acidic repeat containing (ACRC) - coding DNA reference sequence

(used for variant description)

(last modified February 16, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_052957.4 in the ACRC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000023.10, covering ACRC transcript NM_052957.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        ttcccagtggttgcaataacg       c.-481

 .         .         .         .         .         .                g.5081
 gacttagaggtctggacaattcaagtaaggaacaaggctcgcttatccaagttctcgcag       c.-421

 .         .         .         .         .         .                g.5141
 gataaaagtttgttatgaacgatttcacatggtttctctttatcagaaagttgttaggga       c.-361

 .         .         .         .         .         .                g.5201
 cttttaatcgcagaattggcctcgggtgcccacgctctagtattgaaatggcggttttgg       c.-301

 .         .         .         .         .         .                g.5261
 gacaaataagcaacatccgtgggagtggaaagcgacagacctgatcccggaagcgttaca       c.-241

 .         .         .         .         .         .                g.5321
 gctaggcgccaagttcacaggcgcgaagttcaaatttgtcttgtgaccactgtgataggt       c.-181

 .         .         .         .         .         .                g.5381
 gggtacaggggagcgcgggcgagcacacgtgaattactgctaccgccccctaggtccggg       c.-121

 .         .         .         .         .         .                g.5441
 cactataaaggggcctgcgcctggcgttgttcatcgcagttgctccggatctttgcacac       c.-61

 .         .         .         .         .         .        | 02    g.7798
 actccacgggcagttggaggtgagctgctgccggccacgccagaggctgcaacaccag | ac    c.-1

          .         .         .         .         .          | 03    g.19099
 ATGGATGGGTGCAAAAAAGAGCTGCCCCGCTTGCAAGAGCCGGAGGAGGACGAGGATTG | T    c.60
 M  D  G  C  K  K  E  L  P  R  L  Q  E  P  E  E  D  E  D  C  |      p.20

          .         .         .         .       | 04 .         .    g.19527
 TACATCCTTAATGTTCAGTCAAGCAGTGATGACACCAGTGGGTCTT | CTGTGGCCAGAAGA    c.120
 Y  I  L  N  V  Q  S  S  S  D  D  T  S  G  S  S |   V  A  R  R      p.40

          .         . | 05       .         .         .         .    g.21347
 GCTCCGAAGAGACAGGCGAG | TTGCATCCTTAATGTCCAGTCAAGGAGTGGTGACACCAGT    c.180
 A  P  K  R  Q  A  S  |  C  I  L  N  V  Q  S  R  S  G  D  T  S      p.60

         | 06.         .         .         .  | 07      .         . g.24945
 GGGTCTT | CTGTGGCCAGAAGAGCTCCGAAGAGACAGGCGAG | CTCCGTGGTAGTGATTGAC c.240
 G  S  S |   V  A  R  R  A  P  K  R  Q  A  S  |  S  V  V  V  I  D   p.80

          .         .         .         .         .         .       g.25005
 TCTGATTCTGATGAGGAATGTCACACCCATGAAGAGAAGAAAGCTAAGTTATTGGAAATA       c.300
 S  D  S  D  E  E  C  H  T  H  E  E  K  K  A  K  L  L  E  I         p.100

          . | 08       .         .         .         .         .    g.30614
 AACAGCGACG | ATGAGAGTCCGGAGTGTTGTCATGTGAAGCCTGCCATCCAGGAACCTCCA    c.360
 N  S  D  D |   E  S  P  E  C  C  H  V  K  P  A  I  Q  E  P  P      p.120

          .         .         .         .         .         .       g.30674
 ATAGTTATTAGTGATGATGACAATGACGATGACAACGGTAATGATTTGGAAGTTCCCGAC       c.420
 I  V  I  S  D  D  D  N  D  D  D  N  G  N  D  L  E  V  P  D         p.140

          .         .         .         .         .         .       g.30734
 GACAACAGTGATGATTCAGAAGCTCCCGACGACAACAGTGATGATTCGGAAGCTCCTGAC       c.480
 D  N  S  D  D  S  E  A  P  D  D  N  S  D  D  S  E  A  P  D         p.160

          .         .         .         .         .         .       g.30794
 GACAACAGTGATGATTCGGAAGCTCCCGACGACAACAGTGATGATTCGGAAGCTCCCGAC       c.540
 D  N  S  D  D  S  E  A  P  D  D  N  S  D  D  S  E  A  P  D         p.180

          .         .         .         .         .         .       g.30854
 GACAATAGTGATGATTCGGATGTTCCCGACGACAACAGTGATGATTCATCCGACGACAAC       c.600
 D  N  S  D  D  S  D  V  P  D  D  N  S  D  D  S  S  D  D  N         p.200

          .         .         .         .         .         .       g.30914
 AGTGATGATTCATCCGACGACAACAGTGATGATTCGGATGTTCCCGACGACAAGAGTGAT       c.660
 S  D  D  S  S  D  D  N  S  D  D  S  D  V  P  D  D  K  S  D         p.220

          .         .         .         .         .         .       g.30974
 GATTCGGATGTTCCCGACGACAGCAGTGATGATTCGGATGTTCCCGACGACAGCAGTGAT       c.720
 D  S  D  V  P  D  D  S  S  D  D  S  D  V  P  D  D  S  S  D         p.240

          .         .         .         .         .         .       g.31034
 GATTCGGAAGCTCCCGACGACAGCAGTGATGATTCGGAAGCTCCCGACGACAGCAGTGAT       c.780
 D  S  E  A  P  D  D  S  S  D  D  S  E  A  P  D  D  S  S  D         p.260

          .         .         .         .         .         .       g.31094
 GATTCGGAAGCTCCCGACGACAGCAGTGATGATTCGGAAGCTCCCGACGACAGCAGTGAT       c.840
 D  S  E  A  P  D  D  S  S  D  D  S  E  A  P  D  D  S  S  D         p.280

          .         .         .         .         .         .       g.31154
 GATTCGGAAGCTTCCGACGACAGCAGTGATGATTCGGAAGCTTCCGACGACAGCAGTGAT       c.900
 D  S  E  A  S  D  D  S  S  D  D  S  E  A  S  D  D  S  S  D         p.300

          .         .         .         .         .         .       g.31214
 GATTCGGAAGCTCCCGACGACAAGAGTGATGATTCGGATGTTCCCGAAGACAAGAGTGAT       c.960
 D  S  E  A  P  D  D  K  S  D  D  S  D  V  P  E  D  K  S  D         p.320

          .         .         .         .         .         .       g.31274
 GATTCGGATGTTCCCGATGACAATAGTGATGATTTGGAAGTTCCTGTGCCAGCAGAAGAT       c.1020
 D  S  D  V  P  D  D  N  S  D  D  L  E  V  P  V  P  A  E  D         p.340

          .         .         .         .         .         .       g.31334
 TTGTGTAATGAAGGCCAAATTGCTTCAGATGAAGAAGAGCTGGTTGAGGCTGCTGCTGCT       c.1080
 L  C  N  E  G  Q  I  A  S  D  E  E  E  L  V  E  A  A  A  A         p.360

          .         .         .         .         .         .       g.31394
 GTCTCCCAGCATGATTCATCTGATGATGCTGGTGAGCAGGATCTTGGTGAGAATCTCAGC       c.1140
 V  S  Q  H  D  S  S  D  D  A  G  E  Q  D  L  G  E  N  L  S         p.380

          .         .         .         .         .         .       g.31454
 AAACCACCAAGTGATCCTGAGGCTAACCCTGAAGTTTCAGAGAGAAAGCTGCCAACTGAG       c.1200
 K  P  P  S  D  P  E  A  N  P  E  V  S  E  R  K  L  P  T  E         p.400

          .         .         .         .         .         .       g.31514
 GAAGAGCCTGCACCTGTGGTGGAACAATCAGGGAAAAGGAAGTCAAAAACCAAAACTATT       c.1260
 E  E  P  A  P  V  V  E  Q  S  G  K  R  K  S  K  T  K  T  I         p.420

          .         .         .         .         .         .       g.31574
 GTGGAGCCACCGAGGAAAAGGCAGACAAAGACCAAAAATATAGTGGAGCCACCAAGGAAA       c.1320
 V  E  P  P  R  K  R  Q  T  K  T  K  N  I  V  E  P  P  R  K         p.440

          .         .         .         .         .         .       g.31634
 AGGCAGACAAAGACCAAAAATATAGTGGAGCCACTGAGGAAGAGGAAGGCGAAAACCAAA       c.1380
 R  Q  T  K  T  K  N  I  V  E  P  L  R  K  R  K  A  K  T  K         p.460

          .          | 09        .         .         .         .    g.32680
 AATGTATCTGTGACACCTG | GACATAAGAAGCGTGGGCCTTCAAAGAAGAAACCCGGTGCA    c.1440
 N  V  S  V  T  P  G |   H  K  K  R  G  P  S  K  K  K  P  G  A      p.480

          .         .       | 10 .         .         .         .    g.35983
 GCAAAAGTTGAAAAACGCAAGACTAG | GACTCCTAAATGCAAAGTCCCTGGATGTTTCTTG    c.1500
 A  K  V  E  K  R  K  T  R  |  T  P  K  C  K  V  P  G  C  F  L      p.500

          .         .         .         .         .         .       g.36043
 CAAGACCTTGAAAAGTCAAAGAAATACTCTGGAAAAAATTTAAAGCGAAATAAGGATGAA       c.1560
 Q  D  L  E  K  S  K  K  Y  S  G  K  N  L  K  R  N  K  D  E         p.520

          .         .         .         .         .  | 11      .    g.37666
 TTGGTTCAGAGAATCTACGACCTGTTTAACAGATCCGTCTGTGATAAAAAG | CTGCCAGAG    c.1620
 L  V  Q  R  I  Y  D  L  F  N  R  S  V  C  D  K  K   | L  P  E      p.540

          .         .         .         .         .         .       g.37726
 AAACTACGCATAGGCTGGAATAACAAGATGGTGAAAACTGCTGGCTTATGCAGCACTGGT       c.1680
 K  L  R  I  G  W  N  N  K  M  V  K  T  A  G  L  C  S  T  G         p.560

          .         .         .         .         .         .       g.37786
 GAGATGTGGTACCCAAAGTGGCGGCGCTTTGCCAAGATCCAGATTGGCTTGAAAGTCTGC       c.1740
 E  M  W  Y  P  K  W  R  R  F  A  K  I  Q  I  G  L  K  V  C         p.580

          . | 12       .         .         .         .         .    g.39381
 GACTCTGCAG | ACCGAATCCGGGATACCTTGATCCATGAAATGTGCCATGCTGCCTCCTGG    c.1800
 D  S  A  D |   R  I  R  D  T  L  I  H  E  M  C  H  A  A  S  W      p.600

          .         .         .         .         .         .       g.39441
 CTGATTGATGGTATCCATGATTCTCATGGTGACGCATGGAAGTATTATGCCAGGAAATCC       c.1860
 L  I  D  G  I  H  D  S  H  G  D  A  W  K  Y  Y  A  R  K  S         p.620

          .         .         .         .         .         .       g.39501
 AACAGGATACACCCGGAGCTGCCCAGGGTCACCCGTTGCCATAACTATAAGATTAACTAC       c.1920
 N  R  I  H  P  E  L  P  R  V  T  R  C  H  N  Y  K  I  N  Y         p.640

          .         .         .      | 13  .         .         .    g.39863
 AAGGTCCATTATGAATGTACTGGATGCAAAACGAG | GATTGGCTGCTACACCAAATCGTTG    c.1980
 K  V  H  Y  E  C  T  G  C  K  T  R  |  I  G  C  Y  T  K  S  L      p.660

          .         .         .         .         .         .       g.39923
 GACACCAGCCGCTTCATCTGTGCCAAATGCAAGGGGTCTCTGGTCATGGTGCCATTAACT       c.2040
 D  T  S  R  F  I  C  A  K  C  K  G  S  L  V  M  V  P  L  T         p.680

          .         .         .                                     g.39959
 CAGAAAGATGGGACCCGTATTGTGCCCCACGTGTGA                               c.2076
 Q  K  D  G  T  R  I  V  P  H  V  X                                 p.691

          .         .         .         .         .         .       g.40019
 ccatttgctgtgtatgtgcagaagtattatagaaaaattatgcaggagatggctaggatt       c.*60

          .         .         .         .         .         .       g.40079
 agccttggggatgtgatgaaaacacttggcaggaattacaaggcaatgaagaattcttaa       c.*120

          .         .         .         .         .         .       g.40139
 ggttatcttagagtatattaatgtgagctatatcctttactggtaagaagttttagaaaa       c.*180

          .         .         .         .         .         .       g.40199
 gtttgttttgtgaagttaggaatattagaatttaggtactgttaagtaagtaatgttaga       c.*240

          .         .         .         .         .         .       g.40259
 atttaagattcatgttattaacgatgattgaccttaaatagggactctattgctaaccat       c.*300

          .         .         .         .         .         .       g.40319
 tctgtgcccttgacagggtatttctgaagcccttgggatctaccttgggtcttacttgag       c.*360

          .         .         .         .         .         .       g.40379
 ttccatatttttcacatgtagaacaaaatgcaaaagaaaagtgagttttcaagagtggca       c.*420

          .         .         .         .         .         .       g.40439
 ggttgagagaggagaatgctggaaagaggacaagtttgagaggcaacacttaaacactag       c.*480

          .         .         .         .         .         .       g.40499
 ggctactgtggcatctatgtagacaggaaagacaaacgtgtttcataaaattcgttgttg       c.*540

          .         .         .         .         .         .       g.40559
 atggtattgattgaaactatctgagccatgtaatcaaaaaataaaagttttctgcatctt       c.*600

                                                                    g.40560
 g                                                                  c.*601

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Acidic repeat containing protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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