activin A receptor type II-like 1 (ACVRL1) - coding DNA reference sequence

(used for variant description)

(last modified August 18, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000020.2 in the ACVRL1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009549.1, covering ACVRL1 transcript NM_000020.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  aggaaacggtttattaggagggagtggtggagctgggccaggc       c.-241

 .         .         .         .         .         .                g.5103
 aggaagacgctggaataagaaacatttttgctccagcccccatcccagtcccgggaggct       c.-181

 .         .         .         .         .         .                g.5163
 gccgcgccagctgcgccgagcgagcccctccccggctccagcccggtccggggccgcgcc       c.-121

 .         .         .         .         .         .                g.5223
 cggaccccagcccgccgtccagcgctggcggtgcaactgcggccgcgcggtggaggggag       c.-61

 .         .         .         .         .         .     | 02       g.10057
 gtggccccggtccgccgaaggctagcgccccgccacccgcagagcgggcccagag | ggacc    c.-1

          .         .         .         .         .         .       g.10117
 ATGACCTTGGGCTCCCCCAGGAAAGGCCTTCTGATGCTGCTGATGGCCTTGGTGACCCAG       c.60
 M  T  L  G  S  P  R  K  G  L  L  M  L  L  M  A  L  V  T  Q         p.20

   | 03      .         .         .         .         .         .    g.10740
 G | GAGACCCTGTGAAGCCGTCTCGGGGCCCGCTGGTGACCTGCACGTGTGAGAGCCCACAT    c.120
 G |   D  P  V  K  P  S  R  G  P  L  V  T  C  T  C  E  S  P  H      p.40

          .         .         .         .         .         .       g.10800
 TGCAAGGGGCCTACCTGCCGGGGGGCCTGGTGCACAGTAGTGCTGGTGCGGGAGGAGGGG       c.180
 C  K  G  P  T  C  R  G  A  W  C  T  V  V  L  V  R  E  E  G         p.60

          .         .         .         .         .         .       g.10860
 AGGCACCCCCAGGAACATCGGGGCTGCGGGAACTTGCACAGGGAGCTCTGCAGGGGGCGC       c.240
 R  H  P  Q  E  H  R  G  C  G  N  L  H  R  E  L  C  R  G  R         p.80

          .         .         .         .         .         .       g.10920
 CCCACCGAGTTCGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCC       c.300
 P  T  E  F  V  N  H  Y  C  C  D  S  H  L  C  N  H  N  V  S         p.100

          .    | 04    .         .         .         .         .    g.11188
 CTGGTGCTGGAGG | CCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCC    c.360
 L  V  L  E  A |   T  Q  P  P  S  E  Q  P  G  T  D  G  Q  L  A      p.120

          .         .         .         .         .         .       g.11248
 CTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTG       c.420
 L  I  L  G  P  V  L  A  L  L  A  L  V  A  L  G  V  L  G  L         p.140

          .         .         .         .         .         .       g.11308
 TGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCC       c.480
 W  H  V  R  R  R  Q  E  K  Q  R  G  L  H  S  E  L  G  E  S         p.160

          .         .         .         .      | 05  .         .    g.11571
 AGTCTCATCCTGAAAGCATCTGAGCAGGGCGACAGCATGTTGGGG | GACCTCCTGGACAGT    c.540
 S  L  I  L  K  A  S  E  Q  G  D  S  M  L  G   | D  L  L  D  S      p.180

          .         .         .         .         .         .       g.11631
 GACTGCACCACAGGGAGTGGCTCAGGGCTCCCCTTCCTGGTGCAGAGGACAGTGGCACGG       c.600
 D  C  T  T  G  S  G  S  G  L  P  F  L  V  Q  R  T  V  A  R         p.200

          .         .      | 06  .         .         .         .    g.12056
 CAGGTTGCCTTGGTGGAGTGTGTGG | GAAAAGGCCGCTATGGCGAAGTGTGGCGGGGCTTG    c.660
 Q  V  A  L  V  E  C  V  G |   K  G  R  Y  G  E  V  W  R  G  L      p.220

          .         .         .         .         .         .       g.12116
 TGGCACGGTGAGAGTGTGGCCGTCAAGATCTTCTCCTCGAGGGATGAACAGTCCTGGTTC       c.720
 W  H  G  E  S  V  A  V  K  I  F  S  S  R  D  E  Q  S  W  F         p.240

          .         .         .         .         .   | 07     .    g.12815
 CGGGAGACTGAGATCTATAACACAGTGTTGCTCAGACACGACAACATCCTAG | GCTTCATC    c.780
 R  E  T  E  I  Y  N  T  V  L  L  R  H  D  N  I  L  G |   F  I      p.260

          .         .         .         .         .         .       g.12875
 GCCTCAGACATGACCTCCCGCAACTCGAGCACGCAGCTGTGGCTCATCACGCACTACCAC       c.840
 A  S  D  M  T  S  R  N  S  S  T  Q  L  W  L  I  T  H  Y  H         p.280

          .         .         .         .         .         .       g.12935
 GAGCACGGCTCCCTCTACGACTTTCTGCAGAGACAGACGCTGGAGCCCCATCTGGCTCTG       c.900
 E  H  G  S  L  Y  D  F  L  Q  R  Q  T  L  E  P  H  L  A  L         p.300

          .         .         .         .         .         .       g.12995
 AGGCTAGCTGTGTCCGCGGCATGCGGCCTGGCGCACCTGCACGTGGAGATCTTCGGTACA       c.960
 R  L  A  V  S  A  A  C  G  L  A  H  L  H  V  E  I  F  G  T         p.320

          .         .         .         .         .         .       g.13055
 CAGGGCAAACCAGCCATTGCCCACCGCGACTTCAAGAGCCGCAATGTGCTGGTCAAGAGC       c.1020
 Q  G  K  P  A  I  A  H  R  D  F  K  S  R  N  V  L  V  K  S         p.340

          .         .         | 08         .         .         .    g.13650
 AACCTGCAGTGTTGCATCGCCGACCTGG | GCCTGGCTGTGATGCACTCACAGGGCAGCGAT    c.1080
 N  L  Q  C  C  I  A  D  L  G |   L  A  V  M  H  S  Q  G  S  D      p.360

          .         .         .         .         .         .       g.13710
 TACCTGGACATCGGCAACAACCCGAGAGTGGGCACCAAGCGGTACATGGCACCCGAGGTG       c.1140
 Y  L  D  I  G  N  N  P  R  V  G  T  K  R  Y  M  A  P  E  V         p.380

          .         .         .         .         .         .       g.13770
 CTGGACGAGCAGATCCGCACGGACTGCTTTGAGTCCTACAAGTGGACTGACATCTGGGCC       c.1200
 L  D  E  Q  I  R  T  D  C  F  E  S  Y  K  W  T  D  I  W  A         p.400

          .         .         .         .       | 09 .         .    g.16581
 TTTGGCCTGGTGCTGTGGGAGATTGCCCGCCGGACCATCGTGAATG | GCATCGTGGAGGAC    c.1260
 F  G  L  V  L  W  E  I  A  R  R  T  I  V  N  G |   I  V  E  D      p.420

          .         .         .         .         .         .       g.16641
 TATAGACCACCCTTCTATGATGTGGTGCCCAATGACCCCAGCTTTGAGGACATGAAGAAG       c.1320
 Y  R  P  P  F  Y  D  V  V  P  N  D  P  S  F  E  D  M  K  K         p.440

          .         .         .         .         .        | 10.    g.18344
 GTGGTGTGTGTGGATCAGCAGACCCCCACCATCCCTAACCGGCTGGCTGCAGACCCG | GTC    c.1380
 V  V  C  V  D  Q  Q  T  P  T  I  P  N  R  L  A  A  D  P   | V      p.460

          .         .         .         .         .         .       g.18404
 CTCTCAGGCCTAGCTCAGATGATGCGGGAGTGCTGGTACCCAAACCCCTCTGCCCGACTC       c.1440
 L  S  G  L  A  Q  M  M  R  E  C  W  Y  P  N  P  S  A  R  L         p.480

          .         .         .         .         .         .       g.18464
 ACCGCGCTGCGGATCAAGAAGACACTACAAAAAATTAGCAACAGTCCAGAGAAGCCTAAA       c.1500
 T  A  L  R  I  K  K  T  L  Q  K  I  S  N  S  P  E  K  P  K         p.500

          .                                                         g.18476
 GTGATTCAATAG                                                       c.1512
 V  I  Q  X                                                         p.503

          .         .         .         .         .         .       g.18536
 cccaggagcacctgattcctttctgcctgcagggggctgggggggtggggggcagtggat       c.*60

          .         .         .         .         .         .       g.18596
 ggtgccctatctgggtagaggtagtgtgagtgtggtgtgtgctggggatgggcagctgcg       c.*120

          .         .         .         .         .         .       g.18656
 cctgcctgctcggcccccagcccacccagccaaaaatacagctgggctgaaacctgatcc       c.*180

          .         .         .         .         .         .       g.18716
 cctgctgtctggcctgctcaaagcggcaggctccctgacgcctggctctctccccacccc       c.*240

          .         .         .         .         .         .       g.18776
 tatggccagcatggtgcaccccctaccactcccgggacaggatgcaaaagaggctccaga       c.*300

          .         .         .         .         .         .       g.18836
 gtcagagtgccaagccagggaatcccagtcccagactcagagcccgggcctgcactttgc       c.*360

          .         .         .         .         .         .       g.18896
 cccctgcccttgatcaaccccactgccccaccagagctgccagggtggcacagggccctg       c.*420

          .         .         .         .         .         .       g.18956
 tccagcccctggcacacacttccctgccaggcctcagcctctagcataagctccagagag       c.*480

          .         .         .         .         .         .       g.19016
 ccagggcccatcagtttctctctgtggatttgtatctcagctccatgatgccttgggctt       c.*540

          .         .         .         .         .         .       g.19076
 tctgtctcctcaacaagagtgcagcttgctgaatgtcagctgcctgagagagctggggcc       c.*600

          .         .         .         .         .         .       g.19136
 tgacttactagggcattaaatcctaagaggtcctactgaggtgtggcaggatcacaggcc       c.*660

          .         .         .         .         .         .       g.19196
 agtggaaaaagggcaggtcagatgggcaaggcccaggactttcagattaactgagaggat       c.*720

          .         .         .         .         .         .       g.19256
 atcgaggccaagcatggcagggggaaggtcagtgggtgtcaagagacccaggtctgaccc       c.*780

          .         .         .         .         .         .       g.19316
 cggatgtttgctccatgtgacaaaagcaggcctgtctcaggaccttttcttttctttttt       c.*840

          .         .         .         .         .         .       g.19376
 ccttctttttttttttgacacggagtttcgctcttgttgtccaggctagagtgcaatggc       c.*900

          .         .         .         .         .         .       g.19436
 atgatcccagctcaccgcaacgtctacctcccaggttcaaatcattctcttgcctcagac       c.*960

          .         .         .         .         .         .       g.19496
 tcccgagtagctgggattacaggcacatgccaccatgcctggctaattttgtatatttag       c.*1020

          .         .         .         .         .         .       g.19556
 tagaaacagggtttcaccatgctggccatgctggtctcgaactcctgacctcaggtgttc       c.*1080

          .         .         .         .         .         .       g.19616
 cacctacctcagcctcccaaagtgctggggttacaggtgtgagccatcgcgcctggccag       c.*1140

          .         .         .         .         .         .       g.19676
 gacctttgtttcttatctacatattggaagatttggtcctgatgtcctttgaggcttctt       c.*1200

          .         .         .         .         .         .       g.19736
 tagctctagttctctgacacttcagcctatatcacagctaacttcttcagtctcatctat       c.*1260

          .         .         .         .         .         .       g.19796
 tccttatgctccagcccctggcaatttgcctcaagatgggggtttgaaaataactttacc       c.*1320

          .         .         .         .         .         .       g.19856
 tgactcaaggagtgtctggagcacctcctagtctaagtctgcaagctccagttcttgcct       c.*1380

          .         .         .         .         .         .       g.19916
 aaaaccatgccagtggccacccttgggctcagacagctctgggccttttgaccacaagcc       c.*1440

          .         .         .         .         .         .       g.19976
 agcccctcgccctctctgtggcatagtcttctctgccccaggactgcagggcggcttcct       c.*1500

          .         .         .         .         .         .       g.20036
 ccaaggcttccaaggctcaaaagaaatttggctccatccaagaaggctccagctccccta       c.*1560

          .         .         .         .         .         .       g.20096
 ctggcccctggctcaggcccacacccctggccaggcccagagagtgtgtctcaggagaat       c.*1620

          .         .         .         .         .         .       g.20156
 tcaatggctctagagagacacacagaaagtttggcatttggaaatttcaaggatgtatgt       c.*1680

          .         .         .         .         .         .       g.20216
 atgctcacgtatggagcaggttgtcctggtccctgggtgcagggaagtgggctgcaggga       c.*1740

          .         .         .         .         .         .       g.20276
 agtggattggaggggagcttgaggaatataaggagcgggggtggagactcaggctatgga       c.*1800

          .         .         .         .         .         .       g.20336
 caaggacagccccaaggttgggaagacctggccttagtcgtcctcagcctaggggcaggg       c.*1860

          .         .         .         .         .         .       g.20396
 cagtgaagaaagctctccccgctcctgctgtaatgacccagagtagcctccccaggccgg       c.*1920

          .         .         .         .         .         .       g.20456
 catcttatgtgtgtcttccaccatcctcatggtggcacttttctaggcctgtctcccagc       c.*1980

          .         .         .         .         .         .       g.20516
 attgtgcaaggctcggaagagaaccaggaagtgaaactgggtgaaaacagaaagctcaat       c.*2040

          .         .         .         .         .         .       g.20576
 ggatgggctaggttcccagatcattagggcagagtttgcacgtcctctggtcactggaat       c.*2100

          .         .         .         .         .         .       g.20636
 ccacccagcccacgaatcatctccctcttgaaggattttatttctactgggttttggaac       c.*2160

          .         .         .         .         .         .       g.20696
 aaactcctgctgagaccccacagccagaaactgaaagcagcagctccccaaagcctggaa       c.*2220

          .         .         .         .         .         .       g.20756
 aatccctaagagaaggcctggggcaggaagtggagtgacaggggacaggtagagagaagg       c.*2280

          .         .         .         .         .         .       g.20816
 gggcccaatggccagggagtgaaggaggtggcgttgctgagagcagtctgcacatgcttc       c.*2340

          .         .         .         .         .         .       g.20876
 tgtctgagtgcaggaaggtgttccagggtcgaaattacacttctcgtacctggagacgct       c.*2400

          .         .         .         .         .         .       g.20936
 gtttgtgggagcactgggctcatgcctggcacacaataggtctgcaataaaccatggtta       c.*2460

                                                                    g.20944
 aatcctga                                                           c.*2468

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Activin A receptor type II-like 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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