adenylate cyclase 3 (ADCY3) - coding DNA reference sequence

(used for variant description)

(last modified March 18, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_004036.3 in the ADCY3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering ADCY3 transcript NM_004036.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          agttctagctgatcagtgc       c.-181

 .         .         .         .         .         .                g.5079
 tacctgtgctctggaaacccgctctgcgttcctgctggaggtggcctcccctccgcccca       c.-121

 .         .         .         .         .         .                g.5139
 gacaagaagaggccctcagccctcccccggtctcagagagccctgagaggaggcccagtc       c.-61

 .         .         .         .         .         .                g.5199
 cagagctcttcctccgttcccagtccacttctctagggccagtagcagacaccagccagt       c.-1

          .         .         .         .         .         .       g.5259
 ATGCCGAGGAACCAGGGCTTCTCCGAGCCCGAATACTCGGCCGAGTACTCAGCCGAGTAC       c.60
 M  P  R  N  Q  G  F  S  E  P  E  Y  S  A  E  Y  S  A  E  Y         p.20

          .         .         .         .         .         .       g.5319
 TCCGTCAGCCTGCCCTCCGACCCTGACCGCGGGGTGGGCCGGACCCATGAAATCTCGGTC       c.120
 S  V  S  L  P  S  D  P  D  R  G  V  G  R  T  H  E  I  S  V         p.40

          .         .         .         .         .         .       g.5379
 CGGAACTCGGGCTCCTGCCTGTGCCTGCCTCGCTTCATGCGGCTGACTTTCGTGCCGGAG       c.180
 R  N  S  G  S  C  L  C  L  P  R  F  M  R  L  T  F  V  P  E         p.60

          .         .         .         .         .         .       g.5439
 TCCTTGGAGAACCTCTACCAGACCTACTTCAAAAGGCAGCGCCACGAGACCCTGCTGGTG       c.240
 S  L  E  N  L  Y  Q  T  Y  F  K  R  Q  R  H  E  T  L  L  V         p.80

          .         .         .         .         .         .       g.5499
 CTGGTGGTCTTTGCAGCCCTCTTTGACTGCTACGTGGTGGTCATGTGTGCTGTGGTCTTC       c.300
 L  V  V  F  A  A  L  F  D  C  Y  V  V  V  M  C  A  V  V  F         p.100

          .         .         .         .         .         .       g.5559
 TCCAGCGACAAGCTGGCTTCCCTCGCCGTGGCTGGAATTGGACTGGTGTTGGACATCATC       c.360
 S  S  D  K  L  A  S  L  A  V  A  G  I  G  L  V  L  D  I  I         p.120

          .         .         .         .         .         .       g.5619
 CTCTTCGTGCTCTGCAAAAAGGGGCTGCTCCCGGACCGGGTCACCCGCAGAGTGCTGCCC       c.420
 L  F  V  L  C  K  K  G  L  L  P  D  R  V  T  R  R  V  L  P         p.140

          .         .         .         .         .         .       g.5679
 TACGTGCTGTGGCTGCTCATAACCGCCCAGATCTTCTCCTACCTGGGCCTGAACTTCGCG       c.480
 Y  V  L  W  L  L  I  T  A  Q  I  F  S  Y  L  G  L  N  F  A         p.160

          .         .         .         .         .         .       g.5739
 CGTGCCCACGCGGCTAGTGACACGGTGGGCTGGCAGGTCTTCTTTGTCTTCTCCTTCTTC       c.540
 R  A  H  A  A  S  D  T  V  G  W  Q  V  F  F  V  F  S  F  F         p.180

          .         .         .         .         .         .       g.5799
 ATCACGCTGCCCCTCAGCCTCAGCCCCATCGTGATCATCTCCGTGGTCTCCTGTGTGGTG       c.600
 I  T  L  P  L  S  L  S  P  I  V  I  I  S  V  V  S  C  V  V         p.200

          .         .         .         .         .         .       g.5859
 CACACGTTGGTCCTGGGGGTCACCGTGGCCCAGCAGCAGCAGGAGGAGCTCAAGGGGATG       c.660
 H  T  L  V  L  G  V  T  V  A  Q  Q  Q  Q  E  E  L  K  G  M         p.220

          .      | 02  .         .         .         .         .    g.51512
 CAGCTGCTGCGGGAG | ATCCTGGCCAACGTCTTCCTCTACCTGTGCGCCATCGCTGTGGGC    c.720
 Q  L  L  R  E   | I  L  A  N  V  F  L  Y  L  C  A  I  A  V  G      p.240

          .         .         .         .         .         .       g.51572
 ATCATGTCCTACTACATGGCTGACCGCAAGCACCGCAAGGCCTTCCTGGAGGCCCGCCAG       c.780
 I  M  S  Y  Y  M  A  D  R  K  H  R  K  A  F  L  E  A  R  Q         p.260

          .         .         .         .      | 03  .         .    g.81817
 TCGCTGGAGGTGAAGATGAACCTGGAAGAGCAGAGCCAGCAGCAG | GAGAACCTCATGCTT    c.840
 S  L  E  V  K  M  N  L  E  E  Q  S  Q  Q  Q   | E  N  L  M  L      p.280

          .         .         .         .         .         .       g.81877
 TCCATCCTGCCCAAGCACGTGGCTGACGAGATGCTGAAAGACATGAAGAAAGACGAGAGC       c.900
 S  I  L  P  K  H  V  A  D  E  M  L  K  D  M  K  K  D  E  S         p.300

          .         .         .         .         .       | 04 .    g.82523
 CAGAAGGACCAGCAGCAGTTCAACACCATGTACATGTACCGTCACGAGAACGTCAG | CATC    c.960
 Q  K  D  Q  Q  Q  F  N  T  M  Y  M  Y  R  H  E  N  V  S  |  I      p.320

          .         .         .         .         .         .       g.82583
 CTCTTTGCCGACATCGTGGGCTTTACCCAGCTGTCTTCTGCCTGCAGTGCCCAGGAGCTT       c.1020
 L  F  A  D  I  V  G  F  T  Q  L  S  S  A  C  S  A  Q  E  L         p.340

          .         .         .         .         | 05         .    g.82812
 GTGAAGCTGCTCAACGAGCTCTTTGCCCGCTTTGACAAGCTGGCAGCT | AAATACCACCAG    c.1080
 V  K  L  L  N  E  L  F  A  R  F  D  K  L  A  A   | K  Y  H  Q      p.360

          .         .         .         .         .         .       g.82872
 CTGCGGATTAAGATCCTGGGCGACTGCTACTACTGCATCTGCGGCTTGCCCGACTACCGG       c.1140
 L  R  I  K  I  L  G  D  C  Y  Y  C  I  C  G  L  P  D  Y  R         p.380

          .         .         .         .         .       | 06 .    g.84159
 GAGGACCACGCCGTCTGCTCCATCCTCATGGGGCTGGCCATGGTGGAGGCCATCTC | GTAT    c.1200
 E  D  H  A  V  C  S  I  L  M  G  L  A  M  V  E  A  I  S  |  Y      p.400

          .         .         .         .         .         .       g.84219
 GTGCGGGAGAAGACCAAGACTGGGGTGGACATGCGTGTGGGGGTGCACACGGGCACCGTG       c.1260
 V  R  E  K  T  K  T  G  V  D  M  R  V  G  V  H  T  G  T  V         p.420

          .         .         .         .         .         .       g.84279
 CTGGGGGGCGTCCTGGGCCAGAAGCGCTGGCAGTACGACGTGTGGTCGACTGATGTCACT       c.1320
 L  G  G  V  L  G  Q  K  R  W  Q  Y  D  V  W  S  T  D  V  T         p.440

          .         .         .      | 07  .         .         .    g.85589
 GTAGCCAACAAGATGGAGGCCGGCGGCATCCCTGG | GCGCGTGCACATCTCCCAGAGCACC    c.1380
 V  A  N  K  M  E  A  G  G  I  P  G  |  R  V  H  I  S  Q  S  T      p.460

          .         .         .         .         .         .       g.85649
 ATGGACTGCCTGAAAGGGGAGTTTGATGTGGAGCCAGGCGATGGGGGCAGCCGCTGTGAT       c.1440
 M  D  C  L  K  G  E  F  D  V  E  P  G  D  G  G  S  R  C  D         p.480

          .         .         .         .         .         .       g.85709
 TACCTAGAAGAGAAGGGTATTGAAACCTACCTCATCATTGCCTCCAAGCCAGAGGTGAAG       c.1500
 Y  L  E  E  K  G  I  E  T  Y  L  I  I  A  S  K  P  E  V  K         p.500

          .         .         .    | 08    .         .         .    g.87168
 AAAACAGCCACCCAGAATGGCCTCAATGGCTCG | GCCCTGCCCAATGGAGCACCAGCTTCC    c.1560
 K  T  A  T  Q  N  G  L  N  G  S   | A  L  P  N  G  A  P  A  S      p.520

          .         .         .         .         .         .       g.87228
 TCAAAGTCCAGCTCCCCTGCCCTCATTGAGACCAAGGAGCCCAACGGGAGTGCCCACAGC       c.1620
 S  K  S  S  S  P  A  L  I  E  T  K  E  P  N  G  S  A  H  S         p.540

          .         .         .         .   | 09     .         .    g.89268
 AGTGGGTCCACGTCGGAGAAGCCCGAGGAGCAGGATGCCCAG | GCCGACAACCCCTCATTC    c.1680
 S  G  S  T  S  E  K  P  E  E  Q  D  A  Q   | A  D  N  P  S  F      p.560

          .         .         .         .         .         .       g.89328
 CCCAACCCACGCCGGAGGCTGCGCCTGCAGGACCTGGCTGACCGAGTGGTGGATGCCTCT       c.1740
 P  N  P  R  R  R  L  R  L  Q  D  L  A  D  R  V  V  D  A  S         p.580

          .         .         .         .         .         .       g.89388
 GAAGATGAGCACGAGCTCAACCAGCTGCTCAACGAGGCCCTGCTTGAGCGAGAGTCCGCC       c.1800
 E  D  E  H  E  L  N  Q  L  L  N  E  A  L  L  E  R  E  S  A         p.600

       | 10  .         .         .         .         .         .    g.89595
 CAAGT | AGTAAAGAAGAGAAACACCTTCCTCTTGTCCATGCGGTTCATGGACCCCGAGATG    c.1860
 Q  V  |  V  K  K  R  N  T  F  L  L  S  M  R  F  M  D  P  E  M      p.620

          .         .         .         .         .         .       g.89655
 GAAACCCGCTACTCGGTGGAGAAGGAGAAGCAGAGTGGGGCTGCCTTCAGCTGCTCCTGC       c.1920
 E  T  R  Y  S  V  E  K  E  K  Q  S  G  A  A  F  S  C  S  C         p.640

          .         .         .         .        | 11.         .    g.92450
 GTCGTCCTGCTCTGCACGGCCCTGGTCGAGATACTCATCGACCCCTG | GCTAATGACAAAC    c.1980
 V  V  L  L  C  T  A  L  V  E  I  L  I  D  P  W  |  L  M  T  N      p.660

          .         .         .         .         .         .       g.92510
 TATGTGACCTTCATGGTGGGGGAGATTCTGCTCCTCATCCTGACCATCTGCTCCCTGGCT       c.2040
 Y  V  T  F  M  V  G  E  I  L  L  L  I  L  T  I  C  S  L  A         p.680

          .      | 12  .         .         .         .         .    g.93406
 GCCATCTTTCCCCGG | GCCTTTCCTAAGAAGCTTGTGGCCTTCTCAACTTGGATTGACCGG    c.2100
 A  I  F  P  R   | A  F  P  K  K  L  V  A  F  S  T  W  I  D  R      p.700

          .         .         .         .         .         .       g.93466
 ACCCGCTGGGCCAGGAACACCTGGGCCATGCTCGCCATCTTCATCCTGGTGATGGCAAAT       c.2160
 T  R  W  A  R  N  T  W  A  M  L  A  I  F  I  L  V  M  A  N         p.720

          .   | 13     .         .         .         .         .    g.96073
 GTCGTGGACATG | CTCAGCTGTCTCCAGTACTACACGGGACCCAGCAATGCAACGGCAGGG    c.2220
 V  V  D  M   | L  S  C  L  Q  Y  Y  T  G  P  S  N  A  T  A  G      p.740

          .         .         .         .         .         .       g.96133
 ATGGAAACGGAGGGCAGCTGCCTGGAGAACCCCAAGTATTACAACTATGTGGCCGTGCTG       c.2280
 M  E  T  E  G  S  C  L  E  N  P  K  Y  Y  N  Y  V  A  V  L         p.760

          .         .         .         .         .         .       g.96193
 TCCCTCATCGCCACCATCATGCTGGTGCAGGTCAGCCACATGGTGAAGCTCACGCTCATG       c.2340
 S  L  I  A  T  I  M  L  V  Q  V  S  H  M  V  K  L  T  L  M         p.780

          .         .         .         .         .         .       g.96253
 CTGCTCGTCGCAGGCGCCGTGGCCACCATCAACCTCTATGCCTGGCGTCCCGTCTTTGAT       c.2400
 L  L  V  A  G  A  V  A  T  I  N  L  Y  A  W  R  P  V  F  D         p.800

          .         .         .   | 14     .         .         .    g.96606
 GAATACGACCACAAGCGTTTTCGGGAGCACGA | CTTACCTATGGTGGCCTTAGAGCAGATG    c.2460
 E  Y  D  H  K  R  F  R  E  H  D  |  L  P  M  V  A  L  E  Q  M      p.820

          .         .         .      | 15  .         .         .    g.98085
 CAAGGATTCAACCCTGGGCTCAATGGCACTGACAG | GCTGCCCCTGGTGCCTTCCAAGTAC    c.2520
 Q  G  F  N  P  G  L  N  G  T  D  R  |  L  P  L  V  P  S  K  Y      p.840

          .         .         .         .         .        | 16.    g.99653
 TCTATGACGGTGATGGTGTTCCTCATGATGCTCAGCTTCTACTACTTCTCCCGCCAC | GTA    c.2580
 S  M  T  V  M  V  F  L  M  M  L  S  F  Y  Y  F  S  R  H   | V      p.860

          .         .         .         .         .         .       g.99713
 GAAAAACTGGCACGGACACTTTTCTTGTGGAAGATTGAGGTCCACGACCAGAAGGAACGT       c.2640
 E  K  L  A  R  T  L  F  L  W  K  I  E  V  H  D  Q  K  E  R         p.880

          .         .         .         .         .         .       g.99773
 GTCTATGAGATGCGACGCTGGAACGAGGCCTTGGTCACCAACATGTTGCCTGAGCACGTG       c.2700
 V  Y  E  M  R  R  W  N  E  A  L  V  T  N  M  L  P  E  H  V         p.900

          .         .         .       | 17 .         .         .    g.100855
 GCACGCCATTTCCTGGGGTCCAAGAAGAGAGATGAG | GAGCTGTATAGCCAGACGTATGAT    c.2760
 A  R  H  F  L  G  S  K  K  R  D  E   | E  L  Y  S  Q  T  Y  D      p.920

          .         .         .         .         .         .       g.100915
 GAGATTGGAGTCATGTTTGCCTCCCTGCCCAACTTTGCTGACTTCTACACAGAGGAGAGC       c.2820
 E  I  G  V  M  F  A  S  L  P  N  F  A  D  F  Y  T  E  E  S         p.940

          .         .         .         .         .         .       g.100975
 ATCAACAATGGTGGTATTGAGTGTCTGCGTTTCCTCAATGAAATCATCTCAGATTTTGAC       c.2880
 I  N  N  G  G  I  E  C  L  R  F  L  N  E  I  I  S  D  F  D         p.960

     | 18    .         .         .         .         .         .    g.101613
 TCT | CTCCTGGACAATCCCAAGTTCCGGGTGATCACCAAGATCAAAACCATTGGCAGCACG    c.2940
 S   | L  L  D  N  P  K  F  R  V  I  T  K  I  K  T  I  G  S  T      p.980

          .         .         .         .         .         .       g.101673
 TATATGGCGGCTTCAGGAGTCACCCCCGATGTCAACACCAATGGCTTTGCCAGCTCCAAC       c.3000
 Y  M  A  A  S  G  V  T  P  D  V  N  T  N  G  F  A  S  S  N         p.1000

     | 19    .         .         .         .         .         .    g.102603
 AAG | GAAGACAAGTCCGAGAGAGAGCGCTGGCAGCACCTGGCTGACCTGGCCGACTTCGCG    c.3060
 K   | E  D  K  S  E  R  E  R  W  Q  H  L  A  D  L  A  D  F  A      p.1020

          .         .         .         .         .         .       g.102663
 CTGGCCATGAAGGATACGCTCACCAACATCAACAACCAGTCCTTCAATAACTTCATGCTG       c.3120
 L  A  M  K  D  T  L  T  N  I  N  N  Q  S  F  N  N  F  M  L         p.1040

         | 20.         .         .         .         .         .    g.103391
 CGCATAG | GCATGAACAAAGGCGGGGTTCTGGCTGGGGTCATCGGAGCCCGGAAACCACAC    c.3180
 R  I  G |   M  N  K  G  G  V  L  A  G  V  I  G  A  R  K  P  H      p.1060

          .         .         .         .         .         .       g.103451
 TACGACATCTGGGGCAATACAGTCAATGTAGCCAGCAGGATGGAGTCCACGGGGGTCATG       c.3240
 Y  D  I  W  G  N  T  V  N  V  A  S  R  M  E  S  T  G  V  M         p.1080

          .   | 21     .         .         .         .         .    g.104120
 GGCAACATTCAG | GTGGTAGAAGAAACCCAAGTCATCCTCCGAGAGTACGGCTTCCGCTTT    c.3300
 G  N  I  Q   | V  V  E  E  T  Q  V  I  L  R  E  Y  G  F  R  F      p.1100

          .         .         .         .         .         .       g.104180
 GTGAGGCGAGGCCCCATCTTTGTGAAGGGGAAGGGGGAGCTGCTGACCTTCTTCTTGAAG       c.3360
 V  R  R  G  P  I  F  V  K  G  K  G  E  L  L  T  F  F  L  K         p.1120

          .         .         .         .         .         .       g.104240
 GGGCGGGATAAGCTAGCCACCTTCCCCAATGGCCCCTCTGTCACACTGCCCCACCAGGTG       c.3420
 G  R  D  K  L  A  T  F  P  N  G  P  S  V  T  L  P  H  Q  V         p.1140

          .                                                         g.104255
 GTGGACAACTCCTGA                                                    c.3435
 V  D  N  S  X                                                      p.1144

          .         .         .         .         .         .       g.104315
 atggcctcgagcctgcaacagtccaaaccggaagggagaatttattttttgaaactgaag       c.*60

          .         .         .         .         .         .       g.104375
 gaagtcccgaccttcctggattgaagtgcacactcatggactttaggtttagaaacctcc       c.*120

          .         .         .         .         .         .       g.104435
 tcagccttcatttgttcgtggatgtgtgagctctgagggtggccctgctattcctgtgtg       c.*180

          .         .         .         .         .         .       g.104495
 tgcctgtagtgtccccagcataggggtcttaggcatagggctgaacagtccttccagagc       c.*240

          .         .         .         .         .         .       g.104555
 cctcgttccaatccctgccgtccttgcccctgaggggccctgaccactgtgagcaggagg       c.*300

          .         .         .         .         .         .       g.104615
 gtggcagagctgggacaaagctgcctttgccgctgggctttccgggactgtggagggagc       c.*360

          .         .         .         .         .         .       g.104675
 acaggcggggaagctccacttcagacagggcttggtggggcaggacatggctcccatttt       c.*420

          .         .         .         .         .         .       g.104735
 gaagggaggtctccatgtggtccgagtgaggtgagacggccctcgtcctggtgttcctga       c.*480

          .         .         .         .         .         .       g.104795
 tcatcttgaaaggttcttctggaactcctgtccccttagtcatgagaacagaaagtgcaa       c.*540

          .         .         .         .         .         .       g.104855
 tatttcctttcacctggcaggggaggggggatttatttctgaaagaaaaatatataaaca       c.*600

          .         .         .         .         .         .       g.104915
 gatcttctacatttatatttttaatcttctgttaaatacactttccgatattgccttgcc       c.*660

          .         .         .         .         .         .       g.104975
 ttttgagctcttgctacagtcgcctttgctactgctttaagagaatttacaggtattgat       c.*720

          .         .         .         .                           g.105018
 aaagaacaagactgttttattaaaagctttattcaacttgaaa                        c.*763

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Adenylate cyclase 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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