ADAM metallopeptidase with thrombospondin type 1 motif, 19 (ADAMTS19) - coding DNA reference sequence

(used for variant description)

(last modified April 21, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_133638.3 in the ADAMTS19 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering ADAMTS19 transcript NM_133638.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
          .         .         .         .         .         .       g.60
 ATGCGCCTGACTCACATCTGCTGCTGCTGCCTCCTTTACCAGCTGGGGTTCCTGTCGAAT       c.60
 M  R  L  T  H  I  C  C  C  C  L  L  Y  Q  L  G  F  L  S  N         p.20

          .    | 02    .         .         .         .         .    g.739
 GGGATCGTTTCAG | AGCTGCAGTTCGCCCCCGACCGCGAGGAGTGGGAAGTCGTGTTTCCT    c.120
 G  I  V  S  E |   L  Q  F  A  P  D  R  E  E  W  E  V  V  F  P      p.40

          .         .         .         .         .         .       g.799
 GCGCTCTGGCGCCGGGAGCCGGTGGACCCGGCTGGCGGCAGCGGGGGCAGCGCGGACCCG       c.180
 A  L  W  R  R  E  P  V  D  P  A  G  G  S  G  G  S  A  D  P         p.60

          .         .         .         .         .         .       g.859
 GGCTGGGTGCGCGGCGTTGGGGGCGGCGGAAGCGCCCGGGCGCAGGCTGCCGGCAGCTCA       c.240
 G  W  V  R  G  V  G  G  G  G  S  A  R  A  Q  A  A  G  S  S         p.80

          .         .         .         .         .         .       g.919
 CGCGAGGTGCGCTCTGTGGCTCCGGTGCCTTTGGAGGAGCCCGTGGAGGGCCGATCAGAG       c.300
 R  E  V  R  S  V  A  P  V  P  L  E  E  P  V  E  G  R  S  E         p.100

          .         .         .         .         .         .       g.979
 TCCCGGCTCCGGCCCCCGCCGCCGTCGGAGGGTGAGGAGGACGAGGAGCTCGAGTCGCAG       c.360
 S  R  L  R  P  P  P  P  S  E  G  E  E  D  E  E  L  E  S  Q         p.120

          .         .         .         .         .         .       g.1039
 GAGCTGCCGCGGGGATCCAGCGGGGCTGCCGCCTTGTCCCCGGGCGCCCCGGCCTCGTGG       c.420
 E  L  P  R  G  S  S  G  A  A  A  L  S  P  G  A  P  A  S  W         p.140

          .         .         .         .         .         .       g.1099
 CAGCCGCCGCCTCCCCCGCAGCCGCCCCCGTCCCCGCCCCCGGCCCAGCATGCCGAGCCG       c.480
 Q  P  P  P  P  P  Q  P  P  P  S  P  P  P  A  Q  H  A  E  P         p.160

          .         .         .         .         .         .       g.1159
 GATGGCGACGAAGTGTTGCTGCGGATCCCGGCCTTCTCTCGGGACCTGTACCTGCTGCTC       c.540
 D  G  D  E  V  L  L  R  I  P  A  F  S  R  D  L  Y  L  L  L         p.180

          .         .         .         .         .         .       g.1219
 CGGAGAGACGGCCGCTTCCTGGCGCCGCGCTTCGCAGTGGAACAGCGGCCAAATCCCGGC       c.600
 R  R  D  G  R  F  L  A  P  R  F  A  V  E  Q  R  P  N  P  G         p.200

          .         .         .         .         .         .       g.1279
 CCCGGCCCCACGGGGGCAGCATCCGCCCCGCAACCTCCCGCGCCACCAGACGCAGGCTGC       c.660
 P  G  P  T  G  A  A  S  A  P  Q  P  P  A  P  P  D  A  G  C         p.220

          .         .         .         .         .         .       g.1339
 TTCTACACCGGAGCTGTGCTGCGGCACCCTGGCTCGCTGGCTTCTTTCAGCACCTGTGGA       c.720
 F  Y  T  G  A  V  L  R  H  P  G  S  L  A  S  F  S  T  C  G         p.240

           | 03        .         .         .         .         .    g.48718
 GGTGGCCTG | ATGGGATTTATACAGCTCAATGAGGACTTCATATTTATTGAGCCACTCAAT    c.780
 G  G  L   | M  G  F  I  Q  L  N  E  D  F  I  F  I  E  P  L  N      p.260

          .         .         .         .         .         .       g.48778
 GATACAATGGCCATAACAGGTCACCCACACCGTGTATATAGGCAGAAAAGGTCCATGGAG       c.840
 D  T  M  A  I  T  G  H  P  H  R  V  Y  R  Q  K  R  S  M  E         p.280

          .         .         .         .         .      | 04  .    g.65879
 GAAAAGGTCACAGAGAAGTCAGCTCTTCACAGTCATTACTGTGGTATCATTTCAG | ATAAA    c.900
 E  K  V  T  E  K  S  A  L  H  S  H  Y  C  G  I  I  S  D |   K      p.300

          .         .         .         .         .         .       g.65939
 GGAAGACCTAGGTCTAGAAAAATAGCAGAAAGTGGAAGAGGGAAACGATATTCATACAAA       c.960
 G  R  P  R  S  R  K  I  A  E  S  G  R  G  K  R  Y  S  Y  K         p.320

          .         .         .         .         .         .       g.65999
 TTACCTCAAGAATACAACATAGAGACTGTAGTGGTTGCAGACCCAGCAATGGTTTCCTAT       c.1020
 L  P  Q  E  Y  N  I  E  T  V  V  V  A  D  P  A  M  V  S  Y         p.340

          .         .         .         .         | 05         .    g.67350
 CATGGAGCAGATGCAGCCAGGAGATTCATTCTAACCATCTTAAATATG | GTATTTAACCTT    c.1080
 H  G  A  D  A  A  R  R  F  I  L  T  I  L  N  M   | V  F  N  L      p.360

          .         .         .         .         .         .       g.67410
 TTCCAACACAAGAGTCTGAGTGTGCAGGTCAATCTTCGTGTGATAAAGCTTATTCTGCTC       c.1140
 F  Q  H  K  S  L  S  V  Q  V  N  L  R  V  I  K  L  I  L  L         p.380

          .   | 06     .         .         .         .         .    g.68158
 CATGAAACTCCA | CCAGAACTATATATTGGGCATCATGGAGAAAAAATGCTAGAGAGTTTT    c.1200
 H  E  T  P   | P  E  L  Y  I  G  H  H  G  E  K  M  L  E  S  F      p.400

          .         .         .         .         .         .       g.68218
 TGTAAGTGGCAACATGAAGAATTTGGCAAAAAGAATGATATACATTTAGAGATGTCAACA       c.1260
 C  K  W  Q  H  E  E  F  G  K  K  N  D  I  H  L  E  M  S  T         p.420

          .         .         .         .         . | 07       .    g.91464
 AACTGGGGGGAAGACATGACTTCAGTGGATGCAGCTATACTTATAACAAG | GAAAGATTTC    c.1320
 N  W  G  E  D  M  T  S  V  D  A  A  I  L  I  T  R  |  K  D  F      p.440

          .         .         .     | 08   .         .         .    g.136175
 TGTGTGCACAAAGATGAACCATGTGATACTGTTG | GTATAGCTTACTTGAGTGGAATGTGT    c.1380
 C  V  H  K  D  E  P  C  D  T  V  G |   I  A  Y  L  S  G  M  C      p.460

          .         .         .         .         .         .       g.136235
 AGTGAAAAGAGAAAATGTATTATTGCTGAAGACAATGGCTTGAATCTTGCTTTTACAATT       c.1440
 S  E  K  R  K  C  I  I  A  E  D  N  G  L  N  L  A  F  T  I         p.480

          .         . | 09       .         .         .         .    g.160248
 GCTCATGAAATGGGTCACAA | CATGGGCATTAACCATGACAATGACCACCCATCGTGTGCT    c.1500
 A  H  E  M  G  H  N  |  M  G  I  N  H  D  N  D  H  P  S  C  A      p.500

          .         .         .         .         .         .       g.160308
 GATGGTCTTCATATCATGTCTGGTGAATGGATTAAAGGACAGAATCTTGGTGACGTTTCA       c.1560
 D  G  L  H  I  M  S  G  E  W  I  K  G  Q  N  L  G  D  V  S         p.520

          .         .         .         .  | 10      .         .    g.161807
 TGGTCTCGATGTAGCAAGGAAGATTTGGAAAGATTTCTCAG | GTCAAAGGCCAGTAACTGC    c.1620
 W  S  R  C  S  K  E  D  L  E  R  F  L  R  |  S  K  A  S  N  C      p.540

          .         .         .         .         .         .       g.161867
 TTGCTACAAACAAATCCGCAGAGTGTCAATTCTGTGATGGTTCCCTCCAAGCTGCCAGGG       c.1680
 L  L  Q  T  N  P  Q  S  V  N  S  V  M  V  P  S  K  L  P  G         p.560

          .         .         .         .         .         .       g.161927
 ATGACATACACTGCTGATGAACAATGCCAGATCCTTTTTGGGCCATTGGCTTCTTTTTGT       c.1740
 M  T  Y  T  A  D  E  Q  C  Q  I  L  F  G  P  L  A  S  F  C         p.580

          .   | 11     .         .         .         .         .    g.181497
 CAGGAGATGCAG | CATGTTATTTGCACAGGATTATGGTGCAAGGTAGAAGGTGAGAAAGAA    c.1800
 Q  E  M  Q   | H  V  I  C  T  G  L  W  C  K  V  E  G  E  K  E      p.600

          .         .         .         .         .     | 12   .    g.187361
 TGCAGAACCAAGCTAGACCCACCAATGGATGGAACTGACTGTGACCTTGGTAAG | TGGTGT    c.1860
 C  R  T  K  L  D  P  P  M  D  G  T  D  C  D  L  G  K   | W  C      p.620

          .         .         .         .         .         .       g.187421
 AAGGCTGGAGAATGTACCAGCAGGACCTCAGCACCTGAACATCTGGCCGGAGAGTGGAGC       c.1920
 K  A  G  E  C  T  S  R  T  S  A  P  E  H  L  A  G  E  W  S         p.640

          .         .         .         .         .         .       g.187481
 CTGTGGAGTCCTTGTAGCCGAACCTGCAGTGCTGGGATCAGCAGTCGAGAGCGCAAATGT       c.1980
 L  W  S  P  C  S  R  T  C  S  A  G  I  S  S  R  E  R  K  C         p.660

       | 13  .         .         .         .         .         .    g.188443
 CCTGG | GCTAGATTCTGAAGCAAGGGATTGTAATGGTCCCAGAAAACAATACAGAATATGT    c.2040
 P  G  |  L  D  S  E  A  R  D  C  N  G  P  R  K  Q  Y  R  I  C      p.680

          .         .         .         .         .         .       g.188503
 GAGAATCCACCTTGTCCTGCAGGTTTGCCTGGATTCAGAGACTGGCAATGTCAGGCTTAT       c.2100
 E  N  P  P  C  P  A  G  L  P  G  F  R  D  W  Q  C  Q  A  Y         p.700

          .         .         .         .         .         | 14    g.193898
 AGTGTTAGAACTTCCTCCCCAAAGCATATACTTCAGTGGCAAGCTGTCCTGGATGAAG | AA    c.2160
 S  V  R  T  S  S  P  K  H  I  L  Q  W  Q  A  V  L  D  E  E |       p.720

          .         .         .         .         .         .       g.193958
 AAACCATGTGCCTTGTTTTGCTCTCCTGTTGGAAAAGAACAGCCTATTCTTCTATCAGAA       c.2220
 K  P  C  A  L  F  C  S  P  V  G  K  E  Q  P  I  L  L  S  E         p.740

          .         .         .         .         .         .       g.194018
 AAAGTGATGGATGGAACTTCTTGTGGCTATCAGGGATTAGATATCTGTGCAAATGGCAGG       c.2280
 K  V  M  D  G  T  S  C  G  Y  Q  G  L  D  I  C  A  N  G  R         p.760

        | 15 .         .         .         .         .         .    g.198261
 TGCCAG | AAAGTTGGCTGTGATGGTTTATTAGGGTCTCTTGCAAGAGAAGATCATTGTGGT    c.2340
 C  Q   | K  V  G  C  D  G  L  L  G  S  L  A  R  E  D  H  C  G      p.780

          .         .         .         .         .         .       g.198321
 GTATGCAATGGCAATGGAAAATCATGCAAGATCATTAAAGGGGATTTTAATCACACCAGA       c.2400
 V  C  N  G  N  G  K  S  C  K  I  I  K  G  D  F  N  H  T  R         p.800

         | 16.         .         .         .         .         .    g.205142
 GGAGCAG | GTTATGTAGAAGTGCTGGTGATACCTGCTGGAGCAAGAAGAATCAAAGTTGTG    c.2460
 G  A  G |   Y  V  E  V  L  V  I  P  A  G  A  R  R  I  K  V  V      p.820

          .         .         | 17         .         .         .    g.219386
 GAGGAAAAGCCGGCACATAGCTATTTAG | CTCTCCGAGATGCTGGCAAACAGTCTATTAAT    c.2520
 E  E  K  P  A  H  S  Y  L  A |   L  R  D  A  G  K  Q  S  I  N      p.840

          .         .         .         .         .         .       g.219446
 AGTGACTGGAAGATTGAACACTCTGGAGCCTTCAATTTGGCTGGAACTACCGTTCATTAT       c.2580
 S  D  W  K  I  E  H  S  G  A  F  N  L  A  G  T  T  V  H  Y         p.860

          .         .         .         .         .         .       g.219506
 GTAAGACGAGGCCTCTGGGAGAAGATCTCTGCCAAAGGTCCTACTACAGCACCTTTACAT       c.2640
 V  R  R  G  L  W  E  K  I  S  A  K  G  P  T  T  A  P  L  H         p.880

        | 18 .         .         .         .         .         .    g.223764
 CTTCTG | GTGCTCCTGTTTCAGGATCAGAATTATGGTCTTCACTATGAATACACTATCCCA    c.2700
 L  L   | V  L  L  F  Q  D  Q  N  Y  G  L  H  Y  E  Y  T  I  P      p.900

          .         .         .         .         .         .       g.223824
 TCAGACCCTCTTCCAGAAAACCAGAGCTCTAAAGCACCTGAGCCCCTCTTCATGTGGACA       c.2760
 S  D  P  L  P  E  N  Q  S  S  K  A  P  E  P  L  F  M  W  T         p.920

          .         .         .         . | 19       .         .    g.234330
 CACACAAGCTGGGAAGATTGCGATGCCACTTGTGGAGGAG | GAGAAAGGAAGACAACAGTG    c.2820
 H  T  S  W  E  D  C  D  A  T  C  G  G  G |   E  R  K  T  T  V      p.940

          .         .         .         .         .         .       g.234390
 TCCTGCACAAAAATCATGAGCAAAAATATCAGCATTGTGGACAATGAGAAATGCAAATAC       c.2880
 S  C  T  K  I  M  S  K  N  I  S  I  V  D  N  E  K  C  K  Y         p.960

          .         .         .         .         .       | 20 .    g.240982
 TTAACCAAGCCAGAGCCACAGATTCGAAAGTGCAATGAGCAACCATGTCAAACAAG | GTGG    c.2940
 L  T  K  P  E  P  Q  I  R  K  C  N  E  Q  P  C  Q  T  R  |  W      p.980

          .         .         .         .         .         .       g.241042
 ATGATGACAGAATGGACCCCTTGTTCACGAACTTGTGGAAAAGGAATGCAGAGCAGACAA       c.3000
 M  M  T  E  W  T  P  C  S  R  T  C  G  K  G  M  Q  S  R  Q         p.1000

          .         .         .         .         .         .       g.241102
 GTGGCCTGTACCCAACAACTGAGCAATGGAACACTGATTAGAGCCCGAGAGAGGGACTGC       c.3060
 V  A  C  T  Q  Q  L  S  N  G  T  L  I  R  A  R  E  R  D  C         p.1020

          .         .         .         .         .         .       g.241162
 ATTGGGCCCAAGCCCGCCTCTGCCCAGCGCTGTGAGGGCCAGGACTGCATGACCGTGTGG       c.3120
 I  G  P  K  P  A  S  A  Q  R  C  E  G  Q  D  C  M  T  V  W         p.1040

          .         .  | 21      .         .         .         .    g.243868
 GAGGCGGGAGTGTGGTCTGAG | TGTTCAGTCAAGTGTGGCAAAGGCATACGTCATCGGACC    c.3180
 E  A  G  V  W  S  E   | C  S  V  K  C  G  K  G  I  R  H  R  T      p.1060

          .         .         .         .         .         .       g.243928
 GTTAGATGTACCAACCCAAGAAAGAAGTGTGTCCTCTCTACCAGACCCAGGGAGGCTGAA       c.3240
 V  R  C  T  N  P  R  K  K  C  V  L  S  T  R  P  R  E  A  E         p.1080

          .         .         .         .         .     | 22   .    g.274528
 GACTGTGAGGATTATTCAAAATGCTATGTGTGGCGAATGGGTGACTGGTCTAAG | TGCTCA    c.3300
 D  C  E  D  Y  S  K  C  Y  V  W  R  M  G  D  W  S  K   | C  S      p.1100

          .         .         .         .         .         .       g.274588
 ATTACCTGTGGCAAAGGAATGCAGTCCCGTGTAATCCAATGCATGCATAAGATCACAGGA       c.3360
 I  T  C  G  K  G  M  Q  S  R  V  I  Q  C  M  H  K  I  T  G         p.1120

          .         .         .         .         .         .       g.274648
 AGACATGGAAATGAATGTTTTTCCTCAGAAAAACCTGCAGCATACAGGCCATGCCATCTT       c.3420
 R  H  G  N  E  C  F  S  S  E  K  P  A  A  Y  R  P  C  H  L         p.1140

          .         .         .         .         .   | 23     .    g.276665
 CAACCCTGCAATGAGAAAATTAATGTAAATACCATAACATCACCCAGACTGG | CTGCTCTG    c.3480
 Q  P  C  N  E  K  I  N  V  N  T  I  T  S  P  R  L  A |   A  L      p.1160

          .         .         .         .         .         .       g.276725
 ACTTTCAAGTGCCTGGGAGATCAGTGGCCAGTGTACTGCCGAGTGATACGTGAAAAGAAC       c.3540
 T  F  K  C  L  G  D  Q  W  P  V  Y  C  R  V  I  R  E  K  N         p.1180

          .         .         .         .         .         .       g.276785
 CTATGTCAGGACATGCGGTGGTATCAGCGCTGCTGTGAAACATGCAGGGACTTCTATGCC       c.3600
 L  C  Q  D  M  R  W  Y  Q  R  C  C  E  T  C  R  D  F  Y  A         p.1200

          .         .                                               g.276809
 CAAAAGCTGCAGCAGAAGAGTTGA                                           c.3624
 Q  K  L  Q  Q  K  S  X                                             p.1207

          .         .         .         .         .         .       g.276869
 cctctagcaggctggctggatcacagctcttggcaattacattatttataaacacacaca       c.*60

          .         .         .         .         .         .       g.276929
 ctagcatgtttttcagaccaaatattatcagattacatataatttaatcaaattaattta       c.*120

          .         .         .         .         .         .       g.276989
 tttttttgcctgccaaacatccaatgtggtgcttgttttggttacacaaacattttgatt       c.*180

          .         .         .         .         .         .       g.277049
 tatactatatggcttcataaataattttatatgaatgaattagttggatccagtaatata       c.*240

          .         .         .         .         .         .       g.277109
 ataaaaagaaaaaggaaaaaaatagatcattatacttaaaacaagttttcgttgtttgtt       c.*300

          .         .         .         .         .         .       g.277169
 agggctatctctaaggtgctactctctccccaccaataacattgaattatccagaatgta       c.*360

          .         .         .         .         .         .       g.277229
 tactgacttagcataatagtttaggtgtatatgaagagaaactatttttgttttttggtg       c.*420

          .         .         .         .         .         .       g.277289
 tcctgctgcagaattagcccattttctgtcacctgcaggagatgtgtaaacataatgaac       c.*480

          .         .         .         .         .         .       g.277349
 ctcatgctgttgaacaggtttttagagaatgtattatgaatttggttcagatttatagac       c.*540

          .         .         .         .         .         .       g.277409
 atccataggaaaaattctgctgtaattataaccttattttgatatggaaaagaaaagtca       c.*600

          .         .         .         .         .         .       g.277469
 aaatagagactttgatcatgttcatgaacatgtacttgaacacaagtattgtaacaatga       c.*660

          .         .         .         .         .         .       g.277529
 aacactgtaatgatttacactgaatcacaattgcactgttgatatagtgtagagaaatcg       c.*720

          .         .         .         .         .         .       g.277589
 ttagaaatggtgacatcttacaaaaaatgtgtattattttaacatgttatcactagattt       c.*780

          .         .         .         .         .         .       g.277649
 tagctttttttaaatatttttaacaaagaaaacattgatccacccatttccctgtatctt       c.*840

          .         .         .         .         .         .       g.277709
 tttagcagatttattaaagagtatagtacttagcctcacgaatcataattagaaaattta       c.*900

          .         .         .         .         .         .       g.277769
 ctagtatttctcagccttttccctaggaacaaggaaaaacagaaagcatataatacggtg       c.*960

          .         .         .         .         .         .       g.277829
 gtcgtttcattgtgtttttcttccttttaaaaattaaaaagttttacaattatgtgaaac       c.*1020

          .         .         .         .         .         .       g.277889
 gttcaaaagccagcttaaaatttttcttgtgagaaaatattatacatgattcacatgatt       c.*1080

          .         .         .         .         .         .       g.277949
 tcttagatttttcaataaaatatgtaaaacttcccactgagagacaattcttcatagact       c.*1140

          .         .         .         .         .         .       g.278009
 tgtcacatatccacatgtctgatgaacaaaggtactgtctacttttgttctggagtatct       c.*1200

          .         .         .         .         .         .       g.278069
 tctagaggatgtttatagagtgaactgccttggaagatagtatgtctcttgggagcaaag       c.*1260

          .         .         .         .         .         .       g.278129
 ggcaaacatacttctcattataaaagtttcaggttccctaaaattggggtttctttacta       c.*1320

          .         .         .         .         .         .       g.278189
 taagacaatccaatgtatgttctgaggtcacctggctctcttcatgtcaccctttgggaa       c.*1380

          .         .         .         .         .         .       g.278249
 atggggctcaacgagccagtacaggaaaagctgattccctggctactactatcgctgtga       c.*1440

          .         .                                               g.278274
 gtaataaagtcctttgtgtctaatg                                          c.*1465

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ADAM metallopeptidase with thrombospondin type 1 motif, 19 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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