actinin, alpha 2 (ACTN2) - coding DNA reference sequence

(used for variant description)

(last modified May 19, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001103.3 in the ACTN2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009081.1, covering ACTN2 transcript NM_001103.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5024
                     gacgggcggcgcggctattaagccgcgcggcagctgctcg       c.-181

 .         .         .         .         .         .                g.5084
 cagccggagctggtgcttcgcccgagacccagcgcccaggcgtgtcgccccgagaggagc       c.-121

 .         .         .         .         .         .                g.5144
 cgcgcgaaggtcaccccgcgcccgccgcccgccgcccgccgcctccgtgggtccgtttgc       c.-61

 .         .         .         .         .         .                g.5204
 cagtcagcccgtgcgtccgagcccctcgcgccccgccgcagccccggccaaccgagcgcc       c.-1

          .         .         .         .         .         .       g.5264
 ATGAACCAGATAGAGCCCGGCGTGCAGTACAACTACGTGTACGACGAGGATGAGTACATG       c.60
 M  N  Q  I  E  P  G  V  Q  Y  N  Y  V  Y  D  E  D  E  Y  M         p.20

          .         .         .         .         .         .       g.5324
 ATCCAGGAGGAGGAGTGGGACCGCGACCTGCTCCTGGACCCAGCCTGGGAGAAGCAGCAG       c.120
 I  Q  E  E  E  W  D  R  D  L  L  L  D  P  A  W  E  K  Q  Q         p.40

        | 02 .         .         .         .         .         .    g.36442
 AGGAAG | ACCTTCACTGCCTGGTGTAACTCCCACCTAAGGAAAGCCGGCACCCAGATTGAG    c.180
 R  K   | T  F  T  A  W  C  N  S  H  L  R  K  A  G  T  Q  I  E      p.60

          .         .         .         .         .         .       g.36502
 AACATCGAGGAAGACTTCAGGAATGGCCTTAAGCTCATGCTGCTTTTGGAAGTCATCTCA       c.240
 N  I  E  E  D  F  R  N  G  L  K  L  M  L  L  L  E  V  I  S         p.80

   | 03      .         .         .         .         .         .    g.37483
 G | GGGAAAGGCTGCCCAAACCTGACCGGGGAAAAATGCGGTTCCACAAAATTGCTAATGTC    c.300
 G |   E  R  L  P  K  P  D  R  G  K  M  R  F  H  K  I  A  N  V      p.100

          .         .         .         .         .         .       g.37543
 AACAAAGCTTTGGATTACATAGCCAGCAAAGGGGTGAAACTGGTGTCCATCGGCGCTGAA       c.360
 N  K  A  L  D  Y  I  A  S  K  G  V  K  L  V  S  I  G  A  E         p.120

   | 04      .         .         .         .         .         .    g.38694
 G | AAATTGTTGATGGCAATGTGAAAATGACCCTGGGTATGATCTGGACCATCATCCTTCGC    c.420
 E |   I  V  D  G  N  V  K  M  T  L  G  M  I  W  T  I  I  L  R      p.140

          .         .         | 05         .         .         .    g.44495
 TTTGCTATTCAGGATATTTCGGTTGAAG | AAACATCTGCCAAAGAAGGTCTGCTGCTTTGG    c.480
 F  A  I  Q  D  I  S  V  E  E |   T  S  A  K  E  G  L  L  L  W      p.160

          .         .         .         .         .       | 06 .    g.46212
 TGTCAGAGGAAAACTGCTCCTTATAGAAATGTGAACATTCAGAACTTCCATACTAG | CTGG    c.540
 C  Q  R  K  T  A  P  Y  R  N  V  N  I  Q  N  F  H  T  S  |  W      p.180

          .         .         .         .         .         .       g.46272
 AAAGATGGCCTTGGACTCTGTGCCCTCATCCACCGACACCGGCCTGACCTCATTGACTAC       c.600
 K  D  G  L  G  L  C  A  L  I  H  R  H  R  P  D  L  I  D  Y         p.200

          .      | 07  .         .         .         .         .    g.49808
 TCAAAGCTTAACAAG | GATGACCCCATAGGAAATATTAACCTGGCCATGGAAATCGCTGAG    c.660
 S  K  L  N  K   | D  D  P  I  G  N  I  N  L  A  M  E  I  A  E      p.220

          .         .         .        | 08.         .         .    g.54188
 AAGCACCTGGATATTCCTAAAATGTTGGATGCTGAAG | ACATCGTGAACACCCCTAAACCC    c.720
 K  H  L  D  I  P  K  M  L  D  A  E  D |   I  V  N  T  P  K  P      p.240

          .         .         .         .         .         .       g.54248
 GATGAAAGAGCCATCATGACGTACGTCTCTTGCTTCTACCACGCTTTTGCGGGCGCGGAG       c.780
 D  E  R  A  I  M  T  Y  V  S  C  F  Y  H  A  F  A  G  A  E         p.260

     | 09    .         .         .         .         .         .    g.55709
 CAG | GCCGAGACAGCGGCTAACAGGATATGTAAGGTTCTTGCTGTGAATCAAGAGAATGAG    c.840
 Q   | A  E  T  A  A  N  R  I  C  K  V  L  A  V  N  Q  E  N  E      p.280

          .         .         .       | 10 .         .         .    g.57856
 AGGCTGATGGAAGAATATGAGAGGCTAGCGAGTGAG | CTTTTGGAATGGATTCGTCGCACG    c.900
 R  L  M  E  E  Y  E  R  L  A  S  E   | L  L  E  W  I  R  R  T      p.300

          .         .         .         .         .         .       g.57916
 ATCCCCTGGCTGGAGAACCGGACTCCCGAGAAGACCATGCAAGCCATGCAGAAGAAGCTG       c.960
 I  P  W  L  E  N  R  T  P  E  K  T  M  Q  A  M  Q  K  K  L         p.320

          .         .         .         .         .         .       g.57976
 GAGGACTTCCGGGATTACCGCCGGAAGCACAAGCCACCCAAGGTGCAGGAGAAATGCCAG       c.1020
 E  D  F  R  D  Y  R  R  K  H  K  P  P  K  V  Q  E  K  C  Q         p.340

          .         .         .         .         .         .       g.58036
 CTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGGATCAGCAACCGTCCTGCCTTC       c.1080
 L  E  I  N  F  N  T  L  Q  T  K  L  R  I  S  N  R  P  A  F         p.360

          .         .        | 11.         .         .         .    g.61459
 ATGCCCTCCGAGGGCAAGATGGTGTCG | GATATTGCTGGTGCCTGGCAGAGGCTGGAGCAG    c.1140
 M  P  S  E  G  K  M  V  S   | D  I  A  G  A  W  Q  R  L  E  Q      p.380

          .         .         .         .         .         .       g.61519
 GCTGAGAAGGGTTACGAGGAGTGGTTGCTCAATGAGATTCGGAGACTGGAGCGCTTGGAA       c.1200
 A  E  K  G  Y  E  E  W  L  L  N  E  I  R  R  L  E  R  L  E         p.400

          .         .         .         .         .      | 12  .    g.63161
 CACCTGGCTGAGAAGTTCAGGCAGAAGGCCTCAACGCACGAGACTTGGGCTTATG | GCAAA    c.1260
 H  L  A  E  K  F  R  Q  K  A  S  T  H  E  T  W  A  Y  G |   K      p.420

          .         .         .         .         .         .       g.63221
 GAGCAGATCTTGCTGCAGAAGGATTACGAGTCGGCGTCGCTGACAGAGGTGCGGGCTCTG       c.1320
 E  Q  I  L  L  Q  K  D  Y  E  S  A  S  L  T  E  V  R  A  L         p.440

          .         .         .         .         .         .       g.63281
 CTGCGGAAGCACGAGGCGTTCGAGAGCGACCTGGCAGCGCACCAGGACCGCGTGGAGCAG       c.1380
 L  R  K  H  E  A  F  E  S  D  L  A  A  H  Q  D  R  V  E  Q         p.460

          .         .       | 13 .         .         .         .    g.66231
 ATCGCAGCCATCGCGCAGGAGCTCAA | TGAACTGGACTATCACGACGCTGTGAATGTCAAT    c.1440
 I  A  A  I  A  Q  E  L  N  |  E  L  D  Y  H  D  A  V  N  V  N      p.480

          .         .         .         .         .         .       g.66291
 GATCGGTGCCAGAAAATTTGTGACCAGTGGGACCGACTGGGAACGCTTACTCAGAAGAGG       c.1500
 D  R  C  Q  K  I  C  D  Q  W  D  R  L  G  T  L  T  Q  K  R         p.500

          .      | 14  .         .         .         .         .    g.67699
 AGAGAAGCCCTAGAG | AGAATGGAGAAATTGCTAGAAACCATTGATCAGCTTCACCTGGAG    c.1560
 R  E  A  L  E   | R  M  E  K  L  L  E  T  I  D  Q  L  H  L  E      p.520

          .         .         .         .         .         .       g.67759
 TTTGCCAAGAGGGCTGCTCCTTTCAACAATTGGATGGAGGGCGCTATGGAGGATCTGCAA       c.1620
 F  A  K  R  A  A  P  F  N  N  W  M  E  G  A  M  E  D  L  Q         p.540

          .         .         .       | 15 .         .         .    g.70024
 GATATGTTCATTGTCCACAGCATTGAGGAGATCCAG | AGTCTGATCACTGCGCATGAGCAG    c.1680
 D  M  F  I  V  H  S  I  E  E  I  Q   | S  L  I  T  A  H  E  Q      p.560

          .         .         .         .         .         .       g.70084
 TTCAAGGCCACGCTGCCCGAGGCGGACGGAGAGCGGCAGTCCATCATGGCCATCCAGAAC       c.1740
 F  K  A  T  L  P  E  A  D  G  E  R  Q  S  I  M  A  I  Q  N         p.580

          .         .         .         .         .         .       g.70144
 GAGGTGGAGAAGGTGATTCAGAGCTACAACATCAGAATCAGCTCAAGCAACCCGTACAGC       c.1800
 E  V  E  K  V  I  Q  S  Y  N  I  R  I  S  S  S  N  P  Y  S         p.600

          .         .         .          | 16        .         .    g.72498
 ACTGTCACCATGGATGAGCTCCGGACCAAGTGGGACAAG | GTGAAGCAACTCGTGCCCATC    c.1860
 T  V  T  M  D  E  L  R  T  K  W  D  K   | V  K  Q  L  V  P  I      p.620

          .         .         .         .         .         .       g.72558
 CGCGATCAATCCCTGCAGGAGGAGCTGGCTCGCCAGCATGCTAACGAGCGTCTGAGGCGC       c.1920
 R  D  Q  S  L  Q  E  E  L  A  R  Q  H  A  N  E  R  L  R  R         p.640

          .         .         .         .         .     | 17   .    g.73555
 CAGTTTGCTGCCCAAGCCAATGCCATTGGGCCCTGGATCCAGAACAAGATGGAG | GAGATT    c.1980
 Q  F  A  A  Q  A  N  A  I  G  P  W  I  Q  N  K  M  E   | E  I      p.660

          .         .         .         .         .         .       g.73615
 GCCCGGAGCTCCATCCAGATCACAGGAGCCCTGGAAGACCAGATGAACCAGCTGAAGCAG       c.2040
 A  R  S  S  I  Q  I  T  G  A  L  E  D  Q  M  N  Q  L  K  Q         p.680

          .         .         .         .         .         .       g.73675
 TATGAGCACAACATCATCAACTATAAGAACAACATCGACAAGCTGGAGGGAGACCATCAG       c.2100
 Y  E  H  N  I  I  N  Y  K  N  N  I  D  K  L  E  G  D  H  Q         p.700

          .         .         .         .         .     | 18   .    g.76022
 CTCATCCAGGAGGCCCTTGTCTTTGACAACAAGCACACGAACTACACGATGGAG | CACATT    c.2160
 L  I  Q  E  A  L  V  F  D  N  K  H  T  N  Y  T  M  E   | H  I      p.720

          .         .         .         .         .         .       g.76082
 CGTGTTGGATGGGAGCTGCTGCTGACAACCATCGCCAGAACCATCAATGAGGTGGAGACT       c.2220
 R  V  G  W  E  L  L  L  T  T  I  A  R  T  I  N  E  V  E  T         p.740

          .         .         .         .         .         .       g.76142
 CAGATCCTGACGAGAGATGCGAAGGGCATCACCCAGGAGCAGATGAATGAGTTCAGAGCC       c.2280
 Q  I  L  T  R  D  A  K  G  I  T  Q  E  Q  M  N  E  F  R  A         p.760

          .         .  | 19      .         .         .         .    g.78293
 TCCTTCAACCACTTTGACAGG | AGGAAGAATGGCCTGATGGATCATGAGGATTTCAGAGCC    c.2340
 S  F  N  H  F  D  R   | R  K  N  G  L  M  D  H  E  D  F  R  A      p.780

          .         .        | 20.         .         .         .    g.79578
 TGCCTGATTTCCATGGGTTATGACCTG | GGTGAAGCCGAATTTGCCCGCATTATGACCCTG    c.2400
 C  L  I  S  M  G  Y  D  L   | G  E  A  E  F  A  R  I  M  T  L      p.800

          .         .         .         .         .         .       g.79638
 GTAGATCCCAACGGGCAAGGCACCGTCACCTTCCAATCCTTCATCGACTTCATGACTAGA       c.2460
 V  D  P  N  G  Q  G  T  V  T  F  Q  S  F  I  D  F  M  T  R         p.820

          .         .         .         .         .         .       g.79698
 GAGACGGCTGACACCGACACTGCCGAGCAGGTCATCGCCTCCTTCCGGATCCTGGCTTCT       c.2520
 E  T  A  D  T  D  T  A  E  Q  V  I  A  S  F  R  I  L  A  S         p.840

        | 21 .         .         .         .         .         .    g.81045
 GATAAG | CCATACATCCTGGCGGAGGAGCTGCGTCGGGAGCTGCCCCCGGATCAGGCCCAG    c.2580
 D  K   | P  Y  I  L  A  E  E  L  R  R  E  L  P  P  D  Q  A  Q      p.860

          .         .         .         .         .         .       g.81105
 TACTGCATCAAGAGGATGCCCGCCTACTCGGGCCCAGGCAGTGTGCCTGGTGCACTGGAT       c.2640
 Y  C  I  K  R  M  P  A  Y  S  G  P  G  S  V  P  G  A  L  D         p.880

          .         .         .         .                           g.81150
 TACGCTGCGTTCTCTTCCGCACTCTACGGGGAGAGCGATCTGTGA                      c.2685
 Y  A  A  F  S  S  A  L  Y  G  E  S  D  L  X                        p.894

          .         .         .         .         .         .       g.81210
 tgctgagcttctgtaatcactcatcccatcagaatgcaataaaagcggaagtcacagttt       c.*60

          .         .         .         .         .         .       g.81270
 gtttcctggaaactttgacaagctttattaagttgagagagagagaggggaaaaaaaaaa       c.*120

          .         .         .         .         .         .       g.81330
 gcctttcgtagttcagtaattgccagcaatataacacggctaaaatgaagtttttacagt       c.*180

          .         .         .         .         .         .       g.81390
 atatgacatagtgcgcttcataaataggtttatttctgagtttttagcaaaatgtaatga       c.*240

          .         .         .         .         .         .       g.81450
 aatatcaggttgatttctttgattaaacagaacaaattacttgagtaataggaaattagg       c.*300

          .         .         .         .         .         .       g.81510
 aggatctagggacagaaggaaagtgaaaaatgtgaaaatacaaaatacccaagatttaag       c.*360

          .         .         .         .         .         .       g.81570
 accggggggaaaaaaccacaaattggtaaataaaggtttgctatttgtaaaaaatttcat       c.*420

          .         .         .         .         .         .       g.81630
 ttatctctaatatgcttatgtgattgcccctaggggagtatatttgggattctaatgttt       c.*480

          .         .         .         .         .         .       g.81690
 tattttcatgcttatccaaagattactattgtatcttcaaatgaatttaatattgtgaga       c.*540

          .         .         .         .         .         .       g.81750
 tggaactgccggggattaaaaagactacccaaaagatttttggcacttacaatttttaaa       c.*600

          .         .         .         .         .         .       g.81810
 atagtttatgtcatctcttcattatttagggctggatggtcaactcagtcagtgattttt       c.*660

          .         .         .         .         .         .       g.81870
 tgatgcttctcttatcctccagaatagagacctaaggacacgtggaagtcagtttaattg       c.*720

          .         .         .         .         .         .       g.81930
 ccagagagaaggatgcaatcactaggtaaaatgaggtttttaggattatttattgattcc       c.*780

          .         .         .         .         .         .       g.81990
 aggttcccatgctttttgttagagcttattagtacaggttctcaagagatgaccacataa       c.*840

          .         .         .         .         .         .       g.82050
 aagtgctctgtttataaataagcaggtttctgtagtactgactggttcatcacaaggcaa       c.*900

          .         .         .         .         .         .       g.82110
 gtcagaaaccagtatccttctagctctccagtcaggacttccttatgcctctagttttat       c.*960

          .         .         .         .         .         .       g.82170
 gaccggttaaggagaagccagagttagagtaggagaggactaattctcagcagcagtgga       c.*1020

          .         .         .         .         .         .       g.82230
 ggtgagttctttcttttgcggaagctttacatatgttttgtgtagtaggaataactagat       c.*1080

          .         .         .         .         .         .       g.82290
 attttagctagtgtgcggtgtgtgttcacccctgggattggacagtgtatcctaacaagt       c.*1140

          .         .         .         .         .         .       g.82350
 cccatgtctggttctgtgtctaaaggcctgctccatgacacaggatgctacatgcactcc       c.*1200

          .         .         .         .         .         .       g.82410
 tgctagcacatcttgatctgttgaatgttcattctttctttttgctcatactgctgtagg       c.*1260

          .         .         .         .         .         .       g.82470
 ctataattcccccctgtttttccatcttgttgacagcttgtagagaataaagcaggaatt       c.*1320

          .         .         .         .         .         .       g.82530
 ctttttatatctgagtccttaatgatcaggaaatggattacaaacaaacaaaaacagttg       c.*1380

          .         .         .         .         .         .       g.82590
 caaacagcaattaaagcattactagagaagcagtaacatgtctgttacctacagtctgtt       c.*1440

          .         .         .         .         .         .       g.82650
 tgctcagatttttatagatttccaccaacagctggaaatgtaatatttccattccaagct       c.*1500

          .         .         .         .         .         .       g.82710
 gtctgacagcttgactcttcttcctacactgggccatttagaaccttcaacctttatgaa       c.*1560

          .         .         .         .         .         .       g.82770
 tttcacttaatttgcttcattattaagtaattggtagtttccagattcctgaaatatttg       c.*1620

          .         .         .         .         .         .       g.82830
 aatccttgagtttaatgccaaacacttttggggtggtttagatgaactctgactctattt       c.*1680

          .         .         .         .         .         .       g.82890
 tatttcaagtaggtgctatatcccggccataaacccctatagaaaagccagaaagttgtg       c.*1740

          .         .         .         .         .         .       g.82950
 cttcctttgaggctattagggggctctgtggtgttttaggatgggtgtgggtaactcatc       c.*1800

          .         .         .         .         .         .       g.83010
 tacctaaacttttaatttctttacaacattcagcaagagagggggtcagtagtctctatc       c.*1860

          .         .         .         .         .         .       g.83070
 tgctaataaatgaagaaaggaagtaaactctgaaaaataataaacatgtttatactctca       c.*1920

          .         .         .         .         .         .       g.83130
 ttttaggtattatttttatttctgaagctggatgctcaaaaattaaaacgtttataagtt       c.*1980

          .         .         .                                     g.83162
 tctaaattaaacttaatttataaaagaaaaaa                                   c.*2012

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Actinin, alpha 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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