AFG3 ATPase family member 3-like 2 (S. cerevisiae) (AFG3L2) - coding DNA reference sequence

(used for variant description)

(last modified June 27, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_006796.2 in the AFG3L2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023361.1, covering AFG3L2 transcript NM_006796.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               gccgacgtcagcgc       c.-181

 .         .         .         .         .         .                g.5074
 gccggggcggggctggcggcaggagacgccgcgttgagagcttgggctcctccgtgagcc       c.-121

 .         .         .         .         .         .                g.5134
 gccggcgcgcttcgctgcctggcggcctttccccgagccgagcccgcttcccgaggccgc       c.-61

 .         .         .         .         .         .                g.5194
 cagtcgtcgcctgcccgcgcctgcgcagcgtcccgggccgagagggccacggcggcggcc       c.-1

          .         .         .         .         .         .       g.5254
 ATGGCGCACCGCTGTTTGCGGCTGTGGGGCCGGGGCGGCTGCTGGCCCCGCGGCCTACAG       c.60
 M  A  H  R  C  L  R  L  W  G  R  G  G  C  W  P  R  G  L  Q         p.20

          .         .         .         .         .     | 02   .    g.10591
 CAGCTCCTCGTGCCTGGCGGCGTGGGCCCGGGCGAGCAGCCCTGCCTCCGGACG | CTTTAC    c.120
 Q  L  L  V  P  G  G  V  G  P  G  E  Q  P  C  L  R  T   | L  Y      p.40

          .         .         .         .         .         .       g.10651
 CGATTTGTTACAACTCAAGCAAGGGCCAGCAGAAATTCTCTTTTGACAGATATAATTGCT       c.180
 R  F  V  T  T  Q  A  R  A  S  R  N  S  L  L  T  D  I  I  A         p.60

          .         .         .     | 03   .         .         .    g.11376
 GCTTATCAAAGATTCTGTTCTCGACCCCCAAAAG | GATTTGAAAAATACTTTCCTAATGGA    c.240
 A  Y  Q  R  F  C  S  R  P  P  K  G |   F  E  K  Y  F  P  N  G      p.80

          .         .         .         .         .   | 04     .    g.14902
 AAAAATGGAAAAAAAGCTAGTGAACCTAAAGAAGTTATGGGAGAGAAAAAAG | AATCAAAG    c.300
 K  N  G  K  K  A  S  E  P  K  E  V  M  G  E  K  K  E |   S  K      p.100

          .         .         .         .         .         .       g.14962
 CCAGCTGCTACCACACGCTCTTCTGGAGGAGGAGGTGGTGGCGGTGGAAAACGAGGTGGC       c.360
 P  A  A  T  T  R  S  S  G  G  G  G  G  G  G  G  K  R  G  G         p.120

          .         .         .          | 05        .         .    g.15180
 AAGAAAGATGATTCTCACTGGTGGTCCAGGTTTCAGAAG | GGTGACATTCCATGGGACGAC    c.420
 K  K  D  D  S  H  W  W  S  R  F  Q  K   | G  D  I  P  W  D  D      p.140

          .         .         .         .         .         .       g.15240
 AAGGATTTCAGGATGTTCTTCCTCTGGACTGCTCTGTTCTGGGGTGGAGTCATGTTTTAC       c.480
 K  D  F  R  M  F  F  L  W  T  A  L  F  W  G  G  V  M  F  Y         p.160

          .         .         .         .         .         .       g.15300
 TTGCTGCTCAAGAGATCCGGGAGAGAAATCACTTGGAAGGACTTTGTCAATAACTATCTT       c.540
 L  L  L  K  R  S  G  R  E  I  T  W  K  D  F  V  N  N  Y  L         p.180

          .   | 06     .         .         .         .         .    g.18468
 TCAAAAGGAGTA | GTAGACAGATTGGAAGTCGTCAACAAGCGTTTTGTTCGAGTGACCTTT    c.600
 S  K  G  V   | V  D  R  L  E  V  V  N  K  R  F  V  R  V  T  F      p.200

          .         .        | 07.         .         .         .    g.22258
 ACACCAGGAAAAACTCCTGTTGATGGG | CAATACGTTTGGTTTAATATTGGCAGTGTGGAC    c.660
 T  P  G  K  T  P  V  D  G   | Q  Y  V  W  F  N  I  G  S  V  D      p.220

          .         .         .         .         .         .       g.22318
 ACCTTTGAACGGAATCTGGAAACTTTACAGCAGGAATTGGGCATAGAAGGAGAAAATCGG       c.720
 T  F  E  R  N  L  E  T  L  Q  Q  E  L  G  I  E  G  E  N  R         p.240

          .         .         .   | 08     .         .         .    g.23361
 GTGCCTGTTGTCTACATTGCTGAAAGTGATGG | CTCTTTTCTGCTGAGCATGCTGCCTACG    c.780
 V  P  V  V  Y  I  A  E  S  D  G  |  S  F  L  L  S  M  L  P  T      p.260

          .         .         .         .         .         .       g.23421
 GTGCTCATCATCGCCTTCTTGCTCTACACCATCAGAAGAGGGCCTGCTGGCATTGGCCGG       c.840
 V  L  I  I  A  F  L  L  Y  T  I  R  R  G  P  A  G  I  G  R         p.280

          .         .         .         .         .         .       g.23481
 ACAGGCCGAGGGATGGGCGGACTCTTCAGTGTCGGAGAAACCACTGCCAAGGTCTTAAAG       c.900
 T  G  R  G  M  G  G  L  F  S  V  G  E  T  T  A  K  V  L  K         p.300

          .         .         .         .         .         .       g.23541
 GATGAAATTGATGTGAAGTTCAAAGATGTGGCTGGCTGTGAGGAGGCCAAGCTAGAGATC       c.960
 D  E  I  D  V  K  F  K  D  V  A  G  C  E  E  A  K  L  E  I         p.320

          .         .         .         .         .         .       g.23601
 ATGGAATTTGTGAATTTCTTGAAAAACCCAAAGCAGTATCAAGACCTAGGAGCAAAAATC       c.1020
 M  E  F  V  N  F  L  K  N  P  K  Q  Y  Q  D  L  G  A  K  I         p.340

        | 09 .         .         .         .         .         .    g.25499
 CCAAAG | GGTGCCATTCTCACTGGTCCTCCAGGCACTGGGAAGACGCTGCTAGCTAAGGCC    c.1080
 P  K   | G  A  I  L  T  G  P  P  G  T  G  K  T  L  L  A  K  A      p.360

          .         .         .         .         .         .       g.25559
 ACAGCCGGAGAAGCCAATGTCCCCTTCATCACCGTTAGTGGATCTGAGTTTTTGGAGATG       c.1140
 T  A  G  E  A  N  V  P  F  I  T  V  S  G  S  E  F  L  E  M         p.380

          .         .     | 10   .         .         .         .    g.29154
 TTCGTTGGTGTGGGCCCTGCTAGA | GTCCGAGACTTATTTGCCCTTGCTCGGAAGAATGCC    c.1200
 F  V  G  V  G  P  A  R   | V  R  D  L  F  A  L  A  R  K  N  A      p.400

          .         .         .         .         .         .       g.29214
 CCTTGCATCCTCTTCATCGATGAAATCGATGCGGTGGGAAGGAAGAGAGGAAGAGGCAAC       c.1260
 P  C  I  L  F  I  D  E  I  D  A  V  G  R  K  R  G  R  G  N         p.420

          .         .         .         .         .         | 11    g.30865
 TTTGGAGGGCAGAGTGAGCAGGAGAACACACTCAACCAGCTGCTGGTGGAGATGGATG | GT    c.1320
 F  G  G  Q  S  E  Q  E  N  T  L  N  Q  L  L  V  E  M  D  G |       p.440

          .         .         .         .         .         .       g.30925
 TTTAATACAACAACAAATGTCGTCATTTTGGCCGGCACCAATCGACCAGATATCCTGGAC       c.1380
 F  N  T  T  T  N  V  V  I  L  A  G  T  N  R  P  D  I  L  D         p.460

          .         .         .         .       | 12 .         .    g.31080
 CCCGCGCTGCTTAGGCCGGGGCGTTTCGACAGGCAGATCTTTATTG | GACCACCAGACATA    c.1440
 P  A  L  L  R  P  G  R  F  D  R  Q  I  F  I  G |   P  P  D  I      p.480

          .         .         .         .         .         .       g.31140
 AAAGGAAGAGCTTCTATTTTCAAAGTTCATCTCCGACCGCTAAAACTGGACAGTACCCTG       c.1500
 K  G  R  A  S  I  F  K  V  H  L  R  P  L  K  L  D  S  T  L         p.500

          .         .         .         .         .   | 13     .    g.33901
 GAGAAGGATAAATTGGCAAGAAAACTGGCATCTTTAACTCCAGGGTTTTCAG | GTGCTGAT    c.1560
 E  K  D  K  L  A  R  K  L  A  S  L  T  P  G  F  S  G |   A  D      p.520

          .         .         .         .         .         .       g.33961
 GTTGCTAATGTCTGTAATGAAGCTGCGTTGATTGCTGCAAGGCATCTGTCAGATTCCATA       c.1620
 V  A  N  V  C  N  E  A  A  L  I  A  A  R  H  L  S  D  S  I         p.540

          .         .         .         .    | 14    .         .    g.38046
 AATCAGAAACACTTTGAACAGGCAATTGAACGAGTGATTGGTG | GCTTAGAGAAGAAAACG    c.1680
 N  Q  K  H  F  E  Q  A  I  E  R  V  I  G  G |   L  E  K  K  T      p.560

          .         .         .         .         .         .       g.38106
 CAGGTTCTGCAGCCTGAGGAGAAGAAGACTGTGGCATACCACGAAGCAGGCCATGCGGTT       c.1740
 Q  V  L  Q  P  E  E  K  K  T  V  A  Y  H  E  A  G  H  A  V         p.580

          .         .         .          | 15        .         .    g.41896
 GCCGGCTGGTATCTGGAGCACGCAGACCCGCTTTTAAAG | GTATCCATCATCCCACGTGGC    c.1800
 A  G  W  Y  L  E  H  A  D  P  L  L  K   | V  S  I  I  P  R  G      p.600

          .         .         .         .         .         .       g.41956
 AAAGGACTAGGTTATGCTCAGTATTTACCAAAAGAACAATACCTCTATACCAAAGAGCAG       c.1860
 K  G  L  G  Y  A  Q  Y  L  P  K  E  Q  Y  L  Y  T  K  E  Q         p.620

          .         .         .         .         .         .       g.42016
 CTCTTGGATAGGATGTGTATGACTTTAGGTGGTCGAGTCTCTGAAGAAATCTTCTTTGGA       c.1920
 L  L  D  R  M  C  M  T  L  G  G  R  V  S  E  E  I  F  F  G         p.640

          .         .         .         .         .         .       g.42076
 AGAATTACAACTGGTGCTCAAGATGACTTGAGAAAAGTAACTCAGAGTGCATATGCCCAA       c.1980
 R  I  T  T  G  A  Q  D  D  L  R  K  V  T  Q  S  A  Y  A  Q         p.660

  | 16       .         .         .         .         .         .    g.44801
  | ATTGTTCAGTTTGGCATGAATGAAAAGGTTGGGCAAATCTCCTTTGACCTCCCACGTCAG    c.2040
  | I  V  Q  F  G  M  N  E  K  V  G  Q  I  S  F  D  L  P  R  Q      p.680

          .         .         .         .         .         .       g.44861
 GGGGACATGGTATTGGAGAAACCTTACAGTGAAGCCACTGCAAGATTGATAGATGATGAA       c.2100
 G  D  M  V  L  E  K  P  Y  S  E  A  T  A  R  L  I  D  D  E         p.700

          .         .         .         .         .         .       g.44921
 GTACGAATACTTATTAATGATGCTTATAAAAGAACAGTAGCTCTTCTCACAGAAAAGAAA       c.2160
 V  R  I  L  I  N  D  A  Y  K  R  T  V  A  L  L  T  E  K  K         p.720

          .      | 17  .         .         .         .         .    g.52538
 GCTGACGTGGAGAAG | GTTGCTCTTCTGTTGTTAGAAAAAGAAGTATTAGATAAGAATGAT    c.2220
 A  D  V  E  K   | V  A  L  L  L  L  E  K  E  V  L  D  K  N  D      p.740

          .         .         .         .         .         .       g.52598
 ATGGTTGAACTTTTGGGCCCCAGACCATTTGCGGAAAAATCTACCTATGAAGAATTTGTG       c.2280
 M  V  E  L  L  G  P  R  P  F  A  E  K  S  T  Y  E  E  F  V         p.760

          .         .         .         .         .         .       g.52658
 GAAGGCACTGGCAGCTTGGATGAGGACACCTCACTTCCAGAAGGCCTTAAGGACTGGAAC       c.2340
 E  G  T  G  S  L  D  E  D  T  S  L  P  E  G  L  K  D  W  N         p.780

          .         .         .         .         .                 g.52712
 AAGGAGCGGGAAAAGGAGAAAGAGGAGCCCCCGGGTGAGAAAGTTGCCAACTAG             c.2394
 K  E  R  E  K  E  K  E  E  P  P  G  E  K  V  A  N  X               p.797

          .         .         .         .         .         .       g.52772
 aggcccagagggaggccatctcagtctgtccactgtggtttcagctggtgcattatttca       c.*60

          .         .         .         .         .         .       g.52832
 gctgtggctttcagaagaatgggaatgctgcgctgattttagccagccactggcccagct       c.*120

          .         .         .         .         .         .       g.52892
 gaaatgatggggaaaggagtccttagtcctttcagcctcagaggtcacagtgggtggcag       c.*180

          .         .         .         .         .         .       g.52952
 gtgactttccggaggccttgagggaaatgcacactgtcccatagcctcattgggctccca       c.*240

          .         .         .         .         .         .       g.53012
 gacgtgctggaaaggttgagcccagagtggccgaggctggaccctgtggcaccaagtggg       c.*300

          .         .         .         .         .         .       g.53072
 gtcggctgaccgtgtggcagggatcgttgcactggactcttggcgtgtgggaagggatgc       c.*360

          .         .         .         .         .         .       g.53132
 tttctctttgtcgcccactcttcattcctgtttctcctcagttcccctgtgcagatgggc       c.*420

          .         .         .         .         .         .       g.53192
 tgtgaaattaaattggagtcttgataagaacattttaatttgacttaatattttaaagat       c.*480

          .         .         .         .         .         .       g.53252
 tgaatccagatcacttgttgctgtcttaatggaatggttttctacaggagctgtaacata       c.*540

          .         .         .         .         .         .       g.53312
 cttaaaaatatgaatgtattatgtaaatatggcttctttacataaaaaataaaatgtcaa       c.*600

          .         .                                               g.53333
 cactgtacttttctgaacaca                                              c.*621

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The AFG3 ATPase family member 3-like 2 (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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