A kinase (PRKA) anchor protein 3 (AKAP3) - coding DNA reference sequence

(used for variant description)

(last modified January 30, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_001278309.1 in the AKAP3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering AKAP3 transcript NM_001278309.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.1137
                                                      gtctgcg       c.-541

 .         .         .         .         .         .                g.1197
 caagcgctaaccaagaaacgacggtttcgggtagattgttggttaagaagaaagctggga       c.-481

 .         .         .         .         .         .                g.1257
 aagtgaaggagagggggaagaaaggaagtgaaaagactttggctgttggaatctcagatc       c.-421

 .         .         .         .         .         .                g.1317
 tggaataggctgtataggctatttataatctctaattgccgaggaacctgaagttcagag       c.-361

 .         .         .         .         .         .                g.1377
 ttaaccagtgactgactcaggacatgcaaaatggcaagacccgaggtagaagagctcacc       c.-301

 .         .         .         .         .         .      | 02      g.4989
 tttcctgactctcagtttcctgttccctgaaaatgtaagctaagctggcagccctg | tccc    c.-241

 .         .         .         .         .         .                g.5049
 agcaagggggaggtacatggaaggccacaggaagaaacaagatcttgagctgagcaagaa       c.-181

 .         .         .         .         .         .                g.5109
 catcccagcatcttcattgactttaaaagtatattctggagtcttccgtggttcactatt       c.-121

 .         .    | 03    .         .         .         .             g.8219
 ccagtactacagag | attccttatattacatggcaggaggggggtaaactgagggatagtg    c.-61

 .         .         .         .         .         .                g.8279
 aagacaacaataaattaatcaagagctttcctcatatctcagaacctatcctctgtaaga       c.-1

  | 04       .         .         .         .         .         .    g.12041
  | ATGTCAGAAAAGGTTGACTGGTTACAAAGCCAAAATGGAGTATGCAAAGTTGATGTCTAT    c.60
  | M  S  E  K  V  D  W  L  Q  S  Q  N  G  V  C  K  V  D  V  Y      p.20

          .         .         .       | 05 .         .         .    g.21396
 TCTCCTGGAGACAACCAAGCCCAGGACTGGAAAATG | GACACCTCCACGGATCCTGTCAGA    c.120
 S  P  G  D  N  Q  A  Q  D  W  K  M   | D  T  S  T  D  P  V  R      p.40

          .         .         .         .         .         .       g.21456
 GTGCTCAGCTGGCTCCGCAGAGACCTGGAGAAGAGTACAGCAGAGTTCCAAGATGTTCGG       c.180
 V  L  S  W  L  R  R  D  L  E  K  S  T  A  E  F  Q  D  V  R         p.60

          .         .         .         .         .         .       g.21516
 TTCAAACCCGGAGAATCATTTGGTGGGGAAACGTCCAACTCAGGAGACCCACACAAAGGT       c.240
 F  K  P  G  E  S  F  G  G  E  T  S  N  S  G  D  P  H  K  G         p.80

          .         .         .         .         .         .       g.21576
 TTCTCTGTAGACTATTACAACACCACCACCAAGGGCACTCCAGAAAGATTGCATTTTGAG       c.300
 F  S  V  D  Y  Y  N  T  T  T  K  G  T  P  E  R  L  H  F  E         p.100

          .         .         .         .         .         .       g.21636
 ATGACTCACAAAGAGATTCCTTGCCAGGGCCCCAGGGCCCAACTTGGCAACGGGAGTTCA       c.360
 M  T  H  K  E  I  P  C  Q  G  P  R  A  Q  L  G  N  G  S  S         p.120

          .         .         .         .         .         .       g.21696
 GTAGATGAAGTTTCCTTCTATGCTAACCGCCTCACGAATCTAGTCATAGCCATGGCCCGC       c.420
 V  D  E  V  S  F  Y  A  N  R  L  T  N  L  V  I  A  M  A  R         p.140

          .         .         .         .         .         .       g.21756
 AAAGAGATCAATGAGAAGATCGATGGCTCTGAAAACAAATGTGTCTATCAGTCATTGTAC       c.480
 K  E  I  N  E  K  I  D  G  S  E  N  K  C  V  Y  Q  S  L  Y         p.160

          .         .         .         .         .         .       g.21816
 ATGGGGAATGAACCCACACCCACCAAAAGCCTCAGTAAGATAGCATCAGAGCTTGTGAAT       c.540
 M  G  N  E  P  T  P  T  K  S  L  S  K  I  A  S  E  L  V  N         p.180

          .         .         .         .         .         .       g.21876
 GAGACCGTCTCTGCATGTTCCAGGAATGCTGCCCCAGACAAGGCTCCTGGCTCTGGAGAC       c.600
 E  T  V  S  A  C  S  R  N  A  A  P  D  K  A  P  G  S  G  D         p.200

          .         .         .         .         .         .       g.21936
 AGAGTCTCGGGATCATCACAAAGTCCCCCAAATTTGAAATACAAGTCCACTTTGAAGATC       c.660
 R  V  S  G  S  S  Q  S  P  P  N  L  K  Y  K  S  T  L  K  I         p.220

          .         .         .         .         .         .       g.21996
 AAGGAGAGCACCAAAGAAAGACAGGGTCCAGATGACAAGCCTCCTTCTAAGAAGTCTTTC       c.720
 K  E  S  T  K  E  R  Q  G  P  D  D  K  P  P  S  K  K  S  F         p.240

          .         .         .         .         .         .       g.22056
 TTCTATAAGGAAGTGTTTGAATCTCGTAATGGAGATTATGCCAGAGAGGGTGGAAGGTTC       c.780
 F  Y  K  E  V  F  E  S  R  N  G  D  Y  A  R  E  G  G  R  F         p.260

          .         .         .         .         .         .       g.22116
 TTTCCTCGGGAGAGAAAGAGGTTTCGAGGGCAGGAAAGGCCTGATGACTTTACGGCTTCT       c.840
 F  P  R  E  R  K  R  F  R  G  Q  E  R  P  D  D  F  T  A  S         p.280

          .         .         .         .         .         .       g.22176
 GTTAGTGAAGGGATCATGACCTATGCTAACAGTGTGGTATCTGATATGATGGTCTCCATC       c.900
 V  S  E  G  I  M  T  Y  A  N  S  V  V  S  D  M  M  V  S  I         p.300

          .         .         .         .         .         .       g.22236
 ATGAAGACACTGAAGATCCAAGTGAAAGACACAACCATTGCCACCATCCTACTGAAGAAG       c.960
 M  K  T  L  K  I  Q  V  K  D  T  T  I  A  T  I  L  L  K  K         p.320

          .         .         .         .         .         .       g.22296
 GTTCTGCTCAAGCATGCAAAAGAGGTGGTCTCGGATCTCATCGACTCCTTCTTGAGGAAT       c.1020
 V  L  L  K  H  A  K  E  V  V  S  D  L  I  D  S  F  L  R  N         p.340

          .         .         .         .         .         .       g.22356
 CTCCACAGCGTCACAGGGACCCTCATGACTGACACACAGTTTGTCTCGGCTGTGAAAAGA       c.1080
 L  H  S  V  T  G  T  L  M  T  D  T  Q  F  V  S  A  V  K  R         p.360

          .         .         .         .         .         .       g.22416
 ACTGTCTTCTCTCATGGAAGCCAAAAGGCCACAGATATCATGGATGCCATGCTAAGGAAG       c.1140
 T  V  F  S  H  G  S  Q  K  A  T  D  I  M  D  A  M  L  R  K         p.380

          .         .         .         .         .         .       g.22476
 CTGTACAATGTAATGTTTGCCAAGAAAGTCCCTGAGCATGTCAGGAAAGCCCAAGACAAG       c.1200
 L  Y  N  V  M  F  A  K  K  V  P  E  H  V  R  K  A  Q  D  K         p.400

          .         .         .         .         .         .       g.22536
 GCTGAGAGTTATTCCCTCATCTCCATGAAAGGAATGGGTGATCCTAAAAACCGAAATGTG       c.1260
 A  E  S  Y  S  L  I  S  M  K  G  M  G  D  P  K  N  R  N  V         p.420

          .         .         .         .         .         .       g.22596
 AACTTTGCCATGAAATCTGAAACTAAATTGAGAGAAAAAATGTATTCTGAACCCAAATCA       c.1320
 N  F  A  M  K  S  E  T  K  L  R  E  K  M  Y  S  E  P  K  S         p.440

          .         .         .         .         .         .       g.22656
 GAGGAGGAGACTTGTGCGAAAACTCTGGGTGAGCACATTATCAAAGAGGGGCTTACCTTG       c.1380
 E  E  E  T  C  A  K  T  L  G  E  H  I  I  K  E  G  L  T  L         p.460

          .         .         .         .         .         .       g.22716
 TGGCATAAAACTCAGCAGAAAGAATGTAAATCTCTAGGTTTCCAGCATGCAGCATTTGAA       c.1440
 W  H  K  T  Q  Q  K  E  C  K  S  L  G  F  Q  H  A  A  F  E         p.480

          .         .         .         .         .         .       g.22776
 GCTCCCAACACACAGCGTAAGCCTGCATCAGACATTTCCTTTGAGTACCCTGAAGATATT       c.1500
 A  P  N  T  Q  R  K  P  A  S  D  I  S  F  E  Y  P  E  D  I         p.500

          .         .         .         .         .         .       g.22836
 GGCAACCTCAGCCTTCCTCCATATCCTCCAGAGAAACCTGAGAATTTTATGTATGATTCA       c.1560
 G  N  L  S  L  P  P  Y  P  P  E  K  P  E  N  F  M  Y  D  S         p.520

          .         .         .         .         .         .       g.22896
 GACTCCTGGGCCGAGGACCTGATCGTGTCTGCCCTGCTTCTGATTCAATATCACCTGGCC       c.1620
 D  S  W  A  E  D  L  I  V  S  A  L  L  L  I  Q  Y  H  L  A         p.540

          .         .         .         .         .         .       g.22956
 CAGGGAGGAAGAAGGGATGCACGGAGCTTCGTTGAAGCTGCTGGCACCACCAACTTTCCT       c.1680
 Q  G  G  R  R  D  A  R  S  F  V  E  A  A  G  T  T  N  F  P         p.560

          .         .         .         .         .         .       g.23016
 GCCAATGAACCTCCTGTAGCTCCCGATGAATCTTGCCTTAAGTCTGCTCCCATTGTAGGT       c.1740
 A  N  E  P  P  V  A  P  D  E  S  C  L  K  S  A  P  I  V  G         p.580

          .         .         .         .         .         .       g.23076
 GACCAAGAACAAGCAGAAAAGAAGGACCTAAGGAGTGTTTTCTTTAATTTCATCCGGAAC       c.1800
 D  Q  E  Q  A  E  K  K  D  L  R  S  V  F  F  N  F  I  R  N         p.600

          .         .         .         .         .         .       g.23136
 TTACTTAGTGAGACCATTTTCAAGCGTGACCAGAGCCCTGAACCCAAGGTGCCGGAACAG       c.1860
 L  L  S  E  T  I  F  K  R  D  Q  S  P  E  P  K  V  P  E  Q         p.620

          .         .         .         .         .         .       g.23196
 CCAGTTAAGGAAGATAGGAAGTTGTGTGAAAGACCGTTGGCGTCTTCTCCCCCCAGGCTA       c.1920
 P  V  K  E  D  R  K  L  C  E  R  P  L  A  S  S  P  P  R  L         p.640

          .         .         .         .         .         .       g.23256
 TATGAGGATGATGAGACCCCTGGTGCCCTTTCTGGGCTGACCAAGATGGCTGTCAGCCAG       c.1980
 Y  E  D  D  E  T  P  G  A  L  S  G  L  T  K  M  A  V  S  Q         p.660

          .         .         .         .         .         .       g.23316
 ATAGATGGCCACATGAGTGGGCAGATGGTAGAACATCTGATGAACTCAGTGATGAAGCTG       c.2040
 I  D  G  H  M  S  G  Q  M  V  E  H  L  M  N  S  V  M  K  L         p.680

          .         .         .         .         .         .       g.23376
 TGTGTCATCATTGCTAAGTCCTGTGATGCTTCGTTGGCAGAGCTGGGAGATGACAAGTCT       c.2100
 C  V  I  I  A  K  S  C  D  A  S  L  A  E  L  G  D  D  K  S         p.700

          .         .         .         .         .         .       g.23436
 GGAGATGCCAGTAGGCTAACTTCGGCCTTCCCAGATAGTTTATATGAGTGCTTACCAGCC       c.2160
 G  D  A  S  R  L  T  S  A  F  P  D  S  L  Y  E  C  L  P  A         p.720

          .         .         .         .         .         .       g.23496
 AAGGGCACAGGGTCAGCAGAAGCTGTCCTGCAGAATGCCTATCAAGCTATCCATAATGAA       c.2220
 K  G  T  G  S  A  E  A  V  L  Q  N  A  Y  Q  A  I  H  N  E         p.740

          .         .         .         .         .         .       g.23556
 ATGAGAGGCACATCAGGACAGCCCCCTGAAGGGTGTGCAGCACCCACGGTGATTGTCAGC       c.2280
 M  R  G  T  S  G  Q  P  P  E  G  C  A  A  P  T  V  I  V  S         p.760

          .         .         .         .         .         .       g.23616
 AATCACAACCTAACGGACACAGTTCAGAACAAGCAACTCCAAGCCGTCCTTCAATGGGTA       c.2340
 N  H  N  L  T  D  T  V  Q  N  K  Q  L  Q  A  V  L  Q  W  V         p.780

          .         .         .         .         .         .       g.23676
 GCTGCCTCTGAGCTCAATGTCCCTATTTTGTATTTTGCTGGTGATGATGAAGGGATCCAG       c.2400
 A  A  S  E  L  N  V  P  I  L  Y  F  A  G  D  D  E  G  I  Q         p.800

        | 06 .         .         .         .         .         .    g.34337
 GAGAAG | CTACTTCAGCTCTCAGCTGCTGCTGTGGACAAAGGATGCAGTGTGGGCGAGGTT    c.2460
 E  K   | L  L  Q  L  S  A  A  A  V  D  K  G  C  S  V  G  E  V      p.820

          .         .         .         .         .         .       g.34397
 CTGCAGTCGGTGCTGCGCTATGAGAAGGAGCGCCAGCTGAATGAGGCGGTGGGGAATGTC       c.2520
 L  Q  S  V  L  R  Y  E  K  E  R  Q  L  N  E  A  V  G  N  V         p.840

          .         .         .         .                           g.34439
 ACACCGCTGCAGCTGCTGGACTGGCTGATGGTGAACCTGTAA                         c.2562
 T  P  L  Q  L  L  D  W  L  M  V  N  L  X                           p.853

          .         .         .         .         .         .       g.34499
 tcggcaaccccactgctttcccctcttctggcagtggggccggcccttatccccgccctt       c.*60

          .         .         .         .         .         .       g.34559
 ctttctcacttccacatctccccctctatatcctcacagagccctaacattatcttcaca       c.*120

          .         .         .         .         .         .       g.34619
 ccactctcatcaaagacatgtcatcttgtgctagccactggattttgcagattttcctgt       c.*180

          .         .         .         .         .                 g.34670
 ccatgcaagcaaggacgtaaaattaaaaaattacaattaaagggctccaca                c.*231

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The A kinase (PRKA) anchor protein 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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