v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3) - coding DNA reference sequence

(used for variant description)

(last modified December 8, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_005465.4 in the AKT3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering AKT3 transcript NM_005465.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5354
         gctgagtcatcactagagagtgggaagggcagcagcagcagagaatccaaac       c.-61

 .         .         .         .         .         .                g.5414
 cctaaagctgatatcacaaagtaccatttctccaagttgggggctcagaggggagtcatc       c.-1

          .         .         .         .       | 02 .         .    g.152882
 ATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGG | GAGAATATATAAAA    c.60
 M  S  D  V  T  I  V  K  E  G  W  V  Q  K  R  G |   E  Y  I  K      p.20

          .         .         .         .         .         .       g.152942
 AACTGGAGGCCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATATAAAGAG       c.120
 N  W  R  P  R  Y  F  L  L  K  T  D  G  S  F  I  G  Y  K  E         p.40

          .         .         .         .         .   | 03     .    g.183709
 AAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAACTTTTCAGTGGCAA | AATGCCAG    c.180
 K  P  Q  D  V  D  L  P  Y  P  L  N  N  F  S  V  A  K |   C  Q      p.60

          .         .         .         .         .         .       g.183769
 TTAATGAAAACAGAACGACCAAAGCCAAACACATTTATAATCAGATGTCTCCAGTGGACT       c.240
 L  M  K  T  E  R  P  K  P  N  T  F  I  I  R  C  L  Q  W  T         p.80

          .         .         .         .     | 04   .         .    g.202563
 ACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAG | GGAAGAATGGACAGAA    c.300
 T  V  I  E  R  T  F  H  V  D  T  P  E  E  R  |  E  E  W  T  E      p.100

          .         .         .         .         .         .       g.202623
 GCTATCCAGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGT       c.360
 A  I  Q  A  V  A  D  R  L  Q  R  Q  E  E  E  R  M  N  C  S         p.120

          .         .         .         .         .         .       g.202683
 CCAACTTCACAAATTGATAATATAGGAGAGGAAGAGATGGATGCCTCTACAACCCATCAT       c.420
 P  T  S  Q  I  D  N  I  G  E  E  E  M  D  A  S  T  T  H  H         p.140

           | 05        .         .         .         .         .    g.210893
 AAAAGAAAG | ACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGCACTTTTGGG    c.480
 K  R  K   | T  M  N  D  F  D  Y  L  K  L  L  G  K  G  T  F  G      p.160

          .         .         .         .         .         .       g.210953
 AAAGTTATTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAG       c.540
 K  V  I  L  V  R  E  K  A  S  G  K  Y  Y  A  M  K  I  L  K         p.180

          .         .  | 06      .         .         .         .    g.233462
 AAAGAAGTCATTATTGCAAAG | GATGAAGTGGCACACACTCTAACTGAAAGCAGAGTATTA    c.600
 K  E  V  I  I  A  K   | D  E  V  A  H  T  L  T  E  S  R  V  L      p.200

          .         .        | 07.         .         .         .    g.234878
 AAGAACACTAGACATCCCTTTTTAACA | TCCTTGAAATATTCCTTCCAGACAAAAGACCGT    c.660
 K  N  T  R  H  P  F  L  T   | S  L  K  Y  S  F  Q  T  K  D  R      p.220

          .         .         .       | 08 .         .         .    g.275560
 TTGTGTTTTGTGATGGAATATGTTAATGGGGGCGAG | CTGTTTTTCCATTTGTCGAGAGAG    c.720
 L  C  F  V  M  E  Y  V  N  G  G  E   | L  F  F  H  L  S  R  E      p.240

          .         .         .         .         .         .       g.275620
 CGGGTGTTCTCTGAGGACCGCACACGTTTCTATGGTGCAGAAATTGTCTCTGCCTTGGAC       c.780
 R  V  F  S  E  D  R  T  R  F  Y  G  A  E  I  V  S  A  L  D         p.260

          .         .         .          | 09        .         .    g.284757
 TATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAG | TTGGAGAATCTAATGCTGGAC    c.840
 Y  L  H  S  G  K  I  V  Y  R  D  L  K   | L  E  N  L  M  L  D      p.280

          .         .         .         .         .         .       g.284817
 AAAGATGGCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCA       c.900
 K  D  G  H  I  K  I  T  D  F  G  L  C  K  E  G  I  T  D  A         p.300

          .         .         .         .         | 10         .    g.295653
 GCCACCATGAAGACATTCTGTGGCACTCCAGAATATCTGGCACCAGAG | GTGTTAGAAGAT    c.960
 A  T  M  K  T  F  C  G  T  P  E  Y  L  A  P  E   | V  L  E  D      p.320

          .         .         .         .         .         .       g.295713
 AATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTATGAAATGATG       c.1020
 N  D  Y  G  R  A  V  D  W  W  G  L  G  V  V  M  Y  E  M  M         p.340

          .         .         .         .         .         .       g.295773
 TGTGGGAGGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATG       c.1080
 C  G  R  L  P  F  Y  N  Q  D  H  E  K  L  F  E  L  I  L  M         p.360

          .         .         .         .         .         .       g.295833
 GAAGACATTAAATTTCCTCGAACACTCTCTTCAGATGCAAAATCATTGCTTTCAGGGCTC       c.1140
 E  D  I  K  F  P  R  T  L  S  S  D  A  K  S  L  L  S  G  L         p.380

          .         .    | 11    .         .         .         .    g.303024
 TTGATAAAGGATCCAAATAAACG | CCTTGGTGGAGGACCAGATGATGCAAAAGAAATTATG    c.1200
 L  I  K  D  P  N  K  R  |  L  G  G  G  P  D  D  A  K  E  I  M      p.400

          .         .         .         .         .  | 12      .    g.336167
 AGACACAGTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAG | CTTGTACCT    c.1260
 R  H  S  F  F  S  G  V  N  W  Q  D  V  Y  D  K  K   | L  V  P      p.420

          .         .         .         .         .         .       g.336227
 CCTTTTAAACCTCAAGTAACATCTGAGACAGATACTAGATATTTTGATGAAGAATTTACA       c.1320
 P  F  K  P  Q  V  T  S  E  T  D  T  R  Y  F  D  E  E  F  T         p.440

          .         .         .     | 13   .         .         .    g.343276
 GCTCAGACTATTACAATAACACCACCTGAAAAAT | ATGATGAGGATGGTATGGACTGCATG    c.1380
 A  Q  T  I  T  I  T  P  P  E  K  Y |   D  E  D  G  M  D  C  M      p.460

          .         .         .         .         .         .       g.343336
 GACAATGAGAGGCGGCCGCATTTCCCTCAATTTTCCTACTCTGCAAGTGGACGAGAATAA       c.1440
 D  N  E  R  R  P  H  F  P  Q  F  S  Y  S  A  S  G  R  E  X         p.479

          .         .         .         .         .         .       g.343396
 gtctctttcattctgctacttcactgtcatcttcaatttattactgaaaatgattcctgg       c.*60

          .         .         .         .         .         .       g.343456
 acatcaccagtcctagctcttacacatagcaggggcaccttccgacatcccagaccagcc       c.*120

          .         .         .         .         .         .       g.343516
 aagggtcctcacccctcgccacctttcaccctcatgaaaacacacatacacgcaaataca       c.*180

          .         .         .         .         .         .       g.343576
 ctccagtttttgtttttgcatgaaattgtatctcagtctaaggtctcatgctgttgctgc       c.*240

          .         .         .         .         .         .       g.343636
 tactgtcttactattatagcaactttaagaagtaattttccaacctttggaagtcatgag       c.*300

          .         .         .         .         .         .       g.343696
 cccaccattgttcatttgtgcaccaattatcatcttttgatcttttagtttttccctcag       c.*360

          .         .         .         .         .         .       g.343756
 tgaaggctaaatgagatacactgattctaggtacattttttaactttctagaagagaaaa       c.*420

          .         .         .         .         .         .       g.343816
 actaactagactaagaagatttagtttataaattcagaacaagcaattgtggaagggtgg       c.*480

          .         .         .         .         .         .       g.343876
 tggcgtgcatatgtaaagcacatcagatccgtgcgtgaagtaggcatatatcactaagct       c.*540

          .         .         .         .         .         .       g.343936
 gtggctggaattgattaggaagcatttggtagaaggactgaacaactgttgggatatata       c.*600

          .         .         .         .         .         .       g.343996
 tatatatatataattttttttttttaaattcctggtggatactgtagaagaagcccatat       c.*660

          .         .         .         .         .         .       g.344056
 cacatgtggatgtcgagacttcacgggcaatcatgagcaagtgaacactgttctaccaag       c.*720

          .         .         .         .         .         .       g.344116
 aactgaaggcatatgcacagtcaaggtcacttaaagggtcttatgaaacaatttgagcca       c.*780

          .         .         .         .         .         .       g.344176
 gagagcatctttcccctgtgcttggaaaccttttttccttcttgacatttatcacctctg       c.*840

          .         .         .         .         .         .       g.344236
 atggctgaagaatgtagacaggtataatgatactgcttttcaccaaaatttctacaccaa       c.*900

          .         .         .         .         .         .       g.344296
 ggtaaacaggtgtttgccttatttaattttttactttcagttctacgtgaattagctttt       c.*960

          .         .         .         .         .         .       g.344356
 tctcagatgttgaaactttgaatgtccttttatgattttgtttatattgcagtagtattt       c.*1020

          .         .         .         .         .         .       g.344416
 attttttagtgatgagaattgtatgtcatgttagcaaacgcagctccaacttatataaaa       c.*1080

          .         .         .         .         .         .       g.344476
 tagacttactgcagttacttttgacccatgtgcaaggattgtacacgctgatgagaatca       c.*1140

          .         .         .         .         .         .       g.344536
 tgcactttttctcctctgttaaaaaaaatgataaggctctgaaatggaatatattggtta       c.*1200

          .         .         .         .         .         .       g.344596
 gaatttggctttgggagaagagatgctgccatttaaccccttggtactgaaaatgagaaa       c.*1260

          .         .         .         .         .         .       g.344656
 atccccaactatgcatgccaaggggttaatgaaacaaatagctgttgacgtttgctcatt       c.*1320

          .         .         .         .         .         .       g.344716
 taagaatttgaaacgttatgatgacctggcaacaaaaagtaatgaagaaaattgagacct       c.*1380

          .         .         .         .         .         .       g.344776
 gagtgaagataagaaatgatctttacgtggcaaaatgaacacatcttgagtatttaggaa       c.*1440

          .         .         .         .         .         .       g.344836
 atgggcagtgaaggctaagaacctggtgtgtttcttgggatcatggtacatttatcactg       c.*1500

          .         .         .         .         .         .       g.344896
 aattaagccatcagggaaaaaacaacaaaaaaagagaacacctccagcttttctttttct       c.*1560

          .         .         .         .         .         .       g.344956
 gtatatactcatgtcccccagattccaacatttctcactgaaagggggcatgtatgcaaa       c.*1620

          .         .         .         .         .         .       g.345016
 cctcatctttctccttcattaatgatgatcttcagattaaaccctttggtgctaggagct       c.*1680

          .         .         .         .         .         .       g.345076
 gacaatttccaaagcagcctgtgaagtcctaggggctgggggccactcttgcggcaagca       c.*1740

          .         .         .         .         .         .       g.345136
 gaaggccatcctactccgcggagtgatcatggaaatgtattttagttaaactctgacagc       c.*1800

          .         .         .         .         .         .       g.345196
 tcccaaacggaagactacagcatgacgtagtattatgattgcattgtatgaaagagcaag       c.*1860

          .         .         .         .         .         .       g.345256
 tgactttctaagtaggatgaatcatattcatatgcagatgtcttagcctcttgacgctgg       c.*1920

          .         .         .         .         .         .       g.345316
 aagtgtggatttatagctatgaaaccactgctggcagtgggtgggccactgggactgacg       c.*1980

          .         .         .         .         .         .       g.345376
 ggggttaaagggcattttactaaggcagctaagacatattcagacatcaacgttatcctt       c.*2040

          .         .         .         .         .         .       g.345436
 ctttttcatatttctacctgagtgaagttcatccttagtattgagtaggaagttacagta       c.*2100

          .         .         .         .         .         .       g.345496
 aatggtagttcattcttacttacacacatagctaatcttttttttttcacttggaattat       c.*2160

          .         .         .         .         .         .       g.345556
 gttgaatgtttcattttgacaaaaaagtagactagaaggtatgttctttaagttgtcttg       c.*2220

          .         .         .         .         .         .       g.345616
 catccattatataagaaagaaacaggtgagaggaagagcagaaagctgagactggctgat       c.*2280

          .         .         .         .         .         .       g.345676
 gttcagagcacttactcctctagagggaaagcatgacaccgaacactaagcacacagctt       c.*2340

          .         .         .         .         .         .       g.345736
 tttgttgttttggttttttctcccgcaaatcttaaagtgattcccatgaccttggccaag       c.*2400

          .         .         .         .         .         .       g.345796
 gacacttcttaaagattaatgactggcactgacattgccccaggcgggccactcctcaca       c.*2460

          .         .         .         .         .         .       g.345856
 ctggctctcagttcccagccatgcctggggctcagtcacttctattccaccctctgagac       c.*2520

          .         .         .         .         .         .       g.345916
 tccattggtgtcacacaaggtgtcttcttggctttgattttgagaatcccctattttcac       c.*2580

          .         .         .         .         .         .       g.345976
 ttccagatctgtcagctgccatggaggaataatagaaaaccagaaatgcgtgtagaggga       c.*2640

          .         .         .         .         .         .       g.346036
 gatttctaaaacttcccttgtgtcgcccatagttgtagttttgggttctggcaggtggaa       c.*2700

          .         .         .         .         .         .       g.346096
 caccctgaaacctggaatcattctatgagaatacagttcagactttgcagactccagccc       c.*2760

          .         .         .         .         .         .       g.346156
 atactaactgtcatgaagcttgacttcttgtcataatgcagccatcttggaggaaattgg       c.*2820

          .         .         .         .         .         .       g.346216
 ccatttctgcttagatggttggcagggtcgcgctcagctttgctttctacactaattaca       c.*2880

          .         .         .         .         .         .       g.346276
 tagcattattcaagtattgttttccatttcccatccctgatttccagcttcttaaagctg       c.*2940

          .         .         .         .         .         .       g.346336
 actgttcttgcaggggccacttgcttctcctagagtacaaaagtaagggccttccttact       c.*3000

          .         .         .         .         .         .       g.346396
 aactgcagggtctctctattacacctcaacatacacactttgctgctactgtttgtactg       c.*3060

          .         .         .         .         .         .       g.346456
 tctacagtagaatttccttatcttgctcctggtagtgcattacaggcaagcatgaaatgt       c.*3120

          .         .         .         .         .         .       g.346516
 aaagtatttatttaaataaaaagaaaacctctaaattggtaattgaattacctccctgta       c.*3180

          .         .         .         .         .         .       g.346576
 gctttatagtttgtgacatttcttgaccttgctagttctttcattagatctgcgcaagat       c.*3240

          .         .         .         .         .         .       g.346636
 ctagtcatctggttaaggattttaagcagatgcaactataaacccaagaaactgtattac       c.*3300

          .         .         .         .         .         .       g.346696
 tattactgttggtcatactaaacctgtctatttcctgaagtatatgacccacaaggatgt       c.*3360

          .         .         .         .         .         .       g.346756
 ggaataactaggagaaactgtttttgtacactgtacatccttagtatttttacacgtata       c.*3420

          .         .         .         .         .         .       g.346816
 tgatagggatgaacatgattttccttcgtacagacagcttaaataaagcactatgtcaat       c.*3480

          .         .         .         .         .         .       g.346876
 ctgctacttctctgtttattgttgttggatgtggttctataatccccccaaattaaatct       c.*3540

          .         .         .         .         .         .       g.346936
 tctttaatgaaaacatgatttttaatagccccagctggtattaacctaccttgtataaaa       c.*3600

          .         .         .         .         .         .       g.346996
 tgtgacaggaaaatatagaaataattccttgtagctcacacacacacacataggggatca       c.*3660

          .         .         .         .         .         .       g.347056
 tttttacttcagtgaaatggcagtagtgcggttgtgcaaactttgatgaacggctgcttc       c.*3720

          .         .         .         .         .         .       g.347116
 tgaggggaaacgctgacctctcagcactggatttaggatggatgtactgtgaagccaggg       c.*3780

          .         .         .         .         .         .       g.347176
 atgaaggaggtctcagaccctggggacattcagacccgaatcatctatacaacacacggt       c.*3840

          .         .         .         .         .         .       g.347236
 ttggacccagaatctgaaggaatgtagcttttcattaacgtcttcctgataatgtactgc       c.*3900

          .         .         .         .         .         .       g.347296
 tctgcatatttcctttcttagagtgtatttctaacaacatgtcatggcaaattaacaaac       c.*3960

          .         .         .         .         .         .       g.347356
 ttagacgtgggtgatgtagatgggtaggatggctggactgcagtctgacttcacgttgaa       c.*4020

          .         .         .         .         .         .       g.347416
 tcattctggatggggcctttttctgattttacctcataaagctactattgtagaaacttg       c.*4080

          .         .         .         .         .         .       g.347476
 gctttgctcctgtgacgaagccagacagaggaatggcttttgggaccagagtgagtcaag       c.*4140

          .         .         .         .         .         .       g.347536
 catgtatgtgtatgtcacacggccaaatttgagggcattctcacatgtgctcttctctca       c.*4200

          .         .         .         .         .         .       g.347596
 aaaccactggggttgacagatccaggaggctaaaaaaaagtgacctctataattctttaa       c.*4260

          .         .         .         .         .         .       g.347656
 aggtgctatttttagaatattgtataatttattcacagtatatctaaaacagaattaagg       c.*4320

          .         .         .         .         .         .       g.347716
 acaattaaaatatcttatgtgacagcctttatgtctagcacatttgatgaaataaaaaac       c.*4380

          .         .         .         .         .         .       g.347776
 ttctgaatctgaatagaagttctactgtttcaggcttgaaccttttacatgctcaagaga       c.*4440

          .         .         .         .         .         .       g.347836
 ttcaaatggtctctgtgtgtagatcatgccaccgcctccaaagcctaatccacatcactt       c.*4500

          .         .         .         .         .         .       g.347896
 ctgagaggcaaggctgagcatatggtgacatcagctctgtgttgagatggtgatgaggat       c.*4560

          .         .         .         .         .         .       g.347956
 gatggctcgctggccaggcagggcagccgaaggtcagggacctgtcctaactaactgcag       c.*4620

          .         .         .         .         .         .       g.348016
 ccttgcctttagtgtttgtcattctcagatacaacacggtatgtccagtgtccgttttta       c.*4680

          .         .         .         .         .         .       g.348076
 ttactttaaagcatttgagggcttaattgtgtatagtagaaatactattttagacaaata       c.*4740

          .         .         .         .         .         .       g.348136
 attatctgtgtacagatatttgatatactctaagtaaattttctaatttcactaagtacg       c.*4800

          .         .         .         .         .         .       g.348196
 tttttaggctcctctcaaatactgcgtattgaagaaaaaaatctgacaccaccgagccaa       c.*4860

          .         .         .         .         .         .       g.348256
 agatgcttttttgtctgttttcgttgtttaacagaatggaaagagtaatgcatagtgctt       c.*4920

          .         .         .         .         .         .       g.348316
 cctggtgtctcctgattgattgattgtgcacaaagtaggacgataaataaataaaatgga       c.*4980

          .         .         .         .         .         .       g.348376
 gtctgatgggacattgattaaaggtgaaggatgattgatatatagatcatgaaaagaaaa       c.*5040

          .         .         .         .         .         .       g.348436
 atgaatggcaggaaaaaaagtttggtccttaatatactttggcctagttaaaatatgtgc       c.*5100

          .         .         .         .         .         .       g.348496
 ctttttggtgtgttttgttcatcactacaagataaaaaggaaacattacaactcaagtct       c.*5160

          .         .         .         .         .         .       g.348556
 ttaaaaagttcatttattgaaaatcatatgtataacctagcatacgaatgagcagattta       c.*5220

          .         .         .         .         .         .       g.348616
 aacacataacttcaagccatttctgaaaacatacaccaggagctctgctcagctagagtc       c.*5280

          .         .         .         .         .         .       g.348676
 agactccagctccagcccgactgcgtgcggggacagcgcccgcgttgatgaggaccagcc       c.*5340

          .         .         .         .         .         .       g.348736
 ccactgcaggctgaggcggtgtcaccctgggaaggtcgtggtgcgttgtggcatattaag       c.*5400

          .         .         .         .         .         .       g.348796
 tctaaaccagatgaatgtaaatatctctttgtaaatcatttatttcactctgttccatcc       c.*5460

          .         .         .         .         .         .       g.348856
 aggtcagcaatcagattgtggcatgctgggtaactggaaaaaataataaaaagtaagttt       c.*5520

          .                                                         g.348866
 caatagctca                                                         c.*5530

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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