alkaline phosphatase, liver/bone/kidney (ALPL) - coding DNA reference sequence

(used for variant description)

(last modified December 1, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000478.4 in the ALPL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008940.1, covering ALPL transcript NM_000478.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            ccgggcctcactcgggc       c.-241

 .         .         .         .         .         .                g.5077
 cccgcggccgcctttataaggcggcgggggtggtggcccgggccgcgttgcgctcccgcc       c.-181

 .         .         .         .         .         .                g.5137
 actccgcgcccgctatcctggctccgtgctcccacgcgcttgtgcctggacggaccctcg       c.-121

 .         .      | 02  .         .         .         .             g.49657
 ccagtgctctgcgcag | gattggaacatcagttaacatctgaccactgccagcccaccccc    c.-61

 .         .         .         .         .         .                g.49717
 tcccacccacgtcgattgcatctctgggctccagggataaagcaggtcttggggtgcacc       c.-1

          .         .         .         .         .         .       g.49777
 ATGATTTCACCATTCTTAGTACTGGCCATTGGCACCTGCCTTACTAACTCCTTAGTGCCA       c.60
 M  I  S  P  F  L  V  L  A  I  G  T  C  L  T  N  S  L  V  P         p.20

   | 03      .         .         .         .         .         .    g.56320
 G | AGAAAGAGAAAGACCCCAAGTACTGGCGAGACCAAGCGCAAGAGACACTGAAATATGCC    c.120
 E |   K  E  K  D  P  K  Y  W  R  D  Q  A  Q  E  T  L  K  Y  A      p.40

          .         .         .         .         .         .       g.56380
 CTGGAGCTTCAGAAGCTCAACACCAACGTGGCTAAGAATGTCATCATGTTCCTGGGAGAT       c.180
 L  E  L  Q  K  L  N  T  N  V  A  K  N  V  I  M  F  L  G  D         p.60

   | 04      .         .         .         .         .         .    g.56791
 G | GGATGGGTGTCTCCACAGTGACGGCTGCCCGCATCCTCAAGGGTCAGCTCCACCACAAC    c.240
 G |   M  G  V  S  T  V  T  A  A  R  I  L  K  G  Q  L  H  H  N      p.80

          .         .         .         .         .        | 05.    g.58748
 CCTGGGGAGGAGACCAGGCTGGAGATGGACAAGTTCCCCTTCGTGGCCCTCTCCAAG | ACG    c.300
 P  G  E  E  T  R  L  E  M  D  K  F  P  F  V  A  L  S  K   | T      p.100

          .         .         .         .         .         .       g.58808
 TACAACACCAATGCCCAGGTCCCTGACAGTGCCGGCACCGCCACCGCCTACCTGTGTGGG       c.360
 Y  N  T  N  A  Q  V  P  D  S  A  G  T  A  T  A  Y  L  C  G         p.120

          .         .         .         .         .         .       g.58868
 GTGAAGGCCAATGAGGGCACCGTGGGGGTAAGCGCAGCCACTGAGCGTTCCCGGTGCAAC       c.420
 V  K  A  N  E  G  T  V  G  V  S  A  A  T  E  R  S  R  C  N         p.140

          .         .         .         .         .   | 06     .    g.59684
 ACCACCCAGGGGAACGAGGTCACCTCCATCCTGCGCTGGGCCAAGGACGCTG | GGAAATCT    c.480
 T  T  Q  G  N  E  V  T  S  I  L  R  W  A  K  D  A  G |   K  S      p.160

          .         .         .         .         .         .       g.59744
 GTGGGCATTGTGACCACCACGAGAGTGAACCATGCCACCCCCAGCGCCGCCTACGCCCAC       c.540
 V  G  I  V  T  T  T  R  V  N  H  A  T  P  S  A  A  Y  A  H         p.180

          .         .         .         .         .         .       g.59804
 TCGGCTGACCGGGACTGGTACTCAGACAACGAGATGCCCCCTGAGGCCTTGAGCCAGGGC       c.600
 S  A  D  R  D  W  Y  S  D  N  E  M  P  P  E  A  L  S  Q  G         p.200

          .         .         .         .         | 07         .    g.63751
 TGTAAGGACATCGCCTACCAGCTCATGCATAACATCAGGGACATTGAC | GTGATCATGGGG    c.660
 C  K  D  I  A  Y  Q  L  M  H  N  I  R  D  I  D   | V  I  M  G      p.220

          .         .         .         .         .         .       g.63811
 GGTGGCCGGAAATACATGTACCCCAAGAATAAAACTGATGTGGAGTATGAGAGTGACGAG       c.720
 G  G  R  K  Y  M  Y  P  K  N  K  T  D  V  E  Y  E  S  D  E         p.240

          .         .         .         .         .         .       g.63871
 AAAGCCAGGGGCACGAGGCTGGACGGCCTGGACCTCGTTGACACCTGGAAGAGCTTCAAA       c.780
 K  A  R  G  T  R  L  D  G  L  D  L  V  D  T  W  K  S  F  K         p.260

          .   | 08     .         .         .         .         .    g.65988
 CCGAGATACAAG | CACTCCCACTTCATCTGGAACCGCACGGAACTCCTGACCCTTGACCCC    c.840
 P  R  Y  K   | H  S  H  F  I  W  N  R  T  E  L  L  T  L  D  P      p.280

          .         .   | 09     .         .         .         .    g.69338
 CACAATGTGGACTACCTATTGG | GTCTCTTCGAGCCAGGGGACATGCAGTACGAGCTGAAC    c.900
 H  N  V  D  Y  L  L  G |   L  F  E  P  G  D  M  Q  Y  E  L  N      p.300

          .         .         .         .         .         .       g.69398
 AGGAACAACGTGACGGACCCGTCACTCTCCGAGATGGTGGTGGTGGCCATCCAGATCCTG       c.960
 R  N  N  V  T  D  P  S  L  S  E  M  V  V  V  A  I  Q  I  L         p.320

          .         .         .        | 10.         .         .    g.71391
 CGGAAGAACCCCAAAGGCTTCTTCTTGCTGGTGGAAG | GAGGCAGAATTGACCACGGGCAC    c.1020
 R  K  N  P  K  G  F  F  L  L  V  E  G |   G  R  I  D  H  G  H      p.340

          .         .         .         .         .         .       g.71451
 CATGAAGGAAAAGCCAAGCAGGCCCTGCATGAGGCGGTGGAGATGGACCGGGCCATCGGG       c.1080
 H  E  G  K  A  K  Q  A  L  H  E  A  V  E  M  D  R  A  I  G         p.360

          .         .         .         .         .         .       g.71511
 CAGGCAGGCAGCTTGACCTCCTCGGAAGACACTCTGACCGTGGTCACTGCGGACCATTCC       c.1140
 Q  A  G  S  L  T  S  S  E  D  T  L  T  V  V  T  A  D  H  S         p.380

          .         .         .         .          | 11        .    g.72168
 CACGTCTTCACATTTGGTGGATACACCCCCCGTGGCAACTCTATCTTTG | GTCTGGCCCCC    c.1200
 H  V  F  T  F  G  G  Y  T  P  R  G  N  S  I  F  G |   L  A  P      p.400

          .         .         .         .         .         .       g.72228
 ATGCTGAGTGACACAGACAAGAAGCCCTTCACTGCCATCCTGTATGGCAATGGGCCTGGC       c.1260
 M  L  S  D  T  D  K  K  P  F  T  A  I  L  Y  G  N  G  P  G         p.420

          .         .         .         .          | 12        .    g.73029
 TACAAGGTGGTGGGCGGTGAACGAGAGAATGTCTCCATGGTGGACTATG | CTCACAACAAC    c.1320
 Y  K  V  V  G  G  E  R  E  N  V  S  M  V  D  Y  A |   H  N  N      p.440

          .         .         .         .         .         .       g.73089
 TACCAGGCGCAGTCTGCTGTGCCCCTGCGCCACGAGACCCACGGCGGGGAGGACGTGGCC       c.1380
 Y  Q  A  Q  S  A  V  P  L  R  H  E  T  H  G  G  E  D  V  A         p.460

          .         .         .         .         .         .       g.73149
 GTCTTCTCCAAGGGCCCCATGGCGCACCTGCTGCACGGCGTCCACGAGCAGAACTACGTC       c.1440
 V  F  S  K  G  P  M  A  H  L  L  H  G  V  H  E  Q  N  Y  V         p.480

          .         .         .         .         .         .       g.73209
 CCCCACGTGATGGCGTATGCAGCCTGCATCGGGGCCAACCTCGGCCACTGTGCTCCTGCC       c.1500
 P  H  V  M  A  Y  A  A  C  I  G  A  N  L  G  H  C  A  P  A         p.500

          .         .         .         .         .         .       g.73269
 AGCTCGGCAGGCAGCCTTGCTGCAGGCCCCCTGCTGCTCGCGCTGGCCCTCTACCCCCTG       c.1560
 S  S  A  G  S  L  A  A  G  P  L  L  L  A  L  A  L  Y  P  L         p.520

          .                                                         g.73284
 AGCGTCCTGTTCTGA                                                    c.1575
 S  V  L  F  X                                                      p.524

          .         .         .         .         .         .       g.73344
 gggcccagggcccgggcacccacaagcccgtgacagatgccaacttcccacacggcagcc       c.*60

          .         .         .         .         .         .       g.73404
 cccccctcaaggggcagggaggtgggggcctcctcagcctctgcaactgcaagaaagggg       c.*120

          .         .         .         .         .         .       g.73464
 acccaagaaaccaaagtctgccgcccacctcgctcccctctggaatcttccccaagggcc       c.*180

          .         .         .         .         .         .       g.73524
 aaacccacttctggcctccagcctttgctccctccccgctgccctttggccaacagggta       c.*240

          .         .         .         .         .         .       g.73584
 gatttctcttgggcaggcagagagtacagactgcagacattctcaaagcctcttattttt       c.*300

          .         .         .         .         .         .       g.73644
 ctagcgaacgtatttctccagacccagaggccctgaagcctccgtggaacattctggatc       c.*360

          .         .         .         .         .         .       g.73704
 tgaccctcccagtctcatctcctgaccctcccactcccatctccttacctctggaacccc       c.*420

          .         .         .         .         .         .       g.73764
 ccaggccctacaatgctcatgtccctgtccccaggcccagccctccttcaggggagttga       c.*480

          .         .         .         .         .         .       g.73824
 ggtctttctcctcaggacaaggccttgctcactcactcactccaagaccaccagggtccc       c.*540

          .         .         .         .         .         .       g.73884
 aggaagccggtgcctgggtggccatcctacccagcgtggcccaggccgggaagagccacc       c.*600

          .         .         .         .         .         .       g.73944
 tggcagggctcacactcctgggctctgaacacacacgccagctcctctctgaagcgactc       c.*660

          .         .         .         .         .         .       g.74004
 tcctgtttggaacggcaaaaaaaaatttttttttctctttttggtggtggttaaaaggga       c.*720

          .         .         .         .                           g.74048
 acacaaaacatttaaataaaactttccaaatatttccgaggaca                       c.*764

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Alkaline phosphatase, liver/bone/kidney protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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