aldehyde dehydrogenase 1 family, member A3 (ALDH1A3) - coding DNA reference sequence

(used for variant description)

(last modified February 16, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000693.2 in the ALDH1A3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering ALDH1A3 transcript NM_000693.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5044
                 aaagcggcggggagctgccaccccgggagcgggctgcgcagtgt       c.-61

 .         .         .         .         .         .                g.5104
 ccgggccgagccggtgcgccgcagactagggcgcctcgggccagggagcgcggaggagcc       c.-1

          .         .         .         .         .         .       g.5164
 ATGGCCACCGCTAACGGGGCCGTGGAAAACGGGCAGCCGGACAGGAAGCCGCCGGCCCTG       c.60
 M  A  T  A  N  G  A  V  E  N  G  Q  P  D  R  K  P  P  A  L         p.20

          .         .         .          | 02        .         .    g.10484
 CCGCGCCCCATCCGCAACCTGGAGGTCAAGTTCACCAAG | ATATTTATCAACAATGAATGG    c.120
 P  R  P  I  R  N  L  E  V  K  F  T  K   | I  F  I  N  N  E  W      p.40

          .         .         .         .         .         .       g.10544
 CACGAATCCAAGAGTGGGAAAAAGTTTGCTACATGTAACCCTTCAACTCGGGAGCAAATA       c.180
 H  E  S  K  S  G  K  K  F  A  T  C  N  P  S  T  R  E  Q  I         p.60

          .         .     | 03   .         .         .         .    g.12804
 TGTGAAGTGGAAGAAGGAGATAAG | CCCGACGTGGACAAGGCTGTGGAGGCTGCACAGGTT    c.240
 C  E  V  E  E  G  D  K   | P  D  V  D  K  A  V  E  A  A  Q  V      p.80

          .         .         .         .         .         .       g.12864
 GCCTTCCAGAGGGGCTCGCCATGGCGCCGGCTGGATGCCCTGAGTCGTGGGCGGCTGCTG       c.300
 A  F  Q  R  G  S  P  W  R  R  L  D  A  L  S  R  G  R  L  L         p.100

          .         .         .         .      | 04  .         .    g.17721
 CACCAGCTGGCTGACCTGGTGGAGAGGGACCGCGCCACCTTGGCC | GCCCTGGAGACGATG    c.360
 H  Q  L  A  D  L  V  E  R  D  R  A  T  L  A   | A  L  E  T  M      p.120

          .         .         .         .         .         .       g.17781
 GATACAGGGAAGCCATTTCTTCATGCTTTTTTCATCGACCTGGAGGGCTGTATTAGAACC       c.420
 D  T  G  K  P  F  L  H  A  F  F  I  D  L  E  G  C  I  R  T         p.140

          .         .         .         .         .      | 05  .    g.18146
 CTCAGATACTTTGCAGGGTGGGCAGACAAAATCCAGGGCAAGACCATCCCCACAG | ATGAC    c.480
 L  R  Y  F  A  G  W  A  D  K  I  Q  G  K  T  I  P  T  D |   D      p.160

          .         .         .         .         .        | 06.    g.19153
 AACGTCGTGTGCTTCACCAGGCATGAGCCCATTGGTGTCTGTGGGGCCATCACTCCA | TGG    c.540
 N  V  V  C  F  T  R  H  E  P  I  G  V  C  G  A  I  T  P   | W      p.180

          .         .         .         .         .         .       g.19213
 AACTTCCCCCTGCTGATGCTGGTGTGGAAGCTGGCACCCGCCCTCTGCTGTGGGAACACC       c.600
 N  F  P  L  L  M  L  V  W  K  L  A  P  A  L  C  C  G  N  T         p.200

          .         .         .         .         .         .       g.19273
 ATGGTCCTGAAGCCTGCGGAGCAGACACCTCTCACCGCCCTTTATCTCGGCTCTCTGATC       c.660
 M  V  L  K  P  A  E  Q  T  P  L  T  A  L  Y  L  G  S  L  I         p.220

        | 07 .         .         .         .         .         .    g.21183
 AAAGAG | GCCGGGTTCCCTCCAGGAGTGGTGAACATTGTGCCAGGATTCGGGCCCACAGTG    c.720
 K  E   | A  G  F  P  P  G  V  V  N  I  V  P  G  F  G  P  T  V      p.240

          .         .         .         .         .         .       g.21243
 GGAGCAGCAATTTCTTCTCACCCTCAGATCAACAAGATCGCCTTCACCGGCTCCACAGAG       c.780
 G  A  A  I  S  S  H  P  Q  I  N  K  I  A  F  T  G  S  T  E         p.260

  | 08       .         .         .         .         .         .    g.23339
  | GTTGGAAAACTGGTTAAAGAAGCTGCGTCCCGGAGCAATCTGAAGCGGGTGACGCTGGAG    c.840
  | V  G  K  L  V  K  E  A  A  S  R  S  N  L  K  R  V  T  L  E      p.280

          .         .         .         .    | 09    .         .    g.25788
 CTGGGGGGGAAGAACCCCTGCATCGTGTGTGCGGACGCTGACT | TGGACTTGGCAGTGGAG    c.900
 L  G  G  K  N  P  C  I  V  C  A  D  A  D  L |   D  L  A  V  E      p.300

          .         .         .         .         .         .       g.25848
 TGTGCCCATCAGGGAGTGTTCTTCAACCAAGGCCAGTGTTGCACGGCAGCCTCCAGGGTG       c.960
 C  A  H  Q  G  V  F  F  N  Q  G  Q  C  C  T  A  A  S  R  V         p.320

          .         .         .         .         .         .       g.25908
 TTCGTGGAGGAGCAGGTCTACTCTGAGTTTGTCAGGCGGAGCGTGGAGTATGCCAAGAAA       c.1020
 F  V  E  E  Q  V  Y  S  E  F  V  R  R  S  V  E  Y  A  K  K         p.340

          .         .         .         .         | 10         .    g.30731
 CGGCCCGTGGGAGACCCCTTCGATGTCAAAACAGAACAGGGGCCTCAG | ATTGATCAAAAG    c.1080
 R  P  V  G  D  P  F  D  V  K  T  E  Q  G  P  Q   | I  D  Q  K      p.360

          .         .         .         .         .         .       g.30791
 CAGTTCGACAAAATCTTAGAGCTGATCGAGAGTGGGAAGAAGGAAGGGGCCAAGCTGGAA       c.1140
 Q  F  D  K  I  L  E  L  I  E  S  G  K  K  E  G  A  K  L  E         p.380

          .         .         .         .         .         .       g.30851
 TGCGGGGGCTCAGCCATGGAAGACAAGGGGCTCTTCATCAAACCCACTGTCTTCTCAGAA       c.1200
 C  G  G  S  A  M  E  D  K  G  L  F  I  K  P  T  V  F  S  E         p.400

          .         .         .    | 11    .         .         .    g.32344
 GTCACAGACAACATGCGGATTGCCAAAGAGGAG | ATTTTCGGGCCAGTGCAACCAATACTG    c.1260
 V  T  D  N  M  R  I  A  K  E  E   | I  F  G  P  V  Q  P  I  L      p.420

          .         .         .         .         .         .       g.32404
 AAGTTCAAAAGTATCGAAGAAGTGATAAAAAGAGCGAATAGCACCGACTATGGACTCACA       c.1320
 K  F  K  S  I  E  E  V  I  K  R  A  N  S  T  D  Y  G  L  T         p.440

          .         .         .         .         .         .       g.32464
 GCAGCCGTGTTCACAAAAAATCTCGACAAAGCCCTGAAGTTGGCTTCTGCCTTAGAGTCT       c.1380
 A  A  V  F  T  K  N  L  D  K  A  L  K  L  A  S  A  L  E  S         p.460

          .  | 12      .         .         .         .         .    g.33653
 GGAACGGTCTG | GATCAACTGCTACAACGCCCTCTATGCACAGGCTCCATTTGGTGGCTTT    c.1440
 G  T  V  W  |  I  N  C  Y  N  A  L  Y  A  Q  A  P  F  G  G  F      p.480

          .         .       | 13 .         .         .         .    g.39931
 AAAATGTCAGGAAATGGCAGAGAACT | AGGTGAATACGCTTTGGCCGAATACACAGAAGTG    c.1500
 K  M  S  G  N  G  R  E  L  |  G  E  Y  A  L  A  E  Y  T  E  V      p.500

          .         .         .                                     g.39970
 AAAACTGTCACCATCAAACTTGGCGACAAGAACCCCTGA                            c.1539
 K  T  V  T  I  K  L  G  D  K  N  P  X                              p.512

          .         .         .         .         .         .       g.40030
 aggaaaggcggggctccttcctcaaacatcggacggcggaatgtggcagatgaaatgtgc       c.*60

          .         .         .         .         .         .       g.40090
 tggaggaaaaaaatgacatttctgaccttcccgggacacattcttctggaggctttacat       c.*120

          .         .         .         .         .         .       g.40150
 ctactggagttgaatgattgctgttttcctctcactctcctgtttattcaccagactggg       c.*180

          .         .         .         .         .         .       g.40210
 gatgcctataggttgtctgtgaaatcgcagtcctgcctggggagggagctgttggccatt       c.*240

          .         .         .         .         .         .       g.40270
 tctgtgtttccctttaaaccagatcctggagacagtgagatactcagggcgttgttaaca       c.*300

          .         .         .         .         .         .       g.40330
 gggagtggtatttgaagtgtccagcagttgcttgaaatgctttgccgaatctgactccag       c.*360

          .         .         .         .         .         .       g.40390
 taagaatgtgggaaaaccccctgtgtgttctgcaagcagggctcttgcaccagcggtctc       c.*420

          .         .         .         .         .         .       g.40450
 ctcagggtggacctgcttacagagcaagccacgcctctttccgaggtgaaggtgggacca       c.*480

          .         .         .         .         .         .       g.40510
 ttccttgggaaaggattcacagtaaggttttttggtttttgttttttgttttcttgtttt       c.*540

          .         .         .         .         .         .       g.40570
 taaaaaaaggatttcacagtgagaaagttttggttagtgcataccgtggaagggcgccag       c.*600

          .         .         .         .         .         .       g.40630
 ggtctttgtggattgcatgttgacattgaccgtgagattcggcttcaaaccaatactgcc       c.*660

          .         .         .         .         .         .       g.40690
 tttggaatatgacagaatcaatagcccagagagcttagtcaaagacgatatcacggtcta       c.*720

          .         .         .         .         .         .       g.40750
 ccttaaccaaggcactttcttaagcagaaaatattgttgaggttacctttgctgctaaag       c.*780

          .         .         .         .         .         .       g.40810
 atccaatcttctaacgccacaacagcatagcaaatcctaggataattcacctcctcattt       c.*840

          .         .         .         .         .         .       g.40870
 gacaaatcagagctgtaattcgctttaacaaattacgcatttctatcacgttcactaaca       c.*900

          .         .         .         .         .         .       g.40930
 gcttatgataagtctgtgtagtcttccttttctccagttctgttacccaatttagattag       c.*960

          .         .         .         .         .         .       g.40990
 taaagcgtacacaactggaaagactgctgtaataacacagccttgttatttttaagtcct       c.*1020

          .         .         .         .         .         .       g.41050
 attttgatattaatttctgattagttagtaaataacacctggattctatggaggacctcg       c.*1080

          .         .         .         .         .         .       g.41110
 gtcttcatccaagtggcctgagtatttcactggcaggttgtgaatttttcttttcctctt       c.*1140

          .         .         .         .         .         .       g.41170
 tggggatccaaatgatgatgtgcaatttcatgttttaacttgggaaactgaaagtgttcc       c.*1200

          .         .         .         .         .         .       g.41230
 catatagcttcaaaaacaaaaacaaatgtgttatccgacggatacttttatggttactaa       c.*1260

          .         .         .         .         .         .       g.41290
 ctagtactttcctaattgggaaagtagtgcttaagtttgcaaattaagttggggagggca       c.*1320

          .         .         .         .         .         .       g.41350
 ataataaaatgagggcccgtaacagaaccagtgtgtgtataacgaaaaccatgtataaaa       c.*1380

          .         .         .         .         .         .       g.41410
 tgggcctatcacccttgtcagagatataaattaccacatttgccttcccttcatcagcta       c.*1440

          .         .         .         .         .         .       g.41470
 acacttatcacttatactaccaataacttgttaaatcaggatttggcttcatacactgaa       c.*1500

          .         .         .         .         .         .       g.41530
 ttttcagtattttatctcaagtagatatagacactaaccttgatagtgatacgttagagg       c.*1560

          .         .         .         .         .         .       g.41590
 gttcctattcttccattgtacgataatgtctttaatatgaaatgctacattatttataat       c.*1620

          .         .         .         .         .         .       g.41650
 tggtagagttattgtatctttttatagttgtaagtacacagaggtggtatatttaaactt       c.*1680

          .         .         .         .         .         .       g.41710
 ctgtaatatactgtatttagaaatggaaatatatatagtgttaggtttcacttcttttaa       c.*1740

          .         .         .         .         .         .       g.41770
 ggtttacccctgtggtgtggtttaaaaatctataggcctgggaattccgatcctagctgc       c.*1800

          .         .         .         .         .                 g.41823
 agatcgcatcccacaatgcgagaatgataaaataaaattggatatttgagaaa              c.*1853

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Aldehyde dehydrogenase 1 family, member A3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 09
©2004-2014 Leiden University Medical Center