ADAM metallopeptidase domain 9 (ADAM9) - coding DNA reference sequence

(used for variant description)

(last modified August 30, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_003816.2 in the ADAM9 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016335.1, covering ADAM9 transcript NM_003816.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           cggcagggttggaaaatg       c.-61

 .         .         .         .         .         .                g.5078
 atggaagaggcggaggtggaggcgaccgagtgctgagaggaacctgcggaatcggccgag       c.-1

          .         .         .         .         .         .       g.5138
 ATGGGGTCTGGCGCGCGCTTTCCCTCGGGGACCCTTCGTGTCCGGTGGTTGCTGTTGCTT       c.60
 M  G  S  G  A  R  F  P  S  G  T  L  R  V  R  W  L  L  L  L         p.20

          .         .         .        | 02.         .         .    g.15923
 GGCCTGGTGGGCCCAGTCCTCGGTGCGGCGCGGCCAG | GCTTTCAACAGACCTCACATCTT    c.120
 G  L  V  G  P  V  L  G  A  A  R  P  G |   F  Q  Q  T  S  H  L      p.40

          .         .         .         .         .         .       g.15983
 TCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCTAGG       c.180
 S  S  Y  E  I  I  T  P  W  R  L  T  R  E  R  R  E  A  P  R         p.60

          .      | 03  .         .         .         .         .    g.19717
 CCCTATTCAAAACAA | GTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCAC    c.240
 P  Y  S  K  Q   | V  S  Y  V  I  Q  A  E  G  K  E  H  I  I  H      p.80

          .     | 04   .         .         .         .         .    g.22025
 TTGGAAAGGAACAA | AGACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAA    c.300
 L  E  R  N  K  |  D  L  L  P  E  D  F  V  V  Y  T  Y  N  K  E      p.100

          .         .         .    | 05    .         .         .    g.24159
 GGGACTTTAATCACTGACCATCCCAATATACAG | AATCATTGTCATTATCGGGGCTATGTG    c.360
 G  T  L  I  T  D  H  P  N  I  Q   | N  H  C  H  Y  R  G  Y  V      p.120

          .         .         .         .         . | 06       .    g.25243
 GAGGGAGTTCATAATTCATCCATTGCTCTTAGCGACTGTTTTGGACTCAG | AGGATTGCTG    c.420
 E  G  V  H  N  S  S  I  A  L  S  D  C  F  G  L  R  |  G  L  L      p.140

          .         .         .         .         .         .       g.25303
 CATTTAGAGAATGCGAGTTATGGGATTGAACCCCTGCAGAACAGCTCTCATTTTGAGCAC       c.480
 H  L  E  N  A  S  Y  G  I  E  P  L  Q  N  S  S  H  F  E  H         p.160

          .         .         .         .         .         .       g.25363
 ATCATTTATCGAATGGATGATGTCTACAAAGAGCCTCTGAAATGTGGAGTTTCCAACAAG       c.540
 I  I  Y  R  M  D  D  V  Y  K  E  P  L  K  C  G  V  S  N  K         p.180

          .         .         .         .         .         .       g.25423
 GATATAGAGAAAGAAACTGCAAAGGATGAAGAGGAAGAGCCTCCCAGCATGACTCAGCTA       c.600
 D  I  E  K  E  T  A  K  D  E  E  E  E  P  P  S  M  T  Q  L         p.200

        | 07 .         .         .         .         .         .    g.26921
 CTTCGA | AGAAGAAGAGCTGTCTTGCCACAGACCCGGTATGTGGAGCTGTTCATTGTCGTA    c.660
 L  R   | R  R  R  A  V  L  P  Q  T  R  Y  V  E  L  F  I  V  V      p.220

          .   | 08     .         .         .         .         .    g.29705
 GACAAGGAAAGG | TATGACATGATGGGAAGAAATCAGACTGCTGTGAGAGAAGAGATGATT    c.720
 D  K  E  R   | Y  D  M  M  G  R  N  Q  T  A  V  R  E  E  M  I      p.240

          .         .     | 09   .         .         .         .    g.31206
 CTCCTGGCAAACTACTTGGATAGT | ATGTATATTATGTTAAATATTCGAATTGTGCTAGTT    c.780
 L  L  A  N  Y  L  D  S   | M  Y  I  M  L  N  I  R  I  V  L  V      p.260

          .         .         .         .         .         .       g.31266
 GGACTGGAGATTTGGACCAATGGAAACCTGATCAACATAGTTGGGGGTGCTGGTGATGTG       c.840
 G  L  E  I  W  T  N  G  N  L  I  N  I  V  G  G  A  G  D  V         p.280

          .         .         .         .         .         .       g.31326
 CTGGGGAACTTCGTGCAGTGGCGGGAAAAGTTTCTTATCACACGTCGGAGACATGACAGT       c.900
 L  G  N  F  V  Q  W  R  E  K  F  L  I  T  R  R  R  H  D  S         p.300

          .     | 10   .         .         .         .         .    g.33863
 GCACAGCTAGTTCT | AAAGAAAGGTTTTGGTGGAACTGCAGGAATGGCATTTGTGGGAACA    c.960
 A  Q  L  V  L  |  K  K  G  F  G  G  T  A  G  M  A  F  V  G  T      p.320

          .         .         .       | 11 .         .         .    g.34715
 GTGTGTTCAAGGAGCCACGCAGGCGGGATTAATGTG | TTTGGACAAATCACTGTGGAGACA    c.1020
 V  C  S  R  S  H  A  G  G  I  N  V   | F  G  Q  I  T  V  E  T      p.340

          .         .         .         .         .         .       g.34775
 TTTGCTTCCATTGTTGCTCATGAATTGGGTCATAATCTTGGAATGAATCACGATGATGGG       c.1080
 F  A  S  I  V  A  H  E  L  G  H  N  L  G  M  N  H  D  D  G         p.360

          .         .         .         .         . | 12       .    g.49970
 AGAGATTGTTCCTGTGGAGCAAAGAGCTGCATCATGAATTCAGGAGCATC | GGGTTCCAGA    c.1140
 R  D  C  S  C  G  A  K  S  C  I  M  N  S  G  A  S  |  G  S  R      p.380

          .         .         .         .         .         .       g.50030
 AACTTTAGCAGTTGCAGTGCAGAGGACTTTGAGAAGTTAACTTTAAATAAAGGAGGAAAC       c.1200
 N  F  S  S  C  S  A  E  D  F  E  K  L  T  L  N  K  G  G  N         p.400

          .         .         .         .         .         .       g.50090
 TGCCTTCTTAATATTCCAAAGCCTGATGAAGCCTATAGTGCTCCCTCCTGTGGTAATAAG       c.1260
 C  L  L  N  I  P  K  P  D  E  A  Y  S  A  P  S  C  G  N  K         p.420

          .         .         .         .   | 13     .         .    g.62513
 TTGGTGGACGCTGGGGAAGAGTGTGACTGTGGTACTCCAAAG | GAATGTGAATTGGACCCT    c.1320
 L  V  D  A  G  E  E  C  D  C  G  T  P  K   | E  C  E  L  D  P      p.440

          .         .         .         .         .         .       g.62573
 TGCTGCGAAGGAAGTACCTGTAAGCTTAAATCATTTGCTGAGTGTGCATATGGTGACTGT       c.1380
 C  C  E  G  S  T  C  K  L  K  S  F  A  E  C  A  Y  G  D  C         p.460

          .      | 14  .         .         .         .         .    g.63636
 TGTAAAGACTGTCGG | TTCCTTCCAGGAGGTACTTTATGCCGAGGAAAAACCAGTGAGTGT    c.1440
 C  K  D  C  R   | F  L  P  G  G  T  L  C  R  G  K  T  S  E  C      p.480

          .         .         .         .         .         .       g.63696
 GATGTTCCAGAGTACTGCAATGGTTCTTCTCAGTTCTGTCAGCCAGATGTTTTTATTCAG       c.1500
 D  V  P  E  Y  C  N  G  S  S  Q  F  C  Q  P  D  V  F  I  Q         p.500

          .         .         .         .         .         .       g.63756
 AATGGATATCCTTGCCAGAATAACAAAGCCTATTGCTACAACGGCATGTGCCAGTATTAT       c.1560
 N  G  Y  P  C  Q  N  N  K  A  Y  C  Y  N  G  M  C  Q  Y  Y         p.520

          .         .         .  | 15      .         .         .    g.79341
 GATGCTCAATGTCAAGTCATCTTTGGCTCAA | AAGCCAAGGCTGCCCCCAAAGATTGTTTC    c.1620
 D  A  Q  C  Q  V  I  F  G  S  K |   A  K  A  A  P  K  D  C  F      p.540

          .         .         .         .         .         .       g.79401
 ATTGAAGTGAATTCTAAAGGTGACAGATTTGGCAATTGTGGTTTCTCTGGCAATGAATAC       c.1680
 I  E  V  N  S  K  G  D  R  F  G  N  C  G  F  S  G  N  E  Y         p.560

          .        | 16.         .         .         .         .    g.85285
 AAGAAGTGTGCCACTGG | GAATGCTTTGTGTGGAAAGCTTCAGTGTGAGAATGTACAAGAG    c.1740
 K  K  C  A  T  G  |  N  A  L  C  G  K  L  Q  C  E  N  V  Q  E      p.580

          .         .         .         .         .         .       g.85345
 ATACCTGTATTTGGAATTGTGCCTGCTATTATTCAAACGCCTAGTCGAGGCACCAAATGT       c.1800
 I  P  V  F  G  I  V  P  A  I  I  Q  T  P  S  R  G  T  K  C         p.600

          .         .         .         .         .         .       g.85405
 TGGGGTGTGGATTTCCAGCTAGGATCAGATGTTCCAGATCCTGGGATGGTTAACGAAGGC       c.1860
 W  G  V  D  F  Q  L  G  S  D  V  P  D  P  G  M  V  N  E  G         p.620

          .         .  | 17      .         .         .         .    g.90694
 ACAAAATGTGGTGCTGGAAAG | ATCTGTAGAAACTTCCAGTGTGTAGATGCTTCTGTTCTG    c.1920
 T  K  C  G  A  G  K   | I  C  R  N  F  Q  C  V  D  A  S  V  L      p.640

          .         .         .         .   | 18     .         .    g.91000
 AATTATGACTGTGATGTTCAGAAAAAGTGTCATGGACATGGG | GTATGTAATAGCAATAAG    c.1980
 N  Y  D  C  D  V  Q  K  K  C  H  G  H  G   | V  C  N  S  N  K      p.660

          .         .         .         .         .         .       g.91060
 AATTGTCACTGTGAAAATGGCTGGGCTCCCCCAAATTGTGAGACTAAAGGATACGGAGGA       c.2040
 N  C  H  C  E  N  G  W  A  P  P  N  C  E  T  K  G  Y  G  G         p.680

          .         .         | 19         .         .         .    g.98093
 AGTGTGGACAGTGGACCTACATACAATG | AAATGAATACTGCATTGAGGGACGGACTTCTG    c.2100
 S  V  D  S  G  P  T  Y  N  E |   M  N  T  A  L  R  D  G  L  L      p.700

          .         .         .         .         .         .       g.98153
 GTCTTCTTCTTCCTAATTGTTCCCCTTATTGTCTGTGCTATTTTTATCTTCATCAAGAGG       c.2160
 V  F  F  F  L  I  V  P  L  I  V  C  A  I  F  I  F  I  K  R         p.720

          .         .         .         .         . | 20       .    g.99283
 GATCAACTGTGGAGAAGCTACTTCAGAAAGAAGAGATCACAAACATATGA | GTCAGATGGC    c.2220
 D  Q  L  W  R  S  Y  F  R  K  K  R  S  Q  T  Y  E  |  S  D  G      p.740

          .         .         .         .         .         .       g.99343
 AAAAATCAAGCAAACCCTTCTAGACAGCCGGGGAGTGTTCCTCGACATGTTTCTCCAGTG       c.2280
 K  N  Q  A  N  P  S  R  Q  P  G  S  V  P  R  H  V  S  P  V         p.760

          .         | 21         .         .         .         .    g.109919
 ACACCTCCCAGAGAAGTT | CCTATATATGCAAACAGATTTGCAGTACCAACCTATGCAGCC    c.2340
 T  P  P  R  E  V   | P  I  Y  A  N  R  F  A  V  P  T  Y  A  A      p.780

          .         .       | 22 .         .         .         .    g.111655
 AAGCAACCTCAGCAGTTCCCATCAAG | GCCACCTCCACCACAACCGAAAGTATCATCTCAG    c.2400
 K  Q  P  Q  Q  F  P  S  R  |  P  P  P  P  Q  P  K  V  S  S  Q      p.800

          .         .         .         .         .         .       g.111715
 GGAAACTTAATTCCTGCCCGTCCTGCTCCTGCACCTCCTTTATATAGTTCCCTCACTTGA       c.2460
 G  N  L  I  P  A  R  P  A  P  A  P  P  L  Y  S  S  L  T  X         p.819

          .         .         .         .         .         .       g.111775
 tttttttaaccttctttttgcaaatgtcttcagggaactgagctaatacttttttttttt       c.*60

          .         .         .         .         .         .       g.111835
 cttgatgttttcttgaaaagcctttctgttgcaactatgaatgaaaacaaaacaccacaa       c.*120

          .         .         .         .         .         .       g.111895
 aacagacttcactaacacagaaaaacagaaactgagtgtgagagttgtgaaatacaagga       c.*180

          .         .         .         .         .         .       g.111955
 aatgcagtaaagccagggaatttacaataacatttccgtttccatcattgaataagtctt       c.*240

          .         .         .         .         .         .       g.112015
 attcagtcatcggtgaggttaatgcactaatcatggattttttgaacatgttattgcagt       c.*300

          .         .         .         .         .         .       g.112075
 gattctcaaattaactgtattggtgtaagatttttgtcattaagtgtttaagtgttattc       c.*360

          .         .         .         .         .         .       g.112135
 tgaattttctaccttagttatcattaatgtagttcctcattgaacatgtgataatctaat       c.*420

          .         .         .         .         .         .       g.112195
 acctgtgaaaactgactaatcagctgccaataatatctaatatttttcatcatgcacgaa       c.*480

          .         .         .         .         .         .       g.112255
 ttaataatcatcatactctagaatcttgtctgtcactcactacatgaataagcaaatatt       c.*540

          .         .         .         .         .         .       g.112315
 gtcttcaaaagaatgcacaagaaccacaattaagatgtcatattattttgaaagtacaaa       c.*600

          .         .         .         .         .         .       g.112375
 atatactaaaagagtgtgtgtgtattcacgcagttactcgcttccatttttatgaccttt       c.*660

          .         .         .         .         .         .       g.112435
 caactataggtaataactcttagagaaattaatttaatattagaatttctattatgaatc       c.*720

          .         .         .         .         .         .       g.112495
 atgtgaaagcatgacattcgttcacaatagcactattttaaataaattataagctttaag       c.*780

          .         .         .         .         .         .       g.112555
 gtacgaagtatttaatagatctaatcaaatatgttgattcatggctataataaagcagga       c.*840

          .         .         .         .         .         .       g.112615
 gcaattataaaatcttcaatcaattgaacttttacaaaaccacttgagaatttcatgagc       c.*900

          .         .         .         .         .         .       g.112675
 actttaaaatctgaactttcaaagcttgctattaaatcatttagaatgtttacatttact       c.*960

          .         .         .         .         .         .       g.112735
 aaggtgtgctgggtcatgtaaaatattagacactaatattttcatagaaattaggctgga       c.*1020

          .         .         .         .         .         .       g.112795
 gaaagaaggaagaaatggttttcttaaatacctacaaaaaagttactgtggtatctatga       c.*1080

          .         .         .         .         .         .       g.112855
 gttatcatcttagctgtgttaaaaatgaatttttactatggcagatatggtatggatcgt       c.*1140

          .         .         .         .         .         .       g.112915
 aaaattttaagcactaaaaattttttcataacctttcataataaagtttaataataggtt       c.*1200

          .         .         .         .         .         .       g.112975
 tattaactgaatttcattagttttttaaaagtgtttttggtttgtgtatatatacatata       c.*1260

          .         .         .         .         .         .       g.113035
 caaatacaacatttacaataaataaaatacttgaaattctcttttgtgtctcctagtagc       c.*1320

          .         .         .         .         .         .       g.113095
 ttcctactcaactatttataatctcattaattaaaaagttataattttagataaaaattc       c.*1380

          .         .         .         .         .         .       g.113155
 tagtcaaatttttacagatattatctcactaattttcagacttttgccaaagtgtgcaca       c.*1440

          .         .         .         .         .         .       g.113215
 atggctttttgttaataaagaacagattagttttgaagaaggcaaaaatttcagttttct       c.*1500

          .         .         .         .         .         .       g.113275
 gaagacagcatgttattttaacaatcaagtatacatattaaaaattgtgagcaatctcaa       c.*1560

                                                                    g.113276
 a                                                                  c.*1561

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ADAM metallopeptidase domain 9 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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