v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3) - coding DNA reference sequence

(used for variant description)

(last modified December 8, 2015)

This file was created to facilitate the description of sequence variants on transcript NM_181690.2 in the AKT3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029764.1, covering AKT3 transcript NM_181690.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
           .         .         .         .         .                g.5354
         gctgagtcatcactagagagtgggaagggcagcagcagcagagaatccaaac       c.-61

 .         .         .         .         .         .                g.5414
 cctaaagctgatatcacaaagtaccatttctccaagttgggggctcagaggggagtcatc       c.-1

          .         .         .         .       | 02 .         .    g.152882
 ATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGG | GAGAATATATAAAA    c.60
 M  S  D  V  T  I  V  K  E  G  W  V  Q  K  R  G |   E  Y  I  K      p.20

          .         .         .         .         .         .       g.152942
 AACTGGAGGCCAAGATACTTCCTTTTGAAGACAGATGGCTCATTCATAGGATATAAAGAG       c.120
 N  W  R  P  R  Y  F  L  L  K  T  D  G  S  F  I  G  Y  K  E         p.40

          .         .         .         .         .   | 03     .    g.183709
 AAACCTCAAGATGTGGATTTACCTTATCCCCTCAACAACTTTTCAGTGGCAA | AATGCCAG    c.180
 K  P  Q  D  V  D  L  P  Y  P  L  N  N  F  S  V  A  K |   C  Q      p.60

          .         .         .         .         .         .       g.183769
 TTAATGAAAACAGAACGACCAAAGCCAAACACATTTATAATCAGATGTCTCCAGTGGACT       c.240
 L  M  K  T  E  R  P  K  P  N  T  F  I  I  R  C  L  Q  W  T         p.80

          .         .         .         .     | 04   .         .    g.202563
 ACTGTTATAGAGAGAACATTTCATGTAGATACTCCAGAGGAAAG | GGAAGAATGGACAGAA    c.300
 T  V  I  E  R  T  F  H  V  D  T  P  E  E  R  |  E  E  W  T  E      p.100

          .         .         .         .         .         .       g.202623
 GCTATCCAGGCTGTAGCAGACAGACTGCAGAGGCAAGAAGAGGAGAGAATGAATTGTAGT       c.360
 A  I  Q  A  V  A  D  R  L  Q  R  Q  E  E  E  R  M  N  C  S         p.120

          .         .         .         .         .         .       g.202683
 CCAACTTCACAAATTGATAATATAGGAGAGGAAGAGATGGATGCCTCTACAACCCATCAT       c.420
 P  T  S  Q  I  D  N  I  G  E  E  E  M  D  A  S  T  T  H  H         p.140

           | 05        .         .         .         .         .    g.210893
 AAAAGAAAG | ACAATGAATGATTTTGACTATTTGAAACTACTAGGTAAAGGCACTTTTGGG    c.480
 K  R  K   | T  M  N  D  F  D  Y  L  K  L  L  G  K  G  T  F  G      p.160

          .         .         .         .         .         .       g.210953
 AAAGTTATTTTGGTTCGAGAGAAGGCAAGTGGAAAATACTATGCTATGAAGATTCTGAAG       c.540
 K  V  I  L  V  R  E  K  A  S  G  K  Y  Y  A  M  K  I  L  K         p.180

          .         .  | 06      .         .         .         .    g.233462
 AAAGAAGTCATTATTGCAAAG | GATGAAGTGGCACACACTCTAACTGAAAGCAGAGTATTA    c.600
 K  E  V  I  I  A  K   | D  E  V  A  H  T  L  T  E  S  R  V  L      p.200

          .         .        | 07.         .         .         .    g.234878
 AAGAACACTAGACATCCCTTTTTAACA | TCCTTGAAATATTCCTTCCAGACAAAAGACCGT    c.660
 K  N  T  R  H  P  F  L  T   | S  L  K  Y  S  F  Q  T  K  D  R      p.220

          .         .         .       | 08 .         .         .    g.275560
 TTGTGTTTTGTGATGGAATATGTTAATGGGGGCGAG | CTGTTTTTCCATTTGTCGAGAGAG    c.720
 L  C  F  V  M  E  Y  V  N  G  G  E   | L  F  F  H  L  S  R  E      p.240

          .         .         .         .         .         .       g.275620
 CGGGTGTTCTCTGAGGACCGCACACGTTTCTATGGTGCAGAAATTGTCTCTGCCTTGGAC       c.780
 R  V  F  S  E  D  R  T  R  F  Y  G  A  E  I  V  S  A  L  D         p.260

          .         .         .          | 09        .         .    g.284757
 TATCTACATTCCGGAAAGATTGTGTACCGTGATCTCAAG | TTGGAGAATCTAATGCTGGAC    c.840
 Y  L  H  S  G  K  I  V  Y  R  D  L  K   | L  E  N  L  M  L  D      p.280

          .         .         .         .         .         .       g.284817
 AAAGATGGCCACATAAAAATTACAGATTTTGGACTTTGCAAAGAAGGGATCACAGATGCA       c.900
 K  D  G  H  I  K  I  T  D  F  G  L  C  K  E  G  I  T  D  A         p.300

          .         .         .         .         | 10         .    g.295653
 GCCACCATGAAGACATTCTGTGGCACTCCAGAATATCTGGCACCAGAG | GTGTTAGAAGAT    c.960
 A  T  M  K  T  F  C  G  T  P  E  Y  L  A  P  E   | V  L  E  D      p.320

          .         .         .         .         .         .       g.295713
 AATGACTATGGCCGAGCAGTAGACTGGTGGGGCCTAGGGGTTGTCATGTATGAAATGATG       c.1020
 N  D  Y  G  R  A  V  D  W  W  G  L  G  V  V  M  Y  E  M  M         p.340

          .         .         .         .         .         .       g.295773
 TGTGGGAGGTTACCTTTCTACAACCAGGACCATGAGAAACTTTTTGAATTAATATTAATG       c.1080
 C  G  R  L  P  F  Y  N  Q  D  H  E  K  L  F  E  L  I  L  M         p.360

          .         .         .         .         .         .       g.295833
 GAAGACATTAAATTTCCTCGAACACTCTCTTCAGATGCAAAATCATTGCTTTCAGGGCTC       c.1140
 E  D  I  K  F  P  R  T  L  S  S  D  A  K  S  L  L  S  G  L         p.380

          .         .    | 11    .         .         .         .    g.303024
 TTGATAAAGGATCCAAATAAACG | CCTTGGTGGAGGACCAGATGATGCAAAAGAAATTATG    c.1200
 L  I  K  D  P  N  K  R  |  L  G  G  G  P  D  D  A  K  E  I  M      p.400

          .         .         .         .         .  | 12      .    g.336167
 AGACACAGTTTCTTCTCTGGAGTAAACTGGCAAGATGTATATGATAAAAAG | CTTGTACCT    c.1260
 R  H  S  F  F  S  G  V  N  W  Q  D  V  Y  D  K  K   | L  V  P      p.420

          .         .         .         .         .         .       g.336227
 CCTTTTAAACCTCAAGTAACATCTGAGACAGATACTAGATATTTTGATGAAGAATTTACA       c.1320
 P  F  K  P  Q  V  T  S  E  T  D  T  R  Y  F  D  E  E  F  T         p.440

          .         .         .     | 13   .         .         .    g.348824
 GCTCAGACTATTACAATAACACCACCTGAAAAAT | GTCAGCAATCAGATTGTGGCATGCTG    c.1380
 A  Q  T  I  T  I  T  P  P  E  K  C |   Q  Q  S  D  C  G  M  L      p.460

          .                                                     g.348842
 GGTAACTGGAAAAAATAA |                                              c.1399
 G  N  W  K  K  X                                                p.465

        | 14 .         .         .         .         .         .    g.360188
 taaaaa | tcggcttcctacagccagcagcacagtcacccatggaactgttggctttggatt    c.*60

          .         .         .         .         .         .       g.360248
 aaatgtggaattgaacgactacccagaagtgttctggaaagaagcgagatgtgtggcctg       c.*120

          .         .         .         .         .         .       g.360308
 cctcaccgtcctcacccatcaaaagcaccagcaggcacgttaactcgaattctcacaagg       c.*180

          .         .         .         .                           g.360352
 aaaaggccattaaagctcaaggtgcatttcaaactccaggctac                       c.*224

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.