anterior gradient 2 homolog (Xenopus laevis) (AGR2) - coding DNA reference sequence

(used for variant description)

(last modified July 16, 2019)

This file was created to facilitate the description of sequence variants on transcript NM_006408.3 in the AGR2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering AGR2 transcript NM_006408.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.5007
                                                      aatcact       c.-181

 .         .         .         .         .         .                g.5067
 tggggaaaggaaggttcgtttctgagttagcaacaagtaaatgcagcactagtgggtggg       c.-121

 .         .         .         .         .         .                g.5127
 attgaggtatgccctggtgcataaatagagactcagctgtgctggcacactcagaagctt       c.-61

 .         .         .         .         .         .   | 02         g.8318
 ggaccgcatcctagccgccgactcacacaaggcaggtgggtgaggaaatccag | agttgcc    c.-1

          .         .         .         .         .         .       g.8378
 ATGGAGAAAATTCCAGTGTCAGCATTCTTGCTCCTTGTGGCCCTCTCCTACACTCTGGCC       c.60
 M  E  K  I  P  V  S  A  F  L  L  L  V  A  L  S  Y  T  L  A         p.20

          .         .         .         .         .         .       g.8438
 AGAGATACCACAGTCAAACCTGGAGCCAAAAAGGACACAAAGGACTCTCGACCCAAACTG       c.120
 R  D  T  T  V  K  P  G  A  K  K  D  T  K  D  S  R  P  K  L         p.40

          .          | 03        .         .         .         .    g.8772
 CCCCAGACCCTCTCCAGAG | GTTGGGGTGACCAACTCATCTGGACTCAGACATATGAAGAA    c.180
 P  Q  T  L  S  R  G |   W  G  D  Q  L  I  W  T  Q  T  Y  E  E      p.60

          .         .    | 04    .         .         .         .    g.8948
 GCTCTATATAAATCCAAGACAAG | CAACAAACCCTTGATGATTATTCATCACTTGGATGAG    c.240
 A  L  Y  K  S  K  T  S  |  N  K  P  L  M  I  I  H  H  L  D  E      p.80

          .       | 05 .         .         .         .         .    g.10341
 TGCCCACACAGTCAAG | CTTTAAAGAAAGTGTTTGCTGAAAATAAAGAAATCCAGAAATTG    c.300
 C  P  H  S  Q  A |   L  K  K  V  F  A  E  N  K  E  I  Q  K  L      p.100

          .         .         . | 06       .         .         .    g.12450
 GCAGAGCAGTTTGTCCTCCTCAATCTGGTT | TATGAAACAACTGACAAACACCTTTCTCCT    c.360
 A  E  Q  F  V  L  L  N  L  V   | Y  E  T  T  D  K  H  L  S  P      p.120

          .         .         .     | 07   .         .         .    g.15121
 GATGGCCAGTATGTCCCCAGGATTATGTTTGTTG | ACCCATCTCTGACAGTTAGAGCCGAT    c.420
 D  G  Q  Y  V  P  R  I  M  F  V  D |   P  S  L  T  V  R  A  D      p.140

          .         .         .         .         .         | 08    g.17159
 ATCACTGGAAGATATTCAAATCGTCTCTATGCTTACGAACCTGCAGATACAGCTCTGT | TG    c.480
 I  T  G  R  Y  S  N  R  L  Y  A  Y  E  P  A  D  T  A  L  L |       p.160

          .         .         .         .                           g.17207
 CTTGACAACATGAAGAAAGCTCTCAAGTTGCTGAAGACTGAATTGTAA                   c.528
 L  D  N  M  K  K  A  L  K  L  L  K  T  E  L  X                     p.175

          .         .         .         .         .         .       g.17267
 agaaaaaaaatctccaagcccttctgtctgtcaggccttgagacttgaaaccagaagaag       c.*60

          .         .         .         .         .         .       g.17327
 tgtgagaagactggctagtgtggaagcatagtgaacacactgattaggttatggtttaat       c.*120

          .         .         .         .         .         .       g.17387
 gttacaacaactattttttaagaaaaacaagttttagaaatttggtttcaagtgtacatg       c.*180

          .         .         .         .         .         .       g.17447
 tgtgaaaacaatattgtatactaccatagtgagccatgattttctaaaaaaaaaaataaa       c.*240

          .         .                                               g.17475
 tgttttgggggtgttctgttttctccaa                                       c.*268

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Anterior gradient 2 homolog (Xenopus laevis) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.