ADAMTS-like 4 (ADAMTSL4) - coding DNA reference sequence

(used for variant description)

(last modified November 11, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_019032.4 in the ADAMTSL4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012172.1, covering ADAMTSL4 transcript NM_019032.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5056
     ccgccgcggagcgaggttgcctggagagagcgcctgggcgcagaagggttaacggg       c.-181

 .         .         .  | 02      .         .         .             g.5438
 ccaccgggggctcgcagagcag | gagggtgctctcggacggtgtgtcccccactgcactcc    c.-121

 .         .         .         .      | 03  .         .             g.7807
 tgaacttggaggacagggtcgccgcgagggacgcag | agagcaccctccacgcccagatgc    c.-61

 .         .         .         .         .         .                g.7867
 ctgcgtagtttttgtgaccagtccgctcctgcctccccctggggcagtagagggggagcg       c.-1

          .         . | 04       .         .         .         .    g.8161
 ATGGAGAACTGGACTGGCAG | GCCCTGGCTGTATCTGCTGCTGCTTCTGTCCCTCCCTCAG    c.60
 M  E  N  W  T  G  R  |  P  W  L  Y  L  L  L  L  L  S  L  P  Q      p.20

          .         | 05         .         .         .         .    g.8518
 CTCTGCTTGGATCAGGAG | GTGTTGTCCGGACACTCTCTTCAGACACCTACAGAGGAGGGC    c.120
 L  C  L  D  Q  E   | V  L  S  G  H  S  L  Q  T  P  T  E  E  G      p.40

          .         .         .         .         .         .       g.8578
 CAGGGCCCCGAAGGTGTCTGGGGACCTTGGGTCCAGTGGGCCTCTTGCTCCCAGCCCTGC       c.180
 Q  G  P  E  G  V  W  G  P  W  V  Q  W  A  S  C  S  Q  P  C         p.60

          .         .         .         .         .         .       g.8638
 GGGGTGGGGGTGCAGCGCAGGAGCCGGACATGTCAGCTCCCTACAGTGCAGCTCCACCCG       c.240
 G  V  G  V  Q  R  R  S  R  T  C  Q  L  P  T  V  Q  L  H  P         p.80

          .         .         .         .         .         .       g.8698
 AGTCTGCCCCTCCCTCCCCGGCCCCCAAGACATCCAGAAGCCCTCCTCCCCCGGGGCCAG       c.300
 S  L  P  L  P  P  R  P  P  R  H  P  E  A  L  L  P  R  G  Q         p.100

          .         .         .         .         .         .       g.8758
 GGTCCCAGACCCCAGACTTCTCCAGAAACCCTCCCCTTGTACAGGACACAGTCTCGGGGA       c.360
 G  P  R  P  Q  T  S  P  E  T  L  P  L  Y  R  T  Q  S  R  G         p.120

          .         .         .         .         .         .       g.8818
 AGGGGTGGCCCACTTCGAGGTCCCGCTTCCCACCTAGGGAGAGAGGAGACCCAGGAGATT       c.420
 R  G  G  P  L  R  G  P  A  S  H  L  G  R  E  E  T  Q  E  I         p.140

          .     | 06   .         .         .         .         .    g.9050
 CGAGCGGCCAGGAG | GTCCCGGCTTCGAGACCCCATCAAGCCAGGAATGTTCGGTTATGGG    c.480
 R  A  A  R  R  |  S  R  L  R  D  P  I  K  P  G  M  F  G  Y  G      p.160

          .         .         .         .         .         .       g.9110
 AGAGTGCCCTTTGCATTGCCACTGCACCGGAACCGCAGGCACCCTCGGAGCCCACCCAGA       c.540
 R  V  P  F  A  L  P  L  H  R  N  R  R  H  P  R  S  P  P  R         p.180

          .         .         .         .         .         .       g.9170
 TCTGAGCTGTCCCTGATCTCTTCTAGAGGGGAAGAGGCTATTCCGTCCCCTACTCCAAGA       c.600
 S  E  L  S  L  I  S  S  R  G  E  E  A  I  P  S  P  T  P  R         p.200

          .         .         .         .         .         .       g.9230
 GCAGAGCCATTCTCCGCAAACGGCAGCCCCCAAACTGAGCTCCCTCCCACAGAACTGTCT       c.660
 A  E  P  F  S  A  N  G  S  P  Q  T  E  L  P  P  T  E  L  S         p.220

          .         .         .         .         .         .       g.9290
 GTCCACACCCCATCCCCCCAAGCAGAACCTCTAAGCCCTGAAACTGCTCAGACAGAGGTG       c.720
 V  H  T  P  S  P  Q  A  E  P  L  S  P  E  T  A  Q  T  E  V         p.240

          .         .         .         .         .         .       g.9350
 GCCCCCAGAACCAGGCCTGCCCCCCTACGGCATCACCCCAGAGCCCAGGCCTCTGGCACA       c.780
 A  P  R  T  R  P  A  P  L  R  H  H  P  R  A  Q  A  S  G  T         p.260

          .         .         .         .         .         .       g.9410
 GAGCCCCCCTCACCCACGCACTCCTTAGGAGAAGGTGGCTTCTTCCGTGCATCCCCTCAG       c.840
 E  P  P  S  P  T  H  S  L  G  E  G  G  F  F  R  A  S  P  Q         p.280

          .         .         .         .         .         .       g.9470
 CCACGAAGGCCAAGTTCCCAGGGTTGGGCCAGTCCCCAGGTAGCAGGGAGACGCCCTGAT       c.900
 P  R  R  P  S  S  Q  G  W  A  S  P  Q  V  A  G  R  R  P  D         p.300

          .         .         .         .         .         .       g.9530
 CCTTTTCCTTCGGTCCCTCGGGGCCGAGGCCAGCAGGGCCAAGGGCCTTGGGGAACGGGG       c.960
 P  F  P  S  V  P  R  G  R  G  Q  Q  G  Q  G  P  W  G  T  G         p.320

          .         .         .         .         .         .       g.9590
 GGGACTCCTCACGGGCCCCGCCTGGAGCCTGACCCTCAGCACCCGGGCGCCTGGCTGCCC       c.1020
 G  T  P  H  G  P  R  L  E  P  D  P  Q  H  P  G  A  W  L  P         p.340

          .         .         .         .         .         .       g.9650
 CTGCTGAGCAACGGCCCCCATGCCAGCTCCCTCTGGAGCCTCTTTGCTCCCAGTAGCCCT       c.1080
 L  L  S  N  G  P  H  A  S  S  L  W  S  L  F  A  P  S  S  P         p.360

          .         .         .         .         .  | 07      .    g.9952
 ATTCCAAGATGTTCTGGGGAGAGTGAACAGCTAAGAGCCTGCAGCCAAGCG | CCCTGCCCC    c.1140
 I  P  R  C  S  G  E  S  E  Q  L  R  A  C  S  Q  A   | P  C  P      p.380

          .         .         .         .         .         .       g.10012
 CCTGAGCAGCCAGACCCCCGGGCCCTGCAGTGCGCAGCCTTTAACTCCCAGGAATTCATG       c.1200
 P  E  Q  P  D  P  R  A  L  Q  C  A  A  F  N  S  Q  E  F  M         p.400

          .         .         .     | 08   .         .         .    g.11033
 GGCCAGCTGTATCAGTGGGAGCCCTTCACTGAAG | TCCAGGGCTCCCAGCGCTGTGAACTG    c.1260
 G  Q  L  Y  Q  W  E  P  F  T  E  V |   Q  G  S  Q  R  C  E  L      p.420

          .         .         .         .         .         .       g.11093
 AACTGCCGGCCCCGTGGCTTCCGCTTCTATGTCCGTCACACTGAAAAGGTCCAGGATGGG       c.1320
 N  C  R  P  R  G  F  R  F  Y  V  R  H  T  E  K  V  Q  D  G         p.440

          .         .         .         .         .  | 09      .    g.11749
 ACCCTGTGTCAGCCTGGAGCCCCTGACATCTGTGTGGCTGGACGCTGTCTG | AGCCCCGGC    c.1380
 T  L  C  Q  P  G  A  P  D  I  C  V  A  G  R  C  L   | S  P  G      p.460

          .         .         .         .         .         .       g.11809
 TGTGATGGGATCCTTGGCTCTGGCAGGCGTCCTGATGGCTGTGGAGTCTGTGGGGGTGAT       c.1440
 C  D  G  I  L  G  S  G  R  R  P  D  G  C  G  V  C  G  G  D         p.480

          .         .         .         .         .         .       g.11869
 GATTCTACCTGTCGCCTTGTTTCGGGGAACCTCACTGACCGAGGGGGCCCCCTGGGCTAT       c.1500
 D  S  T  C  R  L  V  S  G  N  L  T  D  R  G  G  P  L  G  Y         p.500

          .         .         .         .         .         .       g.11929
 CAGAAGATCTTGTGGATTCCAGCGGGAGCCTTGCGGCTCCAGATTGCCCAGCTCCGGCCT       c.1560
 Q  K  I  L  W  I  P  A  G  A  L  R  L  Q  I  A  Q  L  R  P         p.520

          .       | 10 .         .         .         .         .    g.12243
 AGCTCCAACTACCTGG | CACTTCGTGGCCCTGGGGGCCGGTCCATCATCAATGGGAACTGG    c.1620
 S  S  N  Y  L  A |   L  R  G  P  G  G  R  S  I  I  N  G  N  W      p.540

          .         .         .         .         .         .       g.12303
 GCTGTGGATCCCCCTGGGTCCTACAGGGCCGGCGGGACCGTCTTTCGATATAACCGTCCT       c.1680
 A  V  D  P  P  G  S  Y  R  A  G  G  T  V  F  R  Y  N  R  P         p.560

          .         .         .         .         .         .       g.12363
 CCCAGGGAGGAGGGCAAAGGGGAGAGTCTGTCGGCTGAAGGCCCCACCACCCAGCCTGTG       c.1740
 P  R  E  E  G  K  G  E  S  L  S  A  E  G  P  T  T  Q  P  V         p.580

           | 11        .         .         .         .         .    g.12568
 GATGTCTAT | ATGATCTTTCAGGAGGAAAACCCAGGCGTTTTTTATCAGTATGTCATCTCT    c.1800
 D  V  Y   | M  I  F  Q  E  E  N  P  G  V  F  Y  Q  Y  V  I  S      p.600

          .         .         .         .         .         .       g.12628
 TCACCTCCTCCAATCCTTGAGAACCCCACCCCAGAGCCCCCTGTCCCCCAGCTTCAGCCG       c.1860
 S  P  P  P  I  L  E  N  P  T  P  E  P  P  V  P  Q  L  Q  P         p.620

   | 12      .         .         .         .         .         .    g.12787
 G | AGATTCTGAGGGTGGAGCCCCCACTTGCTCCGGCACCCCGCCCAGCCCGGACCCCAGGC    c.1920
 E |   I  L  R  V  E  P  P  L  A  P  A  P  R  P  A  R  T  P  G      p.640

          .         .         .         .         .         .       g.12847
 ACCCTCCAGCGTCAGGTGCGGATCCCCCAGATGCCCGCCCCGCCCCATCCCAGGACACCC       c.1980
 T  L  Q  R  Q  V  R  I  P  Q  M  P  A  P  P  H  P  R  T  P         p.660

          .         .         .         .         .         .       g.12907
 CTGGGGTCTCCAGCTGCGTACTGGAAACGAGTGGGACACTCTGCATGCTCAGCGTCCTGC       c.2040
 L  G  S  P  A  A  Y  W  K  R  V  G  H  S  A  C  S  A  S  C         p.680

         | 13.         .         .         .         .         .    g.13125
 GGGAAAG | GTGTCTGGCGCCCCATTTTCCTCTGCATCTCCCGTGAGTCGGGAGAGGAACTG    c.2100
 G  K  G |   V  W  R  P  I  F  L  C  I  S  R  E  S  G  E  E  L      p.700

          .         .         .         .         .         .       g.13185
 GATGAACGCAGCTGTGCCGCGGGTGCCAGGCCCCCAGCCTCCCCTGAACCCTGCCACGGC       c.2160
 D  E  R  S  C  A  A  G  A  R  P  P  A  S  P  E  P  C  H  G         p.720

          .        | 14.         .         .         .         .    g.13566
 ACCCCATGCCCCCCATA | CTGGGAGGCTGGCGAGTGGACATCCTGCAGCCGCTCCTGTGGC    c.2220
 T  P  C  P  P  Y  |  W  E  A  G  E  W  T  S  C  S  R  S  C  G      p.740

          .         .         .         .         .         .       g.13626
 CCCGGCACCCAGCACCGCCAGCTGCAGTGCCGGCAGGAATTTGGGGGGGGTGGCTCCTCG       c.2280
 P  G  T  Q  H  R  Q  L  Q  C  R  Q  E  F  G  G  G  G  S  S         p.760

          .         .         .         .         .         .       g.13686
 GTGCCCCCGGAGCGCTGTGGACATCTCCCCCGGCCCAACATCACCCAGTCTTGCCAGCTG       c.2340
 V  P  P  E  R  C  G  H  L  P  R  P  N  I  T  Q  S  C  Q  L         p.780

          .         .         .         .   | 15     .         .    g.14069
 CGCCTCTGTGGCCATTGGGAAGTTGGCTCTCCTTGGAGCCAG | TGCTCCGTGCGGTGCGGC    c.2400
 R  L  C  G  H  W  E  V  G  S  P  W  S  Q   | C  S  V  R  C  G      p.800

          .         .         .         .         .         .       g.14129
 CGGGGCCAGAGAAGCCGGCAGGTTCGCTGTGTTGGGAACAATGGTGATGAAGTGAGCGAG       c.2460
 R  G  Q  R  S  R  Q  V  R  C  V  G  N  N  G  D  E  V  S  E         p.820

          .         .         .         .         .         .       g.14189
 CAGGAGTGTGCGTCAGGCCCCCCGCAGCCCCCCAGCAGAGAGGCCTGTGACATGGGGCCC       c.2520
 Q  E  C  A  S  G  P  P  Q  P  P  S  R  E  A  C  D  M  G  P         p.840

          .         .         .          | 16        .         .    g.14561
 TGTACTACTGCCTGGTTCCACAGCGACTGGAGCTCCAAG | TGCTCAGCCGAGTGTGGGACG    c.2580
 C  T  T  A  W  F  H  S  D  W  S  S  K   | C  S  A  E  C  G  T      p.860

          .         .         .         .         .         .       g.14621
 GGAATCCAGCGGCGCTCTGTGGTCTGCCTTGGGAGTGGGGCAGCCCTCGGGCCAGGCCAG       c.2640
 G  I  Q  R  R  S  V  V  C  L  G  S  G  A  A  L  G  P  G  Q         p.880

          .         .         .         .         .         .       g.14681
 GGGGAAGCAGGAGCAGGAACTGGGCAGAGCTGTCCAACAGGAAGCCGGCCCCCTGACATG       c.2700
 G  E  A  G  A  G  T  G  Q  S  C  P  T  G  S  R  P  P  D  M         p.900

          .         .         .         .         .         .       g.14741
 CGCGCCTGCAGCCTGGGGCCCTGTGAGAGAACTTGGCGCTGGTACACAGGGCCCTGGGGT       c.2760
 R  A  C  S  L  G  P  C  E  R  T  W  R  W  Y  T  G  P  W  G         p.920

     | 17    .         .         .         .         .         .    g.14922
 GAG | TGCTCCTCCGAATGTGGCTCTGGCACACAGCGTAGAGACATCATCTGTGTATCCAAA    c.2820
 E   | C  S  S  E  C  G  S  G  T  Q  R  R  D  I  I  C  V  S  K      p.940

          .         .         .         .         .         .       g.14982
 CTGGGGACGGAGTTCAACGTGACTTCTCCGAGCAACTGTTCTCACCTCCCCAGGCCCCCT       c.2880
 L  G  T  E  F  N  V  T  S  P  S  N  C  S  H  L  P  R  P  P         p.960

          .         .         .         .         .         .       g.15042
 GCCCTGCAGCCCTGTCAAGGGCAGGCCTGCCAGGACCGATGGTTTTCCACGCCCTGGAGC       c.2940
 A  L  Q  P  C  Q  G  Q  A  C  Q  D  R  W  F  S  T  P  W  S         p.980

     | 18    .         .         .         .         .         .    g.15396
 CCA | TGTTCTCGCTCCTGCCAAGGGGGAACGCAGACACGGGAGGTCCAGTGCCTGAGCACC    c.3000
 P   | C  S  R  S  C  Q  G  G  T  Q  T  R  E  V  Q  C  L  S  T      p.1000

          .         .         .         .         .         .       g.15456
 AACCAGACCCTCAGCACCCGATGCCCTCCTCAACTGCGGCCCTCCAGGAAGCGCCCCTGT       c.3060
 N  Q  T  L  S  T  R  C  P  P  Q  L  R  P  S  R  K  R  P  C         p.1020

          .         .         | 19         .         .         .    g.15670
 AACAGCCAACCCTGCAGCCAGCGCCCTG | ATGATCAATGCAAGGACAGCTCTCCACATTGC    c.3120
 N  S  Q  P  C  S  Q  R  P  D |   D  Q  C  K  D  S  S  P  H  C      p.1040

          .         .         .         .         .         .       g.15730
 CCCCTGGTGGTACAGGCCCGGCTCTGCGTCTACCCCTACTACACAGCCACCTGTTGCCGC       c.3180
 P  L  V  V  Q  A  R  L  C  V  Y  P  Y  Y  T  A  T  C  C  R         p.1060

          .         .         .         .                           g.15775
 TCTTGCGCACATGTCCTGGAGCGGTCTCCCCAGGATCCCTCCTGA                      c.3225
 S  C  A  H  V  L  E  R  S  P  Q  D  P  S  X                        p.1074

          .         .         .         .         .         .       g.15835
 aaggggtccggggcaccttcacggttttctgtgccaccatcggtcacccattgatcggcc       c.*60

          .         .         .         .         .         .       g.15895
 cactctgaaccccctggctctccagcctgtcccagtctcagcagggatgtcctccaggtg       c.*120

          .         .         .         .         .         .       g.15955
 acagagggtggcaaggtgactgacacaaagtgactttcagggctgtggtcaggcccatgt       c.*180

          .         .         .         .         .         .       g.16015
 ggtggtgtgatgggtgtgtgcacatatgcctcaggtgtgcttttgggactgcatggatat       c.*240

          .         .         .         .         .         .       g.16075
 gtgtgtgctcaaacgtgtatcacttttcaaaaagaggttacacagactgagaaggacaag       c.*300

          .         .         .         .         .         .       g.16135
 acctgtttccttgagactttcctaggtggaaaggaaagcaagtctgcagttccttgctaa       c.*360

          .         .         .         .         .         .       g.16195
 tctgagctacttagagtgtggtctccccaccaactccagttttgtgccctaagcctcatt       c.*420

          .         .         .         .         .         .       g.16255
 tctcatgttcagacctcacatcttctaagccgccctgtgtctctgaccccttctcatttg       c.*480

          .         .         .         .         .         .       g.16315
 cctagtatctctgcccctgcctccctaattagctagggctggggtcagccactgccaatc       c.*540

          .         .         .         .         .         .       g.16375
 ctgccttactcaggaaggcaggaggaaagagactgcctctccagagcaaggcccagctgg       c.*600

          .         .         .         .         .         .       g.16435
 gcagagggtgaaaaagagaaatgtgagcatccgctcccccaccaccccgcccagccccta       c.*660

          .         .         .         .         .         .       g.16495
 gccccactccctgcctcctgaaatggttcccacccagaactaatttattttttattaaag       c.*720

          .         .                                               g.16516
 atggtcatgacaaatgagaaa                                              c.*741

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The ADAMTS-like 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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