acyl-CoA synthetase family member 3 (ACSF3) - coding DNA reference sequence

(used for variant description)

(last modified October 24, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_174917.3 in the ACSF3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031961.1, covering ACSF3 transcript NM_174917.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            gggggacgcgcttgggc       c.-361

 .         .         .         .         .         .                g.5077
 gacggacgcgccgcgccggggaagctgttgggcgccggaactggtccggcccgactcacg       c.-301

 .         .         .         .         .         .                g.5137
 accccgcgggacccggccggaacccggcccgaccccggcgcgcgcgcggcggaggacgag       c.-241

 .         .         .         .         .       | 02 .             g.9795
 gaagagttgtggcgaggcagatcctgccccgtggccgcggccgtctc | gtgtcccaccggc    c.-181

 .         .         .         .         .         .                g.9855
 cttccgggttccagcgccaggcctggtgcctgccccaggaggatgagcatttgcattgcc       c.-121

 .         .         .         .         .         .                g.9915
 tgcaccttatcgtgcccttccacctgctgaagcagctgtgcctgccgctcttgtgaactg       c.-61

 .         .         .         .          | 03        .             g.11873
 cgaacttccccttacctcctctctctggctcgggagctgg | ctcggccgcctgtcagtgca    c.-1

          .         .         .         .         .         .       g.11933
 ATGCTGCCCCATGTGGTGCTCACCTTCCGGCGCCTGGGCTGCGCCTTGGCGTCCTGCCGG       c.60
 M  L  P  H  V  V  L  T  F  R  R  L  G  C  A  L  A  S  C  R         p.20

          .         .         .         .         .         .       g.11993
 CTGGCGCCTGCGAGACACAGAGGAAGTGGTCTTCTGCACACAGCCCCAGTGGCCCGCTCG       c.120
 L  A  P  A  R  H  R  G  S  G  L  L  H  T  A  P  V  A  R  S         p.40

          .         .         .         .         .         .       g.12053
 GACAGGAGCGCCCCGGTGTTCACCCGTGCCCTGGCCTTTGGGGACAGAATCGCCCTGGTT       c.180
 D  R  S  A  P  V  F  T  R  A  L  A  F  G  D  R  I  A  L  V         p.60

          .         .         .         .         .         .       g.12113
 GACCAGCACGGCCGCCACACGTACAGGGAGCTTTATTCCCGCAGCCTTCGCCTGTCCCAG       c.240
 D  Q  H  G  R  H  T  Y  R  E  L  Y  S  R  S  L  R  L  S  Q         p.80

          .         .         .         .         .         .       g.12173
 GAGATCTGCAGGCTCTGCGGGTGTGTCGGCGGGGACCTCCGGGAGGAGAGGGTCTCCTTC       c.300
 E  I  C  R  L  C  G  C  V  G  G  D  L  R  E  E  R  V  S  F         p.100

          .         .         .         .         .         .       g.12233
 CTATGCGCTAACGATGCCTCCTACGTCGTGGCCCAGTGGGCGTCATGGATGAGTGGCGGT       c.360
 L  C  A  N  D  A  S  Y  V  V  A  Q  W  A  S  W  M  S  G  G         p.120

          .         .         .         .         .         .       g.12293
 GTGGCAGTCCCCCTCTACAGGAAGCATCCCGCGGCCCAGCTGGAGTATGTCATCTGCGAC       c.420
 V  A  V  P  L  Y  R  K  H  P  A  A  Q  L  E  Y  V  I  C  D         p.140

          .         .         .         .         .         .       g.12353
 TCCCAGAGCTCTGTGGTCCTTGCCAGCCAGGAGTACCTGGAGCTCCTGAGCCCGGTGGTC       c.480
 S  Q  S  S  V  V  L  A  S  Q  E  Y  L  E  L  L  S  P  V  V         p.160

          .         .         .         .         .         .       g.12413
 AGGAAGCTGGGGGTCCCGCTGCTGCCGCTCACACCAGCCATCTACACTGGAGCAGTAGAG       c.540
 R  K  L  G  V  P  L  L  P  L  T  P  A  I  Y  T  G  A  V  E         p.180

          .         .         .         .         .         .       g.12473
 GAACCGGCAGAGGTCCCGGTCCCAGAGCAGGGATGGAGGAACAAGGGCGCCATGATCATC       c.600
 E  P  A  E  V  P  V  P  E  Q  G  W  R  N  K  G  A  M  I  I         p.200

          .         .         .         .         .         .       g.12533
 TACACCAGTGGGACCACGGGGAGGCCCAAGGGCGTGCTGAGCACGCACCAAAACATCAGG       c.660
 Y  T  S  G  T  T  G  R  P  K  G  V  L  S  T  H  Q  N  I  R         p.220

        | 04 .         .         .         .         .         .    g.13849
 GCTGTG | GTGACCGGGCTGGTCCACAAGTGGGCATGGACCAAAGACGACGTGATCCTCCAC    c.720
 A  V   | V  T  G  L  V  H  K  W  A  W  T  K  D  D  V  I  L  H      p.240

          .         .         .         .         .         .       g.13909
 GTGCTCCCGCTGCACCACGTCCATGGTGTGGTCAACGCGCTGCTCTGTCCTCTCTGGGTG       c.780
 V  L  P  L  H  H  V  H  G  V  V  N  A  L  L  C  P  L  W  V         p.260

          .         .         .         .   | 05     .         .    g.23301
 GGAGCCACCTGTGTGATGATGCCTGAGTTCAGCCCTCAGCAG | GTTTGGGAAAAGTTCTTA    c.840
 G  A  T  C  V  M  M  P  E  F  S  P  Q  Q   | V  W  E  K  F  L      p.280

          .         .         .         .         .         .       g.23361
 AGTTCTGAAACGCCGCGGATCAATGTCTTTATGGCAGTGCCTACAATATACACCAAGCTG       c.900
 S  S  E  T  P  R  I  N  V  F  M  A  V  P  T  I  Y  T  K  L         p.300

          .         .         .         .         .         .       g.23421
 ATGGAGTACTACGACAGGCATTTTACCCAGCCGCACGCCCAGGATTTCTTGCGTGCAGTT       c.960
 M  E  Y  Y  D  R  H  F  T  Q  P  H  A  Q  D  F  L  R  A  V         p.320

          .        | 06.         .         .         .         .    g.25573
 TGTGAAGAAAAAATTAG | GCTGATGGTCTCAGGCTCAGCTGCCCTGCCCCTCCCAGTGCTG    c.1020
 C  E  E  K  I  R  |  L  M  V  S  G  S  A  A  L  P  L  P  V  L      p.340

          .         .         .         .         .         .       g.25633
 GAGAAGTGGAAGAACATCACGGGCCACACCCTGCTGGAGCGGTATGGCATGACCGAGATC       c.1080
 E  K  W  K  N  I  T  G  H  T  L  L  E  R  Y  G  M  T  E  I         p.360

          .         .         .         .       | 07 .         .    g.32006
 GGCATGGCTCTGTCCGGGCCCCTGACCACTGCCGTGCGCCTGCCAG | GTTCCGTGGGGACC    c.1140
 G  M  A  L  S  G  P  L  T  T  A  V  R  L  P  G |   S  V  G  T      p.380

          .         .         .         .         .         .       g.32066
 CCACTGCCTGGAGTACAGGTGCGCATTGTCTCAGAAAACCCACAGAGGGAAGCCTGCTCC       c.1200
 P  L  P  G  V  Q  V  R  I  V  S  E  N  P  Q  R  E  A  C  S         p.400

          .         .         .          | 08        .         .    g.44348
 TACACCATCCACGCAGAGGGAGACGAGAGGGGGACCAAG | GTGACCCCAGGGTTTGAAGAA    c.1260
 Y  T  I  H  A  E  G  D  E  R  G  T  K   | V  T  P  G  F  E  E      p.420

          .         .         .         .         .         .       g.44408
 AAGGAGGGGGAGCTGCTGGTGAGGGGACCCTCCGTGTTTCGAGAATACTGGAATAAACCA       c.1320
 K  E  G  E  L  L  V  R  G  P  S  V  F  R  E  Y  W  N  K  P         p.440

          .         .         .         .       | 09 .         .    g.56472
 GAAGAAACTAAGAGTGCATTCACCCTGGATGGCTGGTTTAAGACAG | GGGACACCGTGGTG    c.1380
 E  E  T  K  S  A  F  T  L  D  G  W  F  K  T  G |   D  T  V  V      p.460

          .         .         .         .         .         .       g.56532
 TTTAAGGATGGCCAGTACTGGATCCGAGGCCGGACCTCAGTGGACATCATCAAGACTGGA       c.1440
 F  K  D  G  Q  Y  W  I  R  G  R  T  S  V  D  I  I  K  T  G         p.480

          .         .         .         .         .         .       g.56592
 GGCTACAAGGTCAGCGCCCTGGAGGTGGAGTGGCACCTGCTGGCCCACCCCAGCATCACA       c.1500
 G  Y  K  V  S  A  L  E  V  E  W  H  L  L  A  H  P  S  I  T         p.500

   | 10      .         .         .         .         .         .    g.57188
 G | ATGTGGCTGTGATTGGAGTTCCGGATATGACATGGGGCCAGCGGGTCACTGCTGTGGTG    c.1560
 D |   V  A  V  I  G  V  P  D  M  T  W  G  Q  R  V  T  A  V  V      p.520

          .         .         .         .         .    | 11    .    g.65288
 ACCCTCCGAGAAGGACACTCACTGTCCCACAGGGAGCTCAAAGAGTGGGCCAG | AAATGTC    c.1620
 T  L  R  E  G  H  S  L  S  H  R  E  L  K  E  W  A  R  |  N  V      p.540

          .         .         .         .         .         .       g.65348
 CTGGCCCCGTACGCGGTGCCCTCGGAGCTGGTGCTGGTGGAGGAGATCCCGCGGAACCAG       c.1680
 L  A  P  Y  A  V  P  S  E  L  V  L  V  E  E  I  P  R  N  Q         p.560

          .         .         .         .         .                 g.65399
 ATGGGCAAGATTGACAAGAAGGCGCTCATCAGGCACTTCCACCCCTCATGA                c.1731
 M  G  K  I  D  K  K  A  L  I  R  H  F  H  P  S  X                  p.576

          .         .         .         .         .         .       g.65459
 cccggcagactgggactgcgggtctggtggggagcagcagacgtccccttcacaccgaga       c.*60

          .         .         .         .         .         .       g.65519
 accacgggggcccgtccaagacctggcctcccttaaacctgaaccccccaaatcaggtca       c.*120

          .         .         .         .         .         .       g.65579
 cgtagaatcaagaactgtttgggatgaaatcaccatgtggggtccccagcctcgggccag       c.*180

          .         .         .         .         .         .       g.65639
 ttgttgcagctcaaggagaccgtccctggtgtcacctctgcctggtcaccgccgacctca       c.*240

          .         .         .         .         .         .       g.65699
 tctgtgcagcgcggtgcagccagcccctggccccacgtgctgaggcacctcccgccccac       c.*300

          .         .         .         .         .         .       g.65759
 agtgccctgcagttgccaggctctccagggcaggtcccagaggtttcccacaaaaaacaa       c.*360

          .         .         .         .         .         .       g.65819
 agactccactggaggaaacaagcccctgtcccacgccgtctgcacgtgcctgtgcctcac       c.*420

          .         .         .         .         .         .       g.65879
 ccagagccagtgtctcccggcccacataggaggtctgggcagccacccagggggccctcc       c.*480

          .         .         .         .         .         .       g.65939
 tgggaggagctgagggttcacaagcctcccagaaccagccctgtcccatgggttccgtgc       c.*540

          .         .         .         .         .         .       g.65999
 atttcctggtgctgctcttggaggagagcagctcccactgtggggacacctgccaccctg       c.*600

          .         .         .         .         .         .       g.66059
 cacactactgtgtgtccatcagcatgtgtcacagaaagtgcgtggacggatggccccgga       c.*660

          .         .         .         .         .         .       g.66119
 gctgctctgccgtgaccctgcctcaccccccagcgcagggactttccaggtcatctccac       c.*720

          .         .         .         .         .         .       g.66179
 accagcccctcagccggtgaaccctctctcccatcaccgtctccacccagacccccacct       c.*780

          .         .         .         .         .         .       g.66239
 gccccatggcccccatttcatgtctgtggctcaccagcttttccccagacccagctccgg       c.*840

          .         .         .         .         .         .       g.66299
 agcccacaggcgtggccgatgcagaaacctcaggaaggtgtgttgtgaatgttgggtgca       c.*900

          .         .         .         .         .         .       g.66359
 cccacgttgcatttacttagcggggccaattcagatgcacaggggccacatgcagaatcc       c.*960

          .         .         .         .         .         .       g.66419
 agaagtttctggacaattttcagaagaataggctgcctcctccccacagcctgggggaag       c.*1020

          .         .         .         .         .         .       g.66479
 taacagtcatcgcccagcagtgtctggcctgaacttacccagaacattctgcccccggaa       c.*1080

          .         .         .         .         .         .       g.66539
 tgcacgtctgaaagagtggccagaaacgagtgtgccgggcaggaggccagccccatctca       c.*1140

          .         .         .         .         .         .       g.66599
 ggctcacgtgcctctgacaggagaccagccccatctcaggctcacatgcctcgcggacag       c.*1200

          .         .         .         .         .         .       g.66659
 ttggacgtggcctggggcccctgctcacttgagcatgtcgcccaccaagcttgtctgagg       c.*1260

          .         .         .         .         .         .       g.66719
 ccacagagcagcgtcccagccctgttttccaggactggtgggtgccccagtccacggccc       c.*1320

          .         .         .         .         .         .       g.66779
 tgccccacccgaactcctgcctcacggtgtggccttgtgcatccccatggcctgaccccg       c.*1380

          .         .         .         .         .         .       g.66839
 ggaacagtcagaggaaggggtcccgccctcccgccagaggcctggacccaagggaacggc       c.*1440

          .         .         .         .         .         .       g.66899
 agtcagagactacagtccagacgtttgtgtctaggccttgctggtagctaaggaaatgcc       c.*1500

          .         .         .         .         .                 g.66955
 ttctgttgggaaaaggtcaaatttaacatagcaaaatttttacttaattccactaa           c.*1556

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Acyl-CoA synthetase family member 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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