actinin, alpha 3 (gene/pseudogene) (ACTN3) - coding DNA reference sequence

(used for variant description)

(last modified December 12, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_001104.3 in the ACTN3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013304.2, covering ACTN3 transcript NM_001104.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.4958
                        agtgcgaattcgatctggggctgggctgggccctact       c.-61

 .         .         .         .         .         .                g.5018
 taatggggcccgggtgtccgagagcgtgccgagcggagcgaagccaggagcccgatcgag       c.-1

          .         .         .         .         .         .       g.5078
 ATGATGATGGTTATGCAGCCCGAGGGTCTGGGGGCCGGGGAGGGGCGCTTTGCGGGCGGC       c.60
 M  M  M  V  M  Q  P  E  G  L  G  A  G  E  G  R  F  A  G  G         p.20

          .         .         .         .         .         .       g.5138
 GGCGGGGGCGGCGAGTACATGGAACAGGAGGAGGACTGGGACCGCGACCTGCTGCTGGAC       c.120
 G  G  G  G  E  Y  M  E  Q  E  E  D  W  D  R  D  L  L  L  D         p.40

          .         .        | 02.         .         .         .    g.9352
 CCGGCCTGGGAGAAGCAGCAGCGGAAA | ACCTTCACTGCCTGGTGCAACTCACACCTGCGC    c.180
 P  A  W  E  K  Q  Q  R  K   | T  F  T  A  W  C  N  S  H  L  R      p.60

          .         .         .         .         .         .       g.9412
 AAGGCAGGCACCCAGATCGAGAACATCGAGGAAGATTTCCGCAATGGCCTCAAACTCATG       c.240
 K  A  G  T  Q  I  E  N  I  E  E  D  F  R  N  G  L  K  L  M         p.80

          .         .   | 03     .         .         .         .    g.9646
 CTGCTCCTGGAGGTCATTTCAG | GTGAGAGGCTGCCTAGGCCAGATAAAGGCAAGATGCGC    c.300
 L  L  L  E  V  I  S  G |   E  R  L  P  R  P  D  K  G  K  M  R      p.100

          .         .         .         .         .         .       g.9706
 TTCCACAAAATCGCCAACGTTAACAAGGCCCTGGACTTCATTGCCAGCAAGGGGGTTAAA       c.360
 F  H  K  I  A  N  V  N  K  A  L  D  F  I  A  S  K  G  V  K         p.120

          .         .   | 04     .         .         .         .    g.12163
 CTGGTGTCCATTGGTGCTGAAG | AGATTGTTGACGGGAACCTGAAGATGACCCTGGGCATG    c.420
 L  V  S  I  G  A  E  E |   I  V  D  G  N  L  K  M  T  L  G  M      p.140

          .         .         .         .          | 05        .    g.12627
 ATCTGGACCATCATCCTTCGCTTCGCCATCCAGGACATCTCTGTGGAAG | AAACCTCAGCC    c.480
 I  W  T  I  I  L  R  F  A  I  Q  D  I  S  V  E  E |   T  S  A      p.160

          .         .         .         .         .         .       g.12687
 AAGGAAGGCTTGCTTCTGTGGTGCCAGAGGAAGACAGCACCGTACCGCAACGTCAACGTG       c.540
 K  E  G  L  L  L  W  C  Q  R  K  T  A  P  Y  R  N  V  N  V         p.180

          .        | 06.         .         .         .         .    g.13253
 CAGAACTTCCACACCAG | CTGGAAGGATGGCCTGGCCCTCTGTGCCCTCATCCACCGACAC    c.600
 Q  N  F  H  T  S  |  W  K  D  G  L  A  L  C  A  L  I  H  R  H      p.200

          .         .         .       | 07 .         .         .    g.13390
 CGCCCTGACCTCATCGACTACGCCAAACTGCGAAAG | GATGACCCCATCGGAAACCTGAAC    c.660
 R  P  D  L  I  D  Y  A  K  L  R  K   | D  D  P  I  G  N  L  N      p.220

          .         .         .         .         .         | 08    g.14227
 ACTGCCTTTGAGGTGGCAGAGAAATACCTGGACATCCCCAAGATGTTGGATGCAGAAG | AC    c.720
 T  A  F  E  V  A  E  K  Y  L  D  I  P  K  M  L  D  A  E  D |       p.240

          .         .         .         .         .         .       g.14287
 ATTGTGAACACCCCAAAGCCGGATGAGAAGGCCATCATGACCTATGTGTCCTGCTTCTAC       c.780
 I  V  N  T  P  K  P  D  E  K  A  I  M  T  Y  V  S  C  F  Y         p.260

          .         .     | 09   .         .         .         .    g.15249
 CATGCCTTTGCCGGGGCTGAGCAG | GCAGAGACAGCTGCCAACAGGATCTGCAAGGTGCTG    c.840
 H  A  F  A  G  A  E  Q   | A  E  T  A  A  N  R  I  C  K  V  L      p.280

          .         .         .         .         .        | 10.    g.15782
 GCAGTGAACCAGGAAAACGAGAAGCTGATGGAGGAGTATGAGAAGCTTGCCAGTGAG | CTG    c.900
 A  V  N  Q  E  N  E  K  L  M  E  E  Y  E  K  L  A  S  E   | L      p.300

          .         .         .         .         .         .       g.15842
 CTGGAGTGGATCCGCCGCACTGTCCCATGGCTGGAGAACCGTGTGGGTGAGCCCAGCATG       c.960
 L  E  W  I  R  R  T  V  P  W  L  E  N  R  V  G  E  P  S  M         p.320

          .         .         .         .         .         .       g.15902
 AGTGCCATGCAGCGCAAACTAGAGGACTTTCGGGACTACCGGCGTCTGCACAAGCCGCCC       c.1020
 S  A  M  Q  R  K  L  E  D  F  R  D  Y  R  R  L  H  K  P  P         p.340

          .         .         .         .         .         .       g.15962
 CGCATTCAGGAAAAGTGCCAGCTGGAGATCAACTTCAACACACTGCAGACCAAGTTGCGG       c.1080
 R  I  Q  E  K  C  Q  L  E  I  N  F  N  T  L  Q  T  K  L  R         p.360

          .         .         .         .         | 11         .    g.16119
 CTCAGCCACCGGCCTGCCTTCATGCCCTCCGAGGGCAAGCTGGTCTCG | GACATCGCCAAC    c.1140
 L  S  H  R  P  A  F  M  P  S  E  G  K  L  V  S   | D  I  A  N      p.380

          .         .         .         .         .         .       g.16179
 GCCTGGCGGGGGCTGGAGCAGGTGGAAAAGGGCTATGAGGACTGGCTGCTCTCGGAGATC       c.1200
 A  W  R  G  L  E  Q  V  E  K  G  Y  E  D  W  L  L  S  E  I         p.400

          .         .         .         .         .         .       g.16239
 CGGCGCCTGCAGCGACTCCAGCACCTGGCTGAGAAGTTCCGGCAGAAGGCCTCCCTGCAC       c.1260
 R  R  L  Q  R  L  Q  H  L  A  E  K  F  R  Q  K  A  S  L  H         p.420

          .       | 12 .         .         .         .         .    g.17360
 GAAGCCTGGACCCGGG | GAAAGGAGGAGATGCTGAGCCAGCGCGACTACGATTCGGCTTTG    c.1320
 E  A  W  T  R  G |   K  E  E  M  L  S  Q  R  D  Y  D  S  A  L      p.440

          .         .         .         .         .         .       g.17420
 CTACAGGAGGTGCGGGCGTTGCTGCGGCGCCACGAGGCCTTTGAGAGCGACCTGGCGGCG       c.1380
 L  Q  E  V  R  A  L  L  R  R  H  E  A  F  E  S  D  L  A  A         p.460

          .         .         .         .        | 13.         .    g.18061
 CACCAGGACCGCGTGGAGCACATTGCCGCGCTGGCCCAGGAGCTCAA | TGAGCTGGACTAC    c.1440
 H  Q  D  R  V  E  H  I  A  A  L  A  Q  E  L  N  |  E  L  D  Y      p.480

          .         .         .         .         .         .       g.18121
 CACGAGGCAGCCTCAGTGAATAGCCGCTGCCAGGCCATCTGCGATCAGTGGGACAACCTG       c.1500
 H  E  A  A  S  V  N  S  R  C  Q  A  I  C  D  Q  W  D  N  L         p.500

          .         .         .       | 14 .         .         .    g.18275
 GGCACCCTGACCCAGAAGAGGCGGGATGCGCTAGAG | CGGATGGAGAAGCTCCTGGAGACC    c.1560
 G  T  L  T  Q  K  R  R  D  A  L  E   | R  M  E  K  L  L  E  T      p.520

          .         .         .         .         .         .       g.18335
 ATTGACCGGCTGCAACTGGAGTTTGCCCGGCGGGCCGCGCCCTTCAACAACTGGCTGGAT       c.1620
 I  D  R  L  Q  L  E  F  A  R  R  A  A  P  F  N  N  W  L  D         p.540

          .         .         .         .         .        | 15.    g.18656
 GGTGCCGTGGAGGACCTGCAGGACGTGTGGCTGGTACACTCTGTGGAGGAGACCCAG | AGC    c.1680
 G  A  V  E  D  L  Q  D  V  W  L  V  H  S  V  E  E  T  Q   | S      p.560

          .         .         .         .         .         .       g.18716
 CTGCTGACAGCGCACGATCAGTTCAAGGCAACACTGCCCGAGGCTGACCGAGAGCGAGGT       c.1740
 L  L  T  A  H  D  Q  F  K  A  T  L  P  E  A  D  R  E  R  G         p.580

          .         .         .         .         .         .       g.18776
 GCCATCATGGGCATCCAGGGTGAGATCCAGAAGATCTGCCAGACGTATGGGCTGCGGCCC       c.1800
 A  I  M  G  I  Q  G  E  I  Q  K  I  C  Q  T  Y  G  L  R  P         p.600

          .         .         .         .         .         .       g.18836
 TGCTCCACCAATCCCTACATCACCCTCAGCCCGCAGGACATCAACACCAAGTGGGATATG       c.1860
 C  S  T  N  P  Y  I  T  L  S  P  Q  D  I  N  T  K  W  D  M         p.620

  | 16       .         .         .         .         .         .    g.19367
  | GTCCGAAAGCTGGTGCCCAGCTGTGACCAGACACTGCAGGAGGAGCTGGCACGGCAGCAG    c.1920
  | V  R  K  L  V  P  S  C  D  Q  T  L  Q  E  E  L  A  R  Q  Q      p.640

          .         .         .         .         .         .       g.19427
 GTAAACGAGAGGCTCCGGCGACAGTTTGCGGCCCAGGCCAATGCCATTGGACCCTGGATC       c.1980
 V  N  E  R  L  R  R  Q  F  A  A  Q  A  N  A  I  G  P  W  I         p.660

          .      | 17  .         .         .         .         .    g.19583
 CAGGCGAAGGTGGAG | GAAGTGGGGCGGCTGGCAGCAGGGCTAGCTGGCTCTCTGGAGGAG    c.2040
 Q  A  K  V  E   | E  V  G  R  L  A  A  G  L  A  G  S  L  E  E      p.680

          .         .         .         .         .         .       g.19643
 CAGATGGCTGGGCTACGGCAGCAGGAGCAGAACATTATCAACTACAAGACTAACATTGAC       c.2100
 Q  M  A  G  L  R  Q  Q  E  Q  N  I  I  N  Y  K  T  N  I  D         p.700

          .         .         .         .         .         .       g.19703
 CGGCTGGAGGGTGACCACCAGCTGCTGCAGGAGAGCCTGGTGTTCGACAATAAGCACACC       c.2160
 R  L  E  G  D  H  Q  L  L  Q  E  S  L  V  F  D  N  K  H  T         p.720

          .      | 18  .         .         .         .         .    g.20147
 GTCTACAGCATGGAG | CACATCCGCGTGGGCTGGGAGCAGCTGCTCACCTCCATTGCCCGC    c.2220
 V  Y  S  M  E   | H  I  R  V  G  W  E  Q  L  L  T  S  I  A  R      p.740

          .         .         .         .         .         .       g.20207
 ACCATCAATGAAGTGGAGAACCAGGTACTGACCCGAGACGCCAAGGGACTGAGCCAGGAG       c.2280
 T  I  N  E  V  E  N  Q  V  L  T  R  D  A  K  G  L  S  Q  E         p.760

          .         .         .         .   | 19     .         .    g.20355
 CAGCTCAACGAGTTCCGAGCATCCTTCAACCACTTTGACAGG | AAGCAGAATGGGATGATG    c.2340
 Q  L  N  E  F  R  A  S  F  N  H  F  D  R   | K  Q  N  G  M  M      p.780

          .         .         .         .         | 20         .    g.20888
 GAGCCTGATGACTTCCGAGCTTGCCTCATCTCCATGGGCTATGACCTG | GGGGAAGTGGAG    c.2400
 E  P  D  D  F  R  A  C  L  I  S  M  G  Y  D  L   | G  E  V  E      p.800

          .         .         .         .         .         .       g.20948
 TTTGCTCGCATCATGACCATGGTGGACCCCAACGCAGCTGGGGTGGTGACCTTCCAGGCC       c.2460
 F  A  R  I  M  T  M  V  D  P  N  A  A  G  V  V  T  F  Q  A         p.820

          .         .         .         .         .         .       g.21008
 TTCATAGACTTCATGACCCGAGAGACAGCCGAGACTGACACGACTGAGCAAGTTGTAGCT       c.2520
 F  I  D  F  M  T  R  E  T  A  E  T  D  T  T  E  Q  V  V  A         p.840

          .         .        | 21.         .         .         .    g.21148
 TCCTTCAAGATCTTGGCAGGAGACAAG | AACTACATCACCCCCGAGGAGCTGCGGCGCGAG    c.2580
 S  F  K  I  L  A  G  D  K   | N  Y  I  T  P  E  E  L  R  R  E      p.860

          .         .         .         .         .         .       g.21208
 CTCCCTGCCAAGCAGGCCGAGTACTGCATCCGCCGTATGGTGCCCTACAAGGGATCCGGG       c.2640
 L  P  A  K  Q  A  E  Y  C  I  R  R  M  V  P  Y  K  G  S  G         p.880

          .         .         .         .         .         .       g.21268
 GCCCCGGCTGGAGCCCTGGACTACGTGGCCTTCTCCAGTGCCCTCTATGGGGAGAGCGAC       c.2700
 A  P  A  G  A  L  D  Y  V  A  F  S  S  A  L  Y  G  E  S  D         p.900

                                                                    g.21274
 CTTTGA                                                             c.2706
 L  X                                                               p.901

          .         .         .         .         .         .       g.21334
 ccccaaccactgaggttctctatgcaagatggagagaggatgcaccctgtggctgatccc       c.*60

          .         .         .         .         .         .       g.21394
 atccgtccctcggagcaagggcctaagagaaaagccagccaagtgcttctgaataaagat       c.*120

          .                                                         g.21410
 ccctctctgggtctct                                                   c.*136

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Actinin, alpha 3 (gene/pseudogene) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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