adrenoceptor beta 2, surface (ADRB2) - coding DNA reference sequence

(used for variant description)

(last modified July 31, 2017)

This file was created to facilitate the description of sequence variants on transcript NM_000024.5 in the ADRB2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016421.1, covering ADRB2 transcript NM_000024.5.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
           .         .         .         .         .                g.5059
  gcacataacgggcagaacgcactgcgaagcggcttcttcagagcacgggctggaactgg       c.-181

 .         .         .         .         .         .                g.5119
 caggcaccgcgagcccctagcacccgacaagctgagtgtgcaggacgagtccccaccaca       c.-121

 .         .         .         .         .         .                g.5179
 cccacaccacagccgctgaatgaggcttccaggcgtccgctcgcggcccgcagagccccg       c.-61

 .         .         .         .         .         .                g.5239
 ccgtgggtccgcccgctgaggcgcccccagccagtgcgctcacctgccagactgcgcgcc       c.-1

          .         .         .         .         .         .       g.5299
 ATGGGGCAACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAATAGAAGCCATGCGCCG       c.60
 M  G  Q  P  G  N  G  S  A  F  L  L  A  P  N  R  S  H  A  P         p.20

          .         .         .         .         .         .       g.5359
 GACCACGACGTCACGCAGCAAAGGGACGAGGTGTGGGTGGTGGGCATGGGCATCGTCATG       c.120
 D  H  D  V  T  Q  Q  R  D  E  V  W  V  V  G  M  G  I  V  M         p.40

          .         .         .         .         .         .       g.5419
 TCTCTCATCGTCCTGGCCATCGTGTTTGGCAATGTGCTGGTCATCACAGCCATTGCCAAG       c.180
 S  L  I  V  L  A  I  V  F  G  N  V  L  V  I  T  A  I  A  K         p.60

          .         .         .         .         .         .       g.5479
 TTCGAGCGTCTGCAGACGGTCACCAACTACTTCATCACTTCACTGGCCTGTGCTGATCTG       c.240
 F  E  R  L  Q  T  V  T  N  Y  F  I  T  S  L  A  C  A  D  L         p.80

          .         .         .         .         .         .       g.5539
 GTCATGGGCCTGGCAGTGGTGCCCTTTGGGGCCGCCCATATTCTTATGAAAATGTGGACT       c.300
 V  M  G  L  A  V  V  P  F  G  A  A  H  I  L  M  K  M  W  T         p.100

          .         .         .         .         .         .       g.5599
 TTTGGCAACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTGTGCGTCACGGCCAGC       c.360
 F  G  N  F  W  C  E  F  W  T  S  I  D  V  L  C  V  T  A  S         p.120

          .         .         .         .         .         .       g.5659
 ATTGAGACCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATTACTTCACCTTTCAAG       c.420
 I  E  T  L  C  V  I  A  V  D  R  Y  F  A  I  T  S  P  F  K         p.140

          .         .         .         .         .         .       g.5719
 TACCAGAGCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTGATGGTGTGGATTGTG       c.480
 Y  Q  S  L  L  T  K  N  K  A  R  V  I  I  L  M  V  W  I  V         p.160

          .         .         .         .         .         .       g.5779
 TCAGGCCTTACCTCCTTCTTGCCCATTCAGATGCACTGGTACCGGGCCACCCACCAGGAA       c.540
 S  G  L  T  S  F  L  P  I  Q  M  H  W  Y  R  A  T  H  Q  E         p.180

          .         .         .         .         .         .       g.5839
 GCCATCAACTGCTATGCCAATGAGACCTGCTGTGACTTCTTCACGAACCAAGCCTATGCC       c.600
 A  I  N  C  Y  A  N  E  T  C  C  D  F  F  T  N  Q  A  Y  A         p.200

          .         .         .         .         .         .       g.5899
 ATTGCCTCTTCCATCGTGTCCTTCTACGTTCCCCTGGTGATCATGGTCTTCGTCTACTCC       c.660
 I  A  S  S  I  V  S  F  Y  V  P  L  V  I  M  V  F  V  Y  S         p.220

          .         .         .         .         .         .       g.5959
 AGGGTCTTTCAGGAGGCCAAAAGGCAGCTCCAGAAGATTGACAAATCTGAGGGCCGCTTC       c.720
 R  V  F  Q  E  A  K  R  Q  L  Q  K  I  D  K  S  E  G  R  F         p.240

          .         .         .         .         .         .       g.6019
 CATGTCCAGAACCTTAGCCAGGTGGAGCAGGATGGGCGGACGGGGCATGGACTCCGCAGA       c.780
 H  V  Q  N  L  S  Q  V  E  Q  D  G  R  T  G  H  G  L  R  R         p.260

          .         .         .         .         .         .       g.6079
 TCTTCCAAGTTCTGCTTGAAGGAGCACAAAGCCCTCAAGACGTTAGGCATCATCATGGGC       c.840
 S  S  K  F  C  L  K  E  H  K  A  L  K  T  L  G  I  I  M  G         p.280

          .         .         .         .         .         .       g.6139
 ACTTTCACCCTCTGCTGGCTGCCCTTCTTCATCGTTAACATTGTGCATGTGATCCAGGAT       c.900
 T  F  T  L  C  W  L  P  F  F  I  V  N  I  V  H  V  I  Q  D         p.300

          .         .         .         .         .         .       g.6199
 AACCTCATCCGTAAGGAAGTTTACATCCTCCTAAATTGGATAGGCTATGTCAATTCTGGT       c.960
 N  L  I  R  K  E  V  Y  I  L  L  N  W  I  G  Y  V  N  S  G         p.320

          .         .         .         .         .         .       g.6259
 TTCAATCCCCTTATCTACTGCCGGAGCCCAGATTTCAGGATTGCCTTCCAGGAGCTTCTG       c.1020
 F  N  P  L  I  Y  C  R  S  P  D  F  R  I  A  F  Q  E  L  L         p.340

          .         .         .         .         .         .       g.6319
 TGCCTGCGCAGGTCTTCTTTGAAGGCCTATGGGAATGGCTACTCCAGCAACGGCAACACA       c.1080
 C  L  R  R  S  S  L  K  A  Y  G  N  G  Y  S  S  N  G  N  T         p.360

          .         .         .         .         .         .       g.6379
 GGGGAGCAGAGTGGATATCACGTGGAACAGGAGAAAGAAAATAAACTGCTGTGTGAAGAC       c.1140
 G  E  Q  S  G  Y  H  V  E  Q  E  K  E  N  K  L  L  C  E  D         p.380

          .         .         .         .         .         .       g.6439
 CTCCCAGGCACGGAAGACTTTGTGGGCCATCAAGGTACTGTGCCTAGCGATAACATTGAT       c.1200
 L  P  G  T  E  D  F  V  G  H  Q  G  T  V  P  S  D  N  I  D         p.400

          .         .         .         .                           g.6481
 TCACAAGGGAGGAATTGTAGTACAAATGACTCACTGCTGTAA                         c.1242
 S  Q  G  R  N  C  S  T  N  D  S  L  L  X                           p.413

          .         .         .         .         .         .       g.6541
 agcagtttttctacttttaaagacccccccccccaacagaacactaaacagactatttaa       c.*60

          .         .         .         .         .         .       g.6601
 cttgagggtaataaacttagaataaaattgtaaaattgtatagagatatgcagaaggaag       c.*120

          .         .         .         .         .         .       g.6661
 ggcatccttctgccttttttatttttttaagctgtaaaaagagagaaaacttatttgagt       c.*180

          .         .         .         .         .         .       g.6721
 gattatttgttatttgtacagttcagttcctctttgcatggaatttgtaagtttatgtct       c.*240

          .         .         .         .         .         .       g.6781
 aaagagctttagtcctagaggacctgagtctgctatattttcatgacttttccatgtatc       c.*300

          .         .         .         .         .         .       g.6841
 tacctcactattcaagtattaggggtaatatattgctgctggtaatttgtatctgaagga       c.*360

          .         .         .         .         .         .       g.6901
 gattttccttcctacacccttggacttgaggattttgagtatctcggacctttcagctgt       c.*420

          .         .         .         .         .         .       g.6961
 gaacatggactcttcccccactcctcttatttgctcacacggggtattttaggcagggat       c.*480

          .         .         .         .         .         .       g.7021
 ttgaggagcagcttcagttgttttcccgagcaaagtctaaagtttacagtaaataaattg       c.*540

          .         .                                               g.7042
 tttgaccatgccttcattgca                                              c.*561

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Adrenoceptor beta 2, surface protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.