acyl-CoA thioesterase 9 (ACOT9) - coding DNA reference sequence

(used for variant description)

(last modified January 29, 2025)

This file was created to facilitate the description of sequence variants on transcript NM_001037171.1 in the ACOT9 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000023.10, covering ACOT9 transcript NM_001037171.1.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5026
                                   cgcccccggacaccgctgtccggctc       c.-121

 .         .         .         .         .         .                g.5086
 ccgggctgtcctcagcaagggcgcggtctggtactcgtgcgtcttttatcgcctcagttt       c.-61

 .         .         .         .         .         .                g.5146
 ccctccgccgactagcgcgcggggcccggttctccatcgcgcgcacggcagcctagcgca       c.-1

          .         . | 02       .         .         .         .    g.12314
 ATGAGGCGGGCAGCACTGCG | GCTTTGTGCCTTGGGCAAAGGGCAGCTTACTCCTGGAAGA    c.60
 M  R  R  A  A  L  R  |  L  C  A  L  G  K  G  Q  L  T  P  G  R      p.20

          .         .         .         .         .         | 03    g.13925
 GGACTGACTCAAGGACCCCAGAACCCCAAGAAACAGGGAATCTTCCACATTCATGAAG | CA    c.120
 G  L  T  Q  G  P  Q  N  P  K  K  Q  G  I  F  H  I  H  E  A |       p.40

          .         .      | 04  .         .         .         .    g.15108
 TGTTCATCTATACATGTGAATCATG | TTCGAGATAAGTTGCGGGAGATAGTAGGAGCATCC    c.180
 C  S  S  I  H  V  N  H  V |   R  D  K  L  R  E  I  V  G  A  S      p.60

          .  | 05      .         .         .         .         .    g.17353
 ACAAACTGGAG | AGACCATGTGAAGGCAATGGAAGAAAGGAAATTACTTCATAGTTTCTTG    c.240
 T  N  W  R  |  D  H  V  K  A  M  E  E  R  K  L  L  H  S  F  L      p.80

          .         .         .         .         .         .       g.17413
 GCTAAATCACAGGATGGACTGCCTCCTAGGAGAATGAAGGACAGTTATATTGAAGTTCTC       c.300
 A  K  S  Q  D  G  L  P  P  R  R  M  K  D  S  Y  I  E  V  L         p.100

          .         .         .         .         .         .       g.17473
 TTGCCTTTGGGCAGTGAGCCTGAATTACGAGAGAAATATTTGACTGTTCAAAACACCGTA       c.360
 L  P  L  G  S  E  P  E  L  R  E  K  Y  L  T  V  Q  N  T  V         p.120

    | 06     .         .         .         . | 07       .         . g.25557
 AG | ATTTGGCAGGATTCTTGAGGATCTTGACAGCTTGGGAG | TTCTTATTTGTTACATGCAC c.420
 R  |  F  G  R  I  L  E  D  L  D  S  L  G  V |   L  I  C  Y  M  H   p.140

          .         .         .         .         .         .       g.25617
 AACAAAATCCACTCCGCCAAGATGTCTCCTTTATCGATAGTTACAGCCCTGGTGGATAAG       c.480
 N  K  I  H  S  A  K  M  S  P  L  S  I  V  T  A  L  V  D  K         p.160

      | 08   .         .         .         .         .         .    g.26362
 ATTG | ATATGTGTAAGAAGAGCTTGAGCCCAGAACAGGACATTAAGTTCAGTGGCCATGTT    c.540
 I  D |   M  C  K  K  S  L  S  P  E  Q  D  I  K  F  S  G  H  V      p.180

          .         .         .         .         | 09         .    g.35094
 AGCTGGGTCGGGAAGACATCCATGGAAGTGAAGATGCAAATGTTCCAG | TTACATGGTGAT    c.600
 S  W  V  G  K  T  S  M  E  V  K  M  Q  M  F  Q   | L  H  G  D      p.200

          .         .         .         .         .         .       g.35154
 GAATTTTGTCCTGTTTTGGATGCAACATTTGTAATGGTGGCTCGTGATTCTGAAAATAAA       c.660
 E  F  C  P  V  L  D  A  T  F  V  M  V  A  R  D  S  E  N  K         p.220

    | 10     .         .         .         .         .         .    g.40404
 GG | GCCGGCATTTGTAAATCCACTCATCCCTGAAAGCCCAGAGGAAGAGGAGCTCTTTAGA    c.720
 G  |  P  A  F  V  N  P  L  I  P  E  S  P  E  E  E  E  L  F  R      p.240

          . | 11       .         .         .         .         .    g.41601
 CAAGGGGAAT | TGAACAAGGGGAGAAGAATTGCCTTCAGCTCCACGTCGTTACTGAAAATG    c.780
 Q  G  E  L |   N  K  G  R  R  I  A  F  S  S  T  S  L  L  K  M      p.260

          .         .         .         .         .         .       g.41661
 GCCCCCAGCGCTGAGGAGAGGACCACCATACATGAGATGTTTCTCAGCACACTGGATCCA       c.840
 A  P  S  A  E  E  R  T  T  I  H  E  M  F  L  S  T  L  D  P         p.280

    | 12     .         .         .         .         .         .    g.42490
 AA | GACTATAAGTTTTCGGAGTCGAGTTTTACCCTCTAATGCAGTGTGGATGGAGAATTCA    c.900
 K  |  T  I  S  F  R  S  R  V  L  P  S  N  A  V  W  M  E  N  S      p.300

          .         .         .    | 13    .         .         .    g.42723
 AAACTGAAGAGTTTGGAAATTTGCCACCCTCAG | GAGCGGAACATTTTCAATCGGATCTTT    c.960
 K  L  K  S  L  E  I  C  H  P  Q   | E  R  N  I  F  N  R  I  F      p.320

          .         .         .         .         .          | 14    g.43211
 GGTGGTTTCCTTATGAGGAAGGCATATGAACTTGCGTGGGCTACTGCTTGTAGCTTTGG | T    c.1020
 G  G  F  L  M  R  K  A  Y  E  L  A  W  A  T  A  C  S  F  G  |      p.340

          .         .         .         .         .         .       g.43271
 GGTTCTCGACCGTTTGTGGTAGCAGTAGATGACATCATGTTTCAGAAACCTGTTGAGGTT       c.1080
 G  S  R  P  F  V  V  A  V  D  D  I  M  F  Q  K  P  V  E  V         p.360

          .         .        | 15.         .         .         .    g.43479
 GGCTCATTGCTCTTTCTTTCTTCACAG | GTATGCTTTACTCAGAATAATTATATTCAAGTC    c.1140
 G  S  L  L  F  L  S  S  Q   | V  C  F  T  Q  N  N  Y  I  Q  V      p.380

          .         .         .         .         .         .       g.43539
 AGAGTACACAGTGAAGTGGCCTCCCTGCAGGAGAAGCAGCATACAACCACCAATGTCTTT       c.1200
 R  V  H  S  E  V  A  S  L  Q  E  K  Q  H  T  T  T  N  V  F         p.400

          .         .         .         .         .         | 16    g.44310
 CATTTCACGTTCATGTCGGAAAAAGAAGTGCCATTGGTTTTCCCAAAAACATATGGAG | AG    c.1260
 H  F  T  F  M  S  E  K  E  V  P  L  V  F  P  K  T  Y  G  E |       p.420

          .         .         .         .         .         .       g.44370
 TCCATGTTGTACTTAGATGGGCAGCGGCATTTCAACTCCATGAGTGGCCCAGCGACCTTG       c.1320
 S  M  L  Y  L  D  G  Q  R  H  F  N  S  M  S  G  P  A  T  L         p.440

          .         .                                               g.44397
 AGAAAGGACTACCTTGTGGAGCCCTAA                                        c.1347
 R  K  D  Y  L  V  E  P  X                                          p.448

          .         .         .         .         .         .       g.44457
 gaacaccacatttgttgaaaactagcactctacccacagtgacgtggtatctgatgaaga       c.*60

          .         .         .         .         .         .       g.44517
 cctgatcgagtgtattgattttagtattgcttcgtgtcctccacacaggaggaggatgta       c.*120

          .         .         .         .         .         .       g.44577
 ttcagcctttaggatgatcagaaaagcagaaagagagagtggccggatggggctgagggg       c.*180

          .         .         .         .         .                 g.44631
 agaaagaattattaaacaataaatactttcaagacaattttaattgtgaaccta             c.*234

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Acyl-CoA thioesterase 9 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.