asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) (ALG2) - coding DNA reference sequence

(used for variant description)

(last modified October 23, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_033087.3 in the ALG2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008928.1, covering ALG2 transcript NM_033087.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   gagctacgag       c.-61

 .         .         .         .         .         .                g.5070
 cgcggagcttgcgcagaagacccccatcagggtgcggggtgcagttgcggctccagggcc       c.-1

          .         .         .         .         .         .       g.5130
 ATGGCGGAGGAGCAGGGCCGGGAACGGGACTCGGTTCCCAAGCCGTCGGTGCTGTTCCTC       c.60
 M  A  E  E  Q  G  R  E  R  D  S  V  P  K  P  S  V  L  F  L         p.20

          .         .         .         .         .         .       g.5190
 CACCCAGACCTGGGCGTGGGCGGCGCTGAGCGGCTGGTGTTGGACGCGGCGCTGGCGCTG       c.120
 H  P  D  L  G  V  G  G  A  E  R  L  V  L  D  A  A  L  A  L         p.40

          .         .         .         .         .         .       g.5250
 CAGGCGCGCGGGTGTAGCGTGAAGATCTGGACAGCGCACTACGACCCGGGCCACTGTTTC       c.180
 Q  A  R  G  C  S  V  K  I  W  T  A  H  Y  D  P  G  H  C  F         p.60

          .         .         .         .         .         .       g.5310
 GCCGAGAGCCGCGAGCTACCGGTGCGCTGTGCCGGGGACTGGCTGCCGCGAGGCCTGGGC       c.240
 A  E  S  R  E  L  P  V  R  C  A  G  D  W  L  P  R  G  L  G         p.80

          .         .         .         .         .         .       g.5370
 TGGGGCGGCCGCGGCGCCGCCGTCTGCGCCTACGTGCGCATGGTTTTCCTGGCGCTCTAC       c.300
 W  G  G  R  G  A  A  V  C  A  Y  V  R  M  V  F  L  A  L  Y         p.100

          .         .         .         .         | 02         .    g.8140
 GTGCTGTTCCTCGCCGACGAGGAGTTCGACGTGGTAGTGTGCGACCAG | GTGTCTGCCTGT    c.360
 V  L  F  L  A  D  E  E  F  D  V  V  V  C  D  Q   | V  S  A  C      p.120

          .         .         .         .         .         .       g.8200
 ATCCCAGTGTTCAGGCTGGCTAGACGGCGGAAGAAGATCCTATTTTACTGTCACTTCCCA       c.420
 I  P  V  F  R  L  A  R  R  R  K  K  I  L  F  Y  C  H  F  P         p.140

          .         .         .         .         .         .       g.8260
 GATCTGCTTCTCACCAAGAGAGATTCTTTTCTTAAACGACTATACAGGGCCCCAATTGAC       c.480
 D  L  L  L  T  K  R  D  S  F  L  K  R  L  Y  R  A  P  I  D         p.160

          .         .         .         .         .         .       g.8320
 TGGATAGAGGAATACACCACAGGCATGGCAGACTGCATCTTAGTCAACAGCCAGTTCACA       c.540
 W  I  E  E  Y  T  T  G  M  A  D  C  I  L  V  N  S  Q  F  T         p.180

          .         .         .         .         .         .       g.8380
 GCTGCTGTTTTTAAGGAAACATTCAAGTCCCTGTCTCACATAGACCCTGATGTCCTCTAT       c.600
 A  A  V  F  K  E  T  F  K  S  L  S  H  I  D  P  D  V  L  Y         p.200

          .         .         .         .         .         .       g.8440
 CCATCTCTAAATGTCACCAGCTTTGACTCAGTTGTTCCTGAAAAGCTGGATGACCTAGTC       c.660
 P  S  L  N  V  T  S  F  D  S  V  V  P  E  K  L  D  D  L  V         p.220

          .         .         .         .         .         .       g.8500
 CCCAAGGGGAAAAAATTCCTGCTGCTCTCCATCAACAGATACGAAAGGAAGAAAAATCTG       c.720
 P  K  G  K  K  F  L  L  L  S  I  N  R  Y  E  R  K  K  N  L         p.240

          .         .         .         .         .         .       g.8560
 ACTTTGGCACTGGAAGCCCTAGTACAGCTGCGTGGAAGATTGACATCCCAAGATTGGGAG       c.780
 T  L  A  L  E  A  L  V  Q  L  R  G  R  L  T  S  Q  D  W  E         p.260

          .         .         .         .         .         .       g.8620
 AGGGTTCATCTGATCGTGGCAGGTGGTTATGACGAGAGAGTCCTGGAGAATGTGGAACAT       c.840
 R  V  H  L  I  V  A  G  G  Y  D  E  R  V  L  E  N  V  E  H         p.280

          .         .         .         .         .         .       g.8680
 TATCAGGAATTGAAGAAAATGGTCCAACAGTCCGACCTTGGCCAGTATGTGACCTTCTTG       c.900
 Y  Q  E  L  K  K  M  V  Q  Q  S  D  L  G  Q  Y  V  T  F  L         p.300

          .         .         .         .         .         .       g.8740
 AGGTCTTTCTCAGACAAACAGAAAATCTCCCTCCTCCACAGCTGCACGTGTGTGCTTTAC       c.960
 R  S  F  S  D  K  Q  K  I  S  L  L  H  S  C  T  C  V  L  Y         p.320

          .         .         .         .         .         .       g.8800
 ACACCAAGCAATGAGCACTTTGGCATTGTCCCTCTGGAAGCCATGTACATGCAGTGCCCA       c.1020
 T  P  S  N  E  H  F  G  I  V  P  L  E  A  M  Y  M  Q  C  P         p.340

          .         .         .         .         .         .       g.8860
 GTCATTGCTGTTAATTCGGGTGGACCCTTGGAGTCCATTGACCACAGTGTCACAGGGTTT       c.1080
 V  I  A  V  N  S  G  G  P  L  E  S  I  D  H  S  V  T  G  F         p.360

          .         .         .         .         .         .       g.8920
 CTGTGTGAGCCTGACCCGGTGCACTTCTCAGAAGCAATAGAAAAGTTCATCCGTGAACCT       c.1140
 L  C  E  P  D  P  V  H  F  S  E  A  I  E  K  F  I  R  E  P         p.380

          .         .         .         .         .         .       g.8980
 TCCTTAAAAGCCACCATGGGCCTGGCTGGAAGAGCCAGAGTGAAGGAAAAATTTTCCCCT       c.1200
 S  L  K  A  T  M  G  L  A  G  R  A  R  V  K  E  K  F  S  P         p.400

          .         .         .         .         .                 g.9031
 GAAGCATTTACAGAACAGCTCTACCGATATGTTACCAAACTGCTGGTATAA                c.1251
 E  A  F  T  E  Q  L  Y  R  Y  V  T  K  L  L  V  X                  p.416

          .         .         .         .         .         .       g.9091
 tcagattgtttttaagatctccattaatgtcatttttatggattgtagacccagttttga       c.*60

          .         .         .         .         .         .       g.9151
 aaccaaaaaagaaacctagaatctaatgcagaagagatcttttaaaaaataaacttgagt       c.*120

          .         .         .         .         .         .       g.9211
 cttgaatgtgagccactttcctatataccacacctccctgtccacttttcagaaaaacca       c.*180

          .         .         .         .         .         .       g.9271
 tgtcttttatgctataatcattccaaattttgccagtgttaagttacaaatgtggtgtca       c.*240

          .         .         .         .         .         .       g.9331
 ttccatgttcagcagagtattttaattatattttctcgggattattgctcttctgtctat       c.*300

          .         .         .         .         .         .       g.9391
 aaattttgaatgatactgtgccttaattggttttcatagtttaagtgtgtatcattatca       c.*360

          .         .         .         .         .         .       g.9451
 aagttgattaatttggcttcatagtataatgagagcagggctattgtagttcccagattc       c.*420

          .         .         .         .         .         .       g.9511
 aatccaccgaagtgttcactgtcatctgttagggaatttttgtttgtcctgtctttgcct       c.*480

          .         .         .         .         .         .       g.9571
 ggatccatagcgagagtgctctgtattttttttaagataatttgtatttttgcacactga       c.*540

          .         .         .         .         .         .       g.9631
 gatataataaaaggtgtttatcataaaaaagaaacagtattagattttggtctccataat       c.*600

          .         .         .         .         .         .       g.9691
 ctattttggtattgttacgaacatggatatgacaaccaaactggaaatcagaacactagg       c.*660

          .         .         .         .         .         .       g.9751
 gtaaagtggatattgaaatgaagcaagaatattgtcacacatgtgttgtgcatcttgttt       c.*720

          .         .         .         .         .         .       g.9811
 agggtatatttcttaatgtcatctaggtcattagttttgttaatatttgtgttgtcttga       c.*780

          .         .         .         .         .         .       g.9871
 ccaagctcctactaagtataggacacaaatgttttttatcttccaaggcctggctcaaat       c.*840

          .         .         .         .         .         .       g.9931
 gccactgctgcaaagctttctttgaccctctggccacctcccaagccagaagttatcttc       c.*900

          .         .         .         .         .         .       g.9991
 cccctccatgtactctagccttttcatgacactgatattttcgtgacactgacttatagt       c.*960

          .         .         .         .         .         .       g.10051
 tcactgtttacctgttggtctaacagcaaatcataaacagtagttttcaacatacttcta       c.*1020

          .         .         .         .         .         .       g.10111
 aggctaaattcatttccagaagtagcaaagcttactagccaaaggctccacatttatcaa       c.*1080

          .         .         .         .         .         .       g.10171
 ctcttaagagctagacttgagagcctaacagcctatatgattttgtgtaaattgatctct       c.*1140

          .         .         .         .         .         .       g.10231
 atacctcagcttcttcatctgcaaagtgagataattgtactattctactttcctcatagt       c.*1200

          .         .         .         .         .         .       g.10291
 gcggttataacagattatgataatattacaaagtacttaatacttggcatatagtatata       c.*1260

          .         .         .         .         .         .       g.10351
 tattagctattagtattttgcaatttggggatattgaaaattagaaattgcatgttagtt       c.*1320

          .         .         .         .         .         .       g.10411
 catgctgcactaccatattgttcttttggggctcttcaatgggtgaaattccattttaca       c.*1380

          .         .         .         .         .         .       g.10471
 gtttatcatgtgcatctgtatcacaggagtattttggcaaaatgattctgtaccaaaaag       c.*1440

          .         .         .         .         .         .       g.10531
 gagtactataaaatgagggtgccaaatatattgagtcttttatgggattaaaagttctgt       c.*1500

                                                                    g.10540
 tgcattcca                                                          c.*1509

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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