acylglycerol kinase (AGK) - coding DNA reference sequence

(used for variant description)

(last modified June 29, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_018238.3 in the AGK gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032079.1, covering AGK transcript NM_018238.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          atccgagccggttcccgcccccggcccgaactggcccgcgcgcgctcgcag       c.-121

 .         .         .         .         .         .                g.5111
 ccccgcggcggaacccgagggcggcggcagcggtttcccttgaacgagccggggaatctg       c.-61

 .         .         .         .         .      | 02  .             g.9189
 gagggagcacacaggaaaggcagagccgcgagctggaccagccgtg | caaatctctagaag    c.-1

          .         .         .         .         .         .       g.9249
 ATGACGGTGTTCTTTAAAACGCTTCGAAATCACTGGAAGAAAACTACAGCTGGGCTCTGC       c.60
 M  T  V  F  F  K  T  L  R  N  H  W  K  K  T  T  A  G  L  C         p.20

          .         .         .         .  | 03      .         .    g.46887
 CTGCTGACCTGGGGAGGCCATTGGCTCTATGGAAAACACTG | TGATAACCTCCTAAGGAGA    c.120
 L  L  T  W  G  G  H  W  L  Y  G  K  H  C  |  D  N  L  L  R  R      p.40

          .         .  | 04      .         .         .         .    g.50323
 GCAGCCTGTCAAGAAGCTCAG | GTGTTTGGCAATCAACTCATTCCTCCCAATGCACAAGTG    c.180
 A  A  C  Q  E  A  Q   | V  F  G  N  Q  L  I  P  P  N  A  Q  V      p.60

          .         .         .         .  | 05      .         .    g.54946
 AAGAAGGCCACTGTTTTTCTCAATCCTGCAGCTTGCAAAGG | AAAAGCCAGGACTCTATTT    c.240
 K  K  A  T  V  F  L  N  P  A  A  C  K  G  |  K  A  R  T  L  F      p.80

          .         .         .         .         .        | 06.    g.64920
 GAAAAAAATGCTGCCCCGATTTTACATTTATCTGGCATGGATGTGACTATTGTTAAG | ACA    c.300
 E  K  N  A  A  P  I  L  H  L  S  G  M  D  V  T  I  V  K   | T      p.100

          .         .         .         .         .         .       g.64980
 GATTATGAGGGACAAGCCAAGAAACTCCTGGAACTGATGGAAAACACGGATGTGATCATT       c.360
 D  Y  E  G  Q  A  K  K  L  L  E  L  M  E  N  T  D  V  I  I         p.120

          .         .         . | 07       .         .         .    g.67898
 GTTGCAGGAGGAGATGGGACACTGCAGGAG | GTTGTTACTGGTGTTCTTCGACGAACAGAT    c.420
 V  A  G  G  D  G  T  L  Q  E   | V  V  T  G  V  L  R  R  T  D      p.140

     | 08    .         .         .         .         .         .    g.69250
 GAG | GCTACCTTCAGTAAGATTCCCATTGGATTTATCCCACTGGGAGAGACCAGTAGTTTG    c.480
 E   | A  T  F  S  K  I  P  I  G  F  I  P  L  G  E  T  S  S  L      p.160

          .         .         .         | 09         .         .    g.75476
 AGTCATACCCTCTTTGCCGAAAGTGGAAACAAAGTCCA | ACATATTACTGATGCCACACTT    c.540
 S  H  T  L  F  A  E  S  G  N  K  V  Q  |  H  I  T  D  A  T  L      p.180

          .         .         .         .         | 10         .    g.87635
 GCCATTGTGAAAGGAGAGACAGTTCCACTTGATGTCTTGCAGATCAAG | GGTGAAAAGGAA    c.600
 A  I  V  K  G  E  T  V  P  L  D  V  L  Q  I  K   | G  E  K  E      p.200

          .         .         .         .         .         .       g.87695
 CAGCCTGTATTTGCAATGACCGGCCTTCGATGGGGATCTTTCAGAGATGCTGGCGTCAAA       c.660
 Q  P  V  F  A  M  T  G  L  R  W  G  S  F  R  D  A  G  V  K         p.220

          | 11         .         .         .         .         .    g.90734
 GTTAGCAA | GTACTGGTATCTTGGGCCTCTAAAAATCAAAGCAGCCCACTTTTTCAGCACT    c.720
 V  S  K  |  Y  W  Y  L  G  P  L  K  I  K  A  A  H  F  F  S  T      p.240

        | 12 .         .         .         .         .         .    g.95024
 CTTAAG | GAGTGGCCTCAGACTCATCAAGCCTCTATCTCATACACGGGACCTACAGAGAGA    c.780
 L  K   | E  W  P  Q  T  H  Q  A  S  I  S  Y  T  G  P  T  E  R      p.260

          .         .         .         .         .         .       g.95084
 CCTCCCAATGAACCAGAGGAGACCCCTGTACAAAGGCCTTCTTTGTACAGGAGAATATTA       c.840
 P  P  N  E  P  E  E  T  P  V  Q  R  P  S  L  Y  R  R  I  L         p.280

          .         .         .        | 13.         .         .    g.95556
 CGAAGGCTTGCGTCCTACTGGGCACAACCACAGGATG | CCCTTTCCCAAGAGGTGAGCCCG    c.900
 R  R  L  A  S  Y  W  A  Q  P  Q  D  A |   L  S  Q  E  V  S  P      p.300

          .         .         .         .         .         .       g.95616
 GAGGTCTGGAAAGATGTGCAGCTGTCCACCATTGAACTGTCCATCACAACACGGAATAAT       c.960
 E  V  W  K  D  V  Q  L  S  T  I  E  L  S  I  T  T  R  N  N         p.320

          .      | 14  .         .         .         .         .    g.103030
 CAGCTTGACCCGACA | AGCAAAGAAGATTTTCTGAATATCTGCATTGAACCTGACACCATC    c.1020
 Q  L  D  P  T   | S  K  E  D  F  L  N  I  C  I  E  P  D  T  I      p.340

          .         .       | 15 .         .         .         .    g.105281
 AGCAAAGGAGACTTTATAACTATAGG | AAGTCGAAAGGTGAGAAACCCCAAGCTGCACGTG    c.1080
 S  K  G  D  F  I  T  I  G  |  S  R  K  V  R  N  P  K  L  H  V      p.360

          .         .         .         .         .  | 16      .    g.106518
 GAGGGCACGGAGTGTCTCCAAGCCAGCCAGTGCACTTTGCTTATCCCGGAG | GGAGCAGGG    c.1140
 E  G  T  E  C  L  Q  A  S  Q  C  T  L  L  I  P  E   | G  A  G      p.380

          .         .         .         .         .         .       g.106578
 GGCTCTTTTAGCATTGACAGTGAGGAGTATGAAGCGATGCCTGTGGAGGTGAAACTGCTC       c.1200
 G  S  F  S  I  D  S  E  E  Y  E  A  M  P  V  E  V  K  L  L         p.400

          .         .         .         .         .         .       g.106638
 CCCAGGAAGCTGCAGTTCTTCTGTGATCCTAGGAAGAGAGAACAGATGCTCACAAGCCCC       c.1260
 P  R  K  L  Q  F  F  C  D  P  R  K  R  E  Q  M  L  T  S  P         p.420

                                                                    g.106647
 ACCCAGTGA                                                          c.1269
 T  Q  X                                                            p.422

          .         .         .         .         .         .       g.106707
 gcagcagaagacaagcactctgagaccacactttaggccaccggtgggaccaaaagggaa       c.*60

          .         .         .         .         .         .       g.106767
 caggtgcctcagccatcccaacagtgtcgtcagagggtccccagggcattttcatggcaa       c.*120

          .         .         .         .         .         .       g.106827
 gtacccctctgcccccactccagcagtgcttcccaaagtgtgctctgtcacctgctttgc       c.*180

          .         .         .         .         .         .       g.106887
 aatcggcttccattagcgcatgttttattttggtgtgacggttggccctcctaaacacgg       c.*240

          .         .         .         .         .         .       g.106947
 actttcctcaggctggttcaagacggaaaaggactttcttctgttttcttccaaagtgca       c.*300

          .         .         .         .         .         .       g.107007
 accacagtggagagcccacggtgggcttagcctgcctaggcccttccatttctcttcttt       c.*360

          .         .         .         .         .         .       g.107067
 gaccgtgctaggaattccaggaaagtgcattcctgccctggtgaccttttcctatgtcta       c.*420

          .         .         .         .         .         .       g.107127
 ggctcctccacaggtgctgctattttgtgagctccggctcctgtttagcttttatttcag       c.*480

          .         .         .         .         .         .       g.107187
 ttctaacctcagtccagaaacatatgtgaggttgtttccctcttcagccacggctacaat       c.*540

          .         .         .         .         .         .       g.107247
 accggaaaatgctagtttttatttatttttttaagtagtgcttcctaaatggtttgcatg       c.*600

          .         .         .         .         .         .       g.107307
 agagccacctggggtacatgttgaaaacttatttggggtctaccccaaacctaataaccc       c.*660

          .         .         .         .         .         .       g.107367
 aaatttggggatggggcccaggaatatgcatttttaaaaagtcatctgcccttcccaggt       c.*720

          .         .         .         .         .         .       g.107427
 gattctgtaagttgtccctcaactgtacttggagaaatcgtgttttaaagcagtagtcca       c.*780

          .         .         .         .         .         .       g.107487
 caaagtattctgctcatgtgcccccaaaagtattttgaaaaatcatgtataccctcaccc       c.*840

          .         .         .         .         .         .       g.107547
 atctaagttgatatctaaaattttatctaagttggtatctaaaatttttcatgggaagtt       c.*900

          .         .         .         .         .         .       g.107607
 aaatagttgacaaagtatgtatttgctggtgtcgtgtaaatattggtattttaaaataaa       c.*960

          .         .         .         .         .         .       g.107667
 aactgttacatcactattttaaacatatccagtacaatttaaatatcacaacaatttgac       c.*1020

          .         .         .         .         .         .       g.107727
 acccttcattcatttataaaaataaatgagctagttctttagtagttaaacatttcaaat       c.*1080

          .         .         .         .         .         .       g.107787
 tggcttttctccttctgtatttccataccacttttcagccaagaatcctatcataatgta       c.*1140

          .         .         .         .         .         .       g.107847
 atctattatgcccgacatcttttaatcattcaccccattacttcttgtcaacaaaaaata       c.*1200

          .         .         .         .         .         .       g.107907
 taaatggaaattttttttttagctcttgctttaagtgtttgtttgttatctcagtccaga       c.*1260

          .         .         .         .         .         .       g.107967
 accaatattatcgtaattaattattggtatataatgaaaacggtattaattcttggatga       c.*1320

          .         .         .         .         .         .       g.108027
 ttaaaagtttttttattagaatgttctttatcctaattagttcatttatccaagaataca       c.*1380

          .         .         .         .         .         .       g.108087
 tgaatgtgatttacagctgagatggggttcaacctcagctgtattccttgtttctgtata       c.*1440

          .         .         .         .                           g.108132
 gatgtaagcacataaattcgatggaatagaattacgttaacaatg                      c.*1485

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Acylglycerol kinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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