTCTT       c.420
 T  I  N  K  V  C  A  S  G  M  K  A  I  M  M  A  S  Q  S  L         p.140

          .      | 06  .         .         .         .         .    g.22412
 ATGTGTGGACATCAG | GATGTGATGGTGGCAGGTGGGATGGAGAGCATGTCCAATGTTCCA    c.480
 M  C  G  H  Q   | D  V  M  V  A  G  G  M  E  S  M  S  N  V  P      p.160

          .         .         .         .         .         .       g.22472
 TATGTAATGAACAGAGGATCAACACCATATGGTGGGGTAAAGCTTGAAGATTTGATTGTA       c.540
 Y  V  M  N  R  G  S  T  P  Y  G  G  V  K  L  E  D  L  I  V         p.180

          .         .         .          | 07        .         .    g.23555
 AAAGACGGGCTAACTGATGTCTACAATAAAATTCATATG | GGCAGCTGTGCTGAGAATACA    c.600
 K  D  G  L  T  D  V  Y  N  K  I  H  M   | G  S  C  A  E  N  T      p.200

          .         .         .         .         .         .       g.23615
 GCAAAGAAGCTGAATATTGCACGAAATGAACAGGACGCTTATGCTATTAATTCTTATACC       c.660
 A  K  K  L  N  I  A  R  N  E  Q  D  A  Y  A  I  N  S  Y  T         p.220

          .         .         .         .         .         .       g.23675
 AGAAGTAAAGCAGCATGGGAAGCTGGGAAATTTGGAAATGAAGTTATTCCTGTCACAGTT       c.720
 R  S  K  A  A  W  E  A  G  K  F  G  N  E  V  I  P  V  T  V         p.240

          . | 08       .         .         .         .         .    g.25124
 ACAGTAAAAG | GTCAACCAGATGTAGTGGTGAAAGAAGATGAAGAATATAAACGTGTTGAT    c.780
 T  V  K  G |   Q  P  D  V  V  V  K  E  D  E  E  Y  K  R  V  D      p.260

          .         .         .         .       | 09 .         .    g.25920
 TTTAGCAAAGTTCCAAAGCTGAAGACAGTTTTCCAGAAAGAAAATG | GCACAGTAACAGCT    c.840
 F  S  K  V  P  K  L  K  T  V  F  Q  K  E  N  G |   T  V  T  A      p.280

          .         .         .         .         .         .       g.25980
 GCCAATGCCAGTACACTGAATGATGGAGCAGCTGCTCTGGTTCTCATGACGGCAGATGCA       c.900
 A  N  A  S  T  L  N  D  G  A  A  A  L  V  L  M  T  A  D  A         p.300

          .         .         .         . | 10       .         .    g.27472
 GCGAAGAGGCTCAATGTTACACCACTGGCAAGAATAGTAG | CATTTGCTGACGCTGCTGTA    c.960
 A  K  R  L  N  V  T  P  L  A  R  I  V  A |   F  A  D  A  A  V      p.320

          .         .         .         .      | 11  .         .    g.29686
 GAACCTATTGATTTTCCAATTGCTCCTGTATATGCTGCATCTATG | GTTCTTAAAGATGTG    c.1020
 E  P  I  D  F  P  I  A  P  V  Y  A  A  S  M   | V  L  K  D  V      p.340

          .         .         .         .         .         .       g.29746
 GGATTGAAAAAAGAAGATATTGCAATGTGGGAAGTAAATGAAGCCTTTAGTCTGGTTGTA       c.1080
 G  L  K  K  E  D  I  A  M  W  E  V  N  E  A  F  S  L  V  V         p.360

          .         .         .         .         .         .       g.29806
 CTAGCAAACATTAAAATGTTGGAGATTGATCCCCAAAAAGTGAATATCAATGGAGGAGCT       c.1140
 L  A  N  I  K  M  L  E  I  D  P  Q  K  V  N  I  N  G  G  A         p.380

          .         .    | 12    .         .         .         .    g.30776
 GTTTCTCTGGGACATCCAATTGG | GATGTCTGGAGCCAGGATTGTTGGTCATTTGACTCAT    c.1200
 V  S  L  G  H  P  I  G  |  M  S  G  A  R  I  V  G  H  L  T  H      p.400

          .         .         .         .         .         .       g.30836
 GCCTTGAAGCAAGGAGAATACGGTCTTGCCAGTATTTGCAATGGAGGAGGAGGTGCTTCT       c.1260
 A  L  K  Q  G  E  Y  G  L  A  S  I  C  N  G  G  G  G  A  S         p.420

          .         .                                               g.30860
 GCCATGCTAATTCAGAAGCTGTAG                                           c.1284
 A  M  L  I  Q  K  L  X                                             p.427

          .         .         .         .         .         .       g.30920
 acaacctctgctatttaaggagacaaccctatgtgaccagaaggcctgctgtaatcagtg       c.*60

          .         .         .         .         .         .       g.30980
 tgactactgtgggtcagcttatattcagataagctgtttcattttttattattttctatg       c.*120

          .         .         .         .         .         .       g.31040
 ttaacttttaaaaatcaaaatgatgaaatcccaaaacattttgaaattaaaaataaattt       c.*180

          .         .         .         .         .         .       g.31100
 cttcttctgcttttttcttggtaaccttgaaaagtttgatacatttttgcattctgagtc       c.*240

          .         .         .         .         .         .       g.31160
 tatacttatcgaaatatggtagaaataccaatgtgtaatattagtgacttacataagtag       c.*300

          .         .         .         .         .         .       g.31220
 ctagaagtttccatttgtgagaacacatttatatttttgaggattgttaaaggtcaagtg       c.*360

          .         .         .         .         .         .       g.31280
 aatgctctttataggtaatttacatttagtaaattacggtaaattaaattacttctcttt       c.*420

          .         .         .         .         .         .       g.31340
 acagtaagagttggctattctggacaaactagcagtgcttcatataatcactcaaaccac       c.*480

          .         .         .         .         .         .       g.31400
 agtgtgtgcagcagtactagaaacaagacagaagcccatgtcctcagggtctagagtggg       c.*540

          .         .         .         .         .         .       g.31460
 ggcaatttcttataacctcaacattcagggttgggggaggtcaagcagaaaaccctggag       c.*600

          .         .         .         .         .         .       g.31520
 tttgggctctgaattactatagcagcatagagagtgggaagggaggtagaaactgatatg       c.*660

          .         .         .         .         .         .       g.31580
 ctgaatggatatataaaaaagggaacagatcaccacttccaatacacgacaatgcctgtt       c.*720

          .         .         .         .         .                 g.31638
 cttaagcaggacagactgtaacagaagtatctcgcattgcattttatctgggaaaaaa         c.*778

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Acetyl-CoA acetyltransferase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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