aldolase B, fructose-bisphosphate (ALDOB) - coding DNA reference sequence

(used for variant description)

(last modified January 5, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_000035.3 in the ALDOB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012387.1, covering ALDOB transcript NM_000035.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       atctgtcttatttggcagctgc       c.-61

 .         .         .         .         .          | 02            g.9893
 tgcctcacccacagcttttgatatctaggaggactcttctctcccaaact | acctgtcacc    c.-1

          .         .         .         .         .         .       g.9953
 ATGGCCCACCGATTTCCAGCCCTCACCCAGGAGCAGAAGAAGGAGCTCTCAGAAATTGCC       c.60
 M  A  H  R  F  P  A  L  T  Q  E  Q  K  K  E  L  S  E  I  A         p.20

          .         .         .         .         .   | 03     .    g.10822
 CAGAGCATTGTTGCCAATGGAAAGGGGATCCTGGCTGCAGATGAATCTGTAG | GTACCATG    c.120
 Q  S  I  V  A  N  G  K  G  I  L  A  A  D  E  S  V  G |   T  M      p.40

          .         .         .         .         .         .       g.10882
 GGGAACCGCCTGCAGAGGATCAAGGTGGAAAACACTGAAGAGAACCGCCGGCAGTTCCGA       c.180
 G  N  R  L  Q  R  I  K  V  E  N  T  E  E  N  R  R  Q  F  R         p.60

          .         .         .         .         .         .       g.10942
 GAAATCCTCTTCTCTGTGGACAGTTCCATCAACCAGAGCATCGGGGGTGTGATCCTTTTC       c.240
 E  I  L  F  S  V  D  S  S  I  N  Q  S  I  G  G  V  I  L  F         p.80

          .         .         .         .         .         .       g.11002
 CACGAGACCCTCTACCAGAAGGACAGCCAGGGAAAGCTGTTCAGAAACATCCTCAAGGAA       c.300
 H  E  T  L  Y  Q  K  D  S  Q  G  K  L  F  R  N  I  L  K  E         p.100

          .         .     | 04   .         .         .         .    g.12293
 AAGGGGATCGTGGTGGGAATCAAG | TTAGACCAAGGAGGTGCTCCTCTTGCAGGAACAAAC    c.360
 K  G  I  V  V  G  I  K   | L  D  Q  G  G  A  P  L  A  G  T  N      p.120

          .          | 05        .         .         .         .    g.13179
 AAAGAAACCACCATTCAAG | GGCTTGATGGCCTCTCAGAGCGCTGTGCTCAGTACAAGAAA    c.420
 K  E  T  T  I  Q  G |   L  D  G  L  S  E  R  C  A  Q  Y  K  K      p.140

          .         .         .         .         .         .       g.13239
 GATGGTGTTGACTTTGGGAAGTGGCGTGCTGTGCTGAGGATTGCCGACCAGTGTCCATCC       c.480
 D  G  V  D  F  G  K  W  R  A  V  L  R  I  A  D  Q  C  P  S         p.160

          .         .         .         .         .         .       g.13299
 AGCCTCGCTATCCAGGAAAACGCCAACGCCCTGGCTCGCTACGCCAGCATCTGTCAGCAG       c.540
 S  L  A  I  Q  E  N  A  N  A  L  A  R  Y  A  S  I  C  Q  Q         p.180

  | 06       .         .         .         .         .         .    g.14202
  | AATGGACTGGTACCTATTGTTGAACCAGAGGTAATTCCTGATGGAGACCATGACCTGGAA    c.600
  | N  G  L  V  P  I  V  E  P  E  V  I  P  D  G  D  H  D  L  E      p.200

          .         .     | 07   .         .         .         .    g.15189
 CACTGCCAGTATGTTACTGAGAAG | GTCCTGGCTGCTGTCTACAAGGCCCTGAATGACCAT    c.660
 H  C  Q  Y  V  T  E  K   | V  L  A  A  V  Y  K  A  L  N  D  H      p.220

          .         .         .         .         .         .       g.15249
 CATGTTTACCTGGAGGGCACCCTGCTAAAGCCCAACATGGTGACTGCTGGACATGCCTGC       c.720
 H  V  Y  L  E  G  T  L  L  K  P  N  M  V  T  A  G  H  A  C         p.240

          .         .         .         .         .         .       g.15309
 ACCAAGAAGTATACTCCAGAACAAGTAGCTATGGCCACCGTAACAGCTCTCCACCGTACT       c.780
 T  K  K  Y  T  P  E  Q  V  A  M  A  T  V  T  A  L  H  R  T         p.260

          .          | 08        .         .         .         .    g.15779
 GTTCCTGCAGCTGTTCCTG | GCATCTGCTTTTTGTCTGGTGGCATGAGTGAAGAGGATGCC    c.840
 V  P  A  A  V  P  G |   I  C  F  L  S  G  G  M  S  E  E  D  A      p.280

          .         .         .         .         .         .       g.15839
 ACTCTCAACCTCAATGCTATCAACCTTTGCCCTCTACCAAAGCCCTGGAAACTAAGTTTC       c.900
 T  L  N  L  N  A  I  N  L  C  P  L  P  K  P  W  K  L  S  F         p.300

          .         .         .         .         .         .       g.15899
 TCTTATGGACGGGCCCTGCAGGCCAGTGCACTGGCTGCCTGGGGTGGCAAGGCTGCAAAC       c.960
 S  Y  G  R  A  L  Q  A  S  A  L  A  A  W  G  G  K  A  A  N         p.320

          .         .         .          | 09        .         .    g.18897
 AAGGAGGCAACCCAGGAGGCTTTTATGAAGCGGGCCATG | GCTAACTGCCAGGCGGCCAAA    c.1020
 K  E  A  T  Q  E  A  F  M  K  R  A  M   | A  N  C  Q  A  A  K      p.340

          .         .         .         .         .         .       g.18957
 GGACAGTATGTTCACACGGGTTCTTCTGGGGCTGCTTCCACCCAGTCGCTCTTCACAGCC       c.1080
 G  Q  Y  V  H  T  G  S  S  G  A  A  S  T  Q  S  L  F  T  A         p.360

          .                                                         g.18972
 TGCTATACCTACTAG                                                    c.1095
 C  Y  T  Y  X                                                      p.364

          .         .         .         .         .         .       g.19032
 ggtccaatgcccgccagcctagctccagtgcttctagtaggagggctgaaagggagcaac       c.*60

          .         .         .         .         .         .       g.19092
 ttttcctccaatcctggaaattcgacacaattagatttgaactgctggaaatacaacaca       c.*120

          .         .         .         .         .         .       g.19152
 tgttaaatcttaagtacaagggggaaaaaataaatcagttattgaaacataaaaatgaat       c.*180

          .         .         .         .         .         .       g.19212
 accaaggacctgatcaaatttcacacagcagtttccttgcaacactttcagctccccatg       c.*240

          .         .         .         .         .         .       g.19272
 ctccagaatacccacccaagaaaataataggctttaaaacaatatcggctcctcatccaa       c.*300

          .         .         .         .         .         .       g.19332
 agaacaactgctgattgaaacacctcattagctgagtgtagagaagtgcatcttatgaaa       c.*360

          .         .         .         .         .         .       g.19392
 cagtcttagcagtggtaggttgggaaggagatagctgcaaccaaaaaagaaataaatatt       c.*420

          .         .         .         .         .         .       g.19452
 ctataaaccttcagctgctatcgggtttcacttttctgctcttgctgtccaaagactcag       c.*480

          .         .         .         .         .         .       g.19512
 tgtatttcattacttttgactctactagacatgactgggtttcaacagtaaaggtcttca       c.*540

          .         .         .         .         .         .       g.19572
 actcttgctagtcattggaatcaagccgcaaaattttaaaaactgagatgctcaggccac       c.*600

          .         .         .         .         .         .       g.19632
 accccagctcaattaaatcagaaaccctagacttgggatcctctaactattagatttctt       c.*660

          .         .         .         .         .         .       g.19692
 aaagctccctcagtaattccaatgtacagtcaagtttgagaactaccaatctaaatttca       c.*720

          .         .         .         .         .         .       g.19752
 agtttgagggtatttgaaaattaaagccattcacaatacgaagccagctaaaaatgtaga       c.*780

          .         .         .         .         .         .       g.19812
 atgattttgagcaacttgtggagtataataagagaattaatgtgacttcaatgcttggag       c.*840

          .         .         .         .         .         .       g.19872
 cattcttgttcaagtggcccaggtttggtgaaacaggactaccttgtcatctgcacgtcc       c.*900

          .         .         .         .         .         .       g.19932
 aggcatatttcgtagttttgcagtaaataatattcacataatgatactgtattgactttc       c.*960

          .         .         .         .         .         .       g.19992
 aattttcagaattaacctatagttacagcacttaagacaaccagagttataaaagagaat       c.*1020

          .         .         .         .         .         .       g.20052
 ttaaatattataactttggacaatataaaagtgatgatttaactgacagaagctaggaaa       c.*1080

          .         .         .         .         .         .       g.20112
 tataagggggaggagaagtggaagaaagcaaagagagtcaggaatactacttaaaactga       c.*1140

          .         .         .         .         .         .       g.20172
 tgggttaagaaatagtgctttaattctatttaagtaataaaagaaatggatgtaaatcat       c.*1200

          .         .         .         .                           g.20221
 aaaaatatatatctaaaattaaaatattgatggtagtatgctaaatttc                  c.*1249

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Aldolase B, fructose-bisphosphate protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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