alkB, alkylation repair homolog 8 (E. coli) (ALKBH8) - coding DNA reference sequence

(used for variant description)

(last modified November 11, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_138775.2 in the ALKBH8 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering ALKBH8 transcript NM_138775.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        agttttctccaacatggccgc       c.-121

 .         .         .         .         .         .                g.5081
 gcccaggggagatggcgtgcaagtatccgctgcggtgttctggtgctagagtggagaggc       c.-61

 .         .         .         .         .         .    | 02        g.9842
 tggcaaagaagaaggcacacgcatggtgagaatccggcctgagccgaagcggag | tttgct    c.-1

          .         .         .         .         .         .       g.9902
 ATGGACAGCAACCATCAAAGTAATTACAAACTCAGTAAAACTGAGAAGAAGTTCTTAAGG       c.60
 M  D  S  N  H  Q  S  N  Y  K  L  S  K  T  E  K  K  F  L  R         p.20

          .         .         .         .         .         .       g.9962
 AAACAGATTAAAGCCAAGCATACTTTGCTGAGACATGAAGGCATTGAGACAGTATCCTAT       c.120
 K  Q  I  K  A  K  H  T  L  L  R  H  E  G  I  E  T  V  S  Y         p.40

           | 03        .         .         .         .         .    g.13783
 GCCACTCAG | AGCCTGGTTGTTGCCAATGGTGGTTTGGGTAATGGTGTGAGTCGGAACCAG    c.180
 A  T  Q   | S  L  V  V  A  N  G  G  L  G  N  G  V  S  R  N  Q      p.60

          .         .         .         .         .         .       g.13843
 CTGCTCCCGGTTTTAGAGAAATGTGGACTGGTGGATGCTCTCTTAATGCCACCTAACAAG       c.240
 L  L  P  V  L  E  K  C  G  L  V  D  A  L  L  M  P  P  N  K         p.80

          .         .         .         .         .         .       g.13903
 CCGTACTCATTTGCAAGATACAGAACTACAGAAGAATCTAAGAGAGCCTATGTTACCCTC       c.300
 P  Y  S  F  A  R  Y  R  T  T  E  E  S  K  R  A  Y  V  T  L         p.100

          .         .         .         .         .         .       g.13963
 AATGGAAAAGAAGTAGTGGATGATTTAGGACAAAAGATCACTCTGTATTTGAATTTTGTG       c.360
 N  G  K  E  V  V  D  D  L  G  Q  K  I  T  L  Y  L  N  F  V         p.120

         | 04.         .         .         .         .         .    g.16810
 GAAAAAG | TGCAGTGGAAGGAGTTGAGGCCTCAAGCCTTACCACCAGGACTCATGGTAGTA    c.420
 E  K  V |   Q  W  K  E  L  R  P  Q  A  L  P  P  G  L  M  V  V      p.140

          .         .         .         .         .         .       g.16870
 GAAGAAATAATTTCTTCTGAGGAGGAGAAAATGCTTTTGGAAAGTGTTGATTGGACAGAA       c.480
 E  E  I  I  S  S  E  E  E  K  M  L  L  E  S  V  D  W  T  E         p.160

          .          | 05        .         .         .         .    g.17573
 GATACAGACAATCAAAACT | CTCAAAAATCCTTAAAACACAGAAGAGTAAAGCATTTTGGT    c.540
 D  T  D  N  Q  N  S |   Q  K  S  L  K  H  R  R  V  K  H  F  G      p.180

          .         .         .         .         .      | 06  .    g.18828
 TATGAGTTCCACTATGAGAACAACAATGTAGATAAAGATAAGCCATTATCTGGGG | GTCTT    c.600
 Y  E  F  H  Y  E  N  N  N  V  D  K  D  K  P  L  S  G  G |   L      p.200

          .         .         .         .         .         .       g.18888
 CCTGACATTTGTGAAAGCTTTTTGGAGAAATGGTTGAGGAAAGGTTACATTAAACATAAA       c.660
 P  D  I  C  E  S  F  L  E  K  W  L  R  K  G  Y  I  K  H  K         p.220

          .         .         .         . | 07       .         .    g.20932
 CCTGATCAAATGACCATAAATCAGTATGAACCTGGGCAAG | GAATTCCCGCTCATATTGAT    c.720
 P  D  Q  M  T  I  N  Q  Y  E  P  G  Q  G |   I  P  A  H  I  D      p.240

          .         .         .         .         .  | 08      .    g.38338
 ACACATTCCGCTTTTGAGGATGAGATCGTTTCTCTCAGTTTGGGGTCAGAG | ATTGTCATG    c.780
 T  H  S  A  F  E  D  E  I  V  S  L  S  L  G  S  E   | I  V  M      p.260

          .         .         .         .         .         .       g.38398
 GATTTTAAGCACCCAGATGGCATTGCAGTGCCAGTTATGTTGCCTCGTCGGAGTTTGCTG       c.840
 D  F  K  H  P  D  G  I  A  V  P  V  M  L  P  R  R  S  L  L         p.280

          .         .         .         | 09         .         .    g.45165
 GTGATGACAGGAGAATCTAGATACCTTTGGACCCATGG | AATCACGTGCAGAAAATTTGAT    c.900
 V  M  T  G  E  S  R  Y  L  W  T  H  G  |  I  T  C  R  K  F  D      p.300

          .         .         .         .         .         .       g.45225
 ACTGTTCAAGCATCTGAGAGTCTTAAAAGTGGAATTATCACCAGTGATGTTGGAGACTTA       c.960
 T  V  Q  A  S  E  S  L  K  S  G  I  I  T  S  D  V  G  D  L         p.320

          .         .         .         .         .         .       g.45285
 ACTTTAAGCAAGAGGGGACTACGAACATCATTTACATTTAGGAAAGTGAGGCAAACACCT       c.1020
 T  L  S  K  R  G  L  R  T  S  F  T  F  R  K  V  R  Q  T  P         p.340

          . | 10       .         .         .         .         .    g.48230
 TGTAACTGTA | GTTACCCGTTGGTCTGTGATAGCCAGAGGAAAGAGACTCCCCCCTCATTT    c.1080
 C  N  C  S |   Y  P  L  V  C  D  S  Q  R  K  E  T  P  P  S  F      p.360

          .         .         .         .         .         .       g.48290
 CCAGAGAGTGATAAAGAAGCCTCACGGCTGGAGCAAGAGTACGTCCATCAGGTTTATGAA       c.1140
 P  E  S  D  K  E  A  S  R  L  E  Q  E  Y  V  H  Q  V  Y  E         p.380

          .         .         .         .         .         .       g.48350
 GAGATTGCTGGGCACTTCAGCAGCACAAGACATACCCCTTGGCCGCACATTGTGGAGTTT       c.1200
 E  I  A  G  H  F  S  S  T  R  H  T  P  W  P  H  I  V  E  F         p.400

          .         .         .         .         .         .       g.48410
 TTGAAGGCTTTGCCAAGTGGTTCAATAGTGGCTGATATTGGATGTGGTAATGGAAAGTAT       c.1260
 L  K  A  L  P  S  G  S  I  V  A  D  I  G  C  G  N  G  K  Y         p.420

          .         .        | 11.         .         .         .    g.59732
 CTTGGCATCAATAAGGAGTTATATATG | ATTGGTTGTGATCGTAGCCAAAACCTTGTGGAC    c.1320
 L  G  I  N  K  E  L  Y  M   | I  G  C  D  R  S  Q  N  L  V  D      p.440

          .         .         .         .         .         .       g.59792
 ATTTGTAGAGAGAGGCAATTTCAGGCTTTTGTCTGTGATGCATTGGCAGTACCAGTCCGC       c.1380
 I  C  R  E  R  Q  F  Q  A  F  V  C  D  A  L  A  V  P  V  R         p.460

          .         .         .         .         .        | 12.    g.65523
 AGTGGGTCTTGTGATGCCTGCATCTCCATTGCTGTTATTCATCATTTTGCAACAGCA | GAG    c.1440
 S  G  S  C  D  A  C  I  S  I  A  V  I  H  H  F  A  T  A   | E      p.480

          .         .         .         .         .         .       g.65583
 CGTAGAGTGGCAGCTCTCCAAGAAATTGTTCGACTCCTGAGACCAGGTGGGAAGGCACTC       c.1500
 R  R  V  A  A  L  Q  E  I  V  R  L  L  R  P  G  G  K  A  L         p.500

          .         .         .         .         .         .       g.65643
 ATTTATGTCTGGGCAATGGAACAAGAATATAATAAGCAGAAGTCCAAGTATCTTAGAGGA       c.1560
 I  Y  V  W  A  M  E  Q  E  Y  N  K  Q  K  S  K  Y  L  R  G         p.520

          .         .         .         .         .         .       g.65703
 AACAGAAATAGCCAAGGAAAGAAAGAGGAGATGAACAGTGATACCTCAGTGCAGAGGTCA       c.1620
 N  R  N  S  Q  G  K  K  E  E  M  N  S  D  T  S  V  Q  R  S         p.540

          .         .         .         .         .         .       g.65763
 CTTGTGGAGCAAATGCGTGACATGGGCAGTCGAGACTCGGCATCTTCTGTCCCCCGCATT       c.1680
 L  V  E  Q  M  R  D  M  G  S  R  D  S  A  S  S  V  P  R  I         p.560

          .         .         .         .         .         .       g.65823
 AATGACTCTCAGGAAGGAGGATGTAATTCAAGGCAAGTTTCTAATTCCAAGCTGCCTGTT       c.1740
 N  D  S  Q  E  G  G  C  N  S  R  Q  V  S  N  S  K  L  P  V         p.580

          .         .         .         .         .         .       g.65883
 CATGTTAACAGGACTTCTTTTTATTCTCAAGATGTACTGGTTCCCTGGCACCTTAAGGGA       c.1800
 H  V  N  R  T  S  F  Y  S  Q  D  V  L  V  P  W  H  L  K  G         p.600

          .         .         .         .         .         .       g.65943
 AATCCTGATAAAGGCAAACCTGTTGAGCCATTTGGTCCCATAGGATCCCAGGACCCAAGT       c.1860
 N  P  D  K  G  K  P  V  E  P  F  G  P  I  G  S  Q  D  P  S         p.620

          .         .         .         .         .         .       g.66003
 CCTGTGTTTCATCGTTACTACCATGTGTTCCGTGAGGGAGAACTGGAAGGTGCCTGCAGG       c.1920
 P  V  F  H  R  Y  Y  H  V  F  R  E  G  E  L  E  G  A  C  R         p.640

          .         .         .         .         .         .       g.66063
 ACTGTGAGTGATGTCAGAATTCTGCAAAGCTACTACGATCAAGGAAACTGGTGTGTGATT       c.1980
 T  V  S  D  V  R  I  L  Q  S  Y  Y  D  Q  G  N  W  C  V  I         p.660

          .                                                         g.66078
 CTTCAAAAGGCCTGA                                                    c.1995
 L  Q  K  A  X                                                      p.664

          .         .         .         .         .         .       g.66138
 ttatttacctgaacacatcatatataaagaagaaatgctcacttaaaaaaaaagagagaa       c.*60

          .         .         .         .         .         .       g.66198
 taaattaattacccttttaattaaagagaaaacttgtgggaaagtaccaaaggaaagctg       c.*120

          .         .         .         .         .         .       g.66258
 agaaaaatttggaagtagggattcattaggagacattcaaatgtctcctgttggctgaca       c.*180

          .         .         .         .         .         .       g.66318
 tcacagatgtggtgttggctcctcctacttccctaggagaggtggtttctaaaagtgatt       c.*240

          .         .         .         .         .         .       g.66378
 gaagcagtttgtgcagtgtttgtaattcttgggtaagagcccaggattttgaagataata       c.*300

          .         .         .         .         .         .       g.66438
 gttttttagtaaagtgctactaaatgtagtaaatcatgtaggattttagggatgtaatta       c.*360

          .         .         .         .         .         .       g.66498
 tatgttaatacagaaaatagtcctggtcaatagaaaattgtctgaagttttacctatgat       c.*420

          .         .         .         .         .         .       g.66558
 ttttagctctgtaaaatcatagacaataaccattctatttccatgcctgactagcccagg       c.*480

          .         .         .         .         .         .       g.66618
 gctggacgtatagcgggtgtccaataacgtttagtcaatcagataatacccagaacttag       c.*540

          .         .         .         .         .         .       g.66678
 taggagtttcattcaaaaactattttttgaacccaaccatgtaccagttactattttaag       c.*600

          .         .         .         .         .         .       g.66738
 tactgataatgaagcagtgaataagaaagagcaaagctcttgcccttatggtgcttacat       c.*660

          .         .         .         .         .         .       g.66798
 tctagacggggagacagacagcaggcaaatcaataaatagatactatgtgccagatagtg       c.*720

          .         .         .         .         .         .       g.66858
 ataaatgccatgaaaaacataaaatgagagacgattcaccttggagcaaaagattacttt       c.*780

          .         .         .         .         .         .       g.66918
 taagtgactgaaataactactaatcctgactaatttattatcaagagttaattggtattc       c.*840

          .         .         .         .         .         .       g.66978
 caaattcattgagcagggtgctaaaaacaacccaaatgtgctcctttaactcctttgttt       c.*900

          .         .         .         .         .         .       g.67038
 aaatgacaaaagttagaatgtggtcactcagacctaactgtgcccttagagccaaagctg       c.*960

          .         .         .         .         .         .       g.67098
 tggtgtcattattggttatttctagttgattcatagtttgtcccaatccaggttcaatcg       c.*1020

          .         .         .         .         .         .       g.67158
 ggttatttttaagatctgtacaatattgcataatagtaacccagttaacttaccacttag       c.*1080

          .         .         .         .         .         .       g.67218
 gttagatttcctggaggaacaaaggtagaaattcaaccataggtcaaattatcacataga       c.*1140

          .         .         .         .         .         .       g.67278
 aggaaaaggctttttttcaaagaaaaaattttttgaacactttactcccagtatgcatta       c.*1200

          .         .         .         .         .         .       g.67338
 cttttgtagtagtaatgcttaagactgttttaaagaaaaattgctttctgtttaattaat       c.*1260

          .         .         .         .         .         .       g.67398
 gtttactgttattaatgctagtgatacttaatcttgaagcatcaagttttcagaaaccta       c.*1320

          .         .         .         .         .         .       g.67458
 tagtgatcaataatgggtctcagatgagaggatgattatttttttcatggaatttcagtc       c.*1380

          .         .         .         .         .         .       g.67518
 caacatcctggtgtactggtccctctgggatgaatttataaggctcatgatataggaaaa       c.*1440

          .         .         .         .         .         .       g.67578
 ggaatatagggctaaaaatagttttatttctgatataaattctggtacttgacaccaaag       c.*1500

          .         .         .         .         .         .       g.67638
 tttgaagtcaagtcatgccaataaattttaacatccaaatgaaatagatgattttctatg       c.*1560

          .         .         .         .         .         .       g.67698
 aagatgaaaaataccaaaattgactcaagaagggagagaaaatggaagatgttgaaaaat       c.*1620

          .         .         .         .         .         .       g.67758
 agcataggaattcagaactgggctctagaatcagatttcctgagagttgaattctagatc       c.*1680

          .         .         .         .         .         .       g.67818
 tgccatttattagctgtgggattttgggcaaatttcttgactttctgtgcttcagttttc       c.*1740

          .         .         .         .         .         .       g.67878
 ttagctgtaaaattggaagagttgttatgaaaattcactgaaagtatatttgtatacatc       c.*1800

          .         .         .         .         .         .       g.67938
 ataggatagtgtaagaatatagtatggctttgagaaatgttcattattattactcccaga       c.*1860

          .         .         .         .         .         .       g.67998
 ggagttttaggtattaagtgatgccaaatataatttgttaattgtataataaaaatctat       c.*1920

          .                                                         g.68009
 attcttactga                                                        c.*1931

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The AlkB, alkylation repair homolog 8 (E. coli) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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