ADAM metallopeptidase with thrombospondin type 1 motif, 18 (ADAMTS18) - coding DNA reference sequence

(used for variant description)

(last modified May 29, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_199355.2 in the ADAMTS18 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031879.1, covering ADAMTS18 transcript NM_199355.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5059
  aatcaccgcgcggtggagaggcgggcgctcggctccggcgcgctgggggagccagctgg       c.-361

 .         .         .         .         .         .                g.5119
 cgctgtcttccccatcgcctcagacgctcacaccgacacagacagacgcacagacgggcg       c.-301

 .         .         .         .         .         .                g.5179
 ggcagacaccgacagtctcccaaccgtttgcgctccagtcccggcccagggagccccccg       c.-241

 .         .         .         .         .         .                g.5239
 taccctctggggtgccgcaaactgcagctcggcaggcccgcgccgggagaagggagggcg       c.-181

 .         .         .         .         .         .                g.5299
 cgcaggcggccggaggaggggaggtcccagcgcgcccccgctgcgatgtgaacggcggcg       c.-121

 .         .         .         .         .         .                g.5359
 gctctcacctggagccgcacctggggcgccgagctccggggccgcggaaagaatgcgcgc       c.-61

 .         .         .         .         .         .                g.5419
 cgcccgtgcgctccgcctgccgcgtctggccacccgcagccgccgcgtccgcacctgacc       c.-1

          .         .         .         .         .         .       g.5479
 ATGGAGTGCGCCCTCCTGCTCGCGTGTGCCTTCCCGGCTGCGGGTTCGGGCCCGCCGAGG       c.60
 M  E  C  A  L  L  L  A  C  A  F  P  A  A  G  S  G  P  P  R         p.20

          .         .         . | 02       .         .         .    g.5639
 GGCCTGGCGGGACTGGGGCGCGTGGCCAAG | GCGCTCCAGCTGTGCTGCCTCTGCTGTGCG    c.120
 G  L  A  G  L  G  R  V  A  K   | A  L  Q  L  C  C  L  C  C  A      p.40

          .         .         .         .         .         | 03    g.8505
 TCGGTCGCCGCGGCCTTAGCCAGTGACAGCAGCAGCGGCGCCAGCGGATTAAATGATG | AT    c.180
 S  V  A  A  A  L  A  S  D  S  S  S  G  A  S  G  L  N  D  D |       p.60

          .         .         .         .         .         .       g.8565
 TACGTCTTTGTCACGCCAGTAGAAGTAGACTCAGCCGGGTCATATATTTCACACGACATT       c.240
 Y  V  F  V  T  P  V  E  V  D  S  A  G  S  Y  I  S  H  D  I         p.80

          .         .         .         .         .         .       g.8625
 TTGCACAACGGCAGGAAAAAGCGATCGGCGCAGAATGCCAGAAGCTCCCTGCACTACCGA       c.300
 L  H  N  G  R  K  K  R  S  A  Q  N  A  R  S  S  L  H  Y  R         p.100

          .         .         .         .         .         .       g.8685
 TTTTCAGCATTTGGACAGGAACTGCACTTAGAACTTAAGCCCTCGGCGATTTTGAGCAGT       c.360
 F  S  A  F  G  Q  E  L  H  L  E  L  K  P  S  A  I  L  S  S         p.120

          .         .         .         .         .         .       g.8745
 CACTTTATTGTCCAGGTACTTGGAAAAGATGGTGCTTCAGAGACTCAGAAACCCGAGGTG       c.420
 H  F  I  V  Q  V  L  G  K  D  G  A  S  E  T  Q  K  P  E  V         p.140

          .         .         .         .         .         .       g.8805
 CAGCAATGCTTCTATCAGGGATTTATCAGAAATGACAGCTCCTCCTCTGTCGCTGTGTCT       c.480
 Q  Q  C  F  Y  Q  G  F  I  R  N  D  S  S  S  S  V  A  V  S         p.160

          .      | 04  .         .         .         .         .    g.72436
 ACGTGTGCTGGCTTG | TCAGGTTTAATAAGGACACGAAAAAATGAATTCCTCATCTCGCCA    c.540
 T  C  A  G  L   | S  G  L  I  R  T  R  K  N  E  F  L  I  S  P      p.180

          .         .         .         .         .         .       g.72496
 TTACCTCAGCTTCTGGCCCAGGAACACAACTACAGCTCCCCTGCGGGTCACCATCCTCAC       c.600
 L  P  Q  L  L  A  Q  E  H  N  Y  S  S  P  A  G  H  H  P  H         p.200

          .         .         .         .         .         .       g.72556
 GTACTGTACAAAAGGACAGCAGAGGAGAAGATCCAGCGGTACCGTGGCTACCCCGGCTCT       c.660
 V  L  Y  K  R  T  A  E  E  K  I  Q  R  Y  R  G  Y  P  G  S         p.220

          .         .         .         .         .         .       g.72616
 GGCCGGAATTATCCTGGTTACTCCCCAAGTCACATTCCCCATGCATCTCAGAGTCGAGAG       c.720
 G  R  N  Y  P  G  Y  S  P  S  H  I  P  H  A  S  Q  S  R  E         p.240

          .         .         .         .         .         | 05    g.75735
 ACAGAGTATCACCATCGAAGGTTGCAAAAGCAGCATTTTTGTGGACGACGCAAGAAAT | AT    c.780
 T  E  Y  H  H  R  R  L  Q  K  Q  H  F  C  G  R  R  K  K  Y |       p.260

          .         .         .         .         .         .       g.75795
 GCTCCCAAGCCTCCCACAGAGGACACCTATCTAAGGTTTGATGAATATGGGAGCTCTGGG       c.840
 A  P  K  P  P  T  E  D  T  Y  L  R  F  D  E  Y  G  S  S  G         p.280

          .         .         .         .         .         .       g.75855
 CGACCCAGAAGATCAGCTGGAAAATCACAAAAGGGCCTCAATGTGGAAACCCTCGTGGTG       c.900
 R  P  R  R  S  A  G  K  S  Q  K  G  L  N  V  E  T  L  V  V         p.300

          .         .         .         .         .         .       g.75915
 GCAGACAAGAAAATGGTGGAAAAGCATGGCAAGGGAAATGTCACCACATACATTCTCACA       c.960
 A  D  K  K  M  V  E  K  H  G  K  G  N  V  T  T  Y  I  L  T         p.320

          .   | 06     .         .         .         .         .    g.76277
 GTAATGAACATG | GTTTCTGGCCTATTTAAAGATGGGACTATTGGAAGTGACATAAACGTG    c.1020
 V  M  N  M   | V  S  G  L  F  K  D  G  T  I  G  S  D  I  N  V      p.340

          .         .         .       | 07 .         .         .    g.77874
 GTTGTGGTGAGCCTAATTCTTCTGGAACAAGAACCT | GGAGGATTATTGATCAACCATCAT    c.1080
 V  V  V  S  L  I  L  L  E  Q  E  P   | G  G  L  L  I  N  H  H      p.360

          .         .         .         .         .         .       g.77934
 GCAGACCAGTCTCTGAATAGTTTTTGTCAATGGCAGTCTGCCCTCATTGGAAAGAATGGC       c.1140
 A  D  Q  S  L  N  S  F  C  Q  W  Q  S  A  L  I  G  K  N  G         p.380

          .         .         .         .         .         .       g.77994
 AAGAGACATGATCATGCCATCTTACTAACAGGATTTGATATTTGTTCTTGGAAGAATGAA       c.1200
 K  R  H  D  H  A  I  L  L  T  G  F  D  I  C  S  W  K  N  E         p.400

          .       | 08 .         .         .         .         .    g.80735
 CCATGTGACACTCTAG | GGTTTGCCCCCATCAGTGGAATGTGCTCTAAGTACCGAAGTTGT    c.1260
 P  C  D  T  L  G |   F  A  P  I  S  G  M  C  S  K  Y  R  S  C      p.420

          .         .         .         .         .         .       g.80795
 ACCATCAATGAGGACACAGGACTTGGCCTTGCCTTCACCATCGCTCATGAGTCAGGGCAC       c.1320
 T  I  N  E  D  T  G  L  G  L  A  F  T  I  A  H  E  S  G  H         p.440

    | 09     .         .         .         .         .         .    g.84095
 AA | CTTTGGTATGATTCACGATGGAGAAGGGAATCCCTGCAGAAAGGCTGAAGGCAATATC    c.1380
 N  |  F  G  M  I  H  D  G  E  G  N  P  C  R  K  A  E  G  N  I      p.460

          .         .         .         .         .         .       g.84155
 ATGTCTCCCACACTGACCGGAAACAATGGAGTGTTTTCATGGTCTTCCTGCAGCCGCCAG       c.1440
 M  S  P  T  L  T  G  N  N  G  V  F  S  W  S  S  C  S  R  Q         p.480

          .         . | 10       .         .         .         .    g.86268
 TATCTCAAGAAATTCCTCAG | CACACCTCAGGCGGGGTGTCTAGTGGATGAGCCCAAGCAA    c.1500
 Y  L  K  K  F  L  S  |  T  P  Q  A  G  C  L  V  D  E  P  K  Q      p.500

          .         .         .         .         .         .       g.86328
 GCAGGACAGTATAAATATCCGGACAAACTACCAGGACAGATTTATGATGCTGACACACAG       c.1560
 A  G  Q  Y  K  Y  P  D  K  L  P  G  Q  I  Y  D  A  D  T  Q         p.520

          .         .         .         .         .     | 11   .    g.98321
 TGTAAATGGCAATTTGGAGCAAAAGCCAAGTTATGCAGCCTTGGTTTTGTGAAG | GATATT    c.1620
 C  K  W  Q  F  G  A  K  A  K  L  C  S  L  G  F  V  K   | D  I      p.540

          .         .         .         .         .         .       g.98381
 TGCAAATCACTTTGGTGCCACCGAGTAGGCCACAGGTGTGAGACCAAGTTTATGCCCGCA       c.1680
 C  K  S  L  W  C  H  R  V  G  H  R  C  E  T  K  F  M  P  A         p.560

          .         .         . | 12       .         .         .    g.104240
 GCAGAAGGGACCGTTTGTGGCTTGAGTATG | TGGTGTCGGCAAGGCCAGTGCGTAAAGTTT    c.1740
 A  E  G  T  V  C  G  L  S  M   | W  C  R  Q  G  Q  C  V  K  F      p.580

          .         .         .         .         .         .       g.104300
 GGGGAGCTCGGGCCCCGGCCCATCCACGGCCAGTGGTCCGCCTGGTCGAAGTGGTCAGAA       c.1800
 G  E  L  G  P  R  P  I  H  G  Q  W  S  A  W  S  K  W  S  E         p.600

          .         .         .         .         .          | 13    g.114077
 TGTTCCCGGACATGTGGTGGAGGAGTCAAGTTCCAGGAGAGACACTGCAATAACCCCAA | G    c.1860
 C  S  R  T  C  G  G  G  V  K  F  Q  E  R  H  C  N  N  P  K  |      p.620

          .         .         .         .         .         .       g.114137
 CCTCAGTATGGTGGCTTATTCTGTCCAGGTTCTAGCCGTATTTATCAGCTGTGCAATATT       c.1920
 P  Q  Y  G  G  L  F  C  P  G  S  S  R  I  Y  Q  L  C  N  I         p.640

          .         .         .         .         .         .       g.114197
 AACCCTTGCAATGAAAATAGCTTGGATTTTCGGGCTCAACAGTGTGCAGAATATAACAGC       c.1980
 N  P  C  N  E  N  S  L  D  F  R  A  Q  Q  C  A  E  Y  N  S         p.660

          .         .         .         .         .   | 14     .    g.117656
 AAACCTTTCCGTGGATGGTTCTACCAGTGGAAACCCTATACAAAAGTGGAAG | AGGAAGAT    c.2040
 K  P  F  R  G  W  F  Y  Q  W  K  P  Y  T  K  V  E  E |   E  D      p.680

          .         .         .         .         .         .       g.117716
 CGATGCAAACTGTACTGCAAGGCTGAGAACTTTGAATTTTTTTTTGCAATGTCCGGCAAA       c.2100
 R  C  K  L  Y  C  K  A  E  N  F  E  F  F  F  A  M  S  G  K         p.700

          .         .         .         .         .         .       g.117776
 GTGAAAGATGGAACTCCCTGCTCCCCAAACAAAAATGATGTTTGTATTGACGGGGTTTGT       c.2160
 V  K  D  G  T  P  C  S  P  N  K  N  D  V  C  I  D  G  V  C         p.720

     | 15    .         .         .         .         .         .    g.118969
 GAA | CTAGTGGGATGTGATCATGAACTAGGCTCTAAAGCAGTTTCAGATGCTTGTGGCGTT    c.2220
 E   | L  V  G  C  D  H  E  L  G  S  K  A  V  S  D  A  C  G  V      p.740

          .         .         .         .         .         .       g.119029
 TGCAAAGGTGATAATTCAACTTGCAAGTTTTATAAAGGCCTGTACCTCAACCAGCATAAA       c.2280
 C  K  G  D  N  S  T  C  K  F  Y  K  G  L  Y  L  N  Q  H  K         p.760

         | 16.         .         .         .         .         .    g.120074
 GCAAATG | AATATTATCCGGTGGTCCTCATTCCAGCTGGCGCCCGAAGCATCGAAATCCAG    c.2340
 A  N  E |   Y  Y  P  V  V  L  I  P  A  G  A  R  S  I  E  I  Q      p.780

          .         .         .         .         .         .       g.120134
 GAGCTGCAGGTTTCCTCCAGTTACCTCGCAGTTCGAAGCCTCAGTCAAAAGTATTACCTC       c.2400
 E  L  Q  V  S  S  S  Y  L  A  V  R  S  L  S  Q  K  Y  Y  L         p.800

          .         .         .         .         .         .       g.120194
 ACCGGGGGCTGGAGCATCGACTGGCCTGGGGAGTTCCCCTTCGCTGGGACCACGTTTGAA       c.2460
 T  G  G  W  S  I  D  W  P  G  E  F  P  F  A  G  T  T  F  E         p.820

          .         .         .         .         .         .       g.120254
 TACCAGCGCTCTTTCAACCGCCCGGAACGTCTGTACGCGCCAGGGCCCACAAATGAGACG       c.2520
 Y  Q  R  S  F  N  R  P  E  R  L  Y  A  P  G  P  T  N  E  T         p.840

          .   | 17     .         .         .         .         .    g.139758
 CTGGTCTTTGAA | ATTCTGATGCAAGGCAAAAATCCAGGGATAGCTTGGAAGTATGCACTT    c.2580
 L  V  F  E   | I  L  M  Q  G  K  N  P  G  I  A  W  K  Y  A  L      p.860

          .         .         .         .         .         .       g.139818
 CCCAAGGTCATGAATGGAACTCCACCAGCCACAAAAAGACCTGCCTATACCTGGAGTATC       c.2640
 P  K  V  M  N  G  T  P  P  A  T  K  R  P  A  Y  T  W  S  I         p.880

          .         .         .     | 18   .         .         .    g.142725
 GTGCAGTCAGAGTGCTCCGTCTCCTGTGGTGGAG | GTTACATAAATGTAAAGGCCATTTGC    c.2700
 V  Q  S  E  C  S  V  S  C  G  G  G |   Y  I  N  V  K  A  I  C      p.900

          .         .         .         .         .         .       g.142785
 TTGCGAGATCAAAATACTCAAGTCAATTCCTCATTCTGCAGTGCAAAAACCAAGCCAGTA       c.2760
 L  R  D  Q  N  T  Q  V  N  S  S  F  C  S  A  K  T  K  P  V         p.920

          .         .         .         .  | 19      .         .    g.145006
 ACTGAGCCCAAAATCTGCAACGCTTTCTCCTGCCCGGCTTA | CTGGATGCCAGGTGAATGG    c.2820
 T  E  P  K  I  C  N  A  F  S  C  P  A  Y  |  W  M  P  G  E  W      p.940

          .         .         .         .         .         .       g.145066
 AGTACATGCAGCAAGGCCTGTGCTGGAGGCCAGCAGAGCCGAAAGATCCAGTGTGTGCAA       c.2880
 S  T  C  S  K  A  C  A  G  G  Q  Q  S  R  K  I  Q  C  V  Q         p.960

          .         .         .         .         .         .       g.145126
 AAGAAGCCCTTCCAAAAGGAGGAAGCAGTGTTGCATTCTCTCTGTCCAGTGAGCACACCC       c.2940
 K  K  P  F  Q  K  E  E  A  V  L  H  S  L  C  P  V  S  T  P         p.980

          .         .         .         .         .         .       g.145186
 ACTCAGGTCCAAGCCTGCAACAGCCATGCCTGCCCTCCACAATGGAGCCTTGGACCCTGG       c.3000
 T  Q  V  Q  A  C  N  S  H  A  C  P  P  Q  W  S  L  G  P  W         p.1000

        | 20 .         .         .         .         .         .    g.146910
 TCTCAG | TGTTCCAAGACCTGTGGACGAGGGGTGAGGAAGCGTGAACTCCTCTGCAAGGGC    c.3060
 S  Q   | C  S  K  T  C  G  R  G  V  R  K  R  E  L  L  C  K  G      p.1020

          .         .         .         .         .         .       g.146970
 TCTGCCGCAGAAACCCTCCCCGAGAGCCAGTGTACCAGTCTCCCCAGACCTGAGCTGCAG       c.3120
 S  A  A  E  T  L  P  E  S  Q  C  T  S  L  P  R  P  E  L  Q         p.1040

          .         .         .         .         .         .       g.147030
 GAGGGCTGTGTGCTTGGACGATGCCCCAAGAACAGCCGGCTACAGTGGGTCGCTTCTTCG       c.3180
 E  G  C  V  L  G  R  C  P  K  N  S  R  L  Q  W  V  A  S  S         p.1060

           | 21        .         .         .         .         .    g.148687
 TGGAGCGAG | TGTTCTGCAACCTGTGGTTTGGGTGTGAGGAAGAGGGAGATGAAGTGCAGC    c.3240
 W  S  E   | C  S  A  T  C  G  L  G  V  R  K  R  E  M  K  C  S      p.1080

          .         .         .         .         .         .       g.148747
 GAGAAGGGCTTCCAGGGAAAGCTGATAACTTTCCCAGAGCGAAGATGCCGTAATATTAAG       c.3300
 E  K  G  F  Q  G  K  L  I  T  F  P  E  R  R  C  R  N  I  K         p.1100

          .         .         .         .         .         .       g.148807
 AAACCAAATCTGGACTTGGAAGAGACCTGCAACCGACGGGCTTGCCCAGCCCATCCAGTG       c.3360
 K  P  N  L  D  L  E  E  T  C  N  R  R  A  C  P  A  H  P  V         p.1120

          .         .         .         .   | 22     .         .    g.150721
 TACAACATGGTAGCTGGATGGTATTCATTGCCGTGGCAGCAG | TGCACAGTCACCTGTGGG    c.3420
 Y  N  M  V  A  G  W  Y  S  L  P  W  Q  Q   | C  T  V  T  C  G      p.1140

          .         .         .         .         .         .       g.150781
 GGAGGGGTCCAGACCCGGTCAGTCCACTGTGTTCAGCAAGGCCGGCCTTCCTCAAGTTGT       c.3480
 G  G  V  Q  T  R  S  V  H  C  V  Q  Q  G  R  P  S  S  S  C         p.1160

          .         .         .         .         .         .       g.150841
 CTGCTCCATCAGAAACCTCCGGTGCTACGAGCCTGTAATACAAACTTCTGTCCAGCTCCT       c.3540
 L  L  H  Q  K  P  P  V  L  R  A  C  N  T  N  F  C  P  A  P         p.1180

          . | 23       .         .         .         .         .    g.156093
 GAAAAGAGAG | AGGATCCATCCTGCGTAGATTTCTTCAACTGGTGTCACCTAGTTCCTCAG    c.3600
 E  K  R  E |   D  P  S  C  V  D  F  F  N  W  C  H  L  V  P  Q      p.1200

          .         .         .         .         .         .       g.156153
 CATGGTGTCTGCAACCACAAGTTTTACGGAAAACAATGCTGCAAGTCATGCACAAGGAAG       c.3660
 H  G  V  C  N  H  K  F  Y  G  K  Q  C  C  K  S  C  T  R  K         p.1220

                                                                    g.156159
 ATCTGA                                                             c.3666
 I  X                                                               p.1221

          .         .         .         .         .         .       g.156219
 tcttggtgtcctccccagcaccttagggccaggggcttacctttcaacctctagagagac       c.*60

          .         .         .         .         .         .       g.156279
 cagctgcctttgagaccaggagctgagcaccgagaaccatctgtgagctgccgctgtgat       c.*120

          .         .         .         .         .         .       g.156339
 gaaggagcctgctctgaggaacagacaggttgccagtaggcttctagctcaattccctga       c.*180

          .         .         .         .         .         .       g.156399
 agcacgtggtactctgaagcacttgaaaatgggaagcgatgacaaatctgactttaaaaa       c.*240

          .         .         .         .         .         .       g.156459
 aaatctttgatttgcactgttatatgcaagaagtggtgaatcacactgagatacgtcgat       c.*300

          .         .         .         .         .         .       g.156519
 ttggggagagacccccttttgaacttcaaagggttcaagggcaaagacatctgttttaaa       c.*360

          .         .         .         .         .         .       g.156579
 aaggtcctttatgacttcaggtcaaagactgagactcagaactttcaaatctggatggaa       c.*420

          .         .         .         .         .         .       g.156639
 taccttgcctaactgttgcgtggagttcacagttcgactaaccctgtgaacacccaagcc       c.*480

          .         .         .         .         .         .       g.156699
 aggagttctatgagaagccaaatggtgctcgcaattgtgcttgctgctggactggcaagc       c.*540

          .         .         .         .         .         .       g.156759
 ttcatgttatgtttatttggtgtgcgtgtgtctttattattttgtgtaaactatattctg       c.*600

          .         .         .         .         .         .       g.156819
 cttatagagagtctctgagactaaaattgacaacttgaaaagtattccaaggaatattat       c.*660

          .         .         .         .         .         .       g.156879
 gaaaatagggcaacatggactgtttaagatctccatgtaattgaaattcatgcaaggaaa       c.*720

          .         .         .         .         .         .       g.156939
 caactcatagaaaagataaatatggatgcccttcacatgttatcaacctcgtaacttttg       c.*780

          .         .         .         .         .         .       g.156999
 gtgcttgctgaatcagtccatgaaaagctacagcccgctctttgggaatgctacataccc       c.*840

          .         .         .         .         .         .       g.157059
 atttctggtatttaaaaaatatctaggaggagctaaatgacaaaacacagcagtgttttg       c.*900

          .         .         .         .         .         .       g.157119
 agggagaaaggaccatcatttataatgctctgtacatactaccagagctgcttggaaaat       c.*960

          .         .         .         .         .         .       g.157179
 taaaggccacttgtggctttttcctaccaactgatacgtttaaatttgccctaggattga       c.*1020

          .         .         .         .         .         .       g.157239
 gctaacagcaaaaaaaaaaaaaaaaaaaagagagaaagaaaggagtaaacagtggtaata       c.*1080

          .         .         .         .         .         .       g.157299
 aaaaaatccatctgtcttcttgctatgttaatattaataaatcataatatgacaagaccc       c.*1140

          .         .         .         .         .         .       g.157359
 tcactgaataagagtattttcagtcatcagaagccagctgttggtaggcattaatgagtt       c.*1200

          .         .         .         .         .         .       g.157419
 taaaattgttctcaattgaaaaaacatcacactattttgccaaaaccaaagtaattataa       c.*1260

          .         .         .         .         .         .       g.157479
 tactgtgtcctcctgtaattttttgagaagtggttataaagggcatatttacataaattc       c.*1320

          .         .         .         .         .         .       g.157539
 tactttattcctcaacttctttgatgaatgtaacccaattttacttctttaaaaagtctc       c.*1380

          .         .         .         .         .         .       g.157599
 aattcaagctggattagccagctcagcataatcaactagacagtggtttgttaaatttag       c.*1440

          .         .         .         .         .         .       g.157659
 cagcatacttcgttcccattctaattaaagtcatgagttcttgaatcccagagaaataat       c.*1500

          .         .         .         .         .         .       g.157719
 gcttaggaacttctctcaatctgcttggcttggcctagagaagtggccattttatcaaca       c.*1560

          .         .         .         .         .         .       g.157779
 ggaaaaaaaaaaattttctctactacaaccccgttgccttctgaaaaacagcaagttatt       c.*1620

          .         .         .         .         .         .       g.157839
 tctttatataattatcattttattattttatggaaaattaatttattaattaatagccta       c.*1680

          .         .         .         .         .         .       g.157899
 ttatgtgttctcacttgcttctctaagtaatattttgagataaaatgttgaataaaacca       c.*1740

          .         .         .         .         .         .       g.157959
 tggattatagagaaaagtcaaaatatatgtgtaatatttaattattttataagttttata       c.*1800

          .         .                                               g.157987
 ataaagtattccatttctttatctttga                                       c.*1828

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ADAM metallopeptidase with thrombospondin type 1 motif, 18 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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