acid phosphatase 5, tartrate resistant (ACP5) - coding DNA reference sequence

(used for variant description)

(last modified June 29, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001111035.1 in the ACP5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028127.1, covering ACP5 transcript NM_001111035.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          cgc       c.-301

 .         .         .         .         .         .                g.5063
 cggggctcacctgggtcagccctgagccctcgagcagggcggatcggccgctgcctgctt       c.-241

 .         .         .         .         .         .                g.5123
 aaagctggggccgccaggagtgcgatcgcctgcggatctgcagctgggcaccggccgcaa       c.-181

 .         .          | 02        .         .         .             g.5369
 cgcccgccccgcgacggcag | ggactgaagggactcctgaatgtccgcgggacgtgtcgcg    c.-121

 .         .         .         .   | 03     .         .             g.6334
 gcggcgcccagcacggaggaggcaggcagggag | ggaataaaggctcagggaccggcagtt    c.-61

 .         .         .         .         .         .                g.6394
 ctactctagagcccaccagcctctcagagcctccggtgactggcctgtgtctccccctgg       c.-1

  | 04       .         .         .         .         .         .    g.6729
  | ATGGACATGTGGACGGCGCTGCTCATCCTGCAAGCCTTGTTGCTACCCTCCCTGGCTGAT    c.60
  | M  D  M  W  T  A  L  L  I  L  Q  A  L  L  L  P  S  L  A  D      p.20

          .         .         .         .         .         .       g.6789
 GGTGCCACCCCTGCCCTGCGCTTTGTAGCCGTGGGTGACTGGGGAGGGGTCCCCAATGCC       c.120
 G  A  T  P  A  L  R  F  V  A  V  G  D  W  G  G  V  P  N  A         p.40

          .         .         .         .         .         .       g.6849
 CCATTCCACACGGCCCGGGAAATGGCCAATGCCAAGGAGATCGCTCGGACTGTGCAGATC       c.180
 P  F  H  T  A  R  E  M  A  N  A  K  E  I  A  R  T  V  Q  I         p.60

          .         .         .         .         .         .       g.6909
 CTGGGTGCAGACTTCATCCTGTCTCTAGGGGACAATTTTTACTTCACTGGTGTGCAAGAC       c.240
 L  G  A  D  F  I  L  S  L  G  D  N  F  Y  F  T  G  V  Q  D         p.80

          .         .  | 05      .         .         .         .    g.7182
 ATCAATGACAAGAGGTTCCAG | GAGACCTTTGAGGACGTATTCTCTGACCGCTCCCTTCGC    c.300
 I  N  D  K  R  F  Q   | E  T  F  E  D  V  F  S  D  R  S  L  R      p.100

          .         .         .         .         .         .       g.7242
 AAAGTGCCCTGGTACGTGCTAGCCGGAAACCATGACCACCTTGGCAATGTCTCTGCCCAG       c.360
 K  V  P  W  Y  V  L  A  G  N  H  D  H  L  G  N  V  S  A  Q         p.120

          .         .          | 06        .         .         .    g.7429
 ATTGCATACTCTAAGATCTCCAAGCGCTG | GAACTTCCCCAGCCCTTTCTACCGCCTGCAC    c.420
 I  A  Y  S  K  I  S  K  R  W  |  N  F  P  S  P  F  Y  R  L  H      p.140

          .         .         .         .         .         .       g.7489
 TTCAAGATCCCACAGACCAATGTGTCTGTGGCCATTTTTATGCTGGACACAGTGACACTA       c.480
 F  K  I  P  Q  T  N  V  S  V  A  I  F  M  L  D  T  V  T  L         p.160

          .         .         .         .         .         .       g.7549
 TGTGGCAACTCAGATGACTTCCTCAGCCAGCAGCCTGAGAGGCCCCGAGACGTGAAGCTG       c.540
 C  G  N  S  D  D  F  L  S  Q  Q  P  E  R  P  R  D  V  K  L         p.180

          .         .         .         .         .         .       g.7609
 GCCCGCACACAGCTGTCCTGGCTCAAGAAACAGCTGGCGGCGGCCAGGGAGGACTACGTG       c.600
 A  R  T  Q  L  S  W  L  K  K  Q  L  A  A  A  R  E  D  Y  V         p.200

          .         .         .         .         .         .       g.7669
 CTGGTGGCTGGCCACTACCCCGTGTGGTCCATAGCCGAGCACGGGCCTACCCACTGCCTG       c.660
 L  V  A  G  H  Y  P  V  W  S  I  A  E  H  G  P  T  H  C  L         p.220

          .         .         .         .         .         .       g.7729
 GTCAAGCAGCTACGGCCACTGCTGGCCACATACGGGGTCACTGCCTACCTGTGCGGCCAC       c.720
 V  K  Q  L  R  P  L  L  A  T  Y  G  V  T  A  Y  L  C  G  H         p.240

          .      | 07  .         .         .         .         .    g.8779
 GATCACAATCTGCAG | TACCTGCAAGATGAGAATGGCGTGGGCTACGTGCTGAGTGGGGCT    c.780
 D  H  N  L  Q   | Y  L  Q  D  E  N  G  V  G  Y  V  L  S  G  A      p.260

          .         .         .         .         .         .       g.8839
 GGGAATTTCATGGACCCCTCAAAGCGGCACCAGCGCAAGGTCCCCAACGGCTATCTGCGC       c.840
 G  N  F  M  D  P  S  K  R  H  Q  R  K  V  P  N  G  Y  L  R         p.280

          .         .         .         .         .         .       g.8899
 TTCCACTATGGGACTGAAGACTCACTGGGTGGCTTTGCCTATGTGGAGATCAGCTCCAAA       c.900
 F  H  Y  G  T  E  D  S  L  G  G  F  A  Y  V  E  I  S  S  K         p.300

          .         .         .         .         .         .       g.8959
 GAGATGACTGTCACTTACATCGAGGCCTCGGGCAAGTCCCTCTTTAAGACCAGGCTGCCG       c.960
 E  M  T  V  T  Y  I  E  A  S  G  K  S  L  F  K  T  R  L  P         p.320

          .                                                         g.8977
 AGGCGAGCCAGGCCCTGA                                                 c.978
 R  R  A  R  P  X                                                   p.325

          .         .         .         .         .         .       g.9037
 actcccatgactgcccagctctgaggcccgatctccactgttgggtgggtgggccctgcc       c.*60

          .         .         .         .         .         .       g.9097
 gggaccctgctcacaggcaggcttttcctccaacctgtggcgctgcagcagggcaggaag       c.*120

          .         .         .         .         .         .       g.9157
 gggaaacacagctgatgaactgtggtgccacatgacccttgtggcacagatgcccacgta       c.*180

          .         .         .         .         .         .       g.9217
 tgtgaaacacacatggacatgtgtcccagccacagtgttatgctctgtggctggctcacc       c.*240

          .         .         .         .         .         .       g.9277
 tttgctgagttccggggtgcaatgggggagggagggagggaaagcttcctcctaaatcaa       c.*300

          .         .         .         .         .                 g.9327
 gcatctttctgttactgatgttcaataaaagaatagttgccaaggctgaa                 c.*350

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Acid phosphatase 5, tartrate resistant protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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