adenosine deaminase (ADA) - coding DNA reference sequence

(used for variant description)

(last modified September 23, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000022.2 in the ADA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007385.1, covering ADA transcript NM_000022.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5008
                                                     ggcccgtt       c.-121

 .         .         .         .         .         .                g.5068
 aagaagagcgtggccggccgcggccaccgctggccccagggaaagccgagcggccaccga       c.-61

 .         .         .         .         .         .                g.5128
 gccggcagagacccaccgagcggcggcggagggagcagcgccggggcgcacgagggcacc       c.-1

          .         .         .    | 02    .         .         .    g.20474
 ATGGCCCAGACGCCCGCCTTCGACAAGCCCAAA | GTAGAACTGCATGTCCACCTAGACGGA    c.60
 M  A  Q  T  P  A  F  D  K  P  K   | V  E  L  H  V  H  L  D  G      p.20

          .         .         .      | 03  .         .         .    g.27591
 TCCATCAAGCCTGAAACCATCTTATACTATGGCAG | GAGGAGAGGGATCGCCCTCCCAGCT    c.120
 S  I  K  P  E  T  I  L  Y  Y  G  R  |  R  R  G  I  A  L  P  A      p.40

          .         .         .         .         .         .       g.27651
 AACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAAGCCGCTCACCCTTCCAGAC       c.180
 N  T  A  E  G  L  L  N  V  I  G  M  D  K  P  L  T  L  P  D         p.60

          .         .         .         | 04         .         .    g.30158
 TTCCTGGCCAAGTTTGACTACTACATGCCTGCTATCGC | GGGCTGCCGGGAGGCTATCAAA    c.240
 F  L  A  K  F  D  Y  Y  M  P  A  I  A  |  G  C  R  E  A  I  K      p.80

          .         .         .         .         .         .       g.30218
 AGGATCGCCTATGAGTTTGTAGAGATGAAGGCCAAAGAGGGCGTGGTGTATGTGGAGGTG       c.300
 R  I  A  Y  E  F  V  E  M  K  A  K  E  G  V  V  Y  V  E  V         p.100

          .         .         .         .         .         .       g.30278
 CGGTACAGTCCGCACCTGCTGGCCAACTCCAAAGTGGAGCCAATCCCCTGGAACCAGGCT       c.360
 R  Y  S  P  H  L  L  A  N  S  K  V  E  P  I  P  W  N  Q  A         p.120

    | 05     .         .         .         .         .         .    g.31109
 GA | AGGGGACCTCACCCCAGACGAGGTGGTGGCCCTAGTGGGCCAGGGCCTGCAGGAGGGG    c.420
 E  |  G  D  L  T  P  D  E  V  V  A  L  V  G  Q  G  L  Q  E  G      p.140

          .         .         .         .         .         | 06    g.32408
 GAGCGAGACTTCGGGGTCAAGGCCCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCA | AC    c.480
 E  R  D  F  G  V  K  A  R  S  I  L  C  C  M  R  H  Q  P  N |       p.160

          .         .         .         .         .         .       g.32468
 TGGTCCCCCAAGGTGGTGGAGCTGTGTAAGAAGTACCAGCAGCAGACCGTGGTAGCCATT       c.540
 W  S  P  K  V  V  E  L  C  K  K  Y  Q  Q  Q  T  V  V  A  I         p.180

          .         .         .         .         .         .       g.32528
 GACCTGGCTGGAGATGAGACCATCCCAGGAAGCAGCCTCTTGCCTGGACATGTCCAGGCC       c.600
 D  L  A  G  D  E  T  I  P  G  S  S  L  L  P  G  H  V  Q  A         p.200

        | 07 .         .         .         .         .         .    g.33711
 TACCAG | GAGGCTGTGAAGAGCGGCATTCACCGTACTGTCCACGCCGGGGAGGTGGGCTCG    c.660
 Y  Q   | E  A  V  K  S  G  I  H  R  T  V  H  A  G  E  V  G  S      p.220

          .         | 08         .         .         .         .    g.33847
 GCCGAAGTAGTAAAAGAG | GCTGTGGACATACTCAAGACAGAGCGGCTGGGACACGGCTAC    c.720
 A  E  V  V  K  E   | A  V  D  I  L  K  T  E  R  L  G  H  G  Y      p.240

          .         .         .         .         .         .       g.33907
 CACACCCTGGAAGACCAGGCCCTTTATAACAGGCTGCGGCAGGAAAACATGCACTTCGAG       c.780
 H  T  L  E  D  Q  A  L  Y  N  R  L  R  Q  E  N  M  H  F  E         p.260

  | 09       .         .         .         .         .         .    g.34143
  | ATCTGCCCCTGGTCCAGCTACCTCACTGGTGCCTGGAAGCCGGACACGGAGCATGCAGTC    c.840
  | I  C  P  W  S  S  Y  L  T  G  A  W  K  P  D  T  E  H  A  V      p.280

       | 10  .         .         .         .         .         .    g.35643
 ATTCG | GCTCAAAAATGACCAGGCTAACTACTCGCTCAACACAGATGACCCGCTCATCTTC    c.900
 I  R  |  L  K  N  D  Q  A  N  Y  S  L  N  T  D  D  P  L  I  F      p.300

          .         .         .         .         .         .       g.35703
 AAGTCCACCCTGGACACTGATTACCAGATGACCAAACGGGACATGGGCTTTACTGAAGAG       c.960
 K  S  T  L  D  T  D  Y  Q  M  T  K  R  D  M  G  F  T  E  E         p.320

          .      | 11  .         .         .         .         .    g.36379
 GAGTTTAAAAGGCTG | AACATCAATGCGGCCAAATCTAGTTTCCTCCCAGAAGATGAAAAG    c.1020
 E  F  K  R  L   | N  I  N  A  A  K  S  S  F  L  P  E  D  E  K      p.340

          .         .         .         .         .         | 12    g.36890
 AGGGAGCTTCTCGACCTGCTCTATAAAGCCTATGGGATGCCACCTTCAGCCTCTGCAG | GG    c.1080
 R  E  L  L  D  L  L  Y  K  A  Y  G  M  P  P  S  A  S  A  G |       p.360

          .                                                         g.36902
 CAGAACCTCTGA                                                       c.1092
 Q  N  L  X                                                         p.363

          .         .         .         .         .         .       g.36962
 agacgccactcctccaagccttcaccctgtggagtcaccccaactctgtggggctgagca       c.*60

          .         .         .         .         .         .       g.37022
 acatttttacatttattccttccaagaagaccatgatctcaatagtcagttactgatgct       c.*120

          .         .         .         .         .         .       g.37082
 cctgaaccctatgtgtccatttctgcacacacgtatacctcggcatggccgcgtcacttc       c.*180

          .         .         .         .         .         .       g.37142
 tctgattatgtgccctggccagggaccagcgcccttgcacatgggcatggttgaatctga       c.*240

          .         .         .         .         .         .       g.37202
 aaccctccttctgtggcaacttgtactgaaaatctggtgctcaataaagaagcccatggc       c.*300

          .                                                         g.37214
 tggtggcatgca                                                       c.*312

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Adenosine deaminase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 24
©2004-2020 Leiden University Medical Center