apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1) - coding DNA reference sequence

(used for variant description)

(last modified May 3, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_004208.3 in the AIFM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013217.1, covering AIFM1 transcript NM_004208.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.4998
          aatgcggcagcgagtgctacgcctgcgcagtaggcctccggtcgccgttcc       c.-181

 .         .         .         .         .         .                g.5058
 ccttccccggctctagcaggccggcttctctgtccaatgcccacccggagctgggaggag       c.-121

 .         .         .         .         .         .                g.5118
 gagtctgcgtaatgtgcgtgtgaagagactgggggagctggccggggctcacggtgtttg       c.-61

 .         .         .         .         .         .                g.5178
 acccgtcggtcgtgcgtgagaggaaagggaaggaggaggtcccgaatagcggtcgccgaa       c.-1

          .         .         .         .         .         .       g.5238
 ATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAAGCTGGTGCCCTTGGTG       c.60
 M  F  R  C  G  G  L  A  A  G  A  L  K  Q  K  L  V  P  L  V         p.20

          .         .         .         .       | 02 .         .    g.14245
 CGGACCGTGTGCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCCAG | GCAACTTGTTCCAG    c.120
 R  T  V  C  V  R  S  P  R  Q  R  N  R  L  P  G |   N  L  F  Q      p.40

          .         .         .         .         .         .       g.14305
 CGATGGCATGTTCCTCTAGAACTCCAGATGACAAGACAAATGGCTAGCTCTGGTGCATCA       c.180
 R  W  H  V  P  L  E  L  Q  M  T  R  Q  M  A  S  S  G  A  S         p.60

          .         .         .         .         .         .       g.14365
 GGGGGCAAAATCGATAATTCTGTGTTAGTCCTTATTGTGGGCTTATCAACAGTAGGAGCT       c.240
 G  G  K  I  D  N  S  V  L  V  L  I  V  G  L  S  T  V  G  A         p.80

           | 03        .         .         .         .         .    g.21316
 GGTGCCTAT | GCCTACAAGACTATGAAAGAGGATGAAAAAAGATACAATGAAAGAATTTCA    c.300
 G  A  Y   | A  Y  K  T  M  K  E  D  E  K  R  Y  N  E  R  I  S      p.100

          .         .         .         .          | 04        .    g.22968
 GGGTTAGGGCTGACACCAGAACAGAAACAGAAAAAGGCCGCGTTATCTG | CTTCAGAAGGA    c.360
 G  L  G  L  T  P  E  Q  K  Q  K  K  A  A  L  S  A |   S  E  G      p.120

          .         .         .         .         .         .       g.23028
 GAGGAAGTTCCTCAAGACAAGGCGCCAAGTCATGTTCCTTTCCTGCTAATTGGTGGAGGC       c.420
 E  E  V  P  Q  D  K  A  P  S  H  V  P  F  L  L  I  G  G  G         p.140

          .         .         .         .         .     | 05   .    g.23216
 ACAGCTGCTTTTGCTGCAGCCAGATCCATCCGGGCTCGGGATCCTGGGGCCAGG | GTACTG    c.480
 T  A  A  F  A  A  A  R  S  I  R  A  R  D  P  G  A  R   | V  L      p.160

          .         .         .         .         .         .       g.23276
 ATTGTATCTGAAGATCCTGAGCTGCCGTACATGCGACCTCCTCTTTCAAAAGAACTGTGG       c.540
 I  V  S  E  D  P  E  L  P  Y  M  R  P  P  L  S  K  E  L  W         p.180

          .         .         .         .         .         .       g.23336
 TTTTCAGATGACCCAAATGTCACAAAGACACTGCGATTCAAACAGTGGAATGGAAAAGAG       c.600
 F  S  D  D  P  N  V  T  K  T  L  R  F  K  Q  W  N  G  K  E         p.200

       | 06  .         .         .         .         .         .    g.25319
 AGAAG | CATATATTTCCAGCCACCTTCTTTCTATGTCTCTGCTCAGGACCTGCCTCATATT    c.660
 R  S  |  I  Y  F  Q  P  P  S  F  Y  V  S  A  Q  D  L  P  H  I      p.220

          .         .         .       | 07 .         .         .    g.30240
 GAGAATGGTGGTGTGGCTGTCCTCACTGGGAAGAAG | GTAGTACAGCTGGATGTGAGAGAC    c.720
 E  N  G  G  V  A  V  L  T  G  K  K   | V  V  Q  L  D  V  R  D      p.240

          .         .         .         .         .         .       g.30300
 AACATGGTGAAACTTAATGATGGCTCTCAAATAACCTATGAAAAGTGCTTGATTGCAACA       c.780
 N  M  V  K  L  N  D  G  S  Q  I  T  Y  E  K  C  L  I  A  T         p.260

   | 08      .         .         .         .         .         .    g.31021
 G | GAGGTACTCCAAGAAGTCTGTCTGCCATTGATAGGGCTGGAGCAGAGGTGAAGAGTAGA    c.840
 G |   G  T  P  R  S  L  S  A  I  D  R  A  G  A  E  V  K  S  R      p.280

          .         | 09         .         .         .         .    g.32174
 ACAACGCTTTTCAGAAAG | ATTGGAGACTTTAGAAGCTTGGAGAAGATTTCACGGGAAGTC    c.900
 T  T  L  F  R  K   | I  G  D  F  R  S  L  E  K  I  S  R  E  V      p.300

          .         .         .         .         .         .       g.32234
 AAATCAATTACGATTATCGGTGGGGGCTTCCTTGGTAGCGAACTGGCCTGTGCTCTTGGC       c.960
 K  S  I  T  I  I  G  G  G  F  L  G  S  E  L  A  C  A  L  G         p.320

         | 10.         .         .         .         .         .    g.33701
 AGAAAGG | CTCGAGCCTTGGGCACAGAAGTGATTCAACTCTTCCCCGAGAAAGGAAATATG    c.1020
 R  K  A |   R  A  L  G  T  E  V  I  Q  L  F  P  E  K  G  N  M      p.340

          .         .         .         .         .      | 11  .    g.34107
 GGAAAGATCCTCCCCGAATACCTCAGCAACTGGACCATGGAAAAAGTCAGACGAG | AGGGG    c.1080
 G  K  I  L  P  E  Y  L  S  N  W  T  M  E  K  V  R  R  E |   G      p.360

          .         .         .         .         .         .       g.34167
 GTTAAGGTGATGCCCAATGCTATTGTGCAATCCGTTGGAGTCAGCAGTGGCAAGTTACTT       c.1140
 V  K  V  M  P  N  A  I  V  Q  S  V  G  V  S  S  G  K  L  L         p.380

          .         .     | 12   .         .         .         .    g.34684
 ATCAAGCTGAAAGACGGCAGGAAG | GTAGAAACTGACCACATAGTGGCAGCTGTGGGCCTG    c.1200
 I  K  L  K  D  G  R  K   | V  E  T  D  H  I  V  A  A  V  G  L      p.400

          .         .         .         .         .         .       g.34744
 GAGCCCAATGTTGAGTTGGCCAAGACTGGTGGCCTGGAAATAGACTCAGATTTTGGTGGC       c.1260
 E  P  N  V  E  L  A  K  T  G  G  L  E  I  D  S  D  F  G  G         p.420

          .         .         .         .      | 13  .         .    g.37393
 TTCCGGGTAAATGCAGAGCTACAAGCACGCTCTAACATCTGGGTG | GCAGGAGATGCTGCA    c.1320
 F  R  V  N  A  E  L  Q  A  R  S  N  I  W  V   | A  G  D  A  A      p.440

          .         .         .         .         .         .       g.37453
 TGCTTCTACGATATAAAGTTGGGAAGGAGGCGGGTAGAGCACCATGATCACGCTGTTGTG       c.1380
 C  F  Y  D  I  K  L  G  R  R  R  V  E  H  H  D  H  A  V  V         p.460

          .         .         .         .         .         .       g.37513
 AGTGGAAGATTGGCTGGAGAAAATATGACTGGAGCTGCTAAGCCGTACTGGCATCAGTCA       c.1440
 S  G  R  L  A  G  E  N  M  T  G  A  A  K  P  Y  W  H  Q  S         p.480

          | 14         .         .         .         .         .    g.39086
 ATGTTCTG | GAGTGATTTGGGCCCCGATGTTGGCTATGAAGCTATTGGTCTTGTGGACAGT    c.1500
 M  F  W  |  S  D  L  G  P  D  V  G  Y  E  A  I  G  L  V  D  S      p.500

          .         .         .         .         .         .       g.39146
 AGTTTGCCCACAGTTGGTGTTTTTGCAAAAGCAACTGCACAAGACAACCCCAAATCTGCC       c.1560
 S  L  P  T  V  G  V  F  A  K  A  T  A  Q  D  N  P  K  S  A         p.520

          .    | 15    .         .         .         .         .    g.40714
 ACAGAGCAGTCAG | GAACTGGTATCCGATCAGAGAGTGAGACAGAGTCCGAGGCCTCAGAA    c.1620
 T  E  Q  S  G |   T  G  I  R  S  E  S  E  T  E  S  E  A  S  E      p.540

          .         .         .         .         .         .       g.40774
 ATTACTATTCCTCCCAGCACCCCGGCAGTTCCACAGGCTCCCGTCCAGGGGGAGGACTAC       c.1680
 I  T  I  P  P  S  T  P  A  V  P  Q  A  P  V  Q  G  E  D  Y         p.560

          .         .         .         .         .         .       g.40834
 GGCAAAGGTGTCATCTTCTACCTCAGGGACAAAGTGGTCGTGGGGATTGTGCTATGGAAC       c.1740
 G  K  G  V  I  F  Y  L  R  D  K  V  V  V  G  I  V  L  W  N         p.580

          .         .         . | 16       .         .         .    g.41235
 ATCTTTAACCGAATGCCAATAGCAAGGAAG | ATCATTAAGGACGGTGAGCAGCATGAAGAT    c.1800
 I  F  N  R  M  P  I  A  R  K   | I  I  K  D  G  E  Q  H  E  D      p.600

          .         .         .         .                           g.41277
 CTCAATGAAGTAGCCAAACTATTCAACATTCATGAAGACTGA                         c.1842
 L  N  E  V  A  K  L  F  N  I  H  E  D  X                           p.613

          .         .         .         .         .         .       g.41337
 agccccacagtggaattggcaaacccactgcagcccctgagaggaggtcgaatgggtaaa       c.*60

          .         .         .         .         .         .       g.41397
 ggagcatttttttattcagcagactttctctgtgtatgagtgtgaatgatcaagtccttt       c.*120

          .         .         .         .         .         .       g.41457
 gtgaatattttcaactatgtaggtaaattcttaatgttcacatagtgaaataaattctga       c.*180

          .                                                         g.41472
 ttcttctaaattaaa                                                    c.*195

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Apoptosis-inducing factor, mitochondrion-associated, 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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